메뉴 건너뛰기




Volumn 66, Issue 2, 2014, Pages 340-349

Absence of interleukin-17 receptor a signaling prevents autoimmune inflammation of the joint and leads to a Th2-like phenotype in collagen-induced arthritis

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN TYPE 2; IMMUNOGLOBULIN; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2C; INTERLEUKIN 17; INTERLEUKIN 17 RECEPTOR; INTERLEUKIN 17 RECEPTOR A; INTERLEUKIN 23P19; INTERLEUKIN 4; INTERLEUKIN 6; UNCLASSIFIED DRUG;

EID: 84896287860     PISSN: 23265191     EISSN: 23265205     Source Type: Journal    
DOI: 10.1002/art.38229     Document Type: Article
Times cited : (38)

References (50)
  • 1
    • 80053600391 scopus 로고    scopus 로고
    • Recent advances in the IL-17 cytokine family
    • Gaffen SL. Recent advances in the IL-17 cytokine family. Curr Opin Immunol 2011;23: 613-9.
    • (2011) Curr Opin Immunol , vol.23 , pp. 613-619
    • Gaffen, S.L.1
  • 2
    • 79951743212 scopus 로고    scopus 로고
    • Functional specialization of interleukin-17 family members
    • Iwakura Y, Ishigame H, Saijo S, Nakae S. Functional specialization of interleukin-17 family members. Immunity 2011;34: 149-62.
    • (2011) Immunity , vol.34 , pp. 149-162
    • Iwakura, Y.1    Ishigame, H.2    Saijo, S.3    Nakae, S.4
  • 3
    • 55149090692 scopus 로고    scopus 로고
    • Th17 cytokines and mucosal immunity
    • Dubin PJ, Kolls JK. Th17 cytokines and mucosal immunity. Immunol Rev 2008;226: 160-71.
    • (2008) Immunol Rev , vol.226 , pp. 160-171
    • Dubin, P.J.1    Kolls, J.K.2
  • 4
    • 58149296036 scopus 로고    scopus 로고
    • Interleukin-17 in host defence against bacterial, mycobacterial and fungal pathogens
    • Curtis MM, Way SS. Interleukin-17 in host defence against bacterial, mycobacterial and fungal pathogens. Immunology 2009; 126: 177-85.
    • (2009) Immunology , vol.126 , pp. 177-185
    • Curtis, M.M.1    Way, S.S.2
  • 5
    • 67649197343 scopus 로고    scopus 로고
    • Interleukin 17 acts in synergy with B cellactivating factor to influence B cell biology and the pathophysiology of systemic lupus erythematosus
    • Doreau A, Belot A, Bastid J, Riche B, Trescol-Biemont MC, Ranchin B, et al. Interleukin 17 acts in synergy with B cellactivating factor to influence B cell biology and the pathophysiology of systemic lupus erythematosus. Nat Immunol 2009;10: 778-85.
    • (2009) Nat Immunol , vol.10 , pp. 778-785
    • Doreau, A.1    Belot, A.2    Bastid, J.3    Riche, B.4    Trescol-Biemont, M.C.5    Ranchin, B.6
  • 6
    • 38749143286 scopus 로고    scopus 로고
    • Interleukin-17 production in central nervous systeminfiltrating T cells and glial cells is associated with active disease in multiple sclerosis
    • Tzartos JS, Friese MA, Craner MJ, Palace J, Newcombe J, Esiri MM, et al. Interleukin-17 production in central nervous systeminfiltrating T cells and glial cells is associated with active disease in multiple sclerosis. Am J Pathol 2008;172: 146-55.
