Subclinical atherosclerosis among HIV-infected adults attending HIV/AIDS care at two large ambulatory HIV clinics in Uganda

PLoS ONE

Volumn 9, Issue 2, 2014, Pages

  Ssinabulya, Isaac ^a   Kayima, James ^a   Longenecker, Chris ^b   Luwedde, Mary ^a   Semitala, Fred ^a   Kambugu, Andrew ^a   Ameda, Faith ^a   Bugeza, Sam ^a   McComsey, Grace ^b   Freers, Juergen ^a   Nakanjako, Damalie ^a  

^a MAKERERE UNIVERSITY   (Uganda)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; CHOLESTEROL; GLUCOSE; HIGH DENSITY LIPOPROTEIN; LIPID; LOW DENSITY LIPOPROTEIN;

ADULT; AGE; AMBULATORY CARE; ARTERIAL WALL THICKNESS; ARTICLE; ATHEROSCLEROSIS; BIOPHYSICS; BODY MASS; CARDIOVASCULAR RISK; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DISEASE ASSOCIATION; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LIPOPROTEIN BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; PREDICTION; PROTEIN BLOOD LEVEL; RISK ASSESSMENT; SUBCLINICAL ATHEROSCLEROSIS; UGANDA; WAIST CIRCUMFERENCE;

ACQUIRED IMMUNODEFICIENCY SYNDROME; ADULT; ATHEROSCLEROSIS; BODY MASS INDEX; C-REACTIVE PROTEIN; CROSS-SECTIONAL STUDIES; FEMALE; HIV INFECTIONS; HUMANS; LIPOPROTEINS, LDL; MALE; RISK FACTORS; UGANDA;

EID: 84896519860     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0089537     Document Type: Article

References (42)

