Attenuation of early brain injury and learning deficits following experimental subarachnoid hemorrhage secondary to cystatin C: Possible involvement of the autophagy pathway

Molecular Neurobiology

Volumn 49, Issue 2, 2014, Pages 1043-1054

  Liu, Yizhi ^a   Li, Jianke ^a   Wang, Zhong ^a   Yu, Zhengquan ^a   Chen, Gang ^a  

^a SOOCHOW UNIVERSITY   (China)

Author keywords

Autophagy; Cystatin C; Subarachnoid hemorrhage

Indexed keywords

BECLIN 1; BIOLOGICAL MARKER; CYSTATIN C; MICROTUBULE ASSOCIATED PROTEIN; MICROTUBULE ASSOCIATED PROTEIN LIGHT CHAIN 3; UNCLASSIFIED DRUG;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ATTENUATION; AUTOLYSOSOME; AUTOPHAGOSOME; AUTOPHAGY; BLOOD; BLOOD BRAIN BARRIER; BRAIN CORTEX; BRAIN EDEMA; BRAIN INJURY; CELL STRUCTURE; CHIASMATIC CISTERN; COGNITIVE DEFECT; CONTROLLED STUDY; DRUG EFFICACY; DRUG MEGADOSE; DRUG PENETRATION; EARLY BRAIN INJURY; IMMUNOHISTOCHEMISTRY; INJECTION; LEARNING DISORDER; LOW DRUG DOSE; MALE; NERVE CELL; NONHUMAN; RAT; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; SUBARACHNOID HEMORRHAGE; ANIMAL; BRAIN; BRAIN INJURIES; DRUG EFFECTS; LEARNING DISORDERS; METABOLISM; PATHOLOGY; PHYSIOLOGY; RANDOMIZATION; SPRAGUE DAWLEY RAT;

ANIMALS; AUTOPHAGY; BRAIN; BRAIN INJURIES; CYSTATIN C; LEARNING DISORDERS; MALE; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; SUBARACHNOID HEMORRHAGE;

EID: 84896549091     PISSN: 08937648     EISSN: 15591182     Source Type: Journal    
DOI: 10.1007/s12035-013-8579-3     Document Type: Article

References (33)

