Association between FSHR polymorphisms and polycystic ovary syndrome among Chinese women in north China

Journal of Assisted Reproduction and Genetics

Volumn 31, Issue 3, 2014, Pages 371-377

  Wu, Xue Qing ^a   Xu, Su Ming ^a   Liu, Jun Fen ^a   Bi, Xing Yu ^a   Wu, Yuan Xia ^a   Liu, Jing ^a  

^a Shanxi Women and Children Health Center   (China)

Author keywords

Follicle stimulating hormone receptor; Genetic polymorphisms; Polycystic ovary syndrome; Single nucleotide polymorphisms

Indexed keywords

ALANINE; ASPARAGINE; ESTRADIOL; FOLLITROPIN; FOLLITROPIN RECEPTOR; GENOMIC DNA; LUTEINIZING HORMONE; PROGESTERONE; PROLACTIN; SERINE; TESTOSTERONE; THREONINE;

ADULT; ALLELE; ARTICLE; CHINA; CHINESE; CODON; CONTROLLED STUDY; DNA ISOLATION; DNA SEQUENCE; FEMALE; FOLLICLE STIMULATING HORMONE RECEPTOR GENE; FOLLITROPIN BLOOD LEVEL; GENE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; OBESITY; OVARY POLYCYSTIC DISEASE; POLYMERASE CHAIN REACTION; PREGNANCY RATE; PRIORITY JOURNAL; PROLACTIN BLOOD LEVEL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM;

ADULT; ALLELES; CHINA; FEMALE; FOLLICLE STIMULATING HORMONE; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; HUMANS; POLYCYSTIC OVARY SYNDROME; POLYMORPHISM, SINGLE NUCLEOTIDE; PREGNANCY; RECEPTORS, FSH;

EID: 84896064870     PISSN: 10580468     EISSN: 15737330     Source Type: Journal    
DOI: 10.1007/s10815-013-0166-z     Document Type: Article

References (24)

