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Volumn 70, Issue 1-2, 2014, Pages 47-62

Molecular profiling of non-small cell lung cancer;Biologie moléculaire et prise en charge des patients atteints d'adénocarcinomes du poumon

Author keywords

Molecular biology; Non small cell lung cancer

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; PROTEIN TYROSINE KINASE INHIBITOR;

EID: 84895920056     PISSN: 07618417     EISSN: 17762561     Source Type: Journal    
DOI: 10.1016/j.pneumo.2013.11.005     Document Type: Review
Times cited : (1)

References (76)
  • 1
    • 37249003928 scopus 로고    scopus 로고
    • Oncogene addiction: setting the stage for molecularly targeted cancer therapy
    • Sharma S.V., Settleman J. Oncogene addiction: setting the stage for molecularly targeted cancer therapy. Genes Dev 2007, 21:3214-3231.
    • (2007) Genes Dev , vol.21 , pp. 3214-3231
    • Sharma, S.V.1    Settleman, J.2
  • 2
    • 79251490374 scopus 로고    scopus 로고
    • New driver mutations in non-small-cell lung cancer
    • Pao W., Girard N. New driver mutations in non-small-cell lung cancer. Lancet Oncol 2011, 12:175-180.
    • (2011) Lancet Oncol , vol.12 , pp. 175-180
    • Pao, W.1    Girard, N.2
  • 3
    • 38649099966 scopus 로고    scopus 로고
    • KRAS mutations as an independent prognostic factor in patients with advanced colorectal cancer treated with cetuximab
    • Lievre A., Bachet J.B., Boige V., Cayre A., Le Corre D., et al. KRAS mutations as an independent prognostic factor in patients with advanced colorectal cancer treated with cetuximab. J Clin Oncol 2008, 26:374-379.
    • (2008) J Clin Oncol , vol.26 , pp. 374-379
    • Lievre, A.1    Bachet, J.B.2    Boige, V.3    Cayre, A.4    Le Corre, D.5
  • 4
    • 79959795786 scopus 로고    scopus 로고
    • Improved survival with vemurafenib in melanoma with BRAF V600E mutation
    • Chapman P.B., Hauschild A., Robert C., Haanen J.B., Ascierto P., et al. Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N Engl J Med 2011, 364:2507-2516.
    • (2011) N Engl J Med , vol.364 , pp. 2507-2516
    • Chapman, P.B.1    Hauschild, A.2    Robert, C.3    Haanen, J.B.4    Ascierto, P.5
  • 5
    • 2342471392 scopus 로고    scopus 로고
    • Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
    • Lynch T.J., Bell D.W., Sordella R., Gurubhagavatula S., Okimoto R.A., et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med 2004, 350:2129-2139.
    • (2004) N Engl J Med , vol.350 , pp. 2129-2139
    • Lynch, T.J.1    Bell, D.W.2    Sordella, R.3    Gurubhagavatula, S.4    Okimoto, R.A.5
  • 6
    • 4143066760 scopus 로고    scopus 로고
    • Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways
    • Sordella R., Bell D.W., Haber D.A., Settleman J. Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways. Science 2004, 305:1163-1167.
    • (2004) Science , vol.305 , pp. 1163-1167
    • Sordella, R.1    Bell, D.W.2    Haber, D.A.3    Settleman, J.4
  • 7
    • 70349376330 scopus 로고    scopus 로고
    • Molecular predictive and prognostic markers in non-small-cell lung cancer
    • Coate L.E., John T., Tsao M.S., Shepherd F.A. Molecular predictive and prognostic markers in non-small-cell lung cancer. Lancet Oncol 2009, 10:1001-1010.
    • (2009) Lancet Oncol , vol.10 , pp. 1001-1010
    • Coate, L.E.1    John, T.2    Tsao, M.S.3    Shepherd, F.A.4
  • 8
    • 84858961916 scopus 로고    scopus 로고
    • Competitive allele specific TaqMan PCR for KRAS, BRAF and EGFR mutation detection in clinical formalin fixed paraffin embedded samples
    • Didelot A., Le Corre D., Luscan A., Cazes A., Pallier K., et al. Competitive allele specific TaqMan PCR for KRAS, BRAF and EGFR mutation detection in clinical formalin fixed paraffin embedded samples. Exp Mol Pathol 2012, 92:275-280.
    • (2012) Exp Mol Pathol , vol.92 , pp. 275-280
    • Didelot, A.1    Le Corre, D.2    Luscan, A.3    Cazes, A.4    Pallier, K.5
  • 9
    • 0142119289 scopus 로고    scopus 로고
    • Epidermal growth factor receptor in non-small-cell lung carcinomas: correlation between gene copy number and protein expression and impact on prognosis
    • Hirsch F.R., Varella-Garcia M., Bunn P.A., Di Maria M.V., Veve R., et al. Epidermal growth factor receptor in non-small-cell lung carcinomas: correlation between gene copy number and protein expression and impact on prognosis. J Clin Oncol 2003, 21:3798-3807.
    • (2003) J Clin Oncol , vol.21 , pp. 3798-3807
    • Hirsch, F.R.1    Varella-Garcia, M.2    Bunn, P.A.3    Di Maria, M.V.4    Veve, R.5
  • 10
    • 33646576196 scopus 로고    scopus 로고
    • Ethnic differences in response to epidermal growth factor receptor tyrosine kinase inhibitors
    • Calvo E., Baselga J. Ethnic differences in response to epidermal growth factor receptor tyrosine kinase inhibitors. J Clin Oncol 2006, 24:2158-2163.
