Characterization of micro-invasive trabecular bypass stents by ex vivo perfusion and computational flow modeling

Clinical Ophthalmology

Volumn 8, Issue , 2014, Pages 499-506

  Hunter, Kendall S ^a   Fjield, Todd ^b   Heitzmann, Hal ^b   Shandas, Robin ^a   Kahook, Malik Y ^c  

^a The University of Colorado Denver   (United States)

^b Glaukos Corporation   (United States)

^c UNIVERSITY OF COLORADO HOSPITAL   (United States)

Author keywords

Ab interno; CFD; Glaucoma; Intraocular pressure; Istent; Trabecular bypass

Indexed keywords

ARTICLE; COMPUTATIONAL FLUID DYNAMICS; CONTROLLED STUDY; EX VIVO STUDY; EYE; FLOW KINETICS; HUMAN; HUMAN TISSUE; INTRAOCULAR PRESSURE; MATHEMATICAL MODEL; OPHTHALMOLOGICAL IMPLANT; STENT; TISSUE PERFUSION; TRABECULAR BYPASS STENT;

EID: 84896444820     PISSN: 11775467     EISSN: 11775483     Source Type: Book Series    
DOI: 10.2147/OPTH.S56245     Document Type: Article

References (22)

1. Resnikoff S, Pascolini D, Etya'ale D, et al. Global data on visual impairment in the year 2002. Bull World Health Organ. 2004;82(11): 844-851.
2. Boland MV, Ervin AM, Friedman D, et al. Treatment for Glaucoma: Comparative Effectiveness. Comparative Effectiveness Review No 60. (Prepared by the Johns Hopkins University Evidence-based Practice Center under Contract No HHSA 290-2007-10061-I.) AHRQ Publication No 12-EHC038-EF. Rockville, MD: Agency for Healthcare Research and Quality. April 2012. Available from:http://www.effectivehealthcare.ahrq.gov/ehc/products/183/1024/CER60_Glaucoma-Treatment_20120524.pdf. Accessed January 1, 2014.
3. Saheb H, Ahmed II. Micro-invasive glaucoma surgery: current perspectives and future directions. Curr Opin Ophthalmol. 2012;23:96-104.
4. Bahler CK, Smedley GT, Zhou J, Johnson DH. Trabecular bypass stents decrease intraocular pressure in cultured human anterior segments. Am J Ophthalmol. 2004;138(6):988-996.
5. Bahler CK, Hann CR, Fjield T, Haffner D, Heitzmann H, Fautsch MP. Second-generation trabecular meshwork bypass stent (iStent inject) increases outflow facility in cultured human anterior segments. Am J Ophthalmol. 2012;153:1206-1213.
6. Zhou J, Smedley GT. A trabecular bypass flow hypothesis. J Glaucoma. 2005;14(1):74-83.
7. Samuelson TW, Katz LJ, Wells JM, Duh YJ, Giamporcaro JE. Randomized evaluation of the trabecular micro-bypass stent with phacoemulsification in patients with glaucoma and cataract. Ophthalmology. 2011;118:459-467.
8. Belovay GW, Nagi A, Chan B, Rateb M, Ahmed II. Using multiple trabecular micro-bypass stents in cataract patients to treat primary open-angle glaucoma. J Cataract Refract Surg. 2012;38(11):1911-1917.
9. Fea AM. Phacoemulsification versus phacoemulsification with micro-bypass stent implantation in primary open-angle glaucoma. Randomized double-masked clinical trial. J Cataract Refract Surg. 2010;36:407-412.
10. Craven ER, Katz LJ, Wells JM, Giamporcaro JE. Cataract surgery with trabecular micro-bypass stent implantation in patients with mild-moderate open-angle glaucoma and cataract: two-year follow-up. J Cataract Refract Surg. 2012;38:1339-1345.
11. Arriola-Villalobos P, Martínez-de-la-Casa JM, Díaz-Valle D, Fernández-Pérez C, García-Sánchez J, García-Feijoó J. Combined iStent trabecular micro-bypass stent implantation and phacoemulsification for coexistent open-angle glaucoma and cataract: a long-term study. Br J Ophthalmol. 2012;96(5):645-649.
12. Arriola-Villalobos P, Morales-Fernández L, Martínez-de-la-Casa JM, García-Feijoó J.Effects of Glaukos® trabecular stent in the treatment of glaucoma. Eur Ophthalmic Rev. 2013;7(1):10-13.
13. Spiegel D, Wetzel W, Neuhann T, et al. Coexistent primary open-angle glaucoma and cataract: interim analysis of a trabecular micro-bypass stent and concurrent cataract surgery. Eur J Ophthalmol. 2009;19(3): 393-399.
14. Francois J, Rabaey M, Neetens A, Evens L. Further perfusion studies on the outflow of aqueous humor in human eyes. Arch Ophthalmol. 1958;59:683-691.
15. Van Buskirk EM, Grant WM. Lens depression and aqueous outflow in enucleated primate eyes. Am J Ophthalmol. 1973;76:632-640.
16. Moses RA, Grodzki WJ Jr. Choroid tension and facility of aqueous outflow. Invest Ophthalmol Vis Sci. 1977;16(11):1062-1064.
17. Brubaker RF. The effect of intraocular pressure on conventional outflow resistance in the enucleated human eye. Invest Ophthalmol. 1975;14(4):286-292.
18. Dijkstra BG, Ruijter JM, Hoyng PF. Outflow characteristics of isolated anterior segments of human eyes. Invest Ophthalmol Vis Sci. 1996;37(10):2015-2021.
19. Vass C, Hirn C, Unger E, et al. Human aqueous humor viscosity in cataract, primary open angle glaucoma and pseudoexfoliation syndrome. Invest Ophthalmol Vis Sci. 2004;45:E-abstract 5030.
20. Brubaker RF. Measurement of aqueous flow by fluorophotometry. In: Ritch R, Shields MB, Krupin T, editors. The Glaucomas. St Louis: Mosby; 1989:337-344.
21. Epstein DL. Schlemm canal surgery. Glaucoma Today. 2013 September/October:46-49.
22. Rosenquist R, Epstein D, Melamed S, Johnson M, Grant WM. Outflow resistance of enucleated eyes at two different perfusion pressures and different extents of trabeculotomy. Curr Eye Res. 1989;8(12): 1233-1240.