CYTOPROTECTIVE AND ANTIOXIDANT EFFECTS OF THE METHANOL EXTRACT OF EREMOMASTAX SPECIOSA IN RATS.

African Journal of Traditional, Complementary and Alternative Medicines

Volumn 11, Issue 1, 2014, Pages 165-171

  Amang, Perfusion A ^a   Tan, Paul V ^a   Patamaken, Simon A ^a   Mefe, Martial N ^a  

^a UNIVERSITY OF YAOUNDÉ I   (Cameroon)

Author keywords

antioxidant status; cytoprotection; Eremomastax speciosa; gastric ulcers

Indexed keywords

ALCOHOL; ANTIOXIDANT; ANTIULCER AGENT; CATALASE; GLUTATHIONE; HYDROCHLORIC ACID; INDOMETACIN; MALONALDEHYDE; PLANT EXTRACT; SUPEROXIDE DISMUTASE;

ACANTHACEAE; ANIMAL; ANTIOXIDANT STATUS; ARTICLE; BLOOD; CELL PROTECTION; COLD; DRUG EFFECT; EREMOMASTAX SPECIOSA; EXERCISE; GASTRIC ULCERS; LIGATION; MALE; METABOLISM; OXIDATIVE STRESS; PATHOLOGY; PHYTOTHERAPY; PYLORUS; RAT; SECRETION (PROCESS); STOMACH ACID; STOMACH MUCOSA; STOMACH ULCER; WISTAR RAT;

ANTIOXIDANT STATUS; CYTOPROTECTION; EREMOMASTAX SPECIOSA; GASTRIC ULCERS;

ACANTHACEAE; ANIMALS; ANTI-ULCER AGENTS; ANTIOXIDANTS; CATALASE; COLD TEMPERATURE; ETHANOL; GASTRIC ACID; GASTRIC MUCOSA; GLUTATHIONE; HYDROCHLORIC ACID; INDOMETHACIN; LIGATION; MALE; MALONDIALDEHYDE; OXIDATIVE STRESS; PHYTOTHERAPY; PLANT EXTRACTS; PYLORUS; RATS; RATS, WISTAR; RESTRAINT, PHYSICAL; STOMACH ULCER; SUPEROXIDE DISMUTASE;

EID: 84896132621     PISSN: None     EISSN: 25050044     Source Type: Journal    
DOI: 10.4314/ajtcam.v11i1.26     Document Type: Article

References (31)

