A common variant in pre-miR-146 is associated with coronary artery disease risk and its mature miRNA expression

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 761, Issue , 2014, Pages 15-20

  Xiong, Xing dong ^a,b   Cho, Miook ^c   Cai, Xiu ping ^a,b   Cheng, Jie ^a,b   Jing, Xia ^a,b   Cen, Jin ming ^d   Liu, Xinguang ^a,b   Yang, Xi li ^d   Suh, Yousin ^a,c  

^a GUANGDONG MEDICAL UNIVERSITY   (China)

^b Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics   (China)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^d THE FIRST PEOPLE S HOSPITAL OF FOSHAN   (China)

Author keywords

Coronary artery disease; MicroRNA; Risk; Single nucleotide polymorphism

Indexed keywords

MICRORNA; MICRORNA 146A; MICRORNA 196A2; MICRORNA 499; UNCLASSIFIED DRUG;

ADULT; AGED; ALLELE; ARTICLE; CARDIOVASCULAR RISK; CASE CONTROL STUDY; CHINA; CHINESE; CONTROLLED STUDY; CORONARY ARTERY DISEASE; CORRELATION ANALYSIS; DISEASE PREDISPOSITION; FEMALE; GENE EXPRESSION; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HETEROZYGOTE; HOMOZYGOTE; HUMAN; HUMAN CELL; INCIDENCE; MAJOR CLINICAL STUDY; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SINGLE NUCLEOTIDE POLYMORPHISM;

CORONARY ARTERY DISEASE; MICRORNA; RISK; SINGLE NUCLEOTIDE POLYMORPHISM;

AGED; ASIAN CONTINENTAL ANCESTRY GROUP; CASE-CONTROL STUDIES; CORONARY ARTERY DISEASE; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MALE; MICRORNAS; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK;

EID: 84895877814     PISSN: 00275107     EISSN: 09218262     Source Type: Journal    
DOI: 10.1016/j.mrfmmm.2014.01.001     Document Type: Article

References (35)

