Prognostic significance and predictors of the neutrophil-to-lymphocyte ratio in ovarian cancer

Gynecologic Oncology

Volumn 132, Issue 3, 2014, Pages 542-550

  Williams, Kristina A ^a,b   Labidi Galy, S Intidhar ^c   Terry, Kathryn L ^a,b,d   Vitonis, Allison F ^a   Welch, William R ^a   Goodman, Annekathryn ^b,e   Cramer, Daniel W ^a,b,d  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c DANA FARBER CANCER INSTITUTE   (United States)

^d HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^e MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

CA125; Ovarian cancer; Risk factors

Indexed keywords

CA 125 ANTIGEN; TALC;

ADULT; AGED; APPENDECTOMY; ARTICLE; ASCITES; BODY HEIGHT; CANCER GRADING; CANCER GROWTH; CANCER PROGNOSIS; CANCER STAGING; CANCER SURVIVAL; CLEAR CELL CARCINOMA; DISEASE FREE SURVIVAL; ENDOMETRIOSIS; ETHNICITY; FAMILIAL CANCER; FAMILY HISTORY; FEMALE; HEMATOLOGICAL PARAMETERS; HUMAN; HUMAN TISSUE; HYSTERECTOMY; LEUKOCYTE COUNT; LEUKOCYTE DIFFERENTIAL COUNT; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; MASTITIS; MENSTRUAL CYCLE; MIDDLE AGED; MONOCYTE; NEUTROPHIL; NEUTROPHIL COUNT; NEUTROPHIL TO LYMPHOCYTE RATIO; ORAL CONTRACEPTIVE USE; OVARY CANCER; OVERALL SURVIVAL; PARITY; PELVIS; PREMENOPAUSE; PRIORITY JOURNAL; SMOKING; TRANSITIONAL CELL CARCINOMA; UNITED STATES; UTERINE TUBE LIGATION;

CA125; OVARIAN CANCER; RISK FACTORS;

ADULT; AGED; CA-125 ANTIGEN; FEMALE; HUMANS; LEUKOCYTE COUNT; LYMPHOCYTES; MEMBRANE PROTEINS; MIDDLE AGED; NEUTROPHILS; OVARIAN NEOPLASMS;

EID: 84896395258     PISSN: 00908258     EISSN: 10956859     Source Type: Journal    
DOI: 10.1016/j.ygyno.2014.01.026     Document Type: Article

References (35)