    • (2006) J Clin Oncol , vol.24 , pp. 2158-2163
    • Calvo, E.1    Baselga, J.2
  • 11
    • 77349124901 scopus 로고    scopus 로고
    • EGFR mutations and the terminal respiratory unit
    • Yatabe Y. EGFR mutations and the terminal respiratory unit. Cancer Metastasis Rev 2010, 29:23-36.
    • (2010) Cancer Metastasis Rev , vol.29 , pp. 23-36
    • Yatabe, Y.1
  • 12
    • 33846187218 scopus 로고    scopus 로고
    • Update on epidermal growth factor receptor mutations in non-small cell lung cancer
    • Riely G.J., Politi K.A., Miller V.A., Pao W. Update on epidermal growth factor receptor mutations in non-small cell lung cancer. Clin Cancer Res 2006, 12:7232-7241.
    • (2006) Clin Cancer Res , vol.12 , pp. 7232-7241
    • Riely, G.J.1    Politi, K.A.2    Miller, V.A.3    Pao, W.4
  • 13
    • 82355161909 scopus 로고    scopus 로고
    • Spectrum of oncogenic driver mutations in lung adenocarcinomas from East Asian never smokers
    • Li C., Fang R., Sun Y., Han X., Li F., et al. Spectrum of oncogenic driver mutations in lung adenocarcinomas from East Asian never smokers. PLoS One 2011, 6:e28204.
    • (2011) PLoS One , vol.6
    • Li, C.1    Fang, R.2    Sun, Y.3    Han, X.4    Li, F.5
  • 14
    • 79957916527 scopus 로고    scopus 로고
    • Effectiveness of tyrosine kinase inhibitors on "uncommon" epidermal growth factor receptor mutations of unknown clinical significance in non-small cell lung cancer
    • Wu J.Y., Yu C.J., Chang Y.C., Yang C.H., Shih J.Y., et al. Effectiveness of tyrosine kinase inhibitors on "uncommon" epidermal growth factor receptor mutations of unknown clinical significance in non-small cell lung cancer. Clin Cancer Res 2011, 17:3812-3821.
    • (2011) Clin Cancer Res , vol.17 , pp. 3812-3821
    • Wu, J.Y.1    Yu, C.J.2    Chang, Y.C.3    Yang, C.H.4    Shih, J.Y.5
  • 15
    • 28444478439 scopus 로고    scopus 로고
    • Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants
    • Greulich H., Chen T.H., Feng W., Janne P.A., Alvarez J.V., et al. Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants. PLoS Med 2005, 2:e313.
    • (2005) PLoS Med , vol.2
    • Greulich, H.1    Chen, T.H.2    Feng, W.3    Janne, P.A.4    Alvarez, J.V.5
  • 16
    • 59449097754 scopus 로고    scopus 로고
    • Functional analysis of epidermal growth factor receptor (EGFR) mutations and potential implications for EGFR targeted therapy
    • Kancha R.K., von Bubnoff N., Peschel C., Duyster J. Functional analysis of epidermal growth factor receptor (EGFR) mutations and potential implications for EGFR targeted therapy. Clin Cancer Res 2009, 15:460-467.
    • (2009) Clin Cancer Res , vol.15 , pp. 460-467
    • Kancha, R.K.1    von Bubnoff, N.2    Peschel, C.3    Duyster, J.4
  • 18
    • 24344459713 scopus 로고    scopus 로고
    • Epidermal growth factor receptor activating mutations in Spanish gefitinib-treated non-small-cell lung cancer patients
    • Cortes-Funes H., Gomez C., Rosell R., Valero P., Garcia-Giron C., et al. Epidermal growth factor receptor activating mutations in Spanish gefitinib-treated non-small-cell lung cancer patients. Ann Oncol 2005, 16:1081-1086.
    • (2005) Ann Oncol , vol.16 , pp. 1081-1086
    • Cortes-Funes, H.1    Gomez, C.2    Rosell, R.3    Valero, P.4    Garcia-Giron, C.5
  • 19
    • 20244389188 scopus 로고    scopus 로고
    • Predictive and prognostic impact of epidermal growth factor receptor mutation in non-small-cell lung cancer patients treated with gefitinib
    • Han S.W., Kim T.Y., Hwang P.G., Jeong S., Kim J., et al. Predictive and prognostic impact of epidermal growth factor receptor mutation in non-small-cell lung cancer patients treated with gefitinib. J Clin Oncol 2005, 23:2493-2501.
    • (2005) J Clin Oncol , vol.23 , pp. 2493-2501
    • Han, S.W.1    Kim, T.Y.2    Hwang, P.G.3    Jeong, S.4    Kim, J.5
  • 20
    • 20244388126 scopus 로고    scopus 로고
    • Mutations of the epidermal growth factor receptor gene predict prolonged survival after gefitinib treatment in patients with non-small-cell lung cancer with postoperative recurrence
    • Mitsudomi T., Kosaka T., Endoh H., Horio Y., Hida T., et al. Mutations of the epidermal growth factor receptor gene predict prolonged survival after gefitinib treatment in patients with non-small-cell lung cancer with postoperative recurrence. J Clin Oncol 2005, 23:2513-2520.