1. Prins B.P., Lagou V., Asselbergs F.W., Snieder H., Fu J. Genetics of coronary artery disease: genome-wide association studies and beyond. Atherosclerosis 2012, 225:1-10.
2. Kangas-Kontio T., Huotari A., Ruotsalainen H., Herzig K.H., Tamminen M., Ala-Korpela M., Savolainen M.J., Kakko S. Genetic and environmental determinants of total and high-molecular weight adiponectin in families with low HDL-cholesterol and early onset coronary heart disease. Atherosclerosis 2010, 210:479-485.
3. Zdravkovic S., Wienke A., Pedersen N.L., Marenberg M.E., Yashin A.I., De Faire U. Heritability of death from coronary heart disease: a 36-year follow-up of 20 966 Swedish twins. J. Intern. Med. 2002, 252:247-254.
4. Roberts R., Stewart A.F. Genes and coronary artery disease: where are we?. J. Am. Coll. Cardiol. 2012, 60:1715-1721.
5. Schunkert H., Konig I.R., Kathiresan S., Reilly M.P., Assimes T.L., Holm H., Preuss M., Stewart A.F., Barbalic M., Gieger C., Absher D., Aherrahrou Z., Allayee H., Altshuler D., Anand S.S., Andersen K., Anderson J.L., Ardissino D., Ball S.G., Balmforth A.J., Barnes T.A., Becker D.M., Becker L.C., Berger K., Bis J.C., Boekholdt S.M., Boerwinkle E., Braund P.S., Brown M.J., Burnett M.S., Buysschaert I., Cardiogenics, Carlquist J.F., Chen L., Cichon S., Codd V., Davies R.W., Dedoussis G., Dehghan A., Demissie S., Devaney J.M., Diemert P., Do R., Doering A., Eifert S., Mokhtari N.E., Ellis S.G., Elosua R., Engert J.C., Epstein S.E., de Faire U., Fischer M., Folsom A.R., Freyer J., Gigante B., Girelli D., Gretarsdottir S., Gudnason V., Gulcher J.R., Halperin E., Hammond N., Hazen S.L., Hofman A., Horne B.D., Illig T., Iribarren C., Jones G.T., Jukema J.W., Kaiser M.A., Kaplan L.M., Kastelein J.J., Khaw K.T., Knowles J.W., Kolovou G., Kong A., Laaksonen R., Lambrechts D., Leander K., Lettre G., Li M., Lieb W., Loley C., Lotery A.J., Mannucci P.M., Maouche S., Martinelli N., McKeown P.P., Meisinger C., Meitinger T., Melander O., Merlini P.A., Mooser V., Morgan T., Muhleisen T.W., Muhlestein J.B., Munzel T., Musunuru K., Nahrstaedt J., Nelson C.P., Nothen M.M., Olivieri O., Patel R.S., Patterson C.C., Peters A., Peyvandi F., Qu L., Quyyumi A.A., Rader D.J., Rallidis L.S., Rice C., Rosendaal F.R., Rubin D., Salomaa V., Sampietro M.L., Sandhu M.S., Schadt E., Schafer A., Schillert A., Schreiber S., Schrezenmeir J., Schwartz S.M., Siscovick D.S., Sivananthan M., Sivapalaratnam S., Smith A., Smith T.B., Snoep J.D., Soranzo N., Spertus J.A., Stark K., Stirrups K., Stoll M., Tang W.H., Tennstedt S., Thorgeirsson G., Thorleifsson G., Tomaszewski M., Uitterlinden A.G., van Rij A.M., Voight B.F., Wareham N.J., Wells G.A., Wichmann H.E., Wild P.S., Willenborg C., Witteman J.C., Wright B.J., Ye S., Zeller T., Ziegler A., Cambien F., Goodall A.H., Cupples L.A., Quertermous T., Marz W., Hengstenberg C., Blankenberg S., Ouwehand W.H., Hall A.S., Deloukas P., Thompson J.R., Stefansson K., Roberts R., Thorsteinsdottir U., O'Donnell C.J., McPherson R., Erdmann J., Consortium C.A., Samani N.J. Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat. Genet. 2011, 43:333-338.
6. Kong Y.W., Ferland-McCollough D., Jackson T.J., Bushell M. microRNAs in cancer management. Lancet Oncol. 2012, 13:e249-e258.
7. Elton T.S., Sansom S.E., Martin M.M. Cardiovascular disease, single nucleotide polymorphisms; and the renin angiotensin system: is there a microRNA connection?. Int. J. Hypertens. 2010, 2010:1-13.
8. Xu J., Li C.X., Li Y.S., Lv J.Y., Ma Y., Shao T.T., Xu L.D., Wang Y.Y., Du L., Zhang Y.P., Jiang W., Li C.Q., Xiao Y., Li X. MiRNA-miRNA synergistic network: construction via co-regulating functional modules and disease miRNA topological features. Nucleic Acids Res. 2011, 39:825-836.
9. Zhao Y., Srivastava D. A developmental view of microRNA function. Trends Biochem. Sci. 2007, 32:189-197.
10. Thorsen S.B., Obad S., Jensen N.F., Stenvang J., Kauppinen S. The therapeutic potential of microRNAs in cancer. Cancer J. 2012, 18:275-284.
11. Li C., Pei F., Zhu X., Duan D.D., Zeng C. Circulating microRNAs as novel and sensitive biomarkers of acute myocardial Infarction. Clin. Biochem. 2012, 45:727-732.
12. Schonrock N., Gotz J. Decoding the non-coding RNAs in Alzheimer's disease. Cell Mol. Life Sci. 2012, 69:3543-3559.
13. Creemers E.E., Tijsen A.J., Pinto Y.M. Circulating microRNAs: novel biomarkers and extracellular communicators in cardiovascular disease?. Circ. Res. 2012, 110:483-495.
14. Ajit S.K. Circulating microRNAs as biomarkers, therapeutic targets, and signaling molecules. Sensors (Basel) 2012, 12:3359-3369.
15. Zampetaki A., Mayr M. MicroRNAs in vascular and metabolic disease. Circ. Res. 2012, 110:508-522.
