E2 enzyme inhibition by stabilization of a low-affinity interface with ubiquitin.

Nature chemical biology

Volumn 10, Issue 2, 2014, Pages 156-163

  Huang, Hao ^a   Ceccarelli, Derek F ^a   Orlicky, Stephen ^a   St Cyr, Daniel J ^a   Ziemba, Amy ^a   Garg, Pankaj ^a   Plamondon, Serge ^a   Auer, Manfred ^a   Sidhu, Sachdev ^a   Marinier, Anne ^a   Kleiger, Gary ^a   Tyers, Mike ^a   Sicheri, Frank ^a  

^a MOUNT SINAI HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

5-(3',5'-DICHLOROBIPHENYL-4-YL)-2,3-DIHYDROXY-4-(2-METHOXYACETAMIDO)PENT ANOIC ACID; 5 (3',5' DICHLOROBIPHENYL 4 YL) 2,3 DIHYDROXY 4 (2 METHOXYACETAMIDO)PENTANOIC ACID; AMINO ACID; BIPHENYL DERIVATIVE; COORDINATION COMPOUND; ENZYME INHIBITOR; UBIQUITIN; UBIQUITIN CONJUGATING ENZYME;

ARTICLE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; ENZYME ACTIVATION; IC 50; MOLECULAR LIBRARY; PROTEIN BINDING; PROTEIN STABILITY; X RAY CRYSTALLOGRAPHY;

AMINO ACIDS; BINDING SITES; BIPHENYL COMPOUNDS; COORDINATION COMPLEXES; CRYSTALLOGRAPHY, X-RAY; ENZYME ACTIVATION; ENZYME INHIBITORS; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN STABILITY; SMALL MOLECULE LIBRARIES; UBIQUITIN; UBIQUITIN-CONJUGATING ENZYMES;

EID: 84896639811     PISSN: None     EISSN: 15524469     Source Type: None    
DOI: 10.1038/nchembio.1412     Document Type: Article

References (0)