    • (2005) J Clin Oncol , vol.23 , pp. 2513-2520
    • Mitsudomi, T.1    Kosaka, T.2    Endoh, H.3    Horio, Y.4    Hida, T.5
  • 21
    • 23844490782 scopus 로고    scopus 로고
    • Activating mutations in the tyrosine kinase domain of the epidermal growth factor receptor are associated with improved survival in gefitinib-treated chemorefractory lung adenocarcinomas
    • Taron M., Ichinose Y., Rosell R., Mok T., Massuti B., et al. Activating mutations in the tyrosine kinase domain of the epidermal growth factor receptor are associated with improved survival in gefitinib-treated chemorefractory lung adenocarcinomas. Clin Cancer Res 2005, 11:5878-5885.
    • (2005) Clin Cancer Res , vol.11 , pp. 5878-5885
    • Taron, M.1    Ichinose, Y.2    Rosell, R.3    Mok, T.4    Massuti, B.5
  • 22
    • 69949162760 scopus 로고    scopus 로고
    • Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma
    • Mok T.S., Wu Y.L., Thongprasert S., Yang C.H., Chu D.T., et al. Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. N Engl J Med 2009, 361:947-957.
    • (2009) N Engl J Med , vol.361 , pp. 947-957
    • Mok, T.S.1    Wu, Y.L.2    Thongprasert, S.3    Yang, C.H.4    Chu, D.T.5
  • 23
    • 75249087060 scopus 로고    scopus 로고
    • Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3trial
    • Mitsudomi T., Morita S., Yatabe Y., Negoro S., Okamoto I., et al. Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3trial. Lancet Oncol 2010, 11:121-128.
    • (2010) Lancet Oncol , vol.11 , pp. 121-128
    • Mitsudomi, T.1    Morita, S.2    Yatabe, Y.3    Negoro, S.4    Okamoto, I.5
  • 24
    • 33744788136 scopus 로고    scopus 로고
    • The impact of human EGFR kinase domain mutations on lung tumorigenesis and in vivo sensitivity to EGFR-targeted therapies
    • Ji H., Li D., Chen L., Shimamura T., Kobayashi S., et al. The impact of human EGFR kinase domain mutations on lung tumorigenesis and in vivo sensitivity to EGFR-targeted therapies. Cancer Cell 2006, 9:485-495.
    • (2006) Cancer Cell , vol.9 , pp. 485-495
    • Ji, H.1    Li, D.2    Chen, L.3    Shimamura, T.4    Kobayashi, S.5
  • 25
    • 33748066632 scopus 로고    scopus 로고
    • Kinetic analysis of epidermal growth factor receptor somatic mutant proteins shows increased sensitivity to the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib
    • Carey K.D., Garton A.J., Romero M.S., Kahler J., Thomson S., et al. Kinetic analysis of epidermal growth factor receptor somatic mutant proteins shows increased sensitivity to the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib. Cancer Res 2006, 66:8163-8171.
    • (2006) Cancer Res , vol.66 , pp. 8163-8171
    • Carey, K.D.1    Garton, A.J.2    Romero, M.S.3    Kahler, J.4    Thomson, S.5
  • 26
    • 33746034167 scopus 로고    scopus 로고
    • Exon 19deletion mutations of epidermal growth factor receptor are associated with prolonged survival in non-small cell lung cancer patients treated with gefitinib or erlotinib
    • Jackman D.M., Yeap B.Y., Sequist L.V., Lindeman N., Holmes A.J., et al. Exon 19deletion mutations of epidermal growth factor receptor are associated with prolonged survival in non-small cell lung cancer patients treated with gefitinib or erlotinib. Clin Cancer Res 2006, 12:3908-3914.
    • (2006) Clin Cancer Res , vol.12 , pp. 3908-3914
    • Jackman, D.M.1    Yeap, B.Y.2    Sequist, L.V.3    Lindeman, N.4    Holmes, A.J.5
  • 27
    • 84887212361 scopus 로고    scopus 로고
    • Alterations in genes of the EGFR signaling pathway and their relationship to EGFR tyrosine kinase inhibitor sensitivity in lung cancer cell lines
    • Gandhi J., Zhang J., Xie Y., Soh J., Shigematsu H., et al. Alterations in genes of the EGFR signaling pathway and their relationship to EGFR tyrosine kinase inhibitor sensitivity in lung cancer cell lines. PLoS One 2009, 4:e4576.
    • (2009) PLoS One , vol.4
    • Gandhi, J.1    Zhang, J.2    Xie, Y.3    Soh, J.4    Shigematsu, H.5
  • 28
    • 80054931335 scopus 로고    scopus 로고
    • Activity of epidermal growth factor receptor-tyrosine kinase inhibitors in patients with non-small cell lung cancer harboring rare epidermal growth factor receptor mutations
    • De Pas T., Toffalorio F., Manzotti M., Fumagalli C., Spitaleri G., et al. Activity of epidermal growth factor receptor-tyrosine kinase inhibitors in patients with non-small cell lung cancer harboring rare epidermal growth factor receptor mutations. J Thorac Oncol 2011, 6:1895-1901.
    • (2011) J Thorac Oncol , vol.6 , pp. 1895-1901
    • De Pas, T.1    Toffalorio, F.2    Manzotti, M.3    Fumagalli, C.4    Spitaleri, G.5
  • 29
    • 13844317894 scopus 로고    scopus 로고
    • EGFR mutation and resistance of non-small-cell lung cancer to gefitinib
    • Kobayashi S., Boggon T.J., Dayaram T., Janne P.A., Kocher O., et al. EGFR mutation and resistance of non-small-cell lung cancer to gefitinib. N Engl J Med 2005, 352:786-792.
