Atopic dermatitis severity and skin barrier impairment

British Journal of Dermatology

Volumn 170, Issue 3, 2014, Pages 490-491

  Winge, M C G ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; FILAGGRIN; INTERMEDIATE FILAMENT PROTEIN;

ATOPIC DERMATITIS; DISEASE SEVERITY; ENVIRONMENTAL FACTOR; FILAGGRIN GENE; GENE; GENE EXPRESSION; GENETIC PREDISPOSITION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HOMEOSTASIS; HUMAN; HYDRATION; IMMUNOREACTIVITY; LOSS OF FUNCTION MUTATION; META ANALYSIS (TOPIC); NOTE; PH; PRIORITY JOURNAL; SKIN PERMEABILITY; SKIN SENSITIZATION; SKIN WATER LOSS; STRATUM CORNEUM; TRANSCRIPTION REGULATION; UPREGULATION; FEMALE; GENETICS; MALE; MUTATION;

DERMATITIS, ATOPIC; FEMALE; HUMANS; INTERMEDIATE FILAMENT PROTEINS; MALE; MUTATION;

EID: 84896088440     PISSN: 00070963     EISSN: 13652133     Source Type: Journal    
DOI: 10.1111/bjd.12869     Document Type: Note

References (12)

1. Bieber T,. Atopic dermatitis 2.0: from the clinical phenotype to the molecular taxonomy and stratified medicine. Allergy 2013; 67: 1475-82.
2. Brown SJ, McLean WH,. One remarkable molecule: filaggrin. J Invest Dermatol 2013; 132: 751-62.
3. Palmer CN, Irvine AD, Terron-Kwiatkowski A, et al,. Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis. Nat Genet 2006; 38: 441-6.
4. Elias PM, Steinhoff M,. 'Outside-to-inside' (and now back to 'outside') pathogenic mechanisms in atopic dermatitis. J Invest Dermatol 2008; 128: 1067-70. (Pubitemid 351543225)
5. Jungersted JM, Scheer H, Mempel M, et al,. Stratum corneum lipids, skin barrier function and filaggrin mutations in patients with atopic eczema. Allergy 2010; 65: 911-18.
6. Winge MCG, Hoppe T, Berne B, et al,. Filaggrin genotype determines functional and molecular alterations in skin of patients with atopic dermatitis and ichthyosis vulgaris. PLoS ONE 2011; 6: e28254.
7. Pellerin L, Henry J, Hsu CY, et al,. Defects of filaggrin-like proteins in both lesional and nonlesional atopic skin. J Allergy Clin Immunol 2013; 131: 1094-102.
8. Kezic S, O'Regan GM, Yau N, et al,. Levels of filaggrin degradation products are influenced by both filaggrin genotype and atopic dermatitis severity. Allergy 2011; 66: 934-40.
9. Nemoto-Hasebe I, Akiyama M, Nomura T, et al,. Clinical severity correlates with impaired barrier in filaggrin-related eczema. J Invest Dermatol 2009; 129: 682-9.
10. Mõcsai G, Gáspár K, Nagy G, et al,. Severe skin inflammation and filaggrin mutation similarly alter skin barrier in patients with atopic dermatitis. Br J Dermatol 2014 in press; 170: 617-24.
11. Bieber T,. Atopic dermatitis. N Engl J Med 2008; 358: 1483-94.
12. Rodriguez E, Baurecht H, Herberich E, et al,. Meta-analysis of filaggrin polymorphisms in eczema and asthma: robust risk factors in atopic disease. J Allergy Clin Immunol 2009; 123: 1361-70. e7.