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Volumn 33, Issue 1, 2014, Pages 19-32

Toxic effects of lead exposure in rats: Involvement of oxidative stress, genotoxic effect, and the beneficial role of N-acetylcysteine supplemented with selenium

Author keywords

DNA damage; Lead acetate; N acetylcysteine; Selenium

Indexed keywords

5 AMINOLEVULINATE SYNTHASE; ACETYLCHOLINESTERASE; ACETYLCYSTEINE; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CATALASE; CHOLESTEROL; CREATININE; GLUTATHIONE; LEAD ACETATE; MALONALDEHYDE; PORPHOBILINOGEN SYNTHASE; SELENIUM; SUPEROXIDE DISMUTASE; TRIACYLGLYCEROL; UREA; URIC ACID;

EID: 84895882246     PISSN: 07318898     EISSN: None     Source Type: Journal    
DOI: 10.1615/JEnvironPatholToxicolOncol.2014009712     Document Type: Article
Times cited : (29)

References (37)
  • 1
    • 84895879470 scopus 로고    scopus 로고
    • Antioxidative effect of bamboo leaves extract and dl-α-lipoic acid alone or as combined therapy on lead induced nephritic and neuronal oxidative impairment
    • Sood PP, Chiragini HM, Kalia K. Antioxidative effect of bamboo leaves extract and dl-α-lipoic acid alone or as combined therapy on lead induced nephritic and neuronal oxidative impairment. J Cell Tissue Res. 2011;11(1):2471-2478.
    • (2011) J Cell Tissue Res , vol.11 , Issue.1 , pp. 2471-2478
    • Sood, P.P.1    Chiragini, H.M.2    Kalia, K.3
  • 2
    • 77952130578 scopus 로고    scopus 로고
    • Hepatoprotective and some haematological effects of Allium sativum and vitamin C in lead-exposed Wistar rats
    • Ajayi GO, Adeniyi TT, Babayemi DO. Hepatoprotective and some haematological effects of Allium sativum and vitamin C in lead-exposed Wistar rats. Int J Med Med Sci. 2008;3:64-67.
    • (2008) Int J Med Med Sci , vol.3 , pp. 64-67
    • Ajayi, G.O.1    Adeniyi, T.T.2    Babayemi, D.O.3
  • 3
    • 84877736110 scopus 로고    scopus 로고
    • Effect of ascorbic acid and allium sativum on tissue lead level in female Rattus navigicus Niger
    • Adeniyi TT, Ajayi GO, Akinloye OA. Effect of ascorbic acid and allium sativum on tissue lead level in female Rattus navigicus Niger. J Health Biomed Sci. 2008;7(2):38-41.
    • (2008) J Health Biomed Sci , vol.7 , Issue.2 , pp. 38-41
    • Adeniyi, T.T.1    Ajayi, G.O.2    Akinloye, O.A.3
  • 5
    • 0037102716 scopus 로고    scopus 로고
    • Lead induced oxidative damage and its response to combined administration of α lipoic acid and succimers in rats
    • Pande M, Flora SJS. Lead induced oxidative damage and its response to combined administration of α lipoic acid and succimers in rats. Toxicology. 2002;177:187-96.
    • (2002) Toxicology , vol.177 , pp. 187-196
    • Pande, M.1    Flora, S.J.S.2
  • 7
    • 84884151679 scopus 로고    scopus 로고
    • Reversal of lead-induced toxicity due to the effect of antioxidants
    • Sharma S, Shrivastava S, Shukla S. Reversal of lead-induced toxicity due to the effect of antioxidants. J Environ Pathol Toxicol Oncol. 2013;32(2):177-187.
    • (2013) J Environ Pathol Toxicol Oncol , vol.32 , Issue.2 , pp. 177-187
    • Sharma, S.1    Shrivastava, S.2    Shukla, S.3
  • 8
    • 0036013724 scopus 로고    scopus 로고
    • Role of antioxidant and chelating agent against beryllium induced toxicity
    • Johri S, Shukla S, Sharma P. Role of antioxidant and chelating agent against beryllium induced toxicity. Indian J Exp Biol. 2001;5:575-582.
    • (2001) Indian J Exp Biol , vol.5 , pp. 575-582
    • Johri, S.1    Shukla, S.2    Sharma, P.3
  • 9
    • 84945029397 scopus 로고
    • European standardized method for the determination of delta-aminolevulinic acid dehydratase activity in blood
    • Berlin A, Schaller KH. European standardized method for the determination of delta-aminolevulinic acid dehydratase activity in blood. Z Klin Chem Klin Biochem. 1974;12(8):389-90.
    • (1974) Z Klin Chem Klin Biochem , vol.12 , Issue.8 , pp. 389-390
    • Berlin, A.1    Schaller, K.H.2
  • 10
    • 66349129125 scopus 로고
    • A colorimetric method for the determination of serum glutamic oxaloacetic and glutamic pyruvic transaminases
