Increased systemic and adipose tissue inflammation differentiates obese women with T2DM from obese women with normal glucose tolerance

Metabolism: Clinical and Experimental

Volumn 63, Issue 4, 2014, Pages 492-501

  Van Beek, Lianne ^a   Lips, Mirjam A ^a   Visser, Annemieke ^a   Pijl, Hanno ^a   Ioan Facsinay, Andreea ^a   Toes, René ^a   Berends, Frits J ^b   Willems Van Dijk, Ko ^a   Koning, Frits ^a   Van Harmelen, Vanessa ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b RIJNSTATE HOSPITAL   (Netherlands)

Author keywords

Adipose tissue; Crown like structures; Fatty acids; Lymphocytes; Systemic inflammation

Indexed keywords

ADIPONECTIN; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; C REACTIVE PROTEIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; FATTY ACID; GAMMA INTERFERON; GLUCOSE; GLYCEROL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; HYPOCHOLESTEROLEMIC AGENT; INSULIN; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; INTERLEUKIN 8; LEPTIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; METFORMIN; SULFONYLUREA; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA;

ADIPOCYTE; ADIPOSE TISSUE; ADIPOSE TISSUE INFLAMMATION; ADULT; ARTICLE; B LYMPHOCYTE; CD19+ CD38+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ CD25+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL SIZE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOTOXIC T LYMPHOCYTE; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE; HELPER CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; INFLAMMATION; INSULIN SENSITIVITY; INTRAABDOMINAL FAT; LEAN BODY WEIGHT; LEUKOCYTE; LYMPHOCYTE ACTIVATION; MACROPHAGE; MAJOR CLINICAL STUDY; MIDDLE AGED; MORBID OBESITY; NATURAL KILLER CELL; NON INSULIN DEPENDENT DIABETES MELLITUS; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; SUBCUTANEOUS FAT; SYSTEMIC DISEASE; T LYMPHOCYTE;

ADIPOSE TISSUE; CROWN LIKE STRUCTURES; FATTY ACIDS; LYMPHOCYTES; SYSTEMIC INFLAMMATION;

ADIPOSE TISSUE; DIABETES MELLITUS, TYPE 2; FATTY ACIDS, NONESTERIFIED; FEMALE; FLOW CYTOMETRY; GLUCOSE TOLERANCE TEST; GLYCEROL; HUMANS; HYPOGLYCEMIC AGENTS; INTERLEUKIN-6; LYMPHOCYTE COUNT; MIDDLE AGED; OBESITY; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; T-LYMPHOCYTE SUBSETS;

EID: 84896476199     PISSN: 00260495     EISSN: 15328600     Source Type: Journal    
DOI: 10.1016/j.metabol.2013.12.002     Document Type: Article

References (33)

