Emulsion-based colloidal nanosystems for oral delivery of doxorubicin: Improved intestinal paracellular absorption and alleviated cardiotoxicity

International Journal of Pharmaceutics

Volumn 464, Issue 1-2, 2014, Pages 117-126

  Kim, Ji Eon ^a   Yoon, In Soo ^b   Cho, Hyun Jong ^c   Kim, Dong Hwan ^a   Choi, Young Hee ^d   Kim, Dae Duk ^a  

^a Seoul National University   (South Korea)

^b Mokpo National University   (South Korea)

^c Kangwon National University   (South Korea)

^d Dongguk University   (South Korea)

Author keywords

Cardiotoxicity; Colloidal nanosystem; Doxorubicin; Intestinal paracellular absorption; Medium chain glyceride; Oral delivery

Indexed keywords

DOXORUBICIN; MEDIUM CHAIN ACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARDIOTOXICITY; CELL STRAIN CACO 2; COLLOID; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG RELEASE; EMULSION; HUMAN; HUMAN CELL; IN VIVO STUDY; INTESTINE ABSORPTION; JEJUNUM; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; VISCOSITY;

CARDIOTOXICITY; COLLOIDAL NANOSYSTEM; DOXORUBICIN; INTESTINAL PARACELLULAR ABSORPTION; MEDIUM CHAIN GLYCERIDE; ORAL DELIVERY;

ADMINISTRATION, ORAL; ANIMALS; CACO-2 CELLS; CARDIOTOXINS; DOXORUBICIN; DRUG DELIVERY SYSTEMS; EMULSIONS; HUMANS; INTESTINAL ABSORPTION; MALE; MICE; MICE, INBRED ICR; NANOTECHNOLOGY; RATS;

EID: 84896695023     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2014.01.016     Document Type: Article

References (37)