    • (2005) N Engl J Med , vol.352 , pp. 786-792
    • Kobayashi, S.1    Boggon, T.J.2    Dayaram, T.3    Janne, P.A.4    Kocher, O.5
  • 30
  • 31
    • 51049116207 scopus 로고    scopus 로고
    • Lung cancer with epidermal growth factor receptor exon 20mutations is associated with poor gefitinib treatment response
    • Wu J.Y., Wu S.G., Yang C.H., Gow C.H., Chang Y.L., et al. Lung cancer with epidermal growth factor receptor exon 20mutations is associated with poor gefitinib treatment response. Clin Cancer Res 2008, 14:4877-4882.
    • (2008) Clin Cancer Res , vol.14 , pp. 4877-4882
    • Wu, J.Y.1    Wu, S.G.2    Yang, C.H.3    Gow, C.H.4    Chang, Y.L.5
  • 32
    • 61549108338 scopus 로고    scopus 로고
    • EGFR T790M mutation: a double role in lung cancer cell survival?
    • Suda K., Onozato R., Yatabe Y., Mitsudomi T. EGFR T790M mutation: a double role in lung cancer cell survival?. J Thorac Oncol 2009, 4:1-4.
    • (2009) J Thorac Oncol , vol.4 , pp. 1-4
    • Suda, K.1    Onozato, R.2    Yatabe, Y.3    Mitsudomi, T.4
  • 33
    • 40049099220 scopus 로고    scopus 로고
    • The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP
    • Yun C.H., Mengwasser K.E., Toms A.V., Woo M.S., Greulich H., et al. The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP. Proc Natl Acad Sci U S A 2008, 105:2070-2075.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 2070-2075
    • Yun, C.H.1    Mengwasser, K.E.2    Toms, A.V.3    Woo, M.S.4    Greulich, H.5
  • 34
    • 18244371651 scopus 로고    scopus 로고
    • Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain
    • Pao W., Miller V.A., Politi K.A., Riely G.J., Somwar R., et al. Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain. PLoS Med 2005, 2:e73.
    • (2005) PLoS Med , vol.2
    • Pao, W.1    Miller, V.A.2    Politi, K.A.3    Riely, G.J.4    Somwar, R.5
  • 35
    • 79952711946 scopus 로고    scopus 로고
    • Acquired resistance to EGFR tyrosine kinase inhibitors in EGFR-mutant lung cancer: distinct natural history of patients with tumors harboring the T790M mutation
    • Oxnard G.R., Arcila M.E., Sima C.S., Riely G.J., Chmielecki J., et al. Acquired resistance to EGFR tyrosine kinase inhibitors in EGFR-mutant lung cancer: distinct natural history of patients with tumors harboring the T790M mutation. Clin Cancer Res 2011, 17:1616-1622.
    • (2011) Clin Cancer Res , vol.17 , pp. 1616-1622
    • Oxnard, G.R.1    Arcila, M.E.2    Sima, C.S.3    Riely, G.J.4    Chmielecki, J.5
  • 36
    • 84863011443 scopus 로고    scopus 로고
    • Pretreatment epidermal growth factor receptor (EGFR) T790M mutation predicts shorter EGFR tyrosine kinase inhibitor response duration in patients with non-small-cell lung cancer
    • Su K.Y., Chen H.Y., Li K.C., Kuo M.L., Yang J.C., et al. Pretreatment epidermal growth factor receptor (EGFR) T790M mutation predicts shorter EGFR tyrosine kinase inhibitor response duration in patients with non-small-cell lung cancer. J Clin Oncol 2012, 30:433-440.
    • (2012) J Clin Oncol , vol.30 , pp. 433-440
    • Su, K.Y.1    Chen, H.Y.2    Li, K.C.3    Kuo, M.L.4    Yang, J.C.5
  • 37
    • 84867899175 scopus 로고    scopus 로고
    • Highly sensitive detection of EGFR T790M mutation using colony hybridization predicts favorable prognosis of patients with lung cancer harboring activating EGFR mutation
    • Fujita Y., Suda K., Kimura H., Matsumoto K., Arao T., et al. Highly sensitive detection of EGFR T790M mutation using colony hybridization predicts favorable prognosis of patients with lung cancer harboring activating EGFR mutation. J Thorac Oncol 2012, 7:1640-1644.
    • (2012) J Thorac Oncol , vol.7 , pp. 1640-1644
    • Fujita, Y.1    Suda, K.2    Kimura, H.3    Matsumoto, K.4    Arao, T.5
  • 38
    • 72949092456 scopus 로고    scopus 로고
    • Novel mutant-selective EGFR kinase inhibitors against EGFR T790M
    • Zhou W., Ercan D., Chen L., Yun C.H., Li D., et al. Novel mutant-selective EGFR kinase inhibitors against EGFR T790M. Nature 2009, 462:1070-1074.
