Identification of novel Rab27a/melanophilin blockers by pharmacophore-based virtual screening

Applied Biochemistry and Biotechnology

Volumn 172, Issue 4, 2014, Pages 1882-1897

  Joung, Jong Young ^a   Lee, Ha Yeon ^d   Park, Jongil ^d   Lee, Jee Young ^a   Chang, Byung Ha ^a   No, Kyoung Tai ^c   Nam, Ky Youb ^a,b   Hwang, Jae Sung ^d  

^a Bioinformatics and Molecular Design Research Center (BMDRC)   (South Korea)

^b Gachon University   (South Korea)

^c Yonsei University   (South Korea)

^d Kyung Hee University   (South Korea)

Author keywords

Mekanosome tansport; Molecular docking; Pharmacophore based virtual screening; Rab27a melanophilin; Skin pigmentation

Indexed keywords

CELL MEMBRANES; FUNCTIONAL GROUPS; PROTEINS;

MEKANOSOME TANSPORT; MOLECULAR DOCKING; RAB27A/MELANOPHILIN; SKIN PIGMENTATION; VIRTUAL SCREENING;

PHARMACODYNAMICS;

MELANOPHILIN INIHIBITOR; MOLECULAR MOTOR; MYOSIN VA; PROTEIN INHIBITOR; RAB27A PROTEIN; RAB27A PROTEIN INHIBITOR; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CELL TRANSPORT; CONTROLLED STUDY; DRUG SCREENING; HYDROGEN BOND; MELANOMA CELL; MELANOSOME; MOLECULAR MODEL; MOLECULAR RECOGNITION; PHARMACOPHORE; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; SITE DIRECTED MUTAGENESIS; STATIC ELECTRICITY; STRUCTURE ACTIVITY RELATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; HUMANS; MELANOCYTES; MELANOSOMES; RAB GTP-BINDING PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84896315137     PISSN: 02732289     EISSN: 15590291     Source Type: Journal    
DOI: 10.1007/s12010-013-0615-2     Document Type: Article

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