    • (2008) Am J Pathol , vol.172 , pp. 146-155
    • Tzartos, J.S.1    Friese, M.A.2    Craner, M.J.3    Palace, J.4    Newcombe, J.5    Esiri, M.M.6
  • 7
    • 77956338425 scopus 로고    scopus 로고
    • Memory CD4-CD127high T cells from patients with multiple sclerosis produce IL-17 in response to myelin antigens
    • Venken K, Hellings N, Hensen K, Rummens JL, Stinissen P. Memory CD4-CD127high T cells from patients with multiple sclerosis produce IL-17 in response to myelin antigens. J Neuroimmunol 2010;226: 185-91.
    • (2010) J Neuroimmunol , vol.226 , pp. 185-191
    • Venken, K.1    Hellings, N.2    Hensen, K.3    Rummens, J.L.4    Stinissen, P.5
  • 8
    • 77958072084 scopus 로고    scopus 로고
    • Effects of AIN457, a fully human antibody to interleukin- 17A, on psoriasis, rheumatoid arthritis, and uveitis
    • Hueber W, Patel DD, Dryja T, Wright AM, Koroleva I, Bruin G, et al. Effects of AIN457, a fully human antibody to interleukin- 17A, on psoriasis, rheumatoid arthritis, and uveitis. Sci Transl Med 2010;2:52ra72.
    • (2010) Sci Transl Med , vol.2
    • Hueber, W.1    Patel, D.D.2    Dryja, T.3    Wright, A.M.4    Koroleva, I.5    Bruin, G.6
  • 9
    • 0031802932 scopus 로고    scopus 로고
    • Enhancing effect of IL-17 on IL-1-induced IL-6 and leukemia inhibitory factor production by rheumatoid arthritis synoviocytes and its regulation by Th2 cytokines
    • Chabaud M, Fossiez F, Taupin JL, Miossec P. Enhancing effect of IL-17 on IL-1-induced IL-6 and leukemia inhibitory factor production by rheumatoid arthritis synoviocytes and its regulation by Th2 cytokines. J Immunol 1998;161: 409-14.
    • (1998) J Immunol , vol.161 , pp. 409-414
    • Chabaud, M.1    Fossiez, F.2    Taupin, J.L.3    Miossec, P.4
  • 11
    • 84870919913 scopus 로고    scopus 로고
    • Interleukin-17 cytokines are critical in development of fatal lupus glomerulonephritis
    • Pisitkun P, Ha HL, Wang H, Claudio E, Tivy CC, Zhou H, et al. Interleukin-17 cytokines are critical in development of fatal lupus glomerulonephritis. Immunity 2012;37: 1104-15.
    • (2012) Immunity , vol.37 , pp. 1104-1115
    • Pisitkun, P.1    Ha, H.L.2    Wang, H.3    Claudio, E.4    Tivy, C.C.5    Zhou, H.6
  • 12
    • 0035887627 scopus 로고    scopus 로고
    • IL-17F, a novel cytokine selectively expressed in activated T cells and monocytes, regulates angiogenesis and endothelial cell cytokine production
    • Starnes T, Robertson MJ, Sledge G, Kelich S, Nakshatri H, Broxmeyer HE, et al. IL-17F, a novel cytokine selectively expressed in activated T cells and monocytes, regulates angiogenesis and endothelial cell cytokine production. J Immunol 2001;167: 4137-40.
    • (2001) J Immunol , vol.167 , pp. 4137-4140
    • Starnes, T.1    Robertson, M.J.2    Sledge, G.3    Kelich, S.4    Nakshatri, H.5    Broxmeyer, H.E.6
  • 13
    • 17944368518 scopus 로고    scopus 로고
    • IL-17s adopt a cystine knot fold: Structure and activity of a novel cytokine, IL-17F, and implications for receptor binding
    • Hymowitz SG, Filvaroff EH, Yin JP, Lee J, Cai L, Risser P, et al. IL-17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL-17F, and implications for receptor binding. EMBO J 2001;20: 5332-41.