    • (2009) Nature , vol.462 , pp. 1070-1074
    • Zhou, W.1    Ercan, D.2    Chen, L.3    Yun, C.H.4    Li, D.5
  • 39
    • 84877100240 scopus 로고    scopus 로고
    • Analysis of tumor specimens at the time of acquired resistance to EGFR-TKI therapy in 155patients with EGFR-mutant lung cancers
    • Yu H.A., Arcila M.E., Rekhtman N., Sima C.S., Zakowski M.F., et al. Analysis of tumor specimens at the time of acquired resistance to EGFR-TKI therapy in 155patients with EGFR-mutant lung cancers. Clin Cancer Res 2013, 19:2240-2247.
    • (2013) Clin Cancer Res , vol.19 , pp. 2240-2247
    • Yu, H.A.1    Arcila, M.E.2    Rekhtman, N.3    Sima, C.S.4    Zakowski, M.F.5
  • 40
    • 81855208762 scopus 로고    scopus 로고
    • Quantitative detection of EGFR mutations in circulating tumor DNA derived from lung adenocarcinomas
    • Taniguchi K., Uchida J., Nishino K., Kumagai T., Okuyama T., et al. Quantitative detection of EGFR mutations in circulating tumor DNA derived from lung adenocarcinomas. Clin Cancer Res 2011, 17:7808-7815.
    • (2011) Clin Cancer Res , vol.17 , pp. 7808-7815
    • Taniguchi, K.1    Uchida, J.2    Nishino, K.3    Kumagai, T.4    Okuyama, T.5
  • 41
    • 84876946468 scopus 로고    scopus 로고
    • Multiplex picoliter-droplet digital PCR for quantitative assessment of DNA integrity in clinical samples
    • Didelot A., Kotsopoulos S.K., Lupo A., Pekin D., Li X., et al. Multiplex picoliter-droplet digital PCR for quantitative assessment of DNA integrity in clinical samples. Clin Chem 2013, 59:815-823.
    • (2013) Clin Chem , vol.59 , pp. 815-823
    • Didelot, A.1    Kotsopoulos, S.K.2    Lupo, A.3    Pekin, D.4    Li, X.5
  • 42
    • 84873096755 scopus 로고    scopus 로고
    • The presence of mutations in epidermal growth factor receptor gene is not a prognostic factor for long-term outcome after surgical resection of non-small-cell lung cancer
    • Kim Y.T., Seong Y.W., Jung Y.J., Jeon Y.K., Park I.K., et al. The presence of mutations in epidermal growth factor receptor gene is not a prognostic factor for long-term outcome after surgical resection of non-small-cell lung cancer. J Thorac Oncol 2013, 8:171-178.
    • (2013) J Thorac Oncol , vol.8 , pp. 171-178
    • Kim, Y.T.1    Seong, Y.W.2    Jung, Y.J.3    Jeon, Y.K.4    Park, I.K.5
  • 43
    • 84863393080 scopus 로고    scopus 로고
    • Intratumor heterogeneity and branched evolution revealed by multiregion sequencing
    • Gerlinger M., Rowan A.J., Horswell S., Larkin J., Endesfelder D., et al. Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. N Engl J Med 2012, 366:883-892.
    • (2012) N Engl J Med , vol.366 , pp. 883-892
    • Gerlinger, M.1    Rowan, A.J.2    Horswell, S.3    Larkin, J.4    Endesfelder, D.5
  • 44
    • 84871920961 scopus 로고    scopus 로고
    • Consistent mutation status within histologically heterogeneous lung cancer lesions
    • Mattsson J.S., Imgenberg-Kreuz J., Edlund K., Botling J., Micke P. Consistent mutation status within histologically heterogeneous lung cancer lesions. Histopathology 2011, 61:744-748.
    • (2011) Histopathology , vol.61 , pp. 744-748
    • Mattsson, J.S.1    Imgenberg-Kreuz, J.2    Edlund, K.3    Botling, J.4    Micke, P.5
  • 45
    • 80051612067 scopus 로고    scopus 로고
    • Heterogeneous distribution of EGFR mutations is extremely rare in lung adenocarcinoma
    • Yatabe Y., Matsuo K., Mitsudomi T. Heterogeneous distribution of EGFR mutations is extremely rare in lung adenocarcinoma. J Clin Oncol 2011, 29:2972-2977.
    • (2011) J Clin Oncol , vol.29 , pp. 2972-2977
    • Yatabe, Y.1    Matsuo, K.2    Mitsudomi, T.3
  • 47
    • 84890565737 scopus 로고    scopus 로고
    • Heterogeneity of the EGFR mutation status between the primary tumor and metastatic lymph node and the sensitivity to EGFR tyrosine kinase inhibitor in non-small cell lung cancer
    • Shimizu K., Yukawa T., Hirami Y., Okita R., Saisho S., et al. Heterogeneity of the EGFR mutation status between the primary tumor and metastatic lymph node and the sensitivity to EGFR tyrosine kinase inhibitor in non-small cell lung cancer. Target Oncol 2012, 8:237-242.
    • (2012) Target Oncol , vol.8 , pp. 237-242
    • Shimizu, K.1    Yukawa, T.2    Hirami, Y.3    Okita, R.4    Saisho, S.5
  • 48
    • 43649099401 scopus 로고    scopus 로고
    • Intratumor heterogeneity of epidermal growth factor receptor mutations in lung cancer and its correlation to the response to gefitinib
    • Taniguchi K., Okami J., Kodama K., Higashiyama M., Kato K. Intratumor heterogeneity of epidermal growth factor receptor mutations in lung cancer and its correlation to the response to gefitinib. Cancer Sci 2008, 99:929-935.