1. Obel N, Thomsen HF, Kronborg G, Larsen CS, Hildebrandt PR, et al. (2007) Ischemic heart disease in HIV-infected and HIV-uninfected individuals: a population-based cohort study. Clin Infect Dis 44: 1625-1631. (Pubitemid 46871511)
2. Triant VA, Lee H, Hadigan C, Grinspoon SK (2007) Increased acute myocardial infarction rates and cardiovascular risk factors among patients with human immunodeficiency virus disease. J Clin Endocrinol Metab 92: 2506-2512. (Pubitemid 47037350)
3. Currier JS, Taylor A, Boyd F, Dezii CM, Kawabata H, et al. (2003) Coronary heart disease in HIV-infected individuals. J Acquir Immune Defic Syndr 33: 506-512. (Pubitemid 36886080)
4. Friis-Moller N, Sabin CA, Weber R, d'Arminio Monforte A, El-Sadr WM, et al. (2003) Combination antiretroviral therapy and the risk of myocardial infarction. N Engl J Med 349: 1993-2003.
5. Klein D, Hurley LB, Quesenberry Jr CP, Sidney S (2002) Do protease inhibitors increase the risk for coronary heart disease in patients with HIV-1 infection? J Acquir Immune Defic Syndr 30: 471-477.
6. Vittecoq D, Escaut L, Chironi G, Teicher E, Monsuez JJ, et al. (2003) Coronary heart disease in HIV-infected patients in the highly active antiretroviral treatment era. AIDS 17 Suppl 1: S70-76. (Pubitemid 36667783)
7. Gortmaker SL, Hughes M, Cervia J, Brady M, Johnson GM, et al. (2001) Effect of combination therapy including protease inhibitors on mortality among children and adolescents infected with HIV-1. N Engl J Med 345: 1522-1528. (Pubitemid 33144917)
8. Palella Jr FJ, Delaney KM, Moorman AC, Loveless MO, Fuhrer J, et al. (1998) Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators. N Engl J Med 338: 853-860. (Pubitemid 28135961)
9. Sterne JA, Hernan MA, Ledergerber B, Tilling K, Weber R, et al. (2005) Longterm effectiveness of potent antiretroviral therapy in preventing AIDS and death: a prospective cohort study. Lancet 366: 378-384. (Pubitemid 41073955)
10. UNAIDS Global Report (2012) Available: http://www.unaids.org/en/media/ unaids/contentassets/documents/epidemiology/2012/gr2012/20121120.Ac- Accessed: 30 Sep 2013.
11. Szadkowski L, Tseng A, Walmsley SL, Salit I, Raboud JM (2012) Short communication: effects of age on virologic suppression and CD4 cell response in HIV-positive patients initiating combination antiretroviral therapy. AIDS Res Hum Retroviruses 28: 1579-1583.
12. Shor-Posner G, Basit A, Lu Y, Cabrejos C, Chang J, et al. (1993) Hypocholesterolemia is associated with immune dysfunction in early human immunodeficiency virus-1 infection. Am J Med 94: 515-519. (Pubitemid 23142967)
13. Riddler SA, Smit E, Cole SR, Li R, Chmiel JS, et al. (2003) Impact of HIV infection and HAART on serum lipids in men. JAMA 289: 2978-2982. (Pubitemid 37430100)
14. David MH, Hornung R, Fichtenbaum CJ (2002) Ischemic cardiovascular disease in persons with human immunodeficiency virus infection. Clin Infect Dis 34: 98-102. (Pubitemid 33152673)
15. Varriale P, Saravi G, Hernandez E, Carbon F (2004) Acute myocardial infarction in patients infected with human immunodeficiency virus. Am Heart J 147: 55-59. (Pubitemid 38037397)
16. Carr A, Samaras K, Thorisdottir A, Kaufmann GR, Chisholm DJ, et al. (1999) Diagnosis, prediction, and natural course of HIV-1 protease-inhibitor- associated lipodystrophy, hyperlipidaemia, and diabetes mellitus: a cohort study. Lancet 353: 2093-2099. (Pubitemid 29278477)
17. Triant VA, Meigs JB, Grinspoon SK (2009) Association of C-reactive protein and HIV infection with acute myocardial infarction. J Acquir Immune Defic Syndr 51: 268-273.
18. Ross AC, O'Riordan MA, Storer N, Dogra V, McComsey GA (2010) Heightened inflammation is linked to carotid intima-media thickness and endothelial activation in HIV-infected children. Atherosclerosis 211: 492-498.
19. Ross AC, Rizk N, O'Riordan MA, Dogra V, El-Bejjani D, et al. (2009) Relationship between inflammatory markers, endothelial activation markers, and carotid intima-media thickness in HIV-infected patients receiving antiretroviral therapy. Clin Infect Dis 49: 1119-1127.
20. Rohani M, Jogestrand T, Ekberg M, van der Linden J, Kallner G, et al. (2005) Interrelation between the extent of atherosclerosis in the thoracic aorta, carotid intima-media thickness and the extent of coronary artery disease. Atherosclerosis 179: 311-316. (Pubitemid 40364625)
21. Kablak-Ziembicka A, Tracz W, Przewlocki T, Pieniazek P, Sokolowski A, et al. (2004) Association of increased carotid intima-media thickness with the extent of coronary artery disease. Heart 90: 1286-1290. (Pubitemid 39433989)
22. Bots ML, Hoes AW, Koudstaal PJ, Hofman A, Grobbee DE (1997) Common carotid intima-media thickness and risk of stroke and myocardial infarction: the Rotterdam Study. Circulation 96: 1432-1437. (Pubitemid 27375333)
