Hypoglycemic, hepato-renal and antioxidant potential effects of Chamomile recutita flowers ethanolic extract in streptozotocin-diabetic rats

American Journal of Pharmacology and Toxicology

Volumn 9, Issue 1, 2013, Pages 1-12

  Al Musa, Hassan ^a   AL Hashem, Fahaid ^a  

^a KING KHALID UNIVERSITY   (Saudi Arabia)

Author keywords

Chamomile Recutita; Hypoglycemic; Kidney; Liver; Oxidative Stress; Protective Effect

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ANTIDIABETIC AGENT; ANTIOXIDANT; ASPARTATE AMINOTRANSFERASE; CHAMOMILE RECUTITA EXTRACT; CREATININE; GLIBENCLAMIDE; GLUCOSE; GLUTATHIONE PEROXIDASE; INSULIN; PLANT EXTRACT; PROTECTIVE AGENT; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; UNCLASSIFIED DRUG; UREA;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDIABETIC ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DRUG EFFECT; DRUG POTENCY; DRUG SAFETY; DRUG SCREENING; DRUG TOLERABILITY; ENZYME ACTIVITY; FLOWER; GLUCOSE BLOOD LEVEL; INSULIN BLOOD LEVEL; KIDNEY FUNCTION; KIDNEY HOMOGENATE; LD 50; LIPID PEROXIDATION; LIVER FUNCTION; LIVER HOMOGENATE; LIVER PROTECTION; MALE; NONHUMAN; OXIDATIVE STRESS; RAT; RENAL PROTECTION; TREATMENT DURATION; UREA BLOOD LEVEL;

EID: 84896487492     PISSN: 15574962     EISSN: 15574970     Source Type: Journal    
DOI: 10.3844/ajptsp.2014.1.12     Document Type: Article

References (24)