    • (2008) Cancer Sci , vol.99 , pp. 929-935
    • Taniguchi, K.1    Okami, J.2    Kodama, K.3    Higashiyama, M.4    Kato, K.5
  • 49
    • 84873197678 scopus 로고    scopus 로고
    • Frequent intratumoral heterogeneity of EGFR gene copy gain in non-small cell lung cancer
    • Grob T.J., Hoenig T., Clauditz T.S., Atanackovic D., Koenig A.M., et al. Frequent intratumoral heterogeneity of EGFR gene copy gain in non-small cell lung cancer. Lung Cancer 2012, 79:221-227.
    • (2012) Lung Cancer , vol.79 , pp. 221-227
    • Grob, T.J.1    Hoenig, T.2    Clauditz, T.S.3    Atanackovic, D.4    Koenig, A.M.5
  • 50
    • 42049094628 scopus 로고    scopus 로고
    • Epidermal growth factor receptor gene amplification is acquired in association with tumor progression of EGFR-mutated lung cancer
    • Yatabe Y., Takahashi T., Mitsudomi T. Epidermal growth factor receptor gene amplification is acquired in association with tumor progression of EGFR-mutated lung cancer. Cancer Res 2008, 68:2106-2111.
    • (2008) Cancer Res , vol.68 , pp. 2106-2111
    • Yatabe, Y.1    Takahashi, T.2    Mitsudomi, T.3
  • 51
    • 20144386787 scopus 로고    scopus 로고
    • Somatic mutations of the HER2kinase domain in lung adenocarcinomas
    • Shigematsu H., Takahashi T., Nomura M., Majmudar K., Suzuki M., et al. Somatic mutations of the HER2kinase domain in lung adenocarcinomas. Cancer Res 2005, 65:1642-1646.
    • (2005) Cancer Res , vol.65 , pp. 1642-1646
    • Shigematsu, H.1    Takahashi, T.2    Nomura, M.3    Majmudar, K.4    Suzuki, M.5
  • 52
    • 84880661427 scopus 로고    scopus 로고
    • Lung cancer that harbors an HER2mutation: epidemiologic characteristics and therapeutic perspectives
    • Mazieres J., Peters S., Lepage B., Cortot A.B., Barlesi F., et al. Lung cancer that harbors an HER2mutation: epidemiologic characteristics and therapeutic perspectives. J Clin Oncol 2013, 31:1997-2003.
    • (2013) J Clin Oncol , vol.31 , pp. 1997-2003
    • Mazieres, J.1    Peters, S.2    Lepage, B.3    Cortot, A.B.4    Barlesi, F.5
  • 53
    • 38049150665 scopus 로고    scopus 로고
    • MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib
    • Bean J., Brennan C., Shih J.Y., Riely G., Viale A., et al. MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib. Proc Natl Acad Sci U S A 2007, 104:20932-20937.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 20932-20937
    • Bean, J.1    Brennan, C.2    Shih, J.Y.3    Riely, G.4    Viale, A.5
  • 55
    • 65349107082 scopus 로고    scopus 로고
    • KRAS mutations in non-small cell lung cancer
    • Riely G.J., Marks J., Pao W. KRAS mutations in non-small cell lung cancer. Proc Am Thorac Soc 2009, 6:201-205.
    • (2009) Proc Am Thorac Soc , vol.6 , pp. 201-205
    • Riely, G.J.1    Marks, J.2    Pao, W.3
  • 56
    • 84875943507 scopus 로고    scopus 로고
    • KRAS mutation: should we test for it, and does it matter?
    • Roberts P.J., Stinchcombe T.E. KRAS mutation: should we test for it, and does it matter?. J Clin Oncol 2013, 31:1112-1120.
    • (2013) J Clin Oncol , vol.31 , pp. 1112-1120
    • Roberts, P.J.1    Stinchcombe, T.E.2
  • 57
    • 84873415195 scopus 로고    scopus 로고
    • The dominant role of G12C over other KRAS mutation types in the negative prediction of efficacy of epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer
    • Fiala O., Pesek M., Finek J., Benesova L., Belsanova B., et al. The dominant role of G12C over other KRAS mutation types in the negative prediction of efficacy of epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer. Cancer Genet 2013, 206:26-31.
    • (2013) Cancer Genet , vol.206 , pp. 26-31
    • Fiala, O.1    Pesek, M.2    Finek, J.3    Benesova, L.4    Belsanova, B.5
  • 58
    • 79956316170 scopus 로고    scopus 로고
    • Clinical characteristics of patients with lung adenocarcinomas harboring BRAF mutations
    • Paik P.K., Arcila M.E., Fara M., Sima C.S., Miller V.A., et al. Clinical characteristics of patients with lung adenocarcinomas harboring BRAF mutations. J Clin Oncol 2011, 29:2046-2050.
    • (2011) J Clin Oncol , vol.29 , pp. 2046-2050
    • Paik, P.K.1    Arcila, M.E.2    Fara, M.3    Sima, C.S.4    Miller, V.A.5
  • 59
    • 67649225195 scopus 로고    scopus 로고
    • No somatic genetic change in the paxillin gene in non-small-cell lung cancer
    • Pallier K., Houllier A.M., Le Corre D., Cazes A., Laurent-Puig P., et al. No somatic genetic change in the paxillin gene in non-small-cell lung cancer. Mol Carcinog 2009, 48:581-585.
