Acute and subacute pulmonary toxicity caused by a single Intratracheal instillation of colloidal silver nanoparticles in mice: Pathobiological changes and metallothionein responses

Journal of Environmental Pathology, Toxicology and Oncology

Volumn 33, Issue 1, 2014, Pages 59-68

  Kaewamatawong, Theerayuth ^a   Banlunara, Wijit ^a   Maneewattanapinyo, Pattwat ^a   Thammachareon, Chuchaat ^a   Ekgasit, Sanong ^a  

^a CHULALONGKORN UNIVERSITY   (Thailand)

Author keywords

Acute; Lung toxicity; Mouse; Silver nanoparticles; Subacute

Indexed keywords

LAMININ; METALLOTHIONEIN; SILVER NANOPARTICLE; SUPEROXIDE DISMUTASE;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELLULAR PARAMETERS; CHEMICAL PARAMETERS; CONTROLLED STUDY; DRUG INSTILLATION; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; LUNG ALVEOLUS EPITHELIUM; LUNG INJURY; LUNG LAVAGE; LUNG LESION; LUNG TOXICITY; MACROPHAGE; MALE; MOUSE; NONHUMAN; PATHOLOGY; PNEUMONIA; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ACUTE DISEASE; ADMINISTRATION, INHALATION; ANIMALS; COLLOIDS; DISEASE MODELS, ANIMAL; EPITHELIAL CELLS; LUNG; LUNG DISEASES; MACROPHAGES; MALE; METAL NANOPARTICLES; METALLOTHIONEIN; MICE; MICE, INBRED ICR; SILVER; TIME FACTORS;

EID: 84895896829     PISSN: 07318898     EISSN: None     Source Type: Journal    
DOI: 10.1615/JEnvironPatholToxicolOncol.2014010179     Document Type: Article

References (23)

1. Chen X, Schluesener HJ. Nanosilver: A nanoproduct in medical application. Toxicol Lett. 2008;176:1-12.
2. Thomas K, Sayre P. Research strategies for safety evaluation of nanomaterials, Part 1: evaluating the human health implications of exposure to nanoscale materials. Toxicol Sci. 2005;87:316-321.
3. Medina C, Santos-Martinez MJ, Radomski A, Cor-rigan OI, Radomski MW. Nanoparticles: pharmacological and toxicological signifcance. Br J Pharmacol. 2007;150:552-558.
4. Stebounova LV, Adamcakova-Dodd A, Kim JS, Heaweon PH, O'Shaughnessy PT, Grassian VH, Thorne PS. Nanosilver induces minimal lung toxicity or infam-mation in a subacute murine inhalation model. Part Fibre Toxicol. 2011;8:1-12.
5. Dey S, Bakthavatchalu V, Tseng MT, Wu P, Florence RL, Grulke EA, Yokel RA, Dhar SK, Yang H, Chen Y, Clair DK. Interactions between SIRT1 and AP-1 reveal a mechanistic insight into the growth promoting properties of alumina (Al2O3) nanoparticles. Carcinogenesis. 2008;29:1920-1929.
6. Arora S, Jain J, Rajwade JM, Paknikar KM. Cellular responses induced by silver nanoparticles: in vitro studies. Toxicol Lett. 2008;179:93-100.
7. Nordberg M, Nordberg GF. Metallothioneins: historical development and overview. Met Ions Life Sci. 2009;5:1-29.
8. Maneewattanapinyo P, Banlunara W, Thammacharoen C, Ekgasit S, Kaewamatawong T. An evaluation of acute toxicity of colloidal silver nanoparticles. J Vet Med Sci. 2011;73:1417-1423.
9. Kaewamatawong T, Shimada A, Okajima M, Inoue H, Morita T, Inoue K, Takano H. Acute and subacute pulmonary to xicity of low dose of ultrafne colloidal silica particles in mice after intratracheal instillation. Toxicol Pathol. 2006;34:958-965.
10. Aumailley M, Smyte N. The role of laminins in basement membrane function. J Anat. 1998;193:1-21.
11. Kaewamatawong T, Kawamura N, Okajima M, Sawa-da M, Morita T, Shimada A. Acute pulmonary toxicity caused by exposure to colloidal silica: particle size dependent pathological changes in mice. Toxicol Pathol. 2005;33:743-749.
12. Shimada A, Kawamura N, Okajima M, Kaewamatawong T, Inoue H, Morita T. Translocation pathway of the in-tratracheally instilled ultrafne particles from the lung into the blood circulation in the mouse. Toxicol Pathol. 2006;34:949-957.
13. Kenne E, Soehnlein O, Genove G, Rotzius P. Eriksson E, Lindbom L. Immune cell recruitment to inflammatory loci is impaired in mice defcient in basement membrane protein laminin α 4. J Leukoc Biol. 2010;88:523-28.
14. Dunsmore S, Rannels D. Extracellular matrix biology in the lung. Am J Physiol. 1996;270:3-27.
15. Dick CAJ, Brown DM, Donaldson K, Stone V. The role of free radicals in the toxic and infammatory effects of four different ultrafne particles types. Inhal Toxicol. 2003;15:39-52.
16. Donaldson K, Stone V. Current hypotheses on the mechanisms of toxicity of ultrafne particles. Ann Ist Super Sanita. 2003;39:405-410.
17. Choi JE, Kim S, Ahn JH, Youn P, Kang JS, Park K, Yi J, Ryu DY. Induction of oxidative stress and apoptosis by silver nanoparticles in the liver of adult Zebrafsh. Aquat Toxicol. 2010;100:151-159.
18. Miura N, Shinohara Y. Cytotoxic effect and apoptosis induction by silver nanoparticles in Hela cells. Biochem Biophys Res Commun. 2009;390:733-737.
19. Alvarado AE, Quesada I, Hylland K, Marigomez L, Soto M. Quantitative changes in metallothionein expression in target cell-types in the gills of turbot (Scopthalmus maxi-mus) exposed to Cd, Cu, Zn and after a depuration treatment. Aqual Toxicol. 2006;77:64-77.
20. Kaewamatawong T, Rattanapinyopituk K, Ponpornpisit A, Pirarat N, Ruangwises S, Rungsipipat A. Short-term exposure of Nile Tilapia (Oreochromis niloticus) to mercury: histopathological changes, mercury bioaccumula-tion, and protective role of metallothioneins in different exposure routes. Toxicol Pathol. 2012;41(3):470-479.
21. Luther EM, Schmidt MM, Diendorf J, Epple M, Dringen R. Upregulation of metallothioneins after exposure of cultured primary astrocytes to silver nanoparticles. Neu-rochem Res. 2012;37:1639-1648.
22. Kim S, Choi JE, Choi J, Chung KH, Park K, Yi J, Ryu DY. Oxidative stress-dependent toxicity of silver nanoparticles in human hepatoma cells. Toxicol In Vitro. 2009;23(6):1076-1084.
23. Haq F, Mahoney M, Koropatnick J. Signaling events for metallothionein induction. Mutat Res. 2003;533: 211-226.