1. Hop JW, Rinkel GJ, Algra A, van Gijn J (1997) Case-fatality rates and functional outcome after subarachnoid hemorrhage: a systematic review. Stroke 28:660-664 (Pubitemid 27118394)
2. Caner B, Hou J, Altay O, Fuj M 2nd, Zhang JH (2012) Transition of research focus from vasospasm to early brain injury after subarachnoid hemorrhage. J Neurochem 123(Suppl 2):12-21
3. Sehba FA, Hou J, Pluta RM, Zhang JH (2012) The importance of early brain injury after subarachnoid hemorrhage. Prog Neurobiol 97(1):14-37
4. Al-Khindi T, Macdonald RL, Schweizer TA (2010) Cognitive and functional outcome after aneurysmal subarachnoid hemorrhage. Stroke 41(8):e519-e536
5. Gauthier S, Kaur G, Mi W, Tizon B, Levy E (2011) Protective mechanisms by cystatin C in neurodegenerative diseases. Front Biosci (Schol Ed) 3:541-554
6. Barrett AJ, Davies ME, Grubb A (1984) The place of human gammatrace (cystatin C) amongst the cysteine proteinase inhibitors. Biochem Biophys Res Commun 120:631-636 (Pubitemid 14101757)
7. Bobek LA, Levine MJ (1992) Cystatins-inhibitors of cysteine proteinases. Crit Rev Oral Biol Med 3:307-332
8. Lerner UH, Grubb A (1992) Human cystatin C, a cysteine proteinase inhibitor, inhibits bone resorption in vitro stimulated by parathyroid hormone and parathyroid hormone-related peptide of malignancy. J Bone Miner Res 7:433-440
9. Huh CG, Hakansson K, Nathanson CM, Thorgeirsson UP, Jonsson N et al (1999) Decreased metastatic spread in mice homozygous for a null allele of the cystatin C protease inhibitor gene. Mol Pathol 52:332-340 (Pubitemid 30002765)
10. Warfel AH, Zucker-Franklin D, Frangione B, Ghiso J (1987) Constitutive secretion of cystatin C (gamma-trace) by monocytes and macrophages and its downregulation after stimulation. J Exp Med 166:1912-1917
11. Sun Q (1989) Growth stimulation of 3T3 fibroblasts by cystatin. Exp Cell Res 180:150-160
12. Tavera C, Leung-Tack J, Prevot D, Gensac MC, Martinez J et al (1992) Cystatin C secretion by rat glomerular mesangial cells: autocrine loop for in vitro growth-promoting activity. Biochem Biophys Res Commun 182:1082-1088
13. Akopyan T (1991) Protein inhibitors of proteinases from brain. Neurochem Res 16:513-517
14. Hoffmann MC, Nitsch C, Scotti AL, Reinhard E, Monard D (1992) The prolonged presence of glia-derived nexin, an endogenous protease inhibitor, in the hippocampus after ischemia-induced delayed neuronal death. Neuroscience 49:397-408
15. Lee KS, Frank S, Vanderklish P, Arai A, Lynch G(1991) Inhibition of proteolysis protects hippocampal neurons from ischemia. Proc Natl Acad Sci U S A 88:7233-7237 (Pubitemid 21915124)
16. Nagai A, Terashima M, Sheikh AM, Notsu Y, Shimode K et al (2008) Involvement of cystatin C in pathophysiology of CNS diseases. Front Biosci 13:3470-3479 (Pubitemid 351594696)
17. Zerovnik E (2009) The emerging role of cystatins in Alzheimer's disease. Bioessays 31:597-599
18. Wang Z, Shi XY, Yin J, Zuo G, Chen G et al (2012) Role of autophagy in early brain injury after experimental subarachnoid hemorrhage. J Mol Neurosci 46:192-202
19. Chen G, Shi J, Hu Z, Hang C (2008) Inhibitory effect on cerebral inflammatory response following traumatic brain injury in rats: a potential neuroprotective mechanism of N -acetylcysteine. Mediators Inflamm 2008:716458
20. Bederson JB, Connolly ES Jr, Batjer HH, Dacey RG, Dion JE et al (2009) Guidelines for the management of aneurysmal subarachnoid hemorrhage: a statement for healthcare professionals from a special writing group of the Stroke Council, American Heart Association. Stroke 40:994-1025
21. Cahill J, Calvert JW, Zhang JH (2006) Mechanisms of early brain injury after subarachnoid hemorrhage. J Cereb Blood Flow Metab 26:1341-1353
22. Kusaka G, Ishikawa M, Nanda A, Granger DN, Zhang JH (2004) Signaling pathways for early brain injury after subarachnoid hemorrhage. J Cereb Blood Flow Metab 24:916-925 (Pubitemid 39045409)
23. Abrahamson M, Alvarez-Fernandez M, Nathanson CM (2003) Cystatins. Biochem Soc Symp 70:179-199 (Pubitemid 38497225)
24. Levy E, Jaskolski M, Grubb A (2006) The role of cystatin C in cerebral amyloid angiopathy and stroke: cell biology and animal models. Brain Pathol 16:60-70
25. Tizon B, Sahoo S, Yu H, Gauthier S, Kumar AR et al (2010) Induction of autophagy by cystatin C: a mechanism that protects murine primary cortical neurons and neuronal cell lines. PLOS ONE 5:e9819
26. Nagai A, Ryu JK, Kobayash S, Kim SU (2002) Cystatin C induces neuronal cell death in vivo. Ann N YAcad Sci 977:315-321 (Pubitemid 35418170)
27. Cuervo AM (2004) Autophagy: in sickness and in health. Trends Cell Biol 14:70-77
28. He Y, Wan S, Hua Y, Keep RF, Xi G (2008) Autophagy after experimental intracerebral hemorrhage. J Cereb Blood Flow Metab 28:897-905 (Pubitemid 351589625)
29. Carloni S, Buonocore G, Balduini W (2008) Protective role of autophagy in neonatal hypoxia-ischemia induced brain injury. Neurobiol Dis 32:329-339
30. Liu CL, Chen S, Dietrich D, Hu BR (2008) Changes in autophagy after traumatic brain injury. J Cereb Blood Flow Metab 28:674-683 (Pubitemid 351432796)
31. Lee JY, He Y, Sagher O, Keep R, Hua Y et al (2009) Activated autophagy pathway in experimental subarachnoid hemorrhage. Brain Res 1287:126-135
32. Rubinsztein DC, DiFiglia M, Heintz N, Nixon RA, Qin ZH et al (2005) Autophagy and its possible roles in nervous system diseases, damage and repair. Autophagy 1:11-22
33. Liu Y, Cai H, Wang Z, Li J, Wang K et al (2013) Induction of autophagy by cystatin C: a potential mechanism for prevention of cerebral vasospasm after experimental subarachnoid hemorrhage. Eur J Med Res 18:21