Alanine scan of core positions in ubiquitin reveals links between dynamics, stability, and function

Journal of Molecular Biology

Volumn 426, Issue 7, 2014, Pages 1377-1389

  Lee, Shirley Y ^a   Pullen, Lester ^b   Virgil, Daniel J ^b   Castañeda, Carlos A ^a   Abeykoon, Dulith ^a   Bolon, Daniel N A ^b   Fushman, David ^a  

^a Bldg 142   (United States)

^b UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

proteasome; protein function; structural dynamics; thermodynamic stability; ubiquitin recycling

Indexed keywords

ALANINE; UBIQUITIN; MUTANT PROTEIN; PROTEASOME; PROTEIN VARIANT;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CONJUGATION; CONTROLLED STUDY; ENZYME SUBSTRATE; FUNGUS GROWTH; HETERONUCLEAR NUCLEAR MAGNETIC RESONANCE; MOLECULAR WEIGHT; MUTANT; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROCESSING; PROTEIN STABILITY; PROTEIN UNFOLDING; RECEPTOR BINDING; TEMPERATURE; THERMODYNAMICS; YEAST; YEAST CELL; IN VITRO STUDY; MOLECULAR DYNAMICS; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN FOLDING; PROTEIN STRUCTURE; THERMOSTABILITY; WILD TYPE;

PROTEASOME; PROTEIN FUNCTION; STRUCTURAL DYNAMICS; THERMODYNAMIC STABILITY; UBIQUITIN RECYCLING;

POINT MUTATION; SACCHAROMYCES CEREVISIAE; UBIQUITIN;

EID: 84895925342     PISSN: 00222836     EISSN: 10898638     Source Type: Journal    
DOI: 10.1016/j.jmb.2013.10.042     Document Type: Article

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