    • (2001) EMBO J , vol.20 , pp. 5332-5341
    • Hymowitz, S.G.1    Filvaroff, E.H.2    Yin, J.P.3    Lee, J.4    Cai, L.5    Risser, P.6
  • 14
  • 16
    • 34249059942 scopus 로고    scopus 로고
    • Identification of an IL-17-producing NK1.1neg iNKT cell population involved in airway neutrophilia
    • Michel ML, Keller AC, Paget C, Fujio M, Trottein F, Savage PB, et al. Identification of an IL-17-producing NK1.1neg iNKT cell population involved in airway neutrophilia. J Exp Med 2007;204: 995-1001.
    • (2007) J Exp Med , vol.204 , pp. 995-1001
    • Michel, M.L.1    Keller, A.C.2    Paget, C.3    Fujio, M.4    Trottein, F.5    Savage, P.B.6
  • 18
    • 38849097777 scopus 로고    scopus 로고
    • An IL-17F/A heterodimer protein is produced by mouse Th17 cells and induces airway neutrophil recruitment
    • Liang SC, Long AJ, Bennett F, Whitters MJ, Karim R, Collins M, et al. An IL-17F/A heterodimer protein is produced by mouse Th17 cells and induces airway neutrophil recruitment. J Immunol 2007;179: 7791-9.
    • (2007) J Immunol , vol.179 , pp. 7791-7799
    • Liang, S.C.1    Long, A.J.2    Bennett, F.3    Whitters, M.J.4    Karim, R.5    Collins, M.6
  • 19
    • 34250305962 scopus 로고    scopus 로고
    • Identification of an interleukin 17F/17A heterodimer in activated human CD4- T cells
    • Wright JF, Guo Y, Quazi A, Luxenberg DP, Bennett F, Ross JF, et al. Identification of an interleukin 17F/17A heterodimer in activated human CD4- T cells. J Biol Chem 2007;282: 13447-55.
    • (2007) J Biol Chem , vol.282 , pp. 13447-13455
    • Wright, J.F.1    Guo, Y.2    Quazi, A.3    Luxenberg, D.P.4    Bennett, F.5    Ross, J.F.6
  • 20
    • 34248574863 scopus 로고    scopus 로고
    • A novel heterodimeric cytokine consisting of IL-17 and IL-17F regulates inflammatory responses
    • Chang SH, Dong C. A novel heterodimeric cytokine consisting of IL-17 and IL-17F regulates inflammatory responses. Cell Res 2007;17: 435-40.
    • (2007) Cell Res , vol.17 , pp. 435-440
    • Chang, S.H.1    Dong, C.2
  • 21
    • 38449094307 scopus 로고    scopus 로고
    • Identification of the IL-17 receptor related molecule IL- 17RC as the receptor for IL-17F
    • Kuestner RE, Taft DW, Haran A, Brandt CS, Brender T, Lum K, et al. Identification of the IL-17 receptor related molecule IL- 17RC as the receptor for IL-17F. J Immunol 2007;179: 5462-73.
    • (2007) J Immunol , vol.179 , pp. 5462-5473
    • Kuestner, R.E.1    Taft, D.W.2    Haran, A.3    Brandt, C.S.4    Brender, T.5    Lum, K.6
  • 23
    • 77949659096 scopus 로고    scopus 로고
    • IL-17RC: A partner in IL-17 signaling and beyond
    • Ho AW, Gaffen SL. IL-17RC: a partner in IL-17 signaling and beyond. Semin Immunopathol 2010;32: 33-42.
    • (2010) Semin Immunopathol , vol.32 , pp. 33-42
    • Ho, A.W.1    Gaffen, S.L.2
  • 24
    • 58149231532 scopus 로고    scopus 로고
    • Differential roles of interleukin-17A and -17F in host defense against mucoepithelial bacterial infection and allergic responses
    • Ishigame H, Kakuta S, Nagai T, Kadoki M, Nambu A, Komiyama Y, et al. Differential roles of interleukin-17A and -17F in host defense against mucoepithelial bacterial infection and allergic responses. Immunity 2009;30: 108-19.
