Analysis of human embryonic stem cells with regulatable expression of the cell adhesion molecule l1 in regeneration after spinal cord injury

Journal of Neurotrauma

Volumn 31, Issue 6, 2014, Pages 553-564

  Yoo, Myungsik ^a   Lee, Gunho Anthony ^a   Park, Christopher ^a   Cohen, Rick I ^b   Schachner, Melitta ^a,c  

^a RUTGERS UNIVERSITY   (United States)

^b RUTGERS UNIVERSITY   (United States)

^c SHANTOU UNIVERSITY MEDICAL COLLEGE   (China)

Author keywords

Adhesion molecule L1; inducible Tet off system; regulatable expression; spinal cord injury; stem cell transplantation

Indexed keywords

CHONDROITIN SULFATE; DOXYCYCLINE; GREEN FLUORESCENT PROTEIN; NERVE CELL ADHESION MOLECULE L1; PROTEOCHONDROITIN SULFATE; QUANTUM DOT; TYROSINE 3 MONOOXYGENASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL LABELING; CELL MIGRATION; CELL PROLIFERATION; COLONY FORMATION; CONTROLLED STUDY; EMBRYO; EMBRYONIC STEM CELL; ENGRAFTMENT; FEMALE; GENE EXPRESSION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IMMUNOREACTIVITY; IN VITRO STUDY; IN VIVO STUDY; LOCOMOTION; MOUSE; NERVE CELL; NERVE REGENERATION; NONHUMAN; PROMOTER REGION; PROTEIN EXPRESSION; SPINAL CORD COMPRESSION;

ANIMALS; CELL LINE; EMBRYONIC STEM CELLS; HUMANS; MICE; NERVE REGENERATION; NEURAL CELL ADHESION MOLECULE L1; NEUROGENESIS; RECOVERY OF FUNCTION; SPINAL CORD INJURIES;

EID: 84896340295     PISSN: 08977151     EISSN: 15579042     Source Type: Journal    
DOI: 10.1089/neu.2013.2886     Document Type: Article

References (32)

