Design of a peptide inhibitor of tyrosine kinase 2

Protein and Peptide Letters

Volumn 21, Issue 5, 2014, Pages 419-425

  Works, Melissa G ^a   Song, Benben ^a   Kibler, Patrick ^a   Tanga, Mary J ^a   Galande, Amit K ^a   D'Andrea, Annalisa ^a  

^a SRI INTERNATIONAL   (United States)

Author keywords

Antisense peptide; JAK; TYK2; Tyrosine kinase

Indexed keywords

JANUS KINASE 2; JANUS KINASE 2 INHIBITOR; JANUS KINASE INHIBITOR;

ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENZYMATIC ASSAY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME INHIBITOR COMPLEX; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; HYDROPHILICITY; IN VITRO STUDY; INHIBITION KINETICS; STUDY DESIGN;

AMINO ACID SEQUENCE; CELL LINE; DRUG DESIGN; HUMANS; MOLECULAR SEQUENCE DATA; PEPTIDES; PROTEIN KINASE INHIBITORS; TYK2 KINASE;

EID: 84896341476     PISSN: 09298665     EISSN: None     Source Type: Journal    
DOI: 10.2174/0929866520666131203101841     Document Type: Article

References (16)

1. Levitzki, A. Tyrosine kinase inhibitors: Views of selectivity, sensitivity, and clinical performance. Annu. Rev. Pharmacol. Toxicol., 2013, 53, 161-185.
2. Huang, D.; Zhou, T.; Lafleur, K.; Nevado, C.; Caflisch, A. Kinase selectivity potential for inhibitors targeting the ATP binding site: a network analysis. Bioinformatics, 2010, 26, 198-204.
3. Eldar-Finkelman, H.; Eisenstein, M. Peptide inhibitors targeting protein kinases. Curr. Pharm. Des., 2009, 15(21), 2463-2407.
4. Strobl, B.; Stoiber, D.; Sexl, V.; Mueller, M. Tyrosine kinase 2 (TYK2) in cytokine signaling and host immunity. Front. Biosci., 2011, 16, 3214-3232.
5. Sohn, S.J.; Barrett, K.; Van Abbema, A.; Chang, C.; Kohli P.B.; Kanda, H.; Smith, J.; Lai, Y.; Zhou, A.; Zhang, B.; Yang, W.; Williams, K.; Macleod, C.; Hurley, C.A.; Kulagowski, J.J.; Lewin-Koh, N.; Dengler, H.S.; Johnson, A.R.; Ghilardi, N.; Zak, M.; Liang, J.; Blair, W.S.; Magnuson, S.; Wu, L. A restricted role for TYK2 catalytic activity in human cytokine responses revealed by novel TYK2-selective inhibitors. J. Immunol., 2013, 191, 2205-2216.
6. Root-Bernstein, R.S.; Holsworth, D.D. Antisense peptides: a critical mini-review. J. Theor. Biol., 1998, 190, 107-119.
7. Siemion, I.Z.; Cebrat, M.; Kluczyk, A. The problem of amino acid complementarity and antisense peptides. Curr. Protein Pept. Sci., 2004, 5, 507-527.
8. Flowers, L.O.; Johnson, H.M.; Mujtaba, M.G.; Ellis, M.R.; Haider, S.M.I.; Subramaniam, P.S. Characterization of a peptide inhibitor of Janus kinase 2 that mimics suppressor of cytokine signaling 1 function. J. Immunol., 2004, 172, 7510-7518.
9. Mitchell, D.J.; Kim, D.T.; Steinman, L.; Fathman, C.G.; Rothbard, J.B. Polyarginine enters cells more efficiently than other polycationic homopolymers. J. Peptide Res., 2000, 56, 318-325.
10. Karaghiosoff, M.; Neubauer, H.; Lassnig, C.; Kovarik, P.; Schindler, H.; Bogdan, C.; Decker, T.; Brem, G.; Pfeffer, K.; Muller, M. Partial impairment of cytokine responses in Tyk2-deficient mice. Immunity, 2000, 13, 549-560.
11. Minegishi, Y.; Saito, Y.; Morio, T.; Watanabe, K.; Agematsu, K.; Tsuchiya, S.; Takada, H.; Hara, T.; Kawamura, N.; Ariga, T.; Kaneko, H.; Kondo, N.; Tsuge, I.; Yachie, A.; Sakiyama, Y.; Iwata, T.; Bessho, F.; Ohishi, T.; Joh, K.; Imai, K.; Kogawa, K.; Shinohara, M.; Fujieda, M.; Wakiguchi, H.; Pasic, S.; Abinun, M.; Ochs, H.D.; Renner, E.D.; Jansson, A.; Belohradsky, B. H.; Metin, A.; Shimizu, N.; Mizutani, S.; Miyawaki, T.; Nonoyama, S.; Karasuyama, H. Human tyrosine kinase 2 deficiency reveals its requisite roles in multiple cytokine signals involved in innate and acquired immunity. Immunity, 2006, 25, 745-755.
12. Knight, Z.; Shokat, K.M. Features of selective kinase inhibitors. Chem. Biol., 2005, 12(6), 621-637.
13. Ishizaki, M.; Akimoto, T.; Muromoto, R.; Yokoyama, M.; Ohshiro, Y.; Sekine, Y.; Maeda, H.; Shimoda, K.; Oritani, K.; Matsuda, T. Involvement of Tyrosine Kinase-2 in both the IL-12/Th1 and IL- 23/Th17 axes in vivo. J. Immunol., 2011, 187, 181-189.
14. Liang, J.; Van Abbema, A.; Balazs, M.; Barret, K.; Berezhkovsky, L.; Blair, W.; Chang, C.; Delarosa, D.; DeVoss, J.; Driscoll, J.; Eigenbrot, C.; Ghilardi, N.; Gibbons, P.; Halladay, J.; Johnson, A.; Kohli, P.; Lai, Y.; Liu, Y.; Lyssikatos, J.P.; Mantik, P.; Menghrajani, K.; Murray, J.; Peng, I.; Sambrone, A.; Shia, S.; Shin, Y.; Smith, J.; Sohn, S.; Tsui, V.; Ultsch, M.; Wu, L. C.; Xiao, Y.; Yang, W.; Young, J.; Zhang, B.; Zhu, B.; Magnuson, S. Lead optimization of a 4-aminopyridine benzamide scaffold to identify potent, selective and orally bioavailable TYK2 inhibitors. J. Med. Chem., 2013, 56, 4521-4536.
15. Galande, A.K.; Bramlett, K.S.; Trent, J.O.; Burris, T.P.; Wittliff, J.L.; Spatola, A.F. Potent inhibitors of LXXLL-based proteinprotein interactions. Chem. Biochem., 2005, 6, 1991-1998.
16. Freitas, V.M.; Vilas-Boas, V.F.; Pimenta, D.C.; Loureiro, V.L.; Pinheiro, J.J.V.; Camargo, A.C.M.; Moriscot, A.S.; Hoffman, M.P.; Jaeger, R.G. SIKVAV, a laminin α1-derived peptide, interacts with integrins and increases protease activity of a human salivary gland adenoid cystic carcinoma cell line through the ERK 1/2 signaling pathway. Am. J. Path., 2007, 171, 124-138.