    • (2009) Immunity , vol.30 , pp. 108-119
    • Ishigame, H.1    Kakuta, S.2    Nagai, T.3    Kadoki, M.4    Nambu, A.5    Komiyama, Y.6
  • 25
    • 0029555301 scopus 로고
    • Herpesvirus Saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor
    • Yao Z, Fanslow WC, Seldin MF, Rousseau AM, Painter SL, Comeau MR, et al. Herpesvirus Saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor. Immunity 1995; 3: 811-21.
    • (1995) Immunity , vol.3 , pp. 811-821
    • Yao, Z.1    Fanslow, W.C.2    Seldin, M.F.3    Rousseau, A.M.4    Painter, S.L.5    Comeau, M.R.6
  • 26
    • 68849084891 scopus 로고    scopus 로고
    • Structure and signalling in the IL-17 receptor family
    • Gaffen SL. Structure and signalling in the IL-17 receptor family. Nat Rev Immunol 2009;9: 556-67.
    • (2009) Nat Rev Immunol , vol.9 , pp. 556-567
    • Gaffen, S.L.1
  • 27
    • 38949197817 scopus 로고    scopus 로고
    • IL-17/Th17 targeting: On the road to prevent chronic destructive arthritis?
    • Lubberts E. IL-17/Th17 targeting: on the road to prevent chronic destructive arthritis? Cytokine 2008;41: 84-91.
    • (2008) Cytokine , vol.41 , pp. 84-91
    • Lubberts, E.1
  • 28
    • 78650764391 scopus 로고    scopus 로고
    • Th17 cells, but not Th1 cells, from patients with early rheumatoid arthritis are potent inducers of matrix metalloproteinases and proinflammatory cytokines upon synovial fibroblast interaction, including autocrine interleukin-17A production
    • Van Hamburg JP, Asmawidjaja PS, Davelaar N, Mus AM, Colin EM, Hazes JM, et al. Th17 cells, but not Th1 cells, from patients with early rheumatoid arthritis are potent inducers of matrix metalloproteinases and proinflammatory cytokines upon synovial fibroblast interaction, including autocrine interleukin-17A production. Arthritis Rheum 2011;63: 73-83.
    • (2011) Arthritis Rheum , vol.63 , pp. 73-83
    • Van Hamburg, J.P.1    Asmawidjaja, P.S.2    Davelaar, N.3    Mus, A.M.4    Colin, E.M.5    Hazes, J.M.6
  • 29
    • 77950535421 scopus 로고    scopus 로고
    • LY2439821, a humanized anti-interleukin-17 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: A phase i randomized, double-blind, placebo-controlled, proof-of-concept study
    • Genovese MC, Van den Bosch F, Roberson SA, Bojin S, Biagini IM, Ryan P, et al. LY2439821, a humanized anti-interleukin-17 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: a phase I randomized, double-blind, placebo-controlled, proof-of-concept study. Arthritis Rheum 2010;62: 929-39.
    • (2010) Arthritis Rheum , vol.62 , pp. 929-939
    • Genovese, M.C.1    Van Den Bosch, F.2    Roberson, S.A.3    Bojin, S.4    Biagini, I.M.5    Ryan, P.6
  • 30
    • 38449102562 scopus 로고    scopus 로고
    • IL-17B and IL-17C are associated with TNF - Production and contribute to the exacerbation of inflammatory arthritis
    • Yamaguchi Y, Fujio K, Shoda H, Okamoto A, Tsuno NH, Takahashi K, et al. IL-17B and IL-17C are associated with TNF - production and contribute to the exacerbation of inflammatory arthritis. J Immunol 2007;179: 7128-36.