    • Reitman S, Frankel S. A colorimetric method for the determination of serum glutamic oxaloacetic and glutamic pyruvic transaminases. Am J Clin Pathol. 1957;28:56-63.
    • (1957) Am J Clin Pathol , vol.28 , pp. 56-63
    • Reitman, S.1    Frankel, S.2
  • 11
    • 0014247513 scopus 로고
    • Production of lipid peroxides of brain
    • Sharma SK, Krishnamurti CR. Production of lipid peroxides of brain. J Neurochem. 1968;15:147-149.
    • (1968) J Neurochem , vol.15 , pp. 147-149
    • Sharma, S.K.1    Krishnamurti, C.R.2
  • 12
    • 0017066115 scopus 로고
    • Enzymatic assay for glutathione
    • Brehe JE, Burch HB. Enzymatic assay for glutathione. Anal Biochem. 1976;4:189-197.
    • (1976) Anal Biochem , vol.4 , pp. 189-197
    • Brehe, J.E.1    Burch, H.B.2
  • 13
    • 0015523099 scopus 로고
    • The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase
    • Misra HP, Fridovich I. The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. J Biol Chem. 1972;247:3170-3175.
    • (1972) J Biol Chem , vol.247 , pp. 3170-3175
    • Misra, H.P.1    Fridovich, I.2
  • 14
    • 0000024078 scopus 로고
    • Catalase
    • In: Bergmeryer HU, editor, New York: Academic Press
    • Aebi H. Catalase. In: Bergmeryer HU, editor. Methods of enzymatic analysis, vol. 2. New York: Academic Press; 1974. pp. 673-684.
    • (1974) Methods of Enzymatic Analysis , vol.2 , pp. 673-684
    • Aebi, H.1
  • 16
    • 0019209805 scopus 로고
    • Regional distribution of the enzymes of haem biosynthesis and the inhibition of 5-aminoleveu- linate synthase by manganese in the rat brain
    • Maines MD. Regional distribution of the enzymes of haem biosynthesis and the inhibition of 5-aminoleveu- linate synthase by manganese in the rat brain. Biochem J. 1980;190(2):315-21.
    • (1980) Biochem J , vol.190 , Issue.2 , pp. 315-321
    • Maines, M.D.1
  • 18
    • 0015142712 scopus 로고
    • Determination of lead in biological and related materials by atomic absorption spectrophotometry
    • Yeager DW, Cholak J, Henderson FW. Determination of lead in biological and related materials by atomic absorption spectrophotometry. Environ Sci Technol. 1971;5:1020-1022.
    • (1971) Environ Sci Technol , vol.5 , pp. 1020-1022
    • Yeager, D.W.1    Cholak, J.2    Henderson, F.W.3
  • 19
    • 0023919963 scopus 로고
    • A simple technique for quantitation of low levels of DNA damage in individual cells
    • Singh NP, McCoy MT, Tice RR, Schneider LL. A simple technique for quantitation of low levels of DNA damage in individual cells. Exp Cell Res. 1988;175:184-191.
    • (1988) Exp Cell Res , vol.175 , pp. 184-191
    • Singh, N.P.1    McCoy, M.T.2    Tice, R.R.3    Schneider, L.L.4
  • 20
    • 0002785801 scopus 로고    scopus 로고
    • 8th Edition. Ames (IA): Affliated East-West Press
    • Snedecor GW, Cochran WG. Statistical method. 8th Edition. Ames (IA): Affliated East-West Press; 1989. pp. 217-236.
    • Statistical Method , vol.1989 , pp. 217-236
    • Snedecor, G.W.1    Cochran, W.G.2
  • 21
    • 0034669377 scopus 로고    scopus 로고
    • Can antioxidants be benefcial in the treatment of lead poisoning?
    • Gurer H, Ercal N. Can antioxidants be benefcial in the treatment of lead poisoning? Free Rad Biol Med. 2000;29:927-945.
    • (2000) Free Rad Biol Med , vol.29 , pp. 927-945
    • Gurer, H.1    Ercal, N.2
  • 22
    • 36048950689 scopus 로고    scopus 로고
    • Essential metal status, prooxidant/antioxidant effects of MiADMSA in male rats: Age-related effects
    • Flora SJS, Mehta A, Gautam P, Jatav PC, Pathak U. Essential metal status, prooxidant/antioxidant effects of MiADMSA in male rats: age-related effects. Biol Trace Elem Res. 2007;120:235-247.
    • (2007) Biol Trace Elem Res , vol.120 , pp. 235-247
    • Flora, S.J.S.1    Mehta, A.2    Gautam, P.3    Jatav, P.C.4    Pathak, U.5
  • 23
    • 0027439347 scopus 로고
    • Lead-protein interactions as a basis for lead toxicity
    • Goering PL. Lead-protein interactions as a basis for lead toxicity. Neurotoxicology. 1993;14:45-60.
    • (1993) Neurotoxicology , vol.14 , pp. 45-60
    • Goering, P.L.1
  • 25
    • 84878438551 scopus 로고    scopus 로고