1. Abdel-Salam, O.M. (2011). Stem cell therapy for Alzheimer's disease. CNS Neurol. Disord. Drug Targets 10, 459-485.
2. Francis, K.R., and Wei, L. (2010). Human embryonic stem cell neural differentiation and enhanced cell survival promoted by hypoxic preconditioning. Cell Death Dis. 1, e22.
3. Sanchez-Pernaute, R., Studer, L., Ferrari, D., Perrier, A., Lee, H., Viñuela, A., and Isacson, O. (2005). Long-term survival of dopamine neurons derived from parthenogenetic primate embryonic stem cells (cyno-1) after transplantation. Stem Cells 23, 914-922. (Pubitemid 41170947)
4. Shindo, T., Matsumoto, Y., Wang, Q., Kawai, N., Tamiya, T., and Nagao, S. (2006). Differences in the neuronal stem cells survival, neuronal differentiation and neurological improvement after transplantation of neural stem cells between mild and severe experimental traumatic brain injury. J. Med. Invest. 53, 42-51.
5. Theus, M.H., Wei, L., Cui, L., Francis, K., Hu, X., Keogh, C., and Yu, S.P. (2008). In vitro hypoxic preconditioning of embryonic stem cells as a strategy of promoting cell survival and functional benefits after transplantation into the ischemic rat brain. Exp. Neurol. 210, 656-670.
6. Roonprapunt, C., Huang, W., Grill, R., Friedlander, D., Grumet, M., Chen, S., Schachner, M., and Young, W. (2003). Soluble cell adhesion molecule L1-Fc promotes locomotor recovery in rats after spinal cord injury. J. Neurotrauma 20, 871-882. (Pubitemid 37159069)
7. Chen, J., Bernreuther, C., Dihne, M., and Schachner, M. (2005). Cell adhesion molecule L1-transfected embryonic stem cells with enhanced survival support regrowth of corticospinal tract axons in mice after spinal cord injury. J. Neurotrauma 22, 896-906. (Pubitemid 41153874)
8. Runyan, S.A., Roy, R., Zhong, H., and Phelps, P.E. (2005). L1 CAM expression in the superficial dorsal horn is derived from the dorsal root ganglion. J. Comp. Neurol. 485, 267-279. (Pubitemid 40471291)
9. Chen, S., Mantei, N., Dong, L., and Schachner, M. (1999). Prevention of neuronal cell death by neural adhesion molecules L1 and CHL1. J. Neurobiol. 38, 428-439. (Pubitemid 29061918)
10. Kleene, R., Yang, H., Kutsche, M., and Schachner, M. (2001). The neural recognition molecule L1 is a sialic acid-binding lectin for CD24, which induces promotion and inhibition of neurite outgrowth. J. Biol. Chem. 276, 21656-21663.
11. Brummendorf, T. and Rathjen, F.G. (1994). Cell adhesion molecules. 1: immunoglobulin superfamily. Protein Profile 1, 951-1058.
12. Saghatelyan, A., Carleton, A., Lagier, S., de Chevigny, A., and Lledo, P.M. (2003). Local neurons play key roles in the mammalian olfactory bulb. J. Physiol. Paris 97, 517-528. (Pubitemid 38446997)
13. Cui, Y.F., Hargus, G., Xu, J.C., Schmid, J.S., Shen, Y.Q., Glatzel, M., Schachner, M., and Bernreuther, C. (2010). Embryonic stem cellderived L1 overexpressing neural aggregates enhance recovery in Parkinsonian mice. Brain 133, 189-204.
14. Cui, Y.F., Xu, J.C., Hargus, G., Jakovcevski, I., Schachner, M., and Bernreuther, C. (2011). Embryonic stem cell-derived L1 overexpressing neural aggregates enhance recovery after spinal cord injury in mice. PLoS One 6, e17126.
15. Bernreuther, C., Dihne, M., Johann, V., Schiefer, J., Cui, Y., Hargus, G., Schmid, J.S., Xu, J., Kosinski, C.M., and Schachner, M. (2006). Neural cell adhesion molecule L1-transfected embryonic stem cells promote functional recovery after excitotoxic lesion of the mouse striatum. J. Neurosci. 26, 11532-11539. (Pubitemid 44772124)
16. Becker, C.G., Lieberoth, B.C., Morellini, F., Feldner, J., Becker, T., and Schachner, M. (2004). L1.1 is involved in spinal cord regeneration in adult zebrafish. J. Neurosci. 24, 7837-7842. (Pubitemid 39215687)
17. Zhang, Y., Bo, X., Schoepfer, R., Holtmaat, A.J., Verhaagen, J., Emson, P.C., Lieberman, A.R., and Anderson, P.N. (2005). Growthassociated protein GAP-43 and L1 act synergistically to promote regenerative growth of Purkinje cell axons in vivo. Proc. Natl. Acad. Sci. U. S. A. 102, 14883-14888. (Pubitemid 41457150)
18. Xu, G., Nie, D.Y., Wang, W.Z., Zhang, P.H., Shen, J., Ang, B.T., Liu, G.H., Luo, X.G., Chen, N.L., and Xiao, Z.C. (2004). Optic nerve regeneration in polyglycolic acid-chitosan conduits coated with recombinant L1-Fc. Neuroreport 15, 2167-2172. (Pubitemid 39392232)
19. Yamanaka, H., Obata, K., Kobayashi, K., Dai, Y., Fukuoka, T., and Noguchi, K. (2007). Alteration of the cell adhesion molecule L1 expression in a specific subset of primary afferent neurons contributes to neuropathic pain. Eur. J. Neurosci. 25, 1097-1111.
20. Suzuki, M., Kasai, K., and Saeki, Y. (2006). Plasmid DNA sequences present in conventional herpes simplex virus amplicon vectors cause rapid transgene silencing by forming inactive chromatin. J. Virol. 80, 3293-3300.
21. Szulc, J., Wiznerowicz, M., Sauvain, M.O., Trono, D., and Aebischer, P. (2006). A versatile tool for conditional gene expression and knockdown. Nat. Methods 3, 109-116. (Pubitemid 43173309)
22. Nat, R., Nilbratt, M., Narkilahti, S., Winblad, B., Hovatta, O., and Nordberg, A. (2007). Neurogenic neuroepithelial and radial glial cells generated from six human embryonic stem cell lines in serum-free suspension and adherent cultures. Glia 55, 385-399.
23. Ying, Q.L., Stavridis, M., Griffiths, D., Li, M., and Smith, A. (2003). Conversion of embryonic stem cells into neuroectodermal precursors in adherent monoculture. Nat. Biotechnol. 21, 183-186. (Pubitemid 36188218)
24. Steward, O., Zheng, B., and Tessier-Lavigne, M. (2003). False resurrections: distinguishing regenerated from spared axons in the injured central nervous system. J. Comp. Neurol. 459, 1-8. (Pubitemid 36348860)
25. Apostolova, I., Irintchev, A., and Schachner, M. (2006). Tenascin-R restricts posttraumatic remodeling of motoneuron innervation and functional recovery after spinal cord injury in adult mice. J. Neurosci.
26. Curtis, R., Green, D., Lindsay, R.M., and Wilkin, G.P. (1993). Upregulation of GAP-43 and growth of axons in rat spinal cord after compression injury. J. Neurocytol. 22, 51-64. (Pubitemid 23048814)
27. Chen, J., Wu, J., Apostolova, I., Skup, M., Irintchev, A., Kugler, S., and Schachner, M. (2007). Adeno-associated virus-mediated L1 expression promotes functional recovery after spinal cord injury. Brain 130, 954-969. (Pubitemid 47355607)
28. Basso, D.M., Fisher, L.C., Anderson, A.J., Jakeman, L.B., McTigue, D.M., and Popovich, P.G. (2006). Basso Mouse Scale for locomotion detects differences in recovery after spinal cord injury in five common mouse strains. J. Neurotrauma 23, 635-659. (Pubitemid 43728052)
29. Engesser-Cesar, C., Anderson, A.J., Basso, D.M., Edgerton, V.R., and Cotman, C.W. (2005). Voluntary wheel running improves recovery from a moderate spinal cord injury. J. Neurotrauma 22, 157-171.
30. Guseva, D., Zerwas, M., Xiao, M.F., Jakovcevski, I., Irintchev, A., and Schachner, M. (2011). Adhesion molecule L1 overexpressed under the control of the neuronal Thy-1 promoter improves myelination after peripheral nerve injury in adult mice. Exp. Neurol. 229, 339-352.
31. Guseva, D., Angelov, D.N., Irintchev, A., and Schachner, M. (2009). Ablation of adhesion molecule L1 in mice favours Schwann cell proliferation and functional recovery after peripheral nerve injury. Brain 132, 2180-2195.
32. Siesser, P.F., and Maness, P.F. (2009). L1 cell adhesion molecules as regulators of tumor cell invasiveness. Cell Adh. Migr. 3, 275-277.