Effects of a non-focal plasticity protocol on apathy in moderate alzheimer's disease: A randomized, double-blind, sham-controlled trial

Brain Stimulation

Volumn 7, Issue 2, 2014, Pages 308-313

  Suemoto, Claudia Kimie ^a   Apolinario, Daniel ^a   Nakamura Palacios, Ester Miyuki ^b   Lopes, Leonardo ^a   Paraizo Leite, Renata Elaine ^a   Sales, Manuela Castro ^a   Nitrini, Ricardo ^a   Brucki, Sonia Maria ^a   Morillo, Lilian Shafirovitz ^a   Magaldi, Regina Miksian ^a   Fregni, Felipe ^c  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b FEDERAL UNIVERSITY OF ESPÍRITO SANTO   (Brazil)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Alzheimer's disease; Apathy; Cognition; Dementia; Depression; Transcranial direct current stimulation

Indexed keywords

ANTIDEPRESSANT AGENT; CHOLINESTERASE INHIBITOR; HYPNOTIC AGENT; MEMANTINE; NEUROLEPTIC AGENT;

ADULT; AGED; ALZHEIMER DISEASE; APATHY; ARTICLE; CAREGIVER; CAREGIVER BURDEN; CLINICAL ARTICLE; CLINICAL EVALUATION; CLINICAL PROTOCOL; COGNITION; CONTROLLED STUDY; CORNELL SCALE FOR DEPRESSION IN DEMENTIA; DOUBLE BLIND PROCEDURE; EMOTIONAL DISORDER; HUMAN; MIDDLE AGED; MINI MENTAL STATE EXAMINATION; NERVE CELL PLASTICITY; OUTCOME ASSESSMENT; PARALLEL DESIGN; PHASE 2 CLINICAL TRIAL; PREFRONTAL CORTEX; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SKIN BURNING SENSATION; SKIN TINGLING; STRUCTURED QUESTIONNAIRE; TRANSCRANIAL DIRECT CURRENT STIMULATION; VERY ELDERLY; WORD LIST RECALL; WORD RECOGNITION; CLINICAL TRIAL; FEMALE; MALE; PATHOPHYSIOLOGY; PHYSIOLOGY; PROCEDURES; PSYCHOLOGY; TREATMENT OUTCOME;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; APATHY; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; PREFRONTAL CORTEX; TRANSCRANIAL DIRECT CURRENT STIMULATION; TREATMENT OUTCOME;

EID: 84896391410     PISSN: 1935861X     EISSN: 18764754     Source Type: Journal    
DOI: 10.1016/j.brs.2013.10.003     Document Type: Article

References (30)