    • (2007) J Immunol , vol.179 , pp. 7128-7136
    • Yamaguchi, Y.1    Fujio, K.2    Shoda, H.3    Okamoto, A.4    Tsuno, N.H.5    Takahashi, K.6
  • 31
    • 0034705439 scopus 로고    scopus 로고
    • A novel cytokine receptor-ligand pair: Identification, molecular characterization, and in vivo immunomodulatory activity
    • Shi Y, Ullrich SJ, Zhang J, Connolly K, Grzegorzewski KJ, Barber MC, et al. A novel cytokine receptor-ligand pair: identification, molecular characterization, and in vivo immunomodulatory activity. J Biol Chem 2000;275: 19167-76.
    • (2000) J Biol Chem , vol.275 , pp. 19167-19176
    • Shi, Y.1    Ullrich, S.J.2    Zhang, J.3    Connolly, K.4    Grzegorzewski, K.J.5    Barber, M.C.6
  • 32
    • 80755133721 scopus 로고    scopus 로고
    • Interleukin-17C promotes Th17 cell responses and autoimmune disease via interleukin-17 receptor e
    • Chang SH, Reynolds JM, Pappu BP, Chen G, Martinez GJ, Dong C. Interleukin-17C promotes Th17 cell responses and autoimmune disease via interleukin-17 receptor E. Immunity 2011;35: 611-21.
    • (2011) Immunity , vol.35 , pp. 611-621
    • Chang, S.H.1    Reynolds, J.M.2    Pappu, B.P.3    Chen, G.4    Martinez, G.J.5    Dong, C.6
  • 33
    • 56149091567 scopus 로고    scopus 로고
    • Identification of functional roles for both IL-17RB and IL-17RA in mediating IL-25-induced activities
    • Rickel EA, Siegel LA, Yoon BR, Rottman JB, Kugler DG, Swart DA, et al. Identification of functional roles for both IL-17RB and IL-17RA in mediating IL-25-induced activities. J Immunol 2008; 181: 4299-310.
    • (2008) J Immunol , vol.181 , pp. 4299-4310
    • Rickel, E.A.1    Siegel, L.A.2    Yoon, B.R.3    Rottman, J.B.4    Kugler, D.G.5    Swart, D.A.6
  • 34
    • 0036785392 scopus 로고    scopus 로고
    • Transgenic overexpression of human IL-17E results in eosinophilia, B-lymphocyte hyperplasia, and altered antibody production
    • Kim MR, Manoukian R, Yeh R, Silbiger SM, Danilenko DM, Scully S, et al. Transgenic overexpression of human IL-17E results in eosinophilia, B-lymphocyte hyperplasia, and altered antibody production. Blood 2002;100: 2330-40.
    • (2002) Blood , vol.100 , pp. 2330-2340
    • Kim, M.R.1    Manoukian, R.2    Yeh, R.3    Silbiger, S.M.4    Danilenko, D.M.5    Scully, S.6
  • 35
    • 0035575743 scopus 로고    scopus 로고
    • Forced expression of murine IL-17E induces growth retardation, jaundice, a Th2-biased response, and multiorgan inflammation in mice
    • Pan G, French D, Mao W, Maruoka M, Risser P, Lee J, et al. Forced expression of murine IL-17E induces growth retardation, jaundice, a Th2-biased response, and multiorgan inflammation in mice. J Immunol 2001;167: 6559-67.
    • (2001) J Immunol , vol.167 , pp. 6559-6567
    • Pan, G.1    French, D.2    Mao, W.3    Maruoka, M.4    Risser, P.5    Lee, J.6
  • 36
    • 18244405108 scopus 로고    scopus 로고
    • IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in vivo
    • Fort MM, Cheung J, Yen D, Li J, Zurawski SM, Lo S, et al. IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in vivo. Immunity 2001;15: 985-95.
    • (2001) Immunity , vol.15 , pp. 985-995
    • Fort, M.M.1    Cheung, J.2    Yen, D.3    Li, J.4    Zurawski, S.M.5    Lo, S.6
  • 37
    • 0344585384 scopus 로고    scopus 로고
    • Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice
    • Nakae S, Nambu A, Sudo K, Iwakura Y. Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice. J Immunol 2003;171: 6173-7.