1. Franks S. Polycystic ovary syndrome. N Engl J Med. 1995;333(13):853-61.
2. The Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril. 2004;81(1):19-25.
3. Shen Y, Wang L, Zhao Y, You L, Geng L, Gu HF, et al. Evaluation of the association between GHR exon 3 polymorphism and polycystic ovary syndrome among Han Chinese women. Growth Hormon IGF Res. 2011;21(5):248-51.
4. Zhang CW, Zhang XL, Xia YJ, Cao YX, Wang WJ, Xu P, et al. Association between polymorphisms of the CYP11A1 gene and polycystic ovary syndrome in Chinese women. Mol Biol Rep. 2012;39(8):8379-85.
5. Valkenburg O, Uitterlinden AG, Piersma D, Hofman A, Themmen AP, de Jong FH, et al. Genetic polymorphisms of GnRH and gonadotrophic hormone receptors affect the phenotype of polycystic ovary syndrome. Hum Reprod. 2009;24(8):2014-22.
6. Gu BH, Park JM, Baek KH. Genetic variations of follicle stimulating hormone receptor are associated with polycystic ovary syndrome. Int J Mol Med. 2010;26(1):107-12.
7. Fauser BC, Van Heusden AM. Manipulation of human ovarian function: physiological concepts and clinical consequences. Endocr Rev. 1997;18(1):71-106. (Pubitemid 27076456)
8. Gromoll J, Pekel E, Nieschlag E. The structure and organization of the human follicle-stimulating hormone receptor (FSHR) gene. Genomics. 1996;35(2):308-11. (Pubitemid 26250316)
9. Laven JS, Mulders AG, Suryandari DA, Gromoll J, Nieschlag E, Fauser BC, et al. Follicle-stimulating hormone receptor polymorphisms in women with normogonadotropic anovulatory infertility. Fertil Steril. 2003;80(4):986-92. (Pubitemid 37230037)
10. Simoni M, Nieschlag E, Gromoll J. Isoforms and single nucleotide polymorphisms of the FSH receptor gene: implications for human reproduction. Hum Reprod Update. 2002;8(5):413-21. (Pubitemid 35175203)
11. Perez Mayorga M, Gromoll J, Behre HM, Gassner C, Nieschlag E, Simoni M. Ovarian response to follicle-stimulating hormone (FSH) stimulation depends on the FSH receptor genotype. J Clin Endocrinol Metab. 2000;85(9):3365-9.
12. Lussiana C, Guani B, Mari C, Restagno G, Massobrio M, Revelli A. Mutations and polymorphisms of the FSH receptor (FSHR) gene: clinical implications in female fecundity and molecular biology of FSHR protein and gene. Obstet Gynecol Surv. 2008;63(12):785-95.
13. Dolfin E, Guani B, Lussiana C, Mari C, Restagno G, Revelli A. FSH-receptor Ala307Thr polymorphism is associated to polycystic ovary syndrome and to a higher responsiveness to exogenous FSH in Italian women. J Assist Reprod Genet. 2011;28(10):925-30.
14. Unsal T, Konac E, Yesilkaya E, Yilmaz A, Bideci A, Ilke Onen H, et al. Genetic polymorphisms of FSHR, CYP17, CYP1A1, CAPN10, INSR, SERPINE1 genes in adolescent girls with polycystic ovary syndrome. J Assist Reprod Genet. 2009;26(4):205-16.
15. Du J, Zhang W, Guo L, Zhang Z, Shi H, Wang J, et al. Two FSHR variants, haplotypes and meta-analysis in Chinese women with premature ovarian failure and polycystic ovary syndrome. Mol Genet Metab. 2010;100(3):292-5.
16. Fu L, Zhang Z, Zhang A, Xu J, Huang X, Zheng Q, et al. Association study between FSHR Ala307Thr and Ser680Asn variants and polycystic ovary syndrome (PCOS) in Northern Chinese Han women. J Assist Reprod Genet. 2013;30(5):717-21.
17. Archer JS, Chang RJ. Hirsutism and acne in polycystic ovary syndrome. Best Pract Res Clin Obstet Gynaecol. 2004;18(5):737-54. (Pubitemid 40424608)
18. Xu X, Shi Y, Cui Y, Ma J, Che L, Chen ZJ. Endocrine and metabolic characteristics of polycystic ovary syndrome in Chinese women with different phenotypes. Clin Endocrinol. 2012;76(3):425-30.
19. Sundblad V, Chiauzzi VA, Escobar ME, Dain L, Charreau EH. Screening of FSH receptor gene in Argentine women with premature ovarian failure (POF). Mol Cell Endocrinol. 2004;222(1-2):53-9. (Pubitemid 38900815)
20. Sudo S, Kudo M, Wada S, Sato O, Hsueh AJ, Fujimoto S. Genetic and functional analyses of polymorphisms in the human FSH receptor gene. Mol Hum Reprod. 2002;8(10):893-9. (Pubitemid 35174921)
21. Guo M, Chen ZJ, Eijkemans MJ, Goverde AJ, Fauser BC, Macklon NS. Comparison of the phenotype of Chinese versus Dutch Caucasian women presenting with polycystic ovary syndrome and oligo/amenorrhoea. Hum Reprod. 2012;27(5):1481-8.
22. Gambineri A, Pelusi C, Vicennati V, Pagotto U, Pasquali R. Obesity and the polycystic ovary syndrome. Int J Obes Relat Metab Disord. 2002;26(7):883-96. (Pubitemid 34756169)
23. World Health Organization (WHO).Waist circumference and waist-hip ratio: report of a WHO expert consultation, Geneva, 8-11 December 2008. Geneva: WHO; 2011.
24. China's Ministry of Health Control Department. Guideline on the prevention and control of overweight and obesity among Chinese adults (try-out). Beijing: People's Medical Publishing House; 2003.