1. G.M. McKhann, D.S. Knopman, H. Chertkow, B.T. Hyman, C.R. Jack Jr., and C.H. Kawas et al. The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease Alzheimers Dement 7 3 2011 263 269.
2. M. Prince, and J. Jackson World Alzheimer report 2009 Alzheimer's Dis Int 2009 p. 8-10.
3. C.P. Ferri, M. Prince, C. Brayne, H. Brodaty, L. Fratiglioni, and M. Ganguli et al. Global prevalence of dementia: a Delphi consensus study Lancet 366 9503 2005 2112 2117.
4. K.M. Sink, K.F. Holden, and K. Yaffe Pharmacological treatment of neuropsychiatric symptoms of dementia - a review of the evidence JAMA 293 5 2005 596 608.
5. R. Mizrahi, and S.E. Starkstein Epidemiology and management of apathy in patients with Alzheimer's disease Drugs Aging 24 7 2007 547 554.
6. V.A. Holthoff, B. Beuthien-Baumann, E. Kalbe, S. Ludecke, O. Lenz, and G. Zundorf et al. Regional cerebral metabolism in early Alzheimer's disease with clinically significant apathy or depression Biol Psychiatry 57 2005 412 421.
7. S.E. Starkstein, H.S. Mayberg, T.J. Preziosi, P. Andrezejewski, R. Leiguarda, and R.G. Robinson Reliability, validity, and clinical correlates of apathy in Parkinson's disease J Neuropsychiatry Clin Neurosci 4 2 1992 134 139.
8. G. McKhann, D. Drachman, M. Folstein, R. Katzman, D. Price, and E.M. Stadlan Clinical diagnosis of Alzheimer's disease report of the NINCDS-ADRDA work group under the auspices of Department of Health and Human Services Task Force on Alzheimer's disease Neurology 34 7 1984 939 944.
9. M.F. Folstein, S.E. Folstein, and P.R. McHugh "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician J Psychiatr Res 12 3 1975 189 198.
10. G.S. Alexopoulos, R.C. Abrams, R.C. Young, and C.A. Shamoian Cornell scale for depression in dementia Biol Psychiatry 23 3 1988 271 284.
11. P.S. Boggio, L.P. Khoury, D.C.S. Martins, O. Martins, E.C. de Macedo, and F. Fregni Temporal cortex direct current stimulation enhances performance on a visual recognition memory task in Alzheimer disease J Neurol Neurosurg Psychiatry 80 4 2009 444 447.
12. A.R. Brunoni, L. Valiengo, A. Baccaro, T.A. Zanao, J.F. De Oliveira, and A. Goulart et al. The sertraline vs electrical current therapy for treating depression clinical study results from a factorial, randomized, controlled trial JAMA Psychiatry 70 2013 383 391.
13. T. Wagner, F. Fregni, S. Fecteau, A. Grodzinsky, M. Zahn, and A. Pascual-Leone Transcranial direct current stimulation: a computer-based human model study Neuroimage 35 2007 1113 1124.
14. J.L. Cummings, M. Mega, K. Gray, S. Rosenbergthompson, D.A. Carusi, and J. Gornbein The Neuropsychiatric Inventory - comprehensive assessment of psychopathology in dementia Neurology 44 12 1994 2308 2314.
15. R.C. Mohs, D. Knopman, R.C. Petersen, S.H. Ferris, C. Ernesto, and M. Grundman et al. Development of cognitive instruments for use in clinical trials of antidementia drugs: additions to the Alzheimer's Disease Assessment Scale that broaden its scope. The Alzheimer's Disease Cooperative Study Alzheimer Dis Assoc Disord 11 Suppl. 2 1997 S13 S21.
16. H.J. Rosen, S.C. Allison, G.F. Schauer, M.L. Gorno-Tempini, M.W. Weiner, and B.L. Miller Neuroanatomical correlates of behavioural disorders in dementia Brain 128 2005 2612 2625.
17. P.R. Padala, W.J. Burke, V.K. Shostrom, S.C. Bhatia, S.P. Wengel, and J.F. Potter et al. Methylphenidate for apathy and functional status in dementia of the Alzheimer type Am J Geriatr Psychiatry 18 4 2010 371 374.
18. N. Herrmann, L.S. Rothenburg, S.E. Black, M. Ryan, B.A. Liu, and U.E. Busto et al. Methylphenidate for the treatment of apathy in Alzheimer disease: prediction of response using dextroamphetamine challenge J Clin Psychopharmacol 28 3 2008 296 301.
19. J. Mintzer, P. Rosenberg, L. Drye, R. Scherer, N. Herrmann, and K. Lanctot Apathy in dementia methylphenidate trial (ADMET) - preliminary efficacy report Gerontologist 52 2012 625.
20. J. Ferrero-Arias, M. Goni-Imizcoz, J. Gonzalez-Bernal, F. Lara-Ortega, A. da Silva-Gonzalez, and M. Diez-Lopez The efficacy of nonpharmacological treatment for dementia-related apathy Alzheimer Dis Assoc Disord 25 3 2011 213 219.
21. L. Tapia-Arancibia, E. Aliaga, M. Silhol, and S. Arancibia New insights into brain BDNF function in normal aging and Alzheimer disease Brain Res Rev 59 1 2008 201 220.
22. T.V.P. Bliss, and G.L. Collingridge A synaptic model of memory - long-term potentiation in the hippocampus Nature 361 6407 1993 31 39.
23. C.J. Stagg, and M.A. Nitsche Physiological basis of transcranial direct current stimulation Neuroscientist 17 1 2011 37 53.
24. B. Fritsch, J. Reis, K. Martinowich, H.M. Schambra, Y. Ji, and L.G. Cohen et al. Direct current stimulation promotes BDNF-dependent synaptic plasticity: potential implications for motor learning Neuron 66 2 2010 198 204.
25. M.G. Murer, F. Boissiere, Q. Yan, S. Hunot, J. Villares, and B. Faucheux et al. An immunohistochemical study of the distribution of brain-derived neurotrophic factor in the adult human brain, with particular reference to Alzheimer's disease Neuroscience 88 4 1999 1015 1032.
26. P.S. Boggio, R. Ferrucci, S.P. Rigonatti, P. Covre, M. Nitsche, and A. Pascual-Leone et al. Effects of transcranial direct current stimulation on working memory in patients with Parkinson's disease J Neurol Sci 249 2006 31 38.
27. D. Hadley, B.S. Anderson, J.J. Borckardt, A. Arana, X.B. Li, and Z. Nahas et al. Safety, tolerability, and effectiveness of high doses of adjunctive daily left prefrontal repetitive transcranial magnetic stimulation for treatment-resistant depression in a clinical setting J ECT 27 2011 18 25.
28. R. Levy, and B. Dubois Apathy and the functional anatomy of the pre-frontal cortex-basal ganglia circuits Cereb Cortex 16 2006 916 928.
29. R. Ferrucci, F. Mameli, I. Guidi, S. Mrakic-Sposta, M. Vergari, and S. Marceglia et al. Transcranial direct current stimulation improves recognition memory in Alzheimer's disease Neurology 71 2008 493 498.
30. R. Nardone, J. Bergmann, M. Christova, F. Caleri, F. Tezzon, and G. Ladurner et al. Effect of transcranial brain stimulation for the treatment of Alzheimer disease: a review Int J Alzheimers Dis 2012 2012 687909