Cardiopulmonary bypass is associated with hemolysis and acute kidney injury in neonates, infants, and children*

Pediatric Critical Care Medicine

Volumn 15, Issue 3, 2014, Pages

  Mamikonian, Lara S ^a   Mamo, Lisa B ^a   Smith, P Brian ^a,b   Koo, Jeannie ^a   Lodge, Andrew J ^a   Turi, Jennifer L ^a  

^a DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b DUKE CLINICAL RESEARCH INSTITUTE   (United States)

Author keywords

acute kidney injury; cardiopulmonary bypass; cystatin C; hemolysis; neutrophil gelatinase associated lipocalin; pediatrics

Indexed keywords

CREATININE; CYSTATIN C; HAPTOGLOBIN; HEMOGLOBIN; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; ACUTE PHASE PROTEIN; BIOLOGICAL MARKER; LCN2 PROTEIN, HUMAN; LIPOCALIN; ONCOPROTEIN;

ACUTE KIDNEY FAILURE; ADOLESCENT; ARTICLE; CARDIOPULMONARY BYPASS; CLINICAL ARTICLE; CONGENITAL HEART DISEASE; CREATININE BLOOD LEVEL; DISEASE ASSOCIATION; DISEASE DURATION; FEMALE; HEART SURGERY; HEMOGLOBIN BLOOD LEVEL; HEMOLYSIS; HUMAN; MALE; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; URINALYSIS; ACUTE KIDNEY INJURY; BLOOD; CHILD; INFANT; INTENSIVE CARE UNIT; KIDNEY FUNCTION TEST; NEWBORN; PILOT STUDY; PRESCHOOL CHILD; PROSPECTIVE STUDY; URINE;

ACUTE KIDNEY INJURY; ACUTE-PHASE PROTEINS; BIOLOGICAL MARKERS; CARDIOPULMONARY BYPASS; CHILD; CHILD, PRESCHOOL; CYSTATIN C; FEMALE; HAPTOGLOBINS; HEMOLYSIS; HUMANS; INFANT; INFANT, NEWBORN; INTENSIVE CARE UNITS, PEDIATRIC; KIDNEY FUNCTION TESTS; LIPOCALINS; MALE; PILOT PROJECTS; PROSPECTIVE STUDIES; PROTO-ONCOGENE PROTEINS;

EID: 84896402314     PISSN: 15297535     EISSN: 19473893     Source Type: Journal    
DOI: 10.1097/PCC.0000000000000047     Document Type: Article

References (37)