1. Akinnuga, A.M., O. Bamidele, O.A. Ebunlomo, O.S. Adeniyi and G.S. Adeleyea et al., 2010. Hypoglycaemic effects of dietary intake of ripe and unripe lycopersicon esculentum (tomatoes) on streptozotocin-induced diabetes mellitus in rats. OnLine J. Biol. Sci., 10: 50-53. DOI: 10.3844/ojbsci.2010.50.53
2. Al-Attar, A.M., 2010. Physiological study on the effect of acalypha wilkesiana leaves extract on streptozotocin-induced experimental diabetes in male mice. Am. Med. J., 1: 51-58. DOI: 10.3844/amjsp.2010.51.58
3. Cemek, M., S. Kaga, N. Simsek, M.E. Buyukokuroglu and M. Konuk, 2008. Antihyperglycemic and antooxidative potential of Matricaria chamomilla L. In streptozotocin-induced diabetic rats. J. Nat. Med., 62: 284-293. DOI: 10.1007/s11418-008-0228-1
4. Dallak, M., M. Al-Khateeb, M. Abbas, R. Elessa and F. Al-Hashem et al., 2009a. In vivo, acute, normohypoglycemic, antihyperglycemic, insulinotropic actions of orally administered ethanol extract of Citrullus colocynthis (L.) schrab pulp. Am. J. Biochem. Biotechnol., 5: 118-125. DOI: 10.3844/ajbbsp.2009.118.125
5. Dallak, M., N. Bashir, M. Abbas, R.E.M. Haidara and M. Khalil et al., 2009b. Concomitant down regulation of glycolytic enzymes, upregulation of gluconeogenic enzymes and potential hepatonephro-protective effects following the chronic administration of the hypoglycemic, insulinotropic citrullus colocynthis pulp extract. Am. J. Biochem. Biotechnol., 5: 153-161. DOI: 10.3844/ajbbsp.2009.153.161
6. Eddouks, M., A. Lemhadri, N.A. Zeggwah and J.B. Michel, 2005. Potent hypoglycaemic activity of the aqueous extract of chamaemelum nobile in normal and streptozotocininduced diabetic rats. Diabetes Res. Clin. Pract., 67: 189-195. DOI: 10.1016/j.diabres.2004.07.015
7. Emam, M.A., 2012. Comparative evaluation of antidiabetic activity of Rosmarinus officinalis L. and Chamomile recutita in streptozotocin induced diabetic rats. Agric. Biol. J. N. Am., 3: 247-252. DOI: 10.5251/abjna.2012.3.6.247.252
8. Ghosh, S. and S.A. Suryawanshi, 2001. Effect of Vinca rosea extracts in treatment of alloxan rats. Ind. J. Exp. Biol., 39: 748-759. PMID: 12018575
9. Gupta, A.K. and N. Misra, 2006. Hepatoprotective activity of aqueous ethanolic extract of chamomile capitula in paracetamol intoxicated albino rats. Am. J. Pharmacol. Toxicol., 1: 17-20. DOI: 10.3844/ajptsp.2006.17.20
10. Hamden, K., S. Carreau, S. Lajmi, D. Aloulou and D. Kchaou et al., 2008. Hyperglycaemia, stress oxidant, liver dysfunction and histological changes in diabetic male rat pancreas and liver: Protective effect of 17 beta-estradiol. Steroids, 73: 495-501. DOI: 10.1016/j.steroids.2007.12.026.
11. Jacqueline, M.S., L. Jongsoon and F.P. Paul, 1997. Tumor necrosis factor-α-induced insulin resistance in 3T3-L1 adipocytes is accompanied by a loss of insulin receptor substrate-1 and GLUT4 expression without a loss of insulin receptor-mediated signal transduction. J. Biol. Chem., 272: 971-976. DOI: 10.1074/jbc.272.2.971
12. Kato, A., Y. Minoshima, J. Yamamoto, I. Adachi and A.A. Watson et al., 2008. Protective effects of dietarychamomile tea on diabetic complications. J. Agric. Food. Chem., 56: 8206-8211. DOI: 10.1021/jf8014365
13. Khan, C.R. and Y. Shechter, 1991. Insulin, Oral Hypoglycemic Agents and the Pharmacology of the Endocrine Pancreas. In: Goodman and Gillman's The Pharmacological Basis of Therapeutics, Gillman, A.G., T.W. Rall, A.S. Nies and P. Taylor (Eds.), VIIIth Pergamon Press, New York, pp: 1463-1495.
14. Kim, J.S., J.B. Ju, C.W. Choi and S.C. Kim, 2006. Hypoglycaemic and antihyperlipidemic effect of four korean medicinal plants in alloxan induced diabetic rats. Am. J. Biochem. Biotechnol., 2: 154-160. DOI: 10.3844/ajbbsp.2006.154.160
15. Liu, H.R., X.Y. Tang, D.Z. Dai and Y. Dai, 2008. Ethanol extracts of rehmannia complex (Di Huang) containing no Corni fructus improve early diabetic nephropathy by combining suppression on the ETROS axis with modulate hypoglycaemic effect in rats. J. Ethnopharmacol., 118: 466-472. DOI: 10.1016/j.jep.2008.05.015.
16. Lyra, R., M. Oliveira, D. Lins and N. Cavalcanti, 2006. Prevention of type 2 diabetes mellitus. Arq. Bras. Endocrinol. Metab., 50: 239-249. DOI: 10.1590/S0004-27302006000200010
17. OECD, 2002. Guidelines for the testing of chemicals/section 4: Health effects test no. 423: Acute oral toxicity-Acute toxic class method. Organization for Economic Cooperation and Development, Paris, France.
18. OECD, 2008. Guidelines for the testing of chemicals/ no. 407: Repeated dose oral toxicity test method. Organization for Economic Cooperation and Development, Paris, France.
19. Ramesh, B. and K.V. Pugalendi, 2006. Impact of umbelliferone (7-hydroxycoumarin) on hepatic marker enzymes in streptozotocin diabetic rats. Ind. J. Pharmacol., 38: 209-210.
20. Singh, O., Z. Khanam, N. Misra and M.K. Srivastava, 2011. Chamomile (Matricaria chamomilla L.): An overview. Pharmacogn. Rev., 5: 82-95. DOI: 10.4103/0973-7847.79103
21. Srivastava, J.K. and S. Gupta, 2007. Antiproliferative and apoptotic effects of chamomile extract in various human cancer cells. J. Agric. Food Chem., 55: 9470-9478. DOI: 10.1021/jf071953k
22. Tavafi, M., H. Ahmad, A. Tamjidipoor B. Delfanc and A.R. Khalatbarid, 2011. Satureja khozestanica essential oil ameliorates progression of diabetic nephropathy in uninephrectomized diabetic rats. Tissue Cell, 43: 45-51. DOI: 10.1016/j.tice.2010.11.004
23. Zangiabadi, N., V. Sheibani, M. Asadi-Shekaari, M. Shabani and M. Jafari et al., 2011. Effects of melatonin in prevention of neuropathy in STZinduced diabetic rats. Am. J. Pharmacol. Toxicol., 6: 59-67. DOI: 10.3844/ajptsp.2011.59.67
24. Zeggwagh, N., A. Sulpice and T.M. Eddouks, 2007. Anti-hyperglycaemic and hypolipidemic effects of ocimum basilicum aqueous extract in diabetic rats. Am. J. Pharmacol. Toxicol., 2: 123-129. DOI: 10.3844/ajptsp.2007.123.129