Genetic studies of FluMist™ influenza vaccines derived from cold-adapted A/Ann