A PIK3CA mutation detected in plasma from a patient with synchronous primary breast and lung cancers

Human Pathology

Volumn 45, Issue 4, 2014, Pages 880-883

  Jelovac, Danijela ^a   Beaver, Julia A ^a   Balukrishna, Sasidharan ^b   Wong, Hong Yuen ^a   Toro, Patricia Valda ^a   Cimino Mathews, Ashley ^a   Argani, Pedram ^a   Stearns, Vered ^a   Jacobs, Lisa ^a   Vandenberg, Dustin ^a   Kessler, Jill ^a   Jeter, Stacie ^a   Park, Ben H ^a   Wolff, Antonio C ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b CHRISTIAN MEDICAL COLLEGE   (India)

Author keywords

Breast cancer; Digital PCR; Lung cancer; PIK3CA; Plasma tumor DNA

Indexed keywords

AROMATASE INHIBITOR; CISPLATIN; EPIDERMAL GROWTH FACTOR RECEPTOR; GENOMIC DNA; PEMETREXED; PHOSPHATIDYLINOSITOL 3 KINASE; DNA;

ADJUVANT THERAPY; AGED; ARTICLE; BREAST BIOPSY; BREAST CANCER; CANCER COMBINATION CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER SIZE; CANCER STAGING; CANCER SURGERY; CASE REPORT; DIGITAL POLYMERASE CHAIN REACTION; ESTROGEN RECEPTOR POSITIVE BREAST CANCER; EXON; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; FOLLOW UP; HUMAN; HUMAN TISSUE; LOBECTOMY; LUNG NON SMALL CELL CANCER; LYMPH NODE DISSECTION; LYMPH NODE METASTASIS; MULTIMODALITY CANCER THERAPY; MULTIPLE CYCLE TREATMENT; ONCOGENE; ONCOGENE K RAS; PARTIAL MASTECTOMY; PHOSPHATIDYLINOSITOL 3 KINASE CATALYTIC SUBUNIT ALPHA GENE; POLYMERASE CHAIN REACTION; PRIMARY TUMOR; SENTINEL LYMPH NODE BIOPSY; SOMATIC MUTATION; TUMOR BIOPSY; WILD TYPE; BREAST CARCINOMA; CANCER ADJUVANT THERAPY; CANCER HORMONE THERAPY; CANCER PATIENT; CONTROLLED STUDY; GENE IDENTIFICATION; GENETIC ANALYZER; LIMIT OF DETECTION; LIMIT OF QUANTITATION; LOCAL THERAPY; MUTATIONAL ANALYSIS; NON SMALL CELL LUNG CANCER; PIK3CA GENE; PLASMA; SANGER SEQUENCING; SEQUENCE ANALYSIS; TUMOR GENE;

BREAST CANCER; DIGITAL PCR; LUNG CANCER; PIK3CA; PLASMA TUMOR DNA;

AGED; BASE SEQUENCE; BREAST NEOPLASMS; CARCINOMA, NON-SMALL-CELL LUNG; DNA, NEOPLASM; FEMALE; HUMANS; LUNG NEOPLASMS; MUTATION; NEOPLASMS, MULTIPLE PRIMARY; PHOSPHATIDYLINOSITOL 3-KINASES; POLYMERASE CHAIN REACTION;

EID: 84896498189     PISSN: 00468177     EISSN: 15328392     Source Type: Journal    
DOI: 10.1016/j.humpath.2013.10.016     Document Type: Article

References (13)

1. B. Karakas, K.E. Bachman, and B.H. Park Mutation of the PIK3CA oncogene in human cancers Br J Cancer 94 2006 455 459 (Pubitemid 43289745)
2. Distribution of somatic mutations in PIK3CA. Catalogue of somatic mutations in cancer (COSMIC) 2011 Welcome Trust Genome Campus Cambridge, UK
3. J.P. Gustin, B. Karakas, and M.B. Weiss et al. Knockin of mutant PIK3CA activates multiple oncogenic pathways Proc Natl Acad Sci U S A 106 2009 2835 2840
4. S.J. Isakoff, J.A. Engelman, and H.Y. Irie et al. Breast cancer-associated PIK3CA mutations are oncogenic in mammary epithelial cells Cancer Res 65 2005 10992 11000 (Pubitemid 41713369)
5. R.E. Board, A.M. Wardley, and J.M. Dixon et al. Detection of PIK3CA mutations in circulating free DNA in patients with breast cancer Breast Cancer Res Treat 120 2010 461 467
6. S.J. Dawson, D.W. Tsui, and M. Murtaza et al. Analysis of circulating tumor DNA to monitor metastatic breast cancer N Engl J Med 368 2013 1199 1209
7. M.J. Higgins, D. Jelovac, and E. Barnathan et al. Detection of tumor PIK3CA status in metastatic breast cancer using peripheral blood Clin Cancer Res 18 2012 3462 3469
8. D. Dressman, H. Yan, G. Traverso, K.W. Kinzler, and B. Vogelstein Transforming single DNA molecules into fluorescent magnetic particles for detection and enumeration of genetic variations Proc Natl Acad Sci U S A 100 2003 8817 8822 (Pubitemid 36899181)
9. F. Diehl, K. Schmidt, and M.A. Choti et al. Circulating mutant DNA to assess tumor dynamics Nat Med 14 2008 985 990
10. F. Diehl, M. Li, and D. Dressman et al. Detection and quantification of mutations in the plasma of patients with colorectal tumors Proc Natl Acad Sci U S A 102 2005 16368 16373 (Pubitemid 41688920)
11. R.J. Leary, M. Sausen, and I. Kinde et al. Detection of chromosomal alterations in the circulation of cancer patients with whole-genome sequencing Sci Transl Med 4 2012 162ra154
12. S. Misale, R. Yaeger, and S. Hobor et al. Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer Nature 486 2012 532 536
13. J.A. Shaw, K. Page, and K. Blighe et al. Genomic analysis of circulating cell-free DNA infers breast cancer dormancy Genome Res 22 2012 220 231