1. Adjanohoun, J.F., Aboubakar N., Dramane, K., Ebot, M.E., Ekpere, J.A., Enow-Orock, E.G., Focho, D., Gbile, Z.O., Kamanyi, A., Kamsu Kom, J., Keita, A., Mbenkum, T., Mbi, C.N., Nkongmeneck, B., Satabie, B., Sofowora, A., Tamze, V., Wirmum, C.K. (1996). Traditional Medecine and Pharmacopoeia: Contribution to Ethnobotanica and Floristic Studies in Cameroon. Organization of African Unity Scientific, Technical and Research Commision. Centre Nationale de Production des Manuels Scolaires, Porto-Novo. Benin. Pp.22-23.
2. nd edition. Lavoisier, Pp. 309-320.
3. Bulaj, G., Kortemme, T., Goldenberg, D.P. (1998). Ionization: Reactivity relationships for cysteine thiols in polypeptides. Biochemistry. 37: 8965–8972.
4. Carnevale, G., Zanoli, P., Zavatti, M., Baraldi, M. (2011). Further evidence of the antiulcer activity of IAC, a novel free radical scavenger. Pharmacology. 88(3-4):133-6
5. Coskun, T., Alican, I., Yegen, I., San, T., Cetinal, S. and Hurtel, H. (1995). Cyclosporin A reduces the severity of cold restraint induced gastric lesions: role of leucocytes. Digestion. 56: 21-219.
6. de-Faria, FM., Almeid, AC., Luiz-Ferreira, A., Takayama, C., Dunder, R.J., da Silva, M.A., Salvador, M.J., Abdelnur, P.V., Eberlin, M.N., Vilegas, W., Toma, W., Souza-Brito, A.R. (2012). Antioxidant action of mangrove polyphenols against gastric damage induced by absolute ethanol and ischemia-reperfusion in the rat. Sci. Wld. J. 2012:327071. doi: 10.1100/2012/327071.
7. Favier, A. “Le stress oxydant: Intérêt conceptuel et expérimental dans la compréhension des mécanismes des maladies et potentiels thérapeutique.In: mecanismes biochimiques. L’Actu Chim. Nov-Dec. Pp. 108-115.
8. Flemstrom, G., Garner, A., Nylander, O., Hurst, B.C., Heylings, J.R. (1982). Surface epithelial HCO3 transport by mammalian duodenum in vivo. Am. J. Physiol.-Gastr. L. 234: G348-G358.
9. Hara, N., Okabe, S. (1985). Effect of gefernate on acute lesions in rats. Folio. Pharm. Jap. 85: 443-448.
10. nd edition, Pp. 412-525.
11. Konturek, S.J., Brozozowski, T., Piastucki, I., Radecki, T., Dembiska-kiec, A. (1982). Role of locally generated prostaglandins in adaptive cytoprotection. Dig. Dis. Sci. 27: 967-971.
12. Konturek, S.J., Piastucki, I., Brozozowski, T., Dembiska-kiec, T.R.A., Muda, A., Gryglewski, R. 1981. Role of prostaglandins in the formation of aspirin-induced ulcers. Gastroenterology. 80: 4-9.
13. Lambert, K.G. and Kinsly, C.H. (1993). Sex differences and gonadal hormones influence susceptibility to activity-stress paradigm. Physiol. Behav. 53:1085-1090.
14. Meserau, W.A. and Hinchey, E.J. (1973). Effect of gastric acidity in gastric ulceration induced by haemorrhage in the rats utilising a gastric chamber technique. Gastroenterology. 64: 1130-1135.
15. Miller, T.A. (1982). Protective effect of prostaglandins against gastric mucosal damage: current knowledge and proposed mechanisms. Am. J. Physiol.-Gastr. L (8) 245: G601-G603.
16. Misra, H.P. and Fridovich, I. (1972).The role of superoxide anion in the auto oxidation of epinephrine to adrenochrome and a simple assay for superoxide dismutase. J. Biol. Chem. 247(10): 3170-3175.
17. Oates, P.J. and Hakkinen, J.P., (1985). Studies on the mechanism of ethanol-induced gastric damage in rats. Gastroenterology. 94: 10-21.
18. Paiva, S.A., Russell, R.M. (1999). Beta-carotene and other carotenoids as antioxidants. J. Am. Coll. Nutr. 18(5): 426-33.
19. Robert, A., (1981). Prostaglandins and the gastrointestinal tract. In: Johnson, S.R. (Ed). Physiology of the Gastrointestinal Tract. Raven Press, New York, Pp. 1407-1434.
20. Mancinelli, S., de la Fuente, G., Manriquez, V., Aracena, M., Munoz, R., Mancinelli, S. and Munoz, R. (1990). The etiopathogenesis of acute stress ulcer: The role of oxygen free radicals. Rev. Med. Chile. 118(9): 965-970.
21. 2 output in human subjects. Anal. Int. Med. 106: 368-371.
22. Shay, J.P., Komarov, S.A., Fels, S.S., Meranze, D., Grunstein, M., Simpler, H. (1945). A simple method for the uniform production of gastric ulceration in the rat. Gastroenterology. 5: 43-61.
23. Sinha, A.K. (1972). Colorimetric assay of catalase. Anal. Biochem. 47: 389-394.
24. Slater TF. (1984). Overview of methods used for detecting lipid peroxidation. Method Enzymol. 105: 283-305.
25. Ohara, T., Asaki, S. and Toyota, T. (1990). Biological evaluation of superoxide dismutase observed in a state of acute gastric mucosal lesions. Japanese. J. Gastr. 87(1):1-7.
26. Takagi, k. and Okabe, S. (1968). The effects of drugs on stress ulcers in rats. Japanese. J. Pharmacol. 18: 9-18.
27. Takashima, M., Shichiri, M, Hagihara, Y., Yoshida, Y., Niki, E. (2012). Capacity of fucoxanthin for scavenging peroxyl radicals and inhibition of lipid peroxidation in model systems. Free Radical Res. 46(11):1406-1412.
28. Tan, P.V., Nditafon, N.G., Yew,ah M.P., Dimo, T., Ayafor, F.J. (1996). Eremomastax speciosa: effects of leaf aqueous extract on ulcer formation and gastric secretion in rats. J. Ethnopharmacol. 54: 139-142.
29. Tandon, R., Khanna, H.D. and Goel, R.K. (2004). Oxidative stress and antioxidant status in peptic ulcer and gastric carcinoma. Indian J. Phys. Pharmacol. 48(1):15-118.
30. Vera-Arzave, C., Antonio, L.C., Arrieta, J., Cruz-Hernández, G., Velasquez-Mendez, A.M., Reyes-Ramírez, A., Sánchez-Mendoza, M.E. (2012). Gastroprotection of suaveolol isolated from Hyptis suaveolens, against ethanol-induced gastric lesions in Wistar rats: role of prostaglandins, nitric oxide and sulfhydryls. Molecules. 17(8): 8917-27.
31. Whittle, B.J.R. (1977). Mechanisms underlying gastric mucosal damage induced by indomethacin and bile salts, and the actions of prostaglandins. Brit. J. Pharmacol. 60: 455-460.