16. Wu M., Jolicoeur N., Li Z., Zhang L., Fortin Y., L'Abbe D., Yu Z., Shen S.H. Genetic variations of microRNAs in human cancer and their effects on the expression of miRNAs. Carcinogenesis 2008, 29:1710-1716.
17. Zhi H., Wang L., Ma G., Ye X., Yu X., Zhu Y., Zhang Y., Zhang J., Wang B. Polymorphisms of miRNAs genes are associated with the risk and prognosis of coronary artery disease. Clin. Res. Cardiol. 2012, 101:289-296.
18. Ramkaran P., Khan S., Phulukdaree A., Moodley D., Chuturgoon A.A. miR-146a polymorphism influences levels of miR-146a, IRAK-1, and TRAF-6 in young patients with coronary artery disease. Cell Biochem. Biophys. 2013.
19. Yue C., Wang M., Ding B., Wang W., Fu S., Zhou D., Zhang Z., Han S. Polymorphism of the pre-miR-146a is associated with risk of cervical cancer in a Chinese population. Gynecol. Oncol. 2011, 122:33-37.
20. Jazdzewski K., Murray E.L., Franssila K., Jarzab B., Schoenberg D.R., de la Chapelle A. Common SNP in pre-miR-146a decreases mature miR expression and predisposes to papillary thyroid carcinoma. Proc. Natl. Acad. Sci. USA 2008, 105:7269-7274.
21. Shen J., Ambrosone C.B., DiCioccio R.A., Odunsi K., Lele S.B., Zhao H. A functional polymorphism in the miR-146a gene and age of familial breast/ovarian cancer diagnosis. Carcinogenesis 2008, 29:1963-1966.
22. Xu T., Zhu Y., Wei Q.K., Yuan Y., Zhou F., Ge Y.Y., Yang J.R., Su H., Zhuang S.M. A functional polymorphism in the miR-146a gene is associated with the risk for hepatocellular carcinoma. Carcinogenesis 2008, 29:2126-2131.
23. Xu B., Feng N.H., Li P.C., Tao J., Wu D., Zhang Z.D., Tong N., Wang J.F., Song N.H., Zhang W., Hua L.X., Wu H.F. A functional polymorphism in Pre-miR-146a gene is associated with prostate cancer risk and mature miR-146a expression in vivo. Prostate 2010, 70:467-472.
24. Zhou F., Zhu H., Luo D., Wang M., Dong X., Hong Y., Lu B., Zhou Y., Zhou J., Zhang Z., Gong W. A functional polymorphism in pre-miR-146a is associated with susceptibility to gastric cancer in a Chinese population. DNA Cell Biol. 2012, 31:1290-1295.
25. Permuth-Wey J., Thompson R.C., Burton Nabors L., Olson J.J., Browning J.E., Madden M.H., Ann Chen Y., Egan K.M. A functional polymorphism in the pre-miR-146a gene is associated with risk and prognosis in adult glioma. J. Neurooncol. 2011, 105:639-646.
26. Lung R.W., Wang X., Tong J.H., Chau S.L., Lau K.M., Cheng S.H., Woo J.K., Woo J., Leung P.C., Ng M.H., Tang N.L., To K.F. A single nucleotide polymorphism in microRNA-146a is associated with the risk for nasopharyngeal carcinoma. Mol. Carcinog. 2013, 52:28-38.
27. Zhou B., Rao L., Peng Y., Wang Y., Chen Y., Song Y., Zhang L. Common genetic polymorphisms in pre-microRNAs were associated with increased risk of dilated cardiomyopathy. Clin. Chim. Acta 2010, 411:1287-1290.
28. Xu J., Hu Z., Xu Z., Gu H., Yi L., Cao H., Chen J., Tian T., Liang J., Lin Y., Qiu W., Ma H., Shen H., Chen Y. Functional variant in microRNA-196a2 contributes to the susceptibility of congenital heart disease in a Chinese population. Hum. Mutat. 2009, 30:1231-1236.
29. Dupont W.D., Plummer W.D. Power and sample size calculations. A review and computer program. Control Clin. Trials. 1990, 11:116-128.
30. Takahashi Y., Satoh M., Minami Y., Tabuchi T., Itoh T., Nakamura M. Expression of miR-146a/b is associated with the Toll-like receptor 4 signal in coronary artery disease: effect of renin-angiotensin system blockade and statins on miRNA-146a/b and Toll-like receptor 4 levels. Clin. Sci (Lond.) 2010, 119:395-405.
31. Guo M., Mao X., Ji Q., Lang M., Li S., Peng Y., Zhou W., Xiong B., Zeng Q. miR-146a in PBMCs modulates Th1 function in patients with acute coronary syndrome. Immunol. Cell Biol. 2010, 88:555-564.
32. Dong S., Xiong W., Yuan J., Li J., Liu J., Xu X. MiRNA-146a regulates the maturation and differentiation of vascular smooth muscle cells by targeting NF-κB expression. Mol. Med. Rep. 2013, 8:407-412.
33. Raitoharju E., Lyytikainen L.P., Levula M., Oksala N., Mennander A., Tarkka M., Klopp N., Illig T., Kahonen M., Karhunen P.J., Laaksonen R., Lehtimaki T. miR-21, miR-210, miR-34a, and miR-146a/b are up-regulated in human atherosclerotic plaques in the Tampere Vascular Study. Atherosclerosis 2011, 219:211-217.
34. Hu Z., Chen J., Tian T., Zhou X., Gu H., Xu L., Zeng Y., Miao R., Jin G., Ma H., Chen Y., Shen H. Genetic variants of miRNA sequences and non-small cell lung cancer survival. J. Clin. Invest. 2008, 118:2600-2608.
35. Wang F., Ma Y.L., Zhang P., Yang J.J., Chen H.Q., Liu Z.H., Peng J.Y., Zhou Y.K., Qin H.L. A genetic variant in microRNA-196a2 is associated with increased cancer risk: a meta-analysis. Mol. Biol. Rep. 2012, 39:269-275.