    • (2009) Mol Carcinog , vol.48 , pp. 581-585
    • Pallier, K.1    Houllier, A.M.2    Le Corre, D.3    Cazes, A.4    Laurent-Puig, P.5
  • 60
    • 68549083200 scopus 로고    scopus 로고
    • Detection of the transforming AKT1mutation E17K in non-small cell lung cancer by high resolution melting
    • Do H., Solomon B., Mitchell P.L., Fox S.B., Dobrovic A. Detection of the transforming AKT1mutation E17K in non-small cell lung cancer by high resolution melting. BMC Res Notes 2008, 1:14.
    • (2008) BMC Res Notes , vol.1 , pp. 14
    • Do, H.1    Solomon, B.2    Mitchell, P.L.3    Fox, S.B.4    Dobrovic, A.5
  • 61
    • 84873584845 scopus 로고    scopus 로고
    • LKB1inactivation dictates therapeutic response of non-small cell lung cancer to the metabolism drug phenformin
    • Shackelford D.B., Abt E., Gerken L., Vasquez D.S., Seki A., et al. LKB1inactivation dictates therapeutic response of non-small cell lung cancer to the metabolism drug phenformin. Cancer Cell 2013, 23:143-158.
    • (2013) Cancer Cell , vol.23 , pp. 143-158
    • Shackelford, D.B.1    Abt, E.2    Gerken, L.3    Vasquez, D.S.4    Seki, A.5
  • 62
    • 84881245421 scopus 로고    scopus 로고
    • Molecular pathways: ROS1fusion proteins in cancer
    • Davies K.D., Doebele R.C. Molecular pathways: ROS1fusion proteins in cancer. Clin Cancer Res 2013, 19:4040-4050.
    • (2013) Clin Cancer Res , vol.19 , pp. 4040-4050
    • Davies, K.D.1    Doebele, R.C.2
  • 63
    • 84863338079 scopus 로고    scopus 로고
    • ROS1rearrangements define a unique molecular class of lung cancers
    • Bergethon K., Shaw A.T., Ou S.H., Katayama R., Lovly C.M., et al. ROS1rearrangements define a unique molecular class of lung cancers. J Clin Oncol 2012, 30:863-870.
    • (2012) J Clin Oncol , vol.30 , pp. 863-870
    • Bergethon, K.1    Shaw, A.T.2    Ou, S.H.3    Katayama, R.4    Lovly, C.M.5
  • 64
    • 84870748688 scopus 로고    scopus 로고
    • RET fusions define a unique molecular and clinicopathologic subtype of non-small-cell lung cancer
    • Wang R., Hu H., Pan Y., Li Y., Ye T., et al. RET fusions define a unique molecular and clinicopathologic subtype of non-small-cell lung cancer. J Clin Oncol 2012, 30:4352-4360.
    • (2012) J Clin Oncol , vol.30 , pp. 4352-4360
    • Wang, R.1    Hu, H.2    Pan, Y.3    Li, Y.4    Ye, T.5
  • 65
    • 79551563284 scopus 로고    scopus 로고
    • International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma
    • Travis W.D., Brambilla E., Noguchi M., Nicholson A.G., Geisinger K.R., et al. International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma. J Thorac Oncol 2011, 6:244-285.
    • (2011) J Thorac Oncol , vol.6 , pp. 244-285
    • Travis, W.D.1    Brambilla, E.2    Noguchi, M.3    Nicholson, A.G.4    Geisinger, K.R.5
  • 66
    • 79955467025 scopus 로고    scopus 로고
    • Frequent ALK rearrangement and TTF-1/p63co-expression in lung adenocarcinoma with signet-ring cell component
    • Yoshida A., Tsuta K., Watanabe S., Sekine I., Fukayama M., et al. Frequent ALK rearrangement and TTF-1/p63co-expression in lung adenocarcinoma with signet-ring cell component. Lung Cancer 2011, 72:309-315.
    • (2011) Lung Cancer , vol.72 , pp. 309-315
    • Yoshida, A.1    Tsuta, K.2    Watanabe, S.3    Sekine, I.4    Fukayama, M.5
  • 67
    • 79953758265 scopus 로고    scopus 로고
    • Pretreatment molecular biology analysis on small size biopsies
    • Antoine M., Poulot V., Colombat M., Fleury J., Lacave R., et al. Pretreatment molecular biology analysis on small size biopsies. Ann Pathol 2010, 30:67-72.
    • (2010) Ann Pathol , vol.30 , pp. 67-72
    • Antoine, M.1    Poulot, V.2    Colombat, M.3    Fleury, J.4    Lacave, R.5
  • 68
    • 84879290901 scopus 로고    scopus 로고
    • Molecular Testing Guideline for Selection of Lung Cancer Patients for EGFR and ALK Tyrosine Kinase Inhibitors: Guideline from the College of American Pathologists. International Association for the Study of Lung Cancer, and Association for Molecular Pathology
    • Lindeman N.I., Cagle P.T., Beasley M.B., Chitale D.A., Dacic S., et al. Molecular Testing Guideline for Selection of Lung Cancer Patients for EGFR and ALK Tyrosine Kinase Inhibitors: Guideline from the College of American Pathologists. International Association for the Study of Lung Cancer, and Association for Molecular Pathology. J Mol Diagn 2013, 15:415-453.