1. Thakar CV, Worley S, Arrigain S, et al: Influence of renal dysfunction on mortality after cardiac surgery: Modifying effect of preoperative renal function. Kidney Int 2005; 67:1112-1119 (Pubitemid 41623337)
2. Li S, Krawczeski CD, Zappitelli M, et al; TRIBE-AKI Consortium: Incidence, risk factors, and outcomes of acute kidney injury after pediatric cardiac surgery: A prospective multicenter study. Crit Care Med 2011; 39:1493-1499
3. Zappitelli M, Bernier PL, Saczkowski RS, et al: A small post-operative rise in serum creatinine predicts acute kidney injury in children undergoing cardiac surgery. Kidney Int 2009; 76:885-892
4. Kozik DJ, Tweddell JS: Characterizing the inflammatory response to cardiopulmonary bypass in children. Ann Thorac Surg 2006; 81:S2347-S2354 (Pubitemid 43775604)
5. Cruz DN, Ronco C, Katz N: Neutrophil gelatinase-associated lipocalin: A promising biomarker for detecting cardiac surgery-associated acute kidney injury. J Thorac Cardiovasc Surg 2010; 139:1101-1106
6. Vermeulen Windsant IC, Hanssen SJ, Buurman WA, et al: Cardiovascular surgery and organ damage: Time to reconsider the role of hemolysis. J Thorac Cardiovasc Surg 2011; 142:1-11
7. Jones TJ, Elliott MJ: Paediatric CPB: Bypass in a high risk group. Perfusion 2006; 21:229-233 (Pubitemid 44275555)
8. Marwah SS, Blann A, Harrison P, et al: Increased non-transferrin bound iron in plasma-depleted SAG-M red blood cell units. Vox Sang 2002; 82:122-126 (Pubitemid 36806450)
9. Mumby S, Chaturvedi RR, Brierley J, et al: Iron overload in paediatrics undergoing cardiopulmonary bypass. Biochim Biophys Acta 2000; 1500:342-348 (Pubitemid 30123065)
10. Bennett-Guerrero E, Veldman TH, Doctor A, et al: Evolution of adverse changes in stored RBCs. Proc Natl Acad Sci USA 2007; 104:17063-17068 (Pubitemid 350210992)
11. Moore E, Bellomo R, Nichol A: Biomarkers of acute kidney injury in anesthesia, intensive care and major surgery: From the bench to clinical research to clinical practice. Minerva Anestesiol 2010; 76:425-440
12. Mishra J, Dent C, Tarabishi R, et al: Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery. Lancet 2005; 365:1231-1238 (Pubitemid 40469655)
13. Bennett M, Dent CL, Ma Q, et al: Urine NGAL predicts severity of acute kidney injury after cardiac surgery: A prospective study. Clin J Am Soc Nephrol 2008; 3:665-673
14. Villa P, Jiménez M, Soriano MC, et al: Serum cystatin C concentration as a marker of acute renal dysfunction in critically ill patients. Crit Care 2005; 9:R139-R143
15. Lacour-Gayet F, Clarke D, Jacobs J, et al; Aristotle Committee: The Aristotle score for congenital heart surgery. Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 2004; 7:185-191 (Pubitemid 38678737)
16. O'Brien SM, Clarke DR, Jacobs JP, et al: An empirically based tool for analyzing mortality associated with congenital heart surgery. J Thorac Cardiovasc Surg 2009; 138:1139-1153
17. Akcan-Arikan A, Zappitelli M, Loftis LL, et al: Modified RIFLE criteria in critically ill children with acute kidney injury. Kidney Int 2007; 71:1028-1035 (Pubitemid 46741996)
18. Schwartz GJ, Haycock GB, Edelmann CM Jr, et al: A simple estimate of glomerular filtration rate in children derived from body length and plasma creatinine. Pediatrics 1976; 58:259-263
19. Schwartz GJ, Brion LP, Spitzer A: The use of plasma creatinine concentration for estimating glomerular filtration rate in infants, children, and adolescents. Pediatr Clin North Am 1987; 34:571-590 (Pubitemid 17080631)
20. Kumar S, Bandyopadhyay U: Free heme toxicity and its detoxification systems in human. Toxicol Lett 2005; 157:175-188 (Pubitemid 40726102)
21. Carmona F, Manso PH, Vicente WV, et al: Risk stratification in neonates and infants submitted to cardiac surgery with cardiopulmonary bypass: A multimarker approach combining inflammatory mediators, N-terminal pro-B-type natriuretic peptide and troponin I. Cytokine 2008; 42:317-324
22. Liu KD, Altmann C, Smits G, et al: Serum interleukin-6 and interleukin-8 are early biomarkers of acute kidney injury and predict prolonged mechanical ventilation in children undergoing cardiac surgery: A case-control study. Crit Care 2009; 13:R104
23. Hovels-Gurich HH, Schumacher K, Vazquez-Jimenez JF, et al: Cytokine balance in infants undergoing cardiac operation. Ann Thorac Surg 2002; 73:601-608; discussion 608-609 (Pubitemid 34117418)
24. Christen S, Finckh B, Lykkesfeldt J, et al: Oxidative stress precedes peak systemic inflammatory response in pediatric patients undergoing cardiopulmonary bypass operation. Free Radic Biol Med 2005; 38:1323-1332 (Pubitemid 40602834)
25. Aft RL, Mueller GC: Hemin-mediated oxidative degradation of proteins. J Biol Chem 1984; 259:301-305 (Pubitemid 14177654)
26. Balla G, Vercellotti GM, Muller-Eberhard U, et al: Exposure of endothelial cells to free heme potentiates damage mediated by granulocytes and toxic oxygen species. Lab Invest 1991; 64:648-655
27. Balla J, Vercellotti GM, Jeney V, et al: Heme, heme oxygenase, and ferritin: How the vascular endothelium survives (and dies) in an iron-rich environment. Antioxid Redox Signal 2007; 9:2119-2137 (Pubitemid 350059014)
28. Jeney V, Balla J, Yachie A, et al: Pro-oxidant and cytotoxic effects of circulating heme. Blood 2002; 100:879-887 (Pubitemid 34832613)
29. Reiter CD, Wang X, Tanus-Santos JE, et al: Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease. Nat Med 2002; 8:1383-1389 (Pubitemid 36019423)
30. Krawczeski CD, Woo JG, Wang Y, et al: Neutrophil gelatinase-associated lipocalin concentrations predict development of acute kidney injury in neonates and children after cardiopulmonary bypass. J Pediatr 2011; 158:1009.e1-1015.e1
31. Dent CL, Ma Q, Dastrala S, et al: Plasma neutrophil gelatinase-associated lipocalin predicts acute kidney injury, morbidity and mortality after pediatric cardiac surgery: A prospective uncontrolled cohort study. Crit Care 2007; 11:R127
32. Zheng J, Xiao Y, Yao Y, et al: Comparison of urinary biomarkers for early detection of acute kidney injury after cardiopulmonary bypass surgery in infants and young children. Pediatr Cardiol 2013; 34:880-886
33. Lassnigg A, Schmidlin D, Mouhieddine M, et al: Minimal changes of serum creatinine predict prognosis in patients after cardiothoracic surgery: A prospective cohort study. J Am Soc Nephrol 2004; 15:1597-1605 (Pubitemid 38679685)
34. Lassnigg A, Schmid ER, Hiesmayr M, et al: Impact of minimal increases in serum creatinine on outcome in patients after cardiothoracic surgery: Do we have to revise current definitions of acute renal failure Crit Care Med 2008; 36:1129-1137 (Pubitemid 351482661)
35. Mammen C, Al Abbas A, Skippen P, et al: Long-term risk of CKD in children surviving episodes of acute kidney injury in the intensive care unit: A prospective cohort study. Am J Kidney Dis 2012; 59:523-530
36. Ricci Z, Luciano R, Favia I, et al: High-dose fenoldopam reduces postoperative neutrophil gelatinase-associated lipocaline and cystatin C levels in pediatric cardiac surgery. Crit Care 2011; 15:R160
37. Ozment CP, Mamo LB, Campbell ML, et al: Transfusion-related biologic effects and free hemoglobin, heme, and iron. Transfusion 2013; 53:732-740