    • (2003) J Immunol , vol.171 , pp. 6173-6177
    • Nakae, S.1    Nambu, A.2    Sudo, K.3    Iwakura, Y.4
  • 38
    • 78249260653 scopus 로고    scopus 로고
    • The adaptor protein CIKS/ACT1 is necessary for collagen-induced arthritis, and it contributes to the production of collagen-specific antibody
    • Pisitkun P, Claudio E, Ren N, Wang H, Siebenlist U. The adaptor protein CIKS/ACT1 is necessary for collagen-induced arthritis, and it contributes to the production of collagen-specific antibody. Arthritis Rheum 2010;62: 3334-44.
    • (2010) Arthritis Rheum , vol.62 , pp. 3334-3344
    • Pisitkun, P.1    Claudio, E.2    Ren, N.3    Wang, H.4    Siebenlist, U.5
  • 39
    • 17944364849 scopus 로고    scopus 로고
    • Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defense
    • Ye P, Rodriguez FH, Kanaly S, Stocking KL, Schurr J, Schwarzenberger P, et al. Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defense. J Exp Med 2001;194: 519-27.
    • (2001) J Exp Med , vol.194 , pp. 519-527
    • Ye, P.1    Rodriguez, F.H.2    Kanaly, S.3    Stocking, K.L.4    Schurr, J.5    Schwarzenberger, P.6
  • 40
    • 1342324752 scopus 로고    scopus 로고
    • Compromised humoral and delayed-type hypersensitivity responses in IL-23-deficient mice
    • Ghilardi N, Kljavin N, Chen Q, Lucas S, Gurney AL, de Sauvage FJ. Compromised humoral and delayed-type hypersensitivity responses in IL-23-deficient mice. J Immunol 2004;172: 2827-33.
    • (2004) J Immunol , vol.172 , pp. 2827-2833
    • Ghilardi, N.1    Kljavin, N.2    Chen, Q.3    Lucas, S.4    Gurney, A.L.5    De Sauvage, F.J.6
  • 41
    • 61649090825 scopus 로고    scopus 로고
    • GATA-3 protects against severe joint inflammation and bone erosion and reduces differentiation of Th17 cells during experimental arthritis
    • Van Hamburg JP, Mus AM, de Bruijn MJ, de Vogel L, Boon L, Cornelissen F, et al. GATA-3 protects against severe joint inflammation and bone erosion and reduces differentiation of Th17 cells during experimental arthritis. Arthritis Rheum 2009;60: 750-9.
    • (2009) Arthritis Rheum , vol.60 , pp. 750-759
    • Van Hamburg, J.P.1    Mus, A.M.2    De Bruijn, M.J.3    De Vogel, L.4    Boon, L.5    Cornelissen, F.6
  • 42
    • 0035879192 scopus 로고    scopus 로고
    • IL-1-independent role of IL-17 in synovial inflammation and joint destruction during collagen-induced arthritis
    • Lubberts E, Joosten LA, Oppers B, van den Bersselaar L, Coenen- de Roo CJ, Kolls JK, et al. IL-1-independent role of IL-17 in synovial inflammation and joint destruction during collagen-induced arthritis. J Immunol 2001;167: 1004-13.
    • (2001) J Immunol , vol.167 , pp. 1004-1013
    • Lubberts, E.1    Joosten, L.A.2    Oppers, B.3    Van Den Bersselaar, L.4    Coenen-De Roo, C.J.5    Kolls, J.K.6
  • 43
    • 70449728002 scopus 로고    scopus 로고
    • Dendritic cells are crucial for maintenance of tertiary lymphoid structures in the lung of influenza virus-infected mice
    • GeurtsvanKessel CH, Willart MA, Bergen IM, van Rijt LS, Muskens F, Elewaut D, et al. Dendritic cells are crucial for maintenance of tertiary lymphoid structures in the lung of influenza virus-infected mice. J Exp Med 2009;206: 2339-49.
