Cytokine and immunoglobulin isotype profiles during CP7_E2alf vaccination against a challenge with the highly virulent Koslov strain of classical swine fever virus

Research in Veterinary Science

Volumn 96, Issue 2, 2014, Pages 389-395

  Renson, P ^a,b   Le Dimna, M ^a,b   Gabriel, C ^c   Levai, R ^d   Blome, S ^c   Kulcsar, G ^d   Koenen, F ^e   Le Potier, M F ^a,b  

^a FRENCH AGENCY FOR FOOD   (France)

^b UNIVERSITÉ EUROPÉENNE DE BRETAGNE   (France)

^c FEDERAL RESEARCH INSTITUTE FOR ANIMAL HEALTH   (Germany)

^d CENTRAL VETERINARY INSTITUTE   (Hungary)

^e VETERINARY AND AGROCHEMICAL RESEARCH CENTRE   (Belgium)

Author keywords

Classical swine fever virus; CP7_E2alf vaccine; Cytokines; Immune response; Immunoglobulin isotypes; Vaccination

Indexed keywords

ALPHA INTERFERON; CYTOKINE; GAMMA INTERFERON; IMMUNOGLOBULIN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2; IMMUNOGLOBULIN M; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 4; INTERLEUKIN 6; INTERLEUKIN 8; PESTIVIRUS VACCINE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VIRUS VACCINE; IMMUNOGLOBULIN CLASS; LIVE VACCINE;

ANIMAL EXPERIMENT; ARTICLE; CELLULAR IMMUNITY; CLASSICAL SWINE FEVER; CYTOKINE RESPONSE; DRUG EFFECT; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOGLOBULIN PRODUCTION; MUCOSAL IMMUNITY; NONHUMAN; PROTECTION; PROTEIN BLOOD LEVEL; SINGLE DRUG DOSE; SWINE; VACCINATION; VIRUS STRAIN; VIRUS VIRULENCE; ANIMAL; BLOOD; CLASSICAL SWINE FEVER VIRUS; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNOLOGY; NONPARAMETRIC TEST; ORAL DRUG ADMINISTRATION; PROCEDURES; STANDARDS; VETERINARY; VIROLOGY;

CLASSICAL SWINE FEVER VIRUS; SUIDAE;

ADMINISTRATION, ORAL; ANIMALS; CLASSICAL SWINE FEVER; CLASSICAL SWINE FEVER VIRUS; CYTOKINES; ENZYME-LINKED IMMUNOSORBENT ASSAY; IMMUNOGLOBULIN ISOTYPES; STATISTICS, NONPARAMETRIC; SWINE; VACCINATION; VACCINES, ATTENUATED; VIRAL VACCINES;

EID: 84896489169     PISSN: 00345288     EISSN: 15322661     Source Type: Journal    
DOI: 10.1016/j.rvsc.2014.01.002     Document Type: Article

References (31)