1. K. Geddes, J.G. Magalhaes, and S.E. Girardin Unleashing the therapeutic potential of NOD-like receptors Nat Rev Drug Discov 8 2009 465 479
2. T. Bhat, S. Teli, J. Rijal, H. Bhat, M. Raza, and G. Khoueiry et al. Neutrophil to lymphocyte ratio and cardiovascular diseases: a review Expert Rev Cardiovasc Ther 11 2013 55 59
3. G.J. Guthrie, K.A. Charles, C.S. Roxburgh, P.G. Horgan, D.C. McMillan, and S.J. Clarke The systemic inflammation-based neutrophil-lymphocyte ratio: experience in patients with cancer Crit Rev Oncol Hematol 88 2013 218 230
4. E. Buyukkaya, M.F. Karakas, E. Karakas, A.B. Akcay, M. Kurt, and I.H. Tanboga et al. Correlation of neutrophil to lymphocyte ratio with the presence and severity of metabolic syndrome Clin Appl Thromb Hemost Sep 18, 2012 [Epub ahead of print]
5. G. Calapai, A.P. Caputi, C. Mannucci, G.A. Russo, E. Gregg, and R. Puntoni et al. Cardiovascular biomarkers in groups of established smokers after a decade of smoking Basic Clin Pharmacol Toxicol 104 2009 322 328
6. J.S. Chae, J.K. Paik, R. Kang, M. Kim, Y. Choi, and S.H. Lee et al. Mild weight loss reduces inflammatory cytokines, leukocyte count, and oxidative stress in overweight and moderately obese participants treated for 3 years with dietary modification Nutr Res 33 2013 195 203
7. E. Van Tiel, P.H. Peeters, H.A. Smit, N.J. Nagelkerke, A.J. Van Loon, and D.E. Grobbee et al. Quitting smoking may restore hematological characteristics within five years Ann Epidemiol 12 2002 378 388
8. H. Cho, H.W. Hur, S.W. Kim, S.H. Kim, J.H. Kim, and Y.T. Kim et al. Pre-treatment neutrophil to lymphocyte ratio is elevated in epithelial ovarian cancer and predicts survival after treatment Cancer Immunol Immunother 58 2009 15 23
9. M.J. Webb, G.D. Malkasian Jr., and E.O. Jorgensen Factors influencing ovarian cancer survival after chemotherapy Obstet Gynecol 44 1974 564 570
10. J.P. Wolff, and C.F. de Oliveira Lymphocytes in patients with ovarian cancer Obstet Gynecol 45 1975 656 658
11. K. Milne, C. Alexander, J.R. Webb, W. Sun, K. Dillon, and S.E. Kalloger et al. Absolute lymphocyte count is associated with survival in ovarian cancer independent of tumor-infiltrating lymphocytes J Transl Med 10 2012 33
12. S. Bishara, M. Griffin, A. Cargill, A. Bali, M.E. Gore, and S.B. Kaye et al. Pre-treatment white blood cell subtypes as prognostic indicators in ovarian cancer Eur J Obstet Gynecol Reprod Biol 138 2008 71 75
13. J.A. Belisle, S. Horibata, G.A. Jennifer, S. Petrie, A. Kapur, and S. Andre et al. Identification of Siglec-9 as the receptor for MUC16 on human NK cells, B cells, and monocytes Mol Cancer 9 2010 118
14. D.W. Cramer, A.F. Vitonis, W.R. Welch, K.L. Terry, A. Goodman, and B.R. Rueda et al. Correlates of the preoperative level of CA125 at presentation of ovarian cancer Gynecol Oncol 119 2010 462 468
15. P. De Paoli, S. Battistin, and G.F. Santini Age-related changes in human lymphocyte subsets: progressive reduction of the CD4 CD45R (suppressor inducer) population Clin Immunol Immunopathol 48 1988 290 296
16. J. Schwartz, and S.T. Weiss Cigarette smoking and peripheral blood leukocyte differentials Ann Epidemiol 4 1994 236 242
17. D.C. Nieman, D.A. Henson, S.L. Nehlsen-Cannarella, M. Ekkens, A.C. Utter, and D.E. Butterworth et al. Influence of obesity on immune function J Am Diet Assoc 99 1999 294 299
18. J. Green, B.J. Cairns, D. Casabonne, F.L. Wright, G. Reeves, and V. Beral Height and cancer incidence in the Million Women Study: prospective cohort, and meta-analysis of prospective studies of height and total cancer risk Lancet Oncol 12 2011 785 794
19. Ovarian cancer and body size: individual participant meta-analysis including 25,157 women with ovarian cancer from 47 epidemiological studies PLoS Med 9 2012 e1001200
20. G. Lettre Recent progress in the study of the genetics of height Hum Genet 129 2011 465 472
21. E. Widen, S. Ripatti, D.L. Cousminer, I. Surakka, T. Lappalainen, and M.R. Jarvelin et al. Distinct variants at LIN28B influence growth in height from birth to adulthood Am J Hum Genet 86 2010 773 782
22. K.K. Ong, C.E. Elks, S. Li, J.H. Zhao, J. Luan, and L.B. Andersen et al. Genetic variation in LIN28B is associated with the timing of puberty Nat Genet 41 2009 729 733
23. S.H. Beachy, M. Onozawa, Y.J. Chung, C. Slape, S. Bilke, and P. Francis et al. Enforced expression of Lin28b leads to impaired T-cell development, release of inflammatory cytokines, and peripheral T-cell lymphoma Blood 120 2012 1048 1059
24. C. Pelucchi, C. Galeone, R. Talamini, C. Bosetti, M. Montella, and E. Negri et al. Lifetime ovulatory cycles and ovarian cancer risk in 2 Italian case-control studies Am J Obstet Gynecol 196 83 2007 e1 e7
25. K.H. Tung, L.R. Wilkens, A.H. Wu, K. McDuffie, A.M. Nomura, and L.N. Kolonel et al. Effect of anovulation factors on pre- and postmenopausal ovarian cancer risk: revisiting the incessant ovulation hypothesis Am J Epidemiol 161 2005 321 329
26. K.L. Terry, S. Karageorgi, Y.B. Shvetsov, M.A. Merritt, G. Lurie, and P.J. Thompson et al. Genital powder use and risk of ovarian cancer: a pooled analysis of 8,525 cases and 9,859 controls Cancer Prev Res (Phila) 6 2013 811 821
27. D.W. Cramer, K. Williams, A.F. Vitonis, H.S. Yamamoto, A. Stuebe, and W.R. Welch et al. Puerperal mastitis: a reproductive event of importance affecting anti-mucin antibody levels and ovarian cancer risk Cancer Causes Control 24 2013 1911 1923
28. D.W. Cramer, L. Titus-Ernstoff, J.R. McKolanis, W.R. Welch, A.F. Vitonis, and R.S. Berkowitz et al. Conditions associated with antibodies against the tumor-associated antigen MUC1 and their relationship to risk for ovarian cancer Cancer Epidemiol Biomarkers Prev 14 2005 1125 1131
29. S.P. Pinheiro, S.E. Hankinson, S.S. Tworoger, B.A. Rosner, J.R. McKolanis, and O.J. Finn et al. Anti-MUC1 antibodies and ovarian cancer risk: prospective data from the Nurses' Health Studies Cancer Epidemiol Biomarkers Prev 19 2010 1595 1601
30. K.L. Terry, L. Titus-Ernstoff, J.R. McKolanis, W.R. Welch, O.J. Finn, and D.W. Cramer Incessant ovulation, mucin 1 immunity, and risk for ovarian cancer Cancer Epidemiol Biomarkers Prev 16 2007 30 35
31. S. Cho, H. Cho, A. Nam, H.Y. Kim, Y.S. Choi, and K.H. Park et al. Neutrophil-to-lymphocyte ratio as an adjunct to CA-125 for the diagnosis of endometriosis Fertil Steril 90 2008 2073 2079
32. J.A. Parrott, G. Kim, and M.K. Skinner Expression and action of kit ligand/stem cell factor in normal human and bovine ovarian surface epithelium and ovarian cancer Biol Reprod 62 2000 1600 1609
33. P. Pisa, E. Halapi, E.K. Pisa, E. Gerdin, C. Hising, and A. Bucht et al. Selective expression of interleukin 10, interferon gamma, and granulocyte-macrophage colony-stimulating factor in ovarian cancer biopsies Proc Natl Acad Sci U S A 89 1992 7708 7712
34. F. Ponchel, R.J. Verburg, S.J. Bingham, A.K. Brown, J. Moore, and A. Protheroe et al. Interleukin-7 deficiency in rheumatoid arthritis: consequences for therapy-induced lymphopenia Arthritis Res Ther 7 2005 R80 R92
35. J.A. Hamilton Colony-stimulating factors in inflammation and autoimmunity Nat Rev Immunol 8 2008 533 544