Control of hazardous processes in flow: Synthesis of 2-nitroethanol

Journal of Flow Chemistry

Volumn 4, Issue 1, 2014, Pages 26-34

  Roberge, Dominique M ^a   Noti, Christian ^a   Irle, Eberhard ^a   Eyholzer, Markus ^a   Rittiner, Bruno ^a   Penn, Gerhard ^b   Sedelmeier, Gottfried ^b   Schenkel, Berthold ^b  

^a LONZA AG   (Switzerland)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

2 nitroethanol; continuous flow; energetic compound; formaldehyde; hazardous chemistry; Henry reaction; microreactor technology; nitromethane; paraformaldehyde

Indexed keywords

EID: 84896378665     PISSN: 2062249X     EISSN: 20630212     Source Type: Journal    
DOI: 10.1556/JFC-D-13-00016     Document Type: Article

References (21)

1. Sedelmeier, G.; Novartis AG: WO 2008/119804 A1, 2008.
2. Hessel, V.; Loeb, P.; Loewe, H. In Microreactors in Organic Synthesis and Catalysis; Wirth, T., Ed.; Wiley-VCH Verlag GmbH & Co. KGaA: Weinheim, Germany, 2008.
3. Roberge, D. M.; Ducry, L.; Bieler, N.; Cretton, P.; Zimmermann, B. Chem. Eng. Technol. 2005, 28, 318.
4. Yoshida, J.-I.; Nagaki, A.; Yamada, T. Chem. Eur. J. 2008, 14, 7450.
5. Hessel, V.; Kralisch, D.; Kockmann, N.; Noel, T.; Wang, Q. Chem Sus Chem 2013, 6, 746.
6. Damm, M.; Glasnov, T. N.; Kappe, C. O. Org. Process Res. Dev. 2010, 14, 215.
7. Hessel, V.; Cortese, B.; deCroon, M.H. J. M.Chem. Eng. Sci. 2011, 66, 1426
8. de Bellefon, C.; Tanchoux, N.; Caravieilhes, S.; Grenouillet, P.; Hessel, V. Angew. Chem. Int. Ed. 2000, 39, 3442.
9. McMullen, J. P.; Jensen, K. F. Org. Process Res. Dev. 2010, 14, 1169.
10. Kambe, S.; Yasuda, H. Bull. Chem. Soc. Jpn. 1968, 41, 1444.
11. Hays, J. T.; Hager, G. F.; Engelmann, H. M.; Spurlin, H. M. J. Am. Chem. Soc. 1951, 73, 5369.
12. Grob, C.; Jenny, E. F. DE1118772, 1970.
13. Borah, J. C.; Gogoi, S.; Boruwa, J.; Barua, N. B. Synth. Commun. 2005, 35, 873.
14. Hen, L. N.; Russel, W. 1969; Vol. US Patent 3426084.
15. Noland, W. E. Org. Synth. 1973, Coll. Vol. 5, 833.
16. Meyer, R. Explosivstoffe; 6th ed.; VCH: Weinheim, 1985.
17. Roberge, D. M.; Gottsponer, M.; Eyholzer, M.; Kockmann, N. Chem. Today 2009, 27, 8.
18. Holvey, C. P.; Roberge, D. M.; Gottsponer, M.; Kockmann, N.; Macchi, A. Chem. Eng. Process. 2011, 50, 1069.
19. Gorski, I.M.; Makarow, S.P.Berichte der deutschen chemischen Gesellschaft (A and B Series) 1934, 67, 996.
20. Brandes, E.; Gödde, M.; Hirsch, W. Green Process. Synth. 2012, 1, 345.
21. Kockmann, N.; Roberge, D. M. Chem. Eng. Process. 2011, 50, 1017.