    • (2013) J Mol Diagn , vol.15 , pp. 415-453
    • Lindeman, N.I.1    Cagle, P.T.2    Beasley, M.B.3    Chitale, D.A.4    Dacic, S.5
  • 69
    • 84857087591 scopus 로고    scopus 로고
    • Clarifying the spectrum of driver oncogene mutations in biomarker-verified squamous carcinoma of lung: lack of EGFR/KRAS and presence of PIK3CA/AKT1mutations
    • Rekhtman N., Paik P.K., Arcila M.E., Tafe L.J., Oxnard G.R., et al. Clarifying the spectrum of driver oncogene mutations in biomarker-verified squamous carcinoma of lung: lack of EGFR/KRAS and presence of PIK3CA/AKT1mutations. Clin Cancer Res 2012, 18:1167-1170.
    • (2012) Clin Cancer Res , vol.18 , pp. 1167-1170
    • Rekhtman, N.1    Paik, P.K.2    Arcila, M.E.3    Tafe, L.J.4    Oxnard, G.R.5
  • 70
    • 77952573812 scopus 로고    scopus 로고
    • Role of the surgical pathology laboratory in the pre-analytical approach of molecular biology techniques
    • Hofman V., Ilie M., Gavric-Tanga V., Lespinet V., Mari M., et al. Role of the surgical pathology laboratory in the pre-analytical approach of molecular biology techniques. Ann Pathol 2010, 30:85-93.
    • (2010) Ann Pathol , vol.30 , pp. 85-93
    • Hofman, V.1    Ilie, M.2    Gavric-Tanga, V.3    Lespinet, V.4    Mari, M.5
  • 71
    • 0036898005 scopus 로고    scopus 로고
    • Effect of fixatives and tissue processing on the content and integrity of nucleic acids
    • Srinivasan M., Sedmak D., Jewell S. Effect of fixatives and tissue processing on the content and integrity of nucleic acids. Am J Pathol 2002, 161:1961-1970.
    • (2002) Am J Pathol , vol.161 , pp. 1961-1970
    • Srinivasan, M.1    Sedmak, D.2    Jewell, S.3
  • 72
    • 77953291664 scopus 로고    scopus 로고
    • The biology and treatment of EML4-ALK non-small cell lung cancer
    • Sasaki T., Rodig S.J., Chirieac L.R., Janne P.A. The biology and treatment of EML4-ALK non-small cell lung cancer. Eur J Cancer 2010, 46:1773-1780.
    • (2010) Eur J Cancer , vol.46 , pp. 1773-1780
    • Sasaki, T.1    Rodig, S.J.2    Chirieac, L.R.3    Janne, P.A.4
  • 73
    • 78349237453 scopus 로고    scopus 로고
    • Optimizing the detection of lung cancer patients harboring anaplastic lymphoma kinase (ALK) gene rearrangements potentially suitable for ALK inhibitor treatment
    • Camidge D.R., Kono S.A., Flacco A., Tan A.C., Doebele R.C., et al. Optimizing the detection of lung cancer patients harboring anaplastic lymphoma kinase (ALK) gene rearrangements potentially suitable for ALK inhibitor treatment. Clin Cancer Res 2010, 16:5581-5590.
    • (2010) Clin Cancer Res , vol.16 , pp. 5581-5590
    • Camidge, D.R.1    Kono, S.A.2    Flacco, A.3    Tan, A.C.4    Doebele, R.C.5
  • 74
    • 84857792328 scopus 로고    scopus 로고
    • Histologic subtypes, immunohistochemistry, FISH or molecular screening for the accurate diagnosis of ALK-rearrangement in lung cancer: a comprehensive study of Caucasian non-smokers
    • Just P.A., Cazes A., Audebourg A., Cessot A., Pallier K., et al. Histologic subtypes, immunohistochemistry, FISH or molecular screening for the accurate diagnosis of ALK-rearrangement in lung cancer: a comprehensive study of Caucasian non-smokers. Lung Cancer 2012, 76:309-315.
    • (2012) Lung Cancer , vol.76 , pp. 309-315
    • Just, P.A.1    Cazes, A.2    Audebourg, A.3    Cessot, A.4    Pallier, K.5
  • 75
    • 84857781304 scopus 로고    scopus 로고
    • Dual IHC and FISH testing for ALK gene rearrangement in lung adenocarcinomas in a routine practice: a French study
    • McLeer-Florin A., Moro-Sibilot D., Melis A., Salameire D., Lefebvre C., et al. Dual IHC and FISH testing for ALK gene rearrangement in lung adenocarcinomas in a routine practice: a French study. J Thorac Oncol 2012, 7:348-354.
    • (2012) J Thorac Oncol , vol.7 , pp. 348-354
    • McLeer-Florin, A.1    Moro-Sibilot, D.2    Melis, A.3    Salameire, D.4    Lefebvre, C.5
  • 76
    • 84865089246 scopus 로고    scopus 로고
    • Analysis of receptor tyrosine kinase ROS1-positive tumors in non-small cell lung cancer: identification of a FIG-ROS1fusion
    • Rimkunas V.M., Crosby K.E., Li D., Hu Y., Kelly M.E., et al. Analysis of receptor tyrosine kinase ROS1-positive tumors in non-small cell lung cancer: identification of a FIG-ROS1fusion. Clin Cancer Res 2012, 18:4449-4450.
    • (2012) Clin Cancer Res , vol.18 , pp. 4449-4450
    • Rimkunas, V.M.1    Crosby, K.E.2    Li, D.3    Hu, Y.4    Kelly, M.E.5


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