Straightforward single-calibrant quantification of seized designer drugs by liquid chromatography-chemiluminescence nitrogen detection

Forensic Science International

Volumn 237, Issue , 2014, Pages 119-125

  Rasanen, Ilpo ^a   Kyber, Marianne ^b   Szilvay, Ilmari ^b   Rintatalo, Janne ^c   Ojanperä, Ilkka ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b Finnish Customs Laboratory   (Finland)

^c National Bureau of Investigation Finland   (Finland)

Author keywords

Chemiluminescence nitrogen detection; Designer drug; Drug seizure; New psychoactive substances; Reference standard; Street drug

Indexed keywords

CAFFEINE; CANNABINOID; CATHINONE; DESIGNER DRUG; HERBACEOUS AGENT; PHENETHYLAMINE DERIVATIVE; TRYPTAMINE DERIVATIVE; 1-((5-FLUOROPENTYL)-1H-INDOL-3-YL)-(NAPHTHALEN-1-YL)METHANONE; ALLYL COMPOUND; INDOLE DERIVATIVE; N,N-DIALLYL-5-METHOXYTRYPTAMINE; NAPHTHALENE DERIVATIVE; NITROGEN; PSYCHOTROPIC AGENT; STREET DRUG;

ARTICLE; CHEMICAL PARAMETERS; CHEMOLUMINESCENCE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG PURITY; EQUIMOLARITY; FINLAND; LAW ENFORCEMENT; LIMIT OF DETECTION; LIMIT OF QUANTITATION; LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY CHEMOLUMINESCENCE NITROGEN DETECTION; NITROGEN CONCENTRATION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SYSTEMATIC ERROR; UNCERTAINTY; VALIDATION PROCESS; CHEMISTRY; DRUG CONTAMINATION; LUMINESCENCE;

ALLYL COMPOUNDS; CANNABINOIDS; CHROMATOGRAPHY, LIQUID; DESIGNER DRUGS; DRUG CONTAMINATION; INDOLES; LUMINESCENT MEASUREMENTS; NAPHTHALENES; NITROGEN; PSYCHOTROPIC DRUGS; STREET DRUGS; TRYPTAMINES;

EID: 84896093081     PISSN: 03790738     EISSN: 18726283     Source Type: Journal    
DOI: 10.1016/j.forsciint.2014.02.003     Document Type: Article

References (17)

1. King L.A., Kicman A.T. A brief history of 'new psychoactive substances'. Drug Test Anal. 2011, 3:401-403.
2. European Drug Report Trends and developments 2013, EMCDDA, Lisbon, http://www.emcdda.europa.eu/publications/edr/trends-developments/2013 (accessed 20.08.13).
3. Archer R.P., Treble R., Williams K. Reference materials for new psychoactive substances. Drug Test Anal. 2011, 3:505-514.
4. Laks S., Pelander A., Vuori E., Ali-Tolppa E., Sippola E., Ojanperä I. Analysis of street drugs in seized material without primary reference standards. Anal. Chem. 2004, 76:7375-7379.
5. Reitzel L.A., Dalsgaard P.W., Müller I.B., Cornett C. Identification of ten new designer drugs by GC-MS, UPLC-QTOF-MS, and NMR as part of a police investigation of a Danish internet company. Drug Test Anal. 2012, 4:342-354.
6. 1H NMR determination of pharmacologically active substances in dietary supplements and medicines that have been illegally traded over the Internet. Drug Test Anal. 2013, 5:400-411.
7. Lane S., Boughtflower B., Mutton I., Paterson C., Farrant D., Taylor N., Blaxill Z., Carmody C., Borman P. Toward single-calibrant quantification in HPLC. A comparison of three detection strategies: evaporative light scattering, chemiluminescent nitrogen, and proton NMR. Anal. Chem. 2005, 77:4354-4365.
8. Liang X., Patel H., Young J., Shah P., Raglione T. The practical application of implementing the equimolar response principle of chemiluminescent nitrogen detection in pharmaceutical analysis. J. Pharm. Biomed. Anal. 2008, 47:723-730.
9. Singh N., Day P., Katta V.R., Mohammed G.P., Lough W.J. LC purity and related substances screening for mephedrone. J. Pharm. Pharmacol. 2010, 62:1209-1210.
10. Zuba D., Byrska B. Prevalence and co-existence of active components of 'legal highs'. Drug Test Anal. 2013, 5:420-429.
11. Nakajima J., Takahashi M., Seto T., Kanai C., Suzuki J., Yoshida M., Hamano T. Identification and quantitation of two benzoylindoles AM-694 and (4-methoxyphenyl)(1-pentyl-1H-indol-3-yl)methanone, and three cannabimimetic naphthoylindoles JWH-210, JWH-122, and JWH-019 as adulterants in illegal products obtained via the Internet. Forensic Toxicol. 2011, 29:95-110.
12. Choi H., Heo S., Choe S., Yang W., Park Y., Kim E., Chung H., Lee J. Simultaneous analysis of synthetic cannabinoids in the materials seized during drug trafficking using GC-MS. Anal. Bioanal. Chem. 2013, 405:3937-3944.
13. Shah N., Gao M., Tsutsui K., Lu A., Davis J., Scheuerman R., Fitch W.L., Wilgus R.L. A novel approach to high-throughput quality control of parallel synthesis libraries. J. Comb. Chem. 2000, 2:453-456.
14. Yan B., Zhao J., Leopold K., Zhang B., Jiang G. Structure-dependent response of a chemiluminescence nitrogen detector for organic compounds with adjacent nitrogen atoms connected by a single bond. Anal. Chem. 2007, 79:718-726.
15. Bhattachar S.N., Wesley J.A., Seadeek C. Evaluation of the chemiluminescent nitrogen detector for solubility determinations to support drug discovery. J. Pharm. Biomed. Anal. 2006, 41:152-157.
16. Chan K.M., Fujinari E.M. A reversed-phase HPLC method using non-nitrogen-containing mobile phases: capacity factor, mobile phase, and column selectivity for amoxicillin, saccharin, and caffeine. Am. Lab. 2004, 36:18-22.
17. Nussbaum M.A., Baertschi S.W., Jansen P.J. Determination of relative UV response factors for HPLC by use of a chemiluminescent nitrogen-specific detector. J. Pharm. Biomed. Anal. 2002, 27:983-993.