    • (2009) J Exp Med , vol.206 , pp. 2339-2349
    • Geurtsvankessel, C.H.1    Willart, M.A.2    Bergen, I.M.3    Van Rijt, L.S.4    Muskens, F.5    Elewaut, D.6
  • 44
  • 45
    • 0031899715 scopus 로고    scopus 로고
    • B cell-deficient mice do not develop type II collagen-induced arthritis (CIA)
    • Svensson L, Jirholt J, Holmdahl R, Jansson L. B cell-deficient mice do not develop type II collagen-induced arthritis (CIA). Clin Exp Immunol 1998;111: 521-6.
    • (1998) Clin Exp Immunol , vol.111 , pp. 521-526
    • Svensson, L.1    Jirholt, J.2    Holmdahl, R.3    Jansson, L.4
  • 46
    • 23844545819 scopus 로고    scopus 로고
    • Requirement of IL-17 receptor signaling in radiation-resistant cells in the joint for full progression of destructive synovitis
    • Lubberts E, Schwarzenberger P, Huang W, Schurr JR, Peschon JJ, van den Berg WB, et al. Requirement of IL-17 receptor signaling in radiation-resistant cells in the joint for full progression of destructive synovitis. J Immunol 2005;175: 3360-8.
    • (2005) J Immunol , vol.175 , pp. 3360-3368
    • Lubberts, E.1    Schwarzenberger, P.2    Huang, W.3    Schurr, J.R.4    Peschon, J.J.5    Van Den Berg, W.B.6
  • 47
    • 0037331297 scopus 로고    scopus 로고
    • Association of interleukin-18 expression with enhanced levels of both interleukin-1- and tumor necrosis factor - In knee synovial tissue of patients with rheumatoid arthritis
    • Joosten LA, Radstake TR, Lubberts E, van den Bersselaar LA, van Riel PL, van Lent PL, et al. Association of interleukin-18 expression with enhanced levels of both interleukin-1- and tumor necrosis factor - in knee synovial tissue of patients with rheumatoid arthritis. Arthritis Rheum 2003;48: 339-47.
    • (2003) Arthritis Rheum , vol.48 , pp. 339-347
    • Joosten, L.A.1    Radstake, T.R.2    Lubberts, E.3    Van Den Bersselaar, L.A.4    Van Riel, P.L.5    Van Lent, P.L.6
  • 48
    • 0031059255 scopus 로고    scopus 로고
    • Role of interleukin-4 and interleukin-10 in murine collagen-induced arthritis: Protective effect of interleukin- 4 and interleukin-10 treatment on cartilage destruction
    • Joosten LA, Lubberts E, Durez P, Helsen MM, Jacobs MJ, Goldman M, et al. Role of interleukin-4 and interleukin-10 in murine collagen-induced arthritis: protective effect of interleukin- 4 and interleukin-10 treatment on cartilage destruction. Arthritis Rheum 1997;40: 249-60.
    • (1997) Arthritis Rheum , vol.40 , pp. 249-260
    • Joosten, L.A.1    Lubberts, E.2    Durez, P.3    Helsen, M.M.4    Jacobs, M.J.5    Goldman, M.6
  • 50
    • 84887412452 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled, multiple-dose study to evaluate the safety, tolerability, and efficacy of brodalumab (AMG827) in subjects with rheumatoid arthritis and an inadequate response to methotrexate [abstract]
    • Pavelka K, Chon Y, Newmark R, Erondu N, Lin SL. A randomized, double-blind, placebo-controlled, multiple-dose study to evaluate the safety, tolerability, and efficacy of brodalumab (AMG827) in subjects with rheumatoid arthritis and an inadequate response to methotrexate [abstract]. Arthritis Rheum 2012; 64 Suppl:S362.
    • (2012) Arthritis Rheum , vol.64 , Issue.SUPPL.
    • Pavelka, K.1    Chon, Y.2    Newmark, R.3    Erondu, N.4    Lin, S.L.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.