    • Jaggery protects hep-atorenal injury induced by acute exposure to carbon tet-rachloride in Wistar rats
    • Sharma CK, Saxena M, Sharma V. Jaggery protects hep-atorenal injury induced by acute exposure to carbon tet-rachloride in Wistar rats. J Environ Pathol Toxicol Oncol. 2013;32(1):1-7.
    • (2013) J Environ Pathol Toxicol Oncol , vol.32 , Issue.1 , pp. 1-7
    • Sharma, C.K.1    Saxena, M.2    Sharma, V.3
  • 26
    • 84895861120 scopus 로고    scopus 로고
    • Rosa damascena prevents hepatic damage induced by chronic exposure to alcohol in mice
    • Saxena M, Shukla S. Rosa damascena prevents hepatic damage induced by chronic exposure to alcohol in mice. Hepatol Int. 2013;7(Suppl 1):44.
    • (2013) Hepatol Int , vol.7 , Issue.SUPPL. 1 , pp. 44
    • Saxena, M.1    Shukla, S.2
  • 27
    • 5044244052 scopus 로고    scopus 로고
    • Lead induced oxi-dative stress and its recovery following co-administration of melatonin or N-acetylcysteine during chelation with succimer in male rats
    • Flora SJS, Pande M, Kannan Mehta A. Lead induced oxi-dative stress and its recovery following co-administration of melatonin or N-acetylcysteine during chelation with succimer in male rats. Cell Mol Biol. 2004;50:543-551.
    • (2004) Cell Mol Biol , vol.50 , pp. 543-551
    • Flora, S.J.S.1    Pande, M.2    Kannan Mehta, A.3
  • 28
    • 33748142432 scopus 로고    scopus 로고
    • Co-administration of zinc and n-acetylcysteine prevents arsenic-induced tissue oxidative stress in male rats
    • Modi MR, Kaul K, Kannan GM, Flora SJS. Co-administration of zinc and n-acetylcysteine prevents arsenic-induced tissue oxidative stress in male rats. J Trace Elem Med Biol. 2006;20(3):197-204.
    • (2006) J Trace Elem Med Biol , vol.20 , Issue.3 , pp. 197-204
    • Modi, M.R.1    Kaul, K.2    Kannan, G.M.3    Flora, S.J.S.4
  • 29
    • 84872169545 scopus 로고    scopus 로고
    • Nephroprotective effect of jaggery against acute and subchronic toxicity of acetaminophen in Wistar rats
    • Sharma CK, Sharma V. Nephroprotective effect of jaggery against acute and subchronic toxicity of acetaminophen in Wistar rats. J Environ Pathol Toxicol Oncol. 2012;31(3):265-72.
    • (2012) J Environ Pathol Toxicol Oncol , vol.31 , Issue.3 , pp. 265-272
    • Sharma, C.K.1    Sharma, V.2
  • 30
    • 84873319724 scopus 로고    scopus 로고
    • Reversal of carbon tetrachloride-induced hepatic injury by aqueous extract of Artemisia absinthium in Sprague-Dawley rats
    • Saxena M, Shukla, S. Reversal of carbon tetrachloride-induced hepatic injury by aqueous extract of Artemisia absinthium in Sprague-Dawley rats. J Environ Pathol Toxicol Oncol. 2012;31(4):325-334.
    • (2012) J Environ Pathol Toxicol Oncol , vol.31 , Issue.4 , pp. 325-334
    • Saxena, M.1    Shukla, S.2
  • 32
    • 34249671683 scopus 로고    scopus 로고
    • Developmental lead neuro-toxicity: Alterations in brain cholinergic system
    • Reddy G, Devi B, Chetty C. Developmental lead neuro-toxicity: alterations in brain cholinergic system. Neuro-toxicology. 2007;28:402-7.
    • (2007) Neuro-toxicology , vol.28 , pp. 402-407
    • Reddy, G.1    Devi, B.2    Chetty, C.3
  • 35
    • 84895865131 scopus 로고    scopus 로고
    • Reversal of acetaminophen induced acute and subchronic hepatic injury by jaggery in rats
    • Sharma CK, Sharma V. Reversal of acetaminophen induced acute and subchronic hepatic injury by jaggery in rats. Hepatol Int. 2013;7(Suppl 1):121-122.
    • (2013) Hepatol Int , vol.7 , Issue.SUPPL. 1 , pp. 121-122
    • Sharma, C.K.1    Sharma, V.2
  • 37
    • 84862781518 scopus 로고    scopus 로고
    • Characterizing N-acetylcysteine (NAC) and N-acetyl-cysteine amide (NACA) binding for lead poisoning treatment
    • Chen W, Eracal N, Huynh T, Volkov A, Chusuei CC. Characterizing N-acetylcysteine (NAC) and N-acetyl-cysteine amide (NACA) binding for lead poisoning treatment. J Colloid Interface Sci. 2012;371(1):144-149.
    • (2012) J Colloid Interface Sci , vol.371 , Issue.1 , pp. 144-149
    • Chen, W.1    Eracal, N.2    Huynh, T.3    Volkov, A.4    Chusuei, C.C.5


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