A computational model of a microfluidic device to measure the dynamics of oxygen-dependent ATP release from erythrocytes

PLoS ONE

Volumn 8, Issue 11, 2013, Pages

  Sove, Richard J ^a   Ghonaim, Nour ^a   Goldman, Daniel ^a   Ellis, Christopher Gerald ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; HEMOGLOBIN; LUCIFERASE; LUCIFERIN; OXYGEN;

ARTICLE; ERYTHROCYTE; HEMODYNAMICS; LIGHT INTENSITY; MATHEMATICAL MODEL; MICROFLUIDICS; OXYGEN SATURATION; OXYGEN TRANSPORT; SHEAR STRESS; COMPUTER SIMULATION; METABOLISM; MICROFLUIDIC ANALYSIS; SECRETION (PROCESS);

ADENOSINE TRIPHOSPHATE; COMPUTER SIMULATION; ERYTHROCYTES; HEMODYNAMICS; MICROFLUIDIC ANALYTICAL TECHNIQUES; OXYGEN;

EID: 84896698150     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0081537     Document Type: Article

References (16)

1. Dietrich HH, Ellsworth ML, Sprague RS, Dacey RG (2000) Red blood cell regulation of microvascular tone through adenosine triphosphate. Am J Physiol-Heart C 278(4): H1294.
2. Ellsworth ML, Ellis CG, Goldman D, Stephenson AH, Dietrich HH, et al. (2009) Erythrocytes: Oxygen sensors and modulators of vascular tone. Physiology 24(2): 107.
3. Wan J, Ristenpart WD, Stone HA (2008) Dynamics of shear-induced ATP release from red blood cells. Proc Natl Acad Sci USA 105(43): 16432.
4. Ellsworth M (2000) The red blood cell as an oxygen sensor: What is the evidence? Acta Physiol Scand 168(4): 551-9.
5. Sprague RS, Bowles EA, Achilleus D, Stephenson AH, Ellis CG, et al. (2011) A selective phosphodiesterase 3 inhibitor rescues low PO2-induced ATP release from erythrocytes of humans with type 2 diabetes: Implication for vascular control. Am J Physiol-Heart C 301(6): H2466-72.
6. Ghonaim NW, Lau LWM, Goldman D, Ellis CG, Yang J (2011) A Micro-Delivery approach for studying microvascular responses to localized oxygen delivery. Microcirculation 18(8): 646-54.
7. DeLuca M, McElroy WD (2004) Kinetics of the firefly luciferase catalyzed reactions. (1974) Biochemistry-US 13(5): 921-5.
8. Salama K, Eltoukhy H, Hassibi A, Gamal AE, Modeling and simulation of luminescence detection platforms. Biosens Bioelectron 19(11): 1377-86.
9. Arciero JC, Carlson BE, Secomb TW (2008) Theoretical model of metabolic blood flow regulation: roles of ATP release by red blood cells and conducted responses. Am J Physiol-Heart C 295(4): H1562-71.
10. Pries AR, Neuhaus D, Gaehtgens P (1992) Blood viscosity in tube flow: dependence on diameter and hematocrit. Am J Physiol-Heart C 263: H1770-H1778.
11. Moschandreou TE, Ellis CG, Goldman D (2011) Influence of tissue metabolism and capillary oxygen supply on arteriolar oxygen transport: A computational model. Math Biosci 232(1): 1-10.
12. Moyers-Gonzalez MA, Owens RG (2010) Mathematical modelling of the cell-depleted peripheral layer in the steady flow of blood in a tube. Biorheology 47(1): 39-71.
13. Goldman D, Fraser GM, Ellis CG, Sprague RS, Ellsworth ML, et al. (2012) Toward a multiscale description of microvascular flow regulation: O2 dependant release of ATP from human erythrocytes and distribution of ATP in capillary networks. Front Physiol 3: 246.
14. Zhang W, Stone HA, Sherwood JD (1996). Mass Transfer at a microelectrode in channel flow. J Phys Chem 100: 9462-9464.
15. Ellsworth ML, Pittman R, Ellis CG (1987) Measurement of haemoglobin oxygen saturation in capillaries. Am J Physiol-Heart C 252: H1031-H1040.
16. Hubley MJ, Locke BR, Moerland TS (1996) The effects of temperature, pH, and magnesium on the diffusion coefficient of ATP in solutions of physiological ionic strength. Biochem Biophys Acta 1291(2): 115-121.