1. Bensaude E., Turner J.L., Wakeley P.R., Sweetman D.A., Pardieu C., Drew T.W., Wileman T., Powell P.P. Classical swine fever virus induces proinflammatory cytokines and tissue factor expression and inhibits apoptosis and interferon synthesis during the establishment of long-term infection of porcine vascular endothelial cells. Journal of General Virology 2004, 85:1029-1037.
2. Blome S., Aebischer A., Lange E., Hofmann M., Leifer I., Loeffen W., Koenen F., Beer M. Comparative evaluation of live marker vaccine candidates "CP7_E2alf" and "flc11" along with C-strain "Riems" after oral vaccination. Veterinary Microbiology 2012, 158:42-59.
3. Borca M.V., Gudmundsdottir I., Fernandez-Sainz I.J., Holinka L.G., Risatti G.R. Patterns of cellular gene expression in swine macrophages infected with highly virulent classical swine fever virus strain Brescia. Virus Research 2008, 138:89-96.
4. Chase C.C., Elmowalid G., Yousif A.A. The immune response to bovine viral diarrhea virus: a constantly changing picture. The Veterinary Clinics of North America. Food Animal Practice 2004, 20:95-114.
5. Couper K.N., Blount D.G., Riley E.M. IL-10: the master regulator of immunity to infection. Journal of Immunology (Baltimore, Md.: 1950) 2008, 180:5771-5777.
6. Coutelier J.P., van der Logt J.T., Heessen F.W., Warnier G., Van Snick J. IgG2a restriction of murine antibodies elicited by viral infections. Journal of Experimental Medicine 1987, 165:64-69.
7. Crawley A., Raymond C., Wilkie B.N. Control of immunoglobulin isotype production by porcine B-cells cultured with cytokines. Veterinary Immunology and Immunopathology 2003, 91:141-154.
8. Diaz I., Mateu E. Use of ELISPOT and ELISA to evaluate IFN-gamma, IL-10 and IL-4 responses in conventional pigs. Veterinary Immunology and Immunopathology 2005, 106:107-112.
9. Gabriel C., Blome S., Urniza A., Juanola S., Koenen F., Beer M. Towards licensing of CP7_E2alf as marker vaccine against classical swine fever-duration of immunity. Vaccine 2012, 30:2928-2936.
10. Gil-Cruz C., Perez-Shibayama C., Firner S., Waisman A., Bechmann I., Thiel V., Cervantes-Barragan L., Ludewig B. T helper cell- and CD40-dependent germline IgM prevents chronic virus-induced demyelinating disease. Proceedings of the National Academy of Sciences of the United States of America 2012, 109:1233-1238.
11. Gomez-Villamandos J.C., Garcia de Leaniz I., Nunez A., Salguero F.J., Ruiz-Villamor E., Romero-Trevejo J.L., Sanchez-Cordon P.J. Neuropathologic study of experimental classical swine fever. Veterinary Pathology 2006, 43:530-540.
12. Graham S.P., Everett H.E., Haines F.J., Johns H.L., Sosan O.A., Salguero F.J., Clifford D.J., Steinbach F., Drew T.W., Crooke H.R. Challenge of pigs with classical Swine Fever viruses after C-strain vaccination reveals remarkably rapid protection and insights into early immunity. PLoS ONE 2012, 7:e29310.
13. Graham S.P., Haines F.J., Johns H.L., Sosan O., La Rocca S.A., Lamp B., Rumenapf T., Everett H.E., Crooke H.R. Characterisation of vaccine-induced, broadly cross-reactive IFN-gamma secreting T cell responses that correlate with rapid protection against classical swine fever virus. Vaccine 2012, 30:2742-2748.
14. Jamin A., Gorin S., Le Potier M.F., Kuntz-Simon G. Characterization of conventional and plasmacytoid dendritic cells in swine secondary lymphoid organs and blood. Veterinary Immunology and Immunopathology 2006, 114:224-237.
15. Kesik M., Saczynska V., Szewczyk B., Plucienniczak A. Inclusion bodies from recombinant bacteria as a novel system for delivery of vaccine antigen by the oral route. Immunology Letters 2004, 91:197-204.
16. Koenig P., Lange E., Reimann I., Beer M. CP7_E2alf: a safe and efficient marker vaccine strain for oral immunisation of wild boar against classical swine fever virus (CSFV). Vaccine 2007, 25:3391-3399.
17. Leifer I., Lange E., Reimann I., Blome S., Juanola S., Duran J.P., Beer M. Modified live marker vaccine candidate CP7_E2alf provides early onset of protection against lethal challenge infection with classical swine fever virus after both intramuscular and oral immunization. Vaccine 2009, 27:6522-6529.
18. Li W., Mao L., Yang L., Zhou B., Jiang J. Development and partial validation of a recombinant E2-based indirect ELISA for detection of specific IgM antibody responses against classical swine fever virus. Journal of Virological Methods 2013, 191:63-68.
19. Markine-Goriaynoff D., Coutelier J.P. Increased efficacy of the immunoglobulin G2a subclass in antibody-mediated protection against lactate dehydrogenase-elevating virus-induced polioencephalomyelitis revealed with switch mutants. Journal of Virology 2002, 76:432-435.
20. Moennig V., Floegel-Niesmann G., Greiser-Wilke I. Clinical signs and epidemiology of classical swine fever: a review of new knowledge. Veterinary Journal (London, England: 1997) 2003, 165:11-20.
21. Ngo-Giang-Huong N., Candotti D., Goubar A., Autran B., Maynart M., Sicard D., Clauvel J.P., Agut H., Costagliola D., Rouzioux C. HIV type 1-specific IgG2 antibodies: markers of helper T cell type 1 response and prognostic marker of long-term nonprogression. AIDS Research and Human Retroviruses 2001, 17:1435-1446. French Asymptomatic Long-Term Study, G.
22. Piriou L., Chevallier S., Hutet E., Charley B., Le Potier M.F., Albina E. Humoral and cell-mediated immune responses of d/d histocompatible pigs against classical swine fever (CSF) virus. Veterinary Research 2003, 34:389-404.
23. Racine R., McLaughlin M., Jones D.D., Wittmer S.T., MacNamara K.C., Woodland D.L., Winslow G.M. IgM production by bone marrow plasmablasts contributes to long-term protection against intracellular bacterial infection. Journal of Immunology (Baltimore, Md.: 1950) 2011, 186:1011-1021.
24. Reimann I., Depner K., Trapp S., Beer M. An avirulent chimeric Pestivirus with altered cell tropism protects pigs against lethal infection with classical swine fever virus. Virology 2004, 322:143-157.
25. Renson P., Le Dimna M., Keranflech A., Cariolet R., Koenen F., Le Potier M.F. CP7_E2alf oral vaccination confers partial protection against early classical swine fever virus challenge and interferes with pathogeny-related cytokine responses. Veterinary Research 2013, 44:9.
26. Sanchez-Cordon P.J., Nunez A., Salguero F.J., Pedrera M., Fernandez de Marco M., Gomez-Villamandos J.C. Lymphocyte apoptosis and thrombocytopenia in spleen during classical swine fever: role of macrophages and cytokines. Veterinary Pathology 2005, 42:477-488.
27. Tang Q., Guo K., Kang K., Zhang Y., He L., Wang J. Classical swine fever virus NS2 protein promotes interleukin-8 expression and inhibits MG132-induced apoptosis. Virus Genes 2011, 42:355-362.
28. Tignon M., Kulcsar G., Haegeman A., Barna T., Fabian K., Levai R., Van der Stede Y., Farsang A., Vrancken R., Belak K., Koenen F. Classical swine fever: comparison of oronasal immunisation with CP7E2alf marker and C-strain vaccines in domestic pigs. Veterinary Microbiology 2010, 142:59-68.
29. van Oirschot J.T. Vaccinology of classical swine fever: from lab to field. Veterinary Microbiology 2003, 96:367-384.
30. van Rooij E.M., de Bruin M.G., de Visser Y.E., Middel W.G., Boersma W.J., Bianchi A.T. Vaccine-induced T cell-mediated immunity plays a critical role in early protection against pseudorabies virus (suid herpes virus type 1) infection in pigs. Veterinary Immunology and Immunopathology 2004, 99:113-125.
31. Wensvoort G., Boonstra J., Bodzinga B.G. Immunoaffinity purification and characterization of the envelope protein E1 of hog cholera virus. Journal of General Virology 1990, 71:531-540.