1. L. Duvnjak, and M. Duvnjak The metabolic syndrome - an ongoing story J Physiol Pharmacol 60 2009 19 24
2. M. Blüher The distinction of metabolically 'healthy' from 'unhealthy' obese individuals Curr Opin Lipidol 21 1 2010 38 43
3. P. Mathieu, I. Lemieux, and J.P. Després Obesity, inflammation, and cardiovascular risk Clin Pharmacol Ther 87 4 2010 407 416
4. H.J. Harwood Jr. The adipocyte as an endocrine organ in the regulation of metabolic homeostasis Neuropharmacology 63 1 2012 57 75
5. G. Boden Obesity, insulin resistance and free fatty acids Curr Opin Endocrinol Diabetes Obes 18 2 2011 139 143
6. S.P. Weisberg, D. McCann, and M. Desai et al. Obesity is associated with macrophage accumulation in adipose tissue J Clin Invest 112 12 2003 1796 1808
7. M. West Dead adipocytes and metabolic dysfunction: Recent progress Curr Opin Endocrinol Diabetes Obes 16 2 2009 178 182
8. K.P. Karalis, P. Giannogonas, and E. Kodela et al. Mechanisms of obesity and related pathology: Linking immune responses to metabolic stress FEBS J 276 20 2009 5747 5754
9. M. Visser, L.M. Bouter, and G.M. McQuillan et al. Elevated C-reactive protein levels in overweight and obese adults JAMA 282 22 1999 2131 2135
10. J. Womack, P.C. Tien, and J. Feldman et al. Obesity and immune cell counts in women Metabolism 56 2007 998 1004
11. D.C. Nieman, D.A. Henson, and S.L. Nehlsen-Cannarella et al. Influence of obesity on immune function J Am Diet Assoc 99 1999 294 299
12. J.A. Kim, and H.S. Park White blood cell count and abdominal fat distribution in female obese adolescents Metabolism 57 2008 1375 1379
13. D.B. Panagiotakos, C. Pitsavos, and M. Yannakoulia et al. The implication of obesity and central fat on markers of chronic inflammation: The ATTICA study Atherosclerosis 183 2005 308 315
14. K. van der Weerd, W.A. Dik, and B. Schrijver et al. Morbidly obese human subjects have increased peripheral blood CD4 + T cells with skewing toward a Treg- and Th2-dominated phenotype Diabetes 61 2 2012 401 408
15. S. Winer, G. Paltser, and Y. Chan et al. Obesity predisposes to Th17 bias Eur J Immunol 39 2009 2629 2635
16. A. Viardot, L.K. Heilbronn, and D. Samocha-Bonet et al. Obesity is associated with activated and insulin resistant immune cells Diabetes Metab Res Rev 28 5 2012 447 454
17. M. Jagannathan-Bogdan, M.E. McDonnell, and H. Shin et al. Elevated proinflammatory cytokine production by a skewed T cell compartment requires monocytes and promotes inflammation in type 2 diabetes J Immunol 186 2 2011 1162 1172
18. S. Cinti, G. Mitchell, and G. Barbatelli et al. Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans J Lipid Res 46 2005 2347 2355
19. I. Murano, G. Barbatelli, and V. Parisani et al. Dead adipocytes, detected as crown-like structures, are prevalent in visceral fat depots of genetically obese mice J Lipid Res 49 2008 1562 1568
20. A. Gornicka, J. Fettig, and A. Eguchi et al. Adipocyte hypertrophy is associated with lysosomal permeability both in vivo and in vitro: Role in adipose tissue inflammation Am J Physiol Endocrinol Metab 303 5 2012 E597 E606
21. C.M. Apovian, S. Bigornia, and M. Mott et al. Adipose macrophage infiltration is associated with insulin resistance and vascular endothelial dysfunction in obese subjects Arterioscler Thromb Vasc Biol 28 9 2008 1654 1659
22. X.J. Xu, M.S. Gauthier, and D.T. Hess et al. Insulin sensitive and resistant obesity in humans: AMPK activity, oxidative stress, and depot-specific changes in gene expression in adipose tissue J Lipid Res 53 4 2012 792 801
23. U. Kintscher, M. Hartge, and K. Hess et al. T-lymphocyte infiltration in visceral adipose tissue: A primary event in adipose tissue inflammation and the development of obesity-mediated insulin resistance Arterioscler Thromb Vasc Biol 28 2008 1304 1310
24. S. Nishimura, I. Manabe, and M. Nagasaki et al. CD8 + effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity Nat Med 15 2009 914 920
25. A. Ioan-Facsinay, J.C. Kwekkeboom, and S. Westhoff et al. Adipocyte-derived lipids modulate CD4(+) T-cell function Eur J Immunol 43 6 2013 1578 1587
26. A.D. Karelis, M. Faraj, and J.P. Bastard et al. The metabolically healthy but obese individual presents a favorable inflammation profile Clin Endocrinol Metab 90 7 2005 4145 4150
27. C.M. Phillips, and I.J. Perry Does inflammation determine metabolic health status in obese and nonobese adults? J Clin Endocrinol Metab 98 10 2013 E1610 E1619
28. N. Katsiki, D.P. Mikhailidis, and A. Gotzamani-Psarrakou et al. Effect of various treatments on leptin, adiponectin, ghrelin and neuropeptide Y in patients with type 2 diabetes mellitus Expert Opin Ther Targets 15 4 2011 401 420
29. S. Mirza, M. Hossain, and C. Mathews et al. Type 2-diabetes is associated with elevated levels of TNF-alpha, IL-6 and adiponectin and low levels of leptin in a population of Mexican Americans: A cross-sectional study Cytokine 57 1 2012 136 142
30. C.S. Mantzoros, S. Moschos, and I. Avramopoulos et al. Leptin concentrations in relation to body mass index and the tumor necrosis factor-alpha system in humans J Clin Endocrinol Metab 82 1997 3408 3413
31. K. Isoda, J.L. Young, and A. Zirlik et al. Metformin inhibits proinflammatory responses and nuclear factor-kappaB in human vascular wall cells Arterioscler Thromb Vasc Biol 26 3 2006 611 732
32. D.H. Akbar Effect of metformin and sulfonylurea on C-reactive protein level in well-controlled type 2 diabetics with metabolic syndrome Endocrine 20 3 2003 215 218
33. M.E. Solano, V. Sander, and M.R. Wald et al. Dehydroepiandrosterone and metformin regulate proliferation of murine T lymphocytes Clin Exp Immunol 153 2 2008 289 296