Do mast cells play a pathogenetic role in neurofibromatosis type 1 and ulcerative colitis?

Experimental and Molecular Pathology

Volumn 96, Issue 2, 2014, Pages 230-234

  Baratelli, Felicita ^a   Le, Mary ^a   Gershman, George B ^b   French, Samuel W ^a  

^a HARBOR UCLA MEDICAL CENTER   (United States)

^b UCLA Division of Gastroenterology/Hepatology   (United States)

Author keywords

Inflammatory bowel disease; Mast cell; Neurofibromatosis type 1; Ulcerative colitis

Indexed keywords

5 ACETAMIDOSALICYLIC ACID; EOSIN; FERRITIN; FERROUS SULFATE; FOLIC ACID; HEMATOXYLIN; IRON; MESALAZINE; NEURON SPECIFIC ENOLASE; NEUTROPHIL CYTOPLASMIC ANTIBODY; PROTEIN S 100; SODIUM CHLORIDE; STEM CELL FACTOR RECEPTOR;

ADOLESCENT; ANTIBODY TITER; ARTICLE; CAFE AU LAIT SPOT; CASE REPORT; CLINICAL FEATURE; COLON MUCOSA; COLONOSCOPY; DISEASE ACTIVITY; ERYTHROCYTE CONCENTRATE; ESOPHAGOGASTRODUODENOSCOPY; FATIGUE; FERRITIN BLOOD LEVEL; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INFLAMMATORY BOWEL DISEASE; IRON BINDING CAPACITY; IRON BLOOD LEVEL; IRON INTAKE; LOOSE FECES; MALE; MAST CELL; MEAN CORPUSCULAR VOLUME; MICROCYTIC ANEMIA; MICROSCOPY; NEUROFIBROMATOSIS; PATHOGENESIS; PROTEIN EXPRESSION; RETICULOCYTE COUNT; SCHWANN CELL; STAINING; TACHYCARDIA; TENESMUS; ULCERATIVE COLITIS; COLITIS, ULCERATIVE; COMPLICATION; GENETICS; NEUROFIBROMATOSIS 1; PATHOLOGY;

ADOLESCENT; COLITIS, ULCERATIVE; HUMANS; MALE; MAST CELLS; NEUROFIBROMATOSIS 1; SCHWANN CELLS;

EID: 84895998482     PISSN: 00144800     EISSN: 10960945     Source Type: Journal    
DOI: 10.1016/j.yexmp.2014.02.006     Document Type: Article

References (20)

1. Balazas M., Illyes G., Vadasz G. Mast cells in ulcerative colitis. Quantitative and ultrastructural studies. Virchows Arch. B Cell. Pathol. Incl. Mol. Pathol. 1989, 57:353-360.
2. Bretagne J.F., et al. Ulcerative hemorrhagic colitis, hyperparathyroidism and Recklinghausen's disease. Gastroenterol. Clin. Biol. 1980, 4:497-498.
3. Chen S., et al. Nf1-/- Schwann cell-conditioned medium modulates mast cell degranulation by c-kit-mediated hyperactivation of phosphatidylinositol 3-kinase. Am. J. Pathol. 2010, 177:3125-3132.
4. Crivellato E., et al. Low mast cell density in the human duodenal mucosa from chronic inflammatory duodenal bowel disorders is associated with defective villous architecture. Eur. J. Clin. Invest. 2003, 33:601-610.
5. Dvorak A.M., et al. Ultrastructural evidence for piecemeal and anaphylactic degranulation of human gut mucosal mast cells in vivo. Int. Arch. Allergy Immunol. 1992, 99:74-83.
6. Farhadi A. Mucosal mast cells are pivotal elements in inflammatory bowel disease that connect the dots: stress, intestinal hypermeability and inflammation. World J. Gastroenterol. 2007, 13:3027-3030.
7. He S.-H. Key role of mast cells and their major secretory products in inflammatory bowel disease. World J. Gastroenterol. 2004, 10:209-318.
8. Jett K., Friedman J.M. Clinical and genetic aspects of neurofibromatosis 1. Genet. Med. 2009, 12:1-11.
9. Kashiwase Y., et al. Quantitative analysis of mast cells in benign and malignant colonic lesions: immunohistochemical study on formalin-fixed, paraffin-embedded tissues. Allergol. Immunopathol. 2008, 36:271-276.
10. Khosrotehrani K., et al. Subcutaneous neurofibromas are associated with mortality in neurofibromatosis 1: a cohort study of 703 patients. Am. J. Med. Genet. 2005, 132A:49-53.
11. King T., et al. Colonic mucosal mast cell distribution at line of demarcation of active ulcerative colitis. Dig. Dis. Sci. 1992, 37:490-45.
12. Raithel M. Effect of substance P on histamine secretion from gut mucosa in inflammatory bowel disease. Scand. J. Gastroenterol. 1999, 34:496-503.
13. Staser k, Yang F.-C., Clapp D.W. Plexiform neurofibroma genesis: question of NF1gene dose and hyperactive mast cells. Curr. Opin. Hematol. 2010, 17:287-293.
14. Staser k, Yang F.-C., Clapp D.W. Mast cells and the neurofibroma microenvironment. Blood 2013, 116:157-164.
15. Stasikowska-Kanicka O., et al. Mast cells and eosinophils are involved in activation of ulcerative colitis. Adv. Med. Sci. 2012, 11:1-7.
16. Stoyanova I.I., Gulubova M.V. Mast cells and inflammatory mediators in chronic ulcerative colitis. Acta Histochem. 2002, 104:185-192.
17. Tavakkoli H., et al. Ulcerative colitis and neurofibromatosis type 1 with bilateral psoas muscle: a case report. J. Res. Med. Sci. 2009, 14:261-265.
18. Trucker T., et al. Different patterns of mast cells distinguish diffuse from encapsulated neurofibromas in patients with neurofibromatosis type 1. J. Histochem. Cytochem. 2011, 59:584-590.
19. Walls A.F., et al. Roles of mast cell and basophil in asthma. Clin. Exp. Allergy Rev. 2001, 1:68-72.
20. Yoshida Y., Adachi K., Yamamoto O. Local mast cell histamine levels in neurofibromatosis type 1. Acta Derm. Venereol. 2010, 90:1-3.