1. G.L. Amidon, H. Lennernas, V.P. Shah, and J.R. Crison A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability Pharm. Res. 12 1995 413 420
2. P. Artursson, and J. Karlsson Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells Biochem. Biophys. Res. Commun. 175 1991 880 885
3. B.J. Aungst Intestinal permeation enhancers J. Pharm. Sci. 89 2000 429 442
4. D.M. Benival, and P.V. Devarajan Lipomer of doxorubicin hydrochloride for enhanced oral bioavailability Int. J. Pharm. 423 2012 554 561
5. L. Bromberg Polymeric micelles in oral chemotherapy J. Control. Release 128 2008 99 112
6. L. Bromberg, and V. Alakhov Effects of polyether-modified poly(acrylic acid) microgels on doxorubicin transport in human intestinal epithelial Caco-2 cell layers J. Control. Release 88 2003 11 22 (Pubitemid 36175538)
7. M.B. Cheng, J.C. Wang, Y.H. Li, X.Y. Liu, X. Zhang, D.W. Chen, S.F. Zhou, and Q. Zhang Characterization of water-in-oil microemulsion for oral delivery of earthworm fibrinolytic enzyme J. Control. Release 129 2008 41 48
8. J.S. Choi, Y.J. Piao, and K.W. Kang Effects of quercetin on the bioavailability of doxorubicin in rats: role of CYP3A4 and P-gp inhibition by quercetin Arch. Pharm. Res. 34 2011 607 613
9. P.P. Constantinides, J.P. Scalart, C. Lancaster, J. Marcello, G. Marks, H. Ellens, and P.L. Smith Formulation and intestinal absorption enhancement evaluation of water-in-oil microemulsions incorporating medium-chain glycerides Pharm. Res. 11 1994 1385 1390 (Pubitemid 24339642)
10. P.P. Constantinides, G. Welzel, H. Ellens, P.L. Smith, S. Sturgis, S.H. Yiv, and A.B. Owen Water-in-oil microemulsions containing medium-chain fatty acids/salts: formulation and intestinal absorption enhancement evaluation Pharm. Res. 13 1996 210 215 (Pubitemid 26072140)
11. M.D. DeMario, and M.J. Ratain Oral chemotherapy: rationale and future directions J. Clin. Oncol. 16 1998 2557 2567 (Pubitemid 28309055)
12. Y. Dong, and S.S. Feng Poly(d,l-lactide-co-glycolide)/montmorillonite nanoparticles for oral delivery of anticancer drugs Biomaterials 26 2005 6068 6076 (Pubitemid 40805612)
13. U. Fagerholm Prediction of human pharmacokinetics - gastrointestinal absorption J. Pharm. Pharmacol. 59 2007 905 916 (Pubitemid 47051070)
14. E. Gundogdu, I.G. Alvarez, and E. Karasulu Improvement of effect of water-in-oil microemulsion as an oral delivery system for fexofenadine: in vitro and in vivo studies Int. J. Nanomed. 6 2011 1631 1640
15. Z. Hu, R. Tawa, T. Konishi, N. Shibata, and K. Takada A novel emulsifier, labrasol, enhances gastrointestinal absorption of gentamicin Life Sci. 69 2001 2899 2910 (Pubitemid 33030278)
16. S. Jain, S.R. Patil, N.K. Swarnakar, and A.K. Agrawal Oral delivery of doxorubicin using novel polyelectrolyte-stabilized liposomes (layersomes) Mol. Pharm. 9 2012 2626 2635
17. S.K. Jha, R. Karki, D.P. Venkatesh, and A. Geethalakshami Formulation development & characterization of microemulsion drug delivery systems containing antiulcer drug Int. J. Drug Dev. Res. 3 2011 336 343
18. D.R. Kalaria, G. Sharma, V. Beniwal, and M.N. Ravi Kumar Design of biodegradable nanoparticles for oral delivery of doxorubicin: in vivo pharmacokinetics and toxicity studies in rats Pharm. Res. 26 2009 492 501
19. H.Y. Karasulu, B. Karabulut, E. Goker, T. Guneri, and F. Gabor Controlled release of methotrexate from w/o microemulsion and its in vitro antitumor activity Drug Deliv. 14 2007 225 233 (Pubitemid 46759432)
20. K. Kawakami, T. Yoshikawa, T. Hayashi, Y. Nishihara, and K. Masuda Microemulsion formulation for enhanced absorption of poorly soluble drugs: II. In vivo study J. Control. Release 81 2002 75 82 (Pubitemid 34454851)
21. K. Kawakami, T. Yoshikawa, Y. Moroto, E. Kanaoka, K. Takahashi, Y. Nishihara, and K. Masuda Microemulsion formulation for enhanced absorption of poorly soluble drugs: I. Prescription design J. Control. Release 81 2002 65 74 (Pubitemid 34454850)
22. W. Ke, Y. Zhao, R. Huang, C. Jiang, and Y. Pei Enhanced oral bioavailability of doxorubicin in a dendrimer drug delivery system J. Pharm. Sci. 97 2008 2208 2216
23. J.E. Kim, H.J. Cho, J.S. Kim, C.K. Shim, S.J. Chung, M.H. Oak, I.S. Yoon, and D.D. Kim The limited intestinal absorption via paracellular pathway is responsible for the low oral bioavailability of doxorubicin Xenobiotica 43 2013 579 591
24. K. Koga, N. Takarada, and K. Takada Nano-sized water-in-oil-in-water emulsion enhances intestinal absorption of calcein, a high solubility and low permeability compound Eur. J. Pharm. Biopharm. 74 2010 223 232
25. K. Le Lay, E. Myon, S. Hill, L. Riou-Franca, D. Scott, M. Sidhu, D. Dunlop, and R. Launois Comparative cost-minimisation of oral and intravenous chemotherapy for first-line treatment of non-small cell lung cancer in the UK NHS system Eur. J. Health Econ. 8 2007 145 151 (Pubitemid 46742894)
26. S. Maher, T.W. Leonard, J. Jacobsen, and D.J. Brayden Safety and efficacy of sodium caprate in promoting oral drug absorption: from in vitro to the clinic Adv. Drug Deliv. Rev. 61 2009 1427 1449
27. J. Qi, J. Zhuang, W. Wu, Y. Lu, Y. Song, Z. Zhang, J. Jia, and Q. Ping Enhanced effect and mechanism of water-in-oil microemulsion as an oral delivery system of hydroxysafflor yellow A Int. J. Nanomed. 6 2011 985 991
28. R. Saitoh, K. Sugano, N. Takata, T. Tachibana, A. Higashida, Y. Nabuchi, and Y. Aso Correction of permeability with pore radius of tight junctions in Caco-2 monolayers improves the prediction of the dose fraction of hydrophilic drugs absorbed by humans Pharm. Res. 21 2004 749 755 (Pubitemid 39011295)
29. M.H. Schwarzbach, S. Eisold, T. Burguete, F. Willeke, P. Klein-Bauernschmitt, J.R. Schlehofer, C. Herfarth, R. Ridder, and M. von Knebel Doeberitz Sensitization of sarcoma cells to doxorubicin treatment by concomitant wild-type adeno-associated virus type 2 (AAV-2) infection Int. J. Oncol. 20 2002 1211 1218
30. X. Sha, G. Yan, Y. Wu, J. Li, and X. Fang Effect of self-microemulsifying drug delivery systems containing labrasol on tight junctions in Caco-2 cells Eur. J. Pharm. Sci. 24 2005 477 486 (Pubitemid 40387261)
31. R. Silva, H. Carmo, R. Dinis-Oliveira, A. Cordeiro-da-Silva, S.C. Lima, F. Carvalho, L. Bastos Mde, and F. Remiao In vitro study of P-glycoprotein induction as an antidotal pathway to prevent cytotoxicity in Caco-2 cells Arch. Toxicol. 85 2011 315 326
32. R.B. van Breemen, and Y. Li Caco-2 cell permeability assays to measure drug absorption Expert Opin. Drug Metab. Toxicol. 1 2005 175 185
33. Y.M. Yin, F.D. Cui, C.F. Mu, M.K. Choi, J.S. Kim, S.J. Chung, C.K. Shim, and D.D. Kim Docetaxel microemulsion for enhanced oral bioavailability: preparation and in vitro and in vivo evaluation J. Control. Release 140 2009 86 94
34. I.S. Yoon, M.K. Choi, J.S. Kim, C.K. Shim, S.J. Chung, and D.D. Kim Pharmacokinetics and first-pass elimination of metoprolol in rats: contribution of intestinal first-pass extraction to low bioavailability of metoprolol Xenobiotica 41 2011 243 251
35. I. Yoon, S. Han, Y.H. Choi, H.E. Kang, H.J. Cho, J.S. Kim, C.K. Shim, S.J. Chung, S. Chong, and D.D. Kim Saturable sinusoidal uptake is rate-determining process in hepatic elimination of docetaxel in rats Xenobiotica 42 2012 1110 1119
36. L. Yu, and S. Zeng Transport characteristics of zolmitriptan in a human intestinal epithelial cell line Caco-2 J. Pharm. Pharmacol. 59 2007 655 660 (Pubitemid 47051108)
37. Z. Zhang, and S.S. Feng Nanoparticles of poly(lactide)/vitamin E TPGS copolymer for cancer chemotherapy: synthesis, formulation, characterization and in vitro drug release Biomaterials 27 2006 262 270 (Pubitemid 41278528)