23. O'Leary DH, Polak JF, Kronmal RA, Manolio TA, Burke GL, et al. (1999) Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular Health Study Collaborative Research Group. N Engl J Med 340: 14-22. (Pubitemid 29024679)
24. Nakanjako D, Kiragga A, Ibrahim F, Castelnuovo B, Kamya MR, et al. (2008) Sub-optimal CD4 reconstitution despite viral suppression in an urban cohort on antiretroviral therapy (ART) in sub-Saharan Africa: frequency and clinical significance. AIDS Res Ther 5:23.
25. Nakanjako D, Ssewanyana I, Nabatanzi R, Kiragga A, Kamya MR, et al. (2013) Impaired T-cell proliferation among HAART-treated adults with suboptimal CD4 recovery in an African cohort. BMC Immunol 14:26.
26. Roman MJ, Naqvi TZ, Gardin JM, Gerhard-Herman M, Jaff M, et al. (2006) Clinical application of noninvasive vascular ultrasound in cardiovascular risk stratification: a report from the American Society of Echocardiography and the Society of Vascular Medicine and Biology. J Am Soc Echocardiogr 19: 943-954. (Pubitemid 44118704)
27. de Groot E, Hovingh GK, Wiegman A, Duriez P, Smit AJ, et al. (2004) Measurement of arterial wall thickness as a surrogate marker for atherosclerosis. Circulation 109: III33-38. (Pubitemid 38786441)
28. Parra S, Coll B, Aragones G, Marsillach J, Beltran R, et al. (2010) Nonconcordance between subclinical atherosclerosis and the calculated Framingham risk score in HIV-infected patients: relationships with serum markers of oxidation and inflammation. HIV Med 11: 225-231.
29. De Socio GV, Martinelli C, Ricci E, Orofino G, Valsecchi L, et al. (2010) Relations between cardiovascular risk estimates and subclinical atherosclerosis in naive HIV patients: results from the HERMES study. Int J STD AIDS 21: 267-272.
30. Maggi P, Lillo A, Perilli F, Maserati R, Chirianni A (2004) Colour-Doppler ultrasonography of carotid vessels in patients treated with antiretroviral therapy: a comparative study. AIDS 18: 1023-1028. (Pubitemid 38591193)
31. Fitch KV, Looby SE, Rope A, Eneh P, Hemphill L, et al. (2012) Effects of aging and smoking on carotid intima-media thickness in HIV-infection. AIDS 27: 49-57.
32. Mangili A, Polak JF, Skinner SC, Gerrior J, Sheehan H, et al. (2011) HIV infection and progression of carotid and coronary atherosclerosis: the CARE study. J Acquir Immune Defic Syndr 58: 148-153.
33. Stein JH, Hsue PY (2012) Inflammation, immune activation, and CVD risk in individuals with HIV infection. JAMA 308: 405-406.
34. Hsue PY, Lo JC, Franklin A, Bolger AF, Martin JN, et al. (2004) Progression of atherosclerosis as assessed by carotid intima-media thickness in patients with HIV infection. Circulation 109: 1603-1608. (Pubitemid 38451715)
35. Currier JS, Kendall MA, Zackin R, Henry WK, Alston-Smith B, et al. (2005) Carotid artery intima-media thickness and HIV infection: traditional risk factors overshadow impact of protease inhibitor exposure. AIDS 19: 927-933. (Pubitemid 40834935)
36. Mangili A, Gerrior J, Tang AM, O'Leary DH, Polak JK, et al. (2006) Risk of cardiovascular disease in a cohort of HIV-infected adults: a study using carotid intima-media thickness and coronary artery calcium score. Clin Infect Dis 43: 1482-1489. (Pubitemid 44845654)
37. Dogan S, Duivenvoorden R, Grobbee DE, Kastelein JJ, Shear CL, et al. (2010) Completeness of carotid intima media thickness measurements depends on body composition: the RADIANCE 1 and 2 trials. J Atheroscler Thromb 17: 526-535.
38. Shikuma CM, Ribaudo HJ, Zheng Y, Gulick RM, Meyer WA, et al. (2011) Change in high-sensitivity c-reactive protein levels following initiation of efavirenz-based antiretroviral regimens in HIV-infected individuals. AIDS Res Hum Retroviruses 27: 461-468.
39. Boger MS, Shintani A, Redhage LA, Mitchell V, Haas DW, et al. (2009) Highly sensitive C-reactive protein, body mass index, and serum lipids in HIV-infected persons receiving antiretroviral therapy: a longitudinal study. J Acquir Immune Defic Syndr 52: 480-487.
40. Masia M, Bernal E, Padilla S, Graells ML, Jarrin I, et al. (2007) The role of Creactive protein as a marker for cardiovascular risk associated with antiretroviral therapy in HIV-infected patients. Atherosclerosis 195: 167-171. (Pubitemid 47569983)
41. Guimaraes MM, Greco DB, Figueiredo SM, Foscolo RB, Oliveira Jr AR, et al. (2008) High-sensitivity C-reactive protein levels in HIV-infected patients treated or not with antiretroviral drugs and their correlation with factors related to cardiovascular risk and HIV infection. Atherosclerosis 201: 434-439.
42. Calabro P, Chang DW, Willerson JT, Yeh ET (2005) Release of C-reactive protein in response to inflammatory cytokines by human adipocytes: linking obesity to vascular inflammation. J Am Coll Cardiol 46: 1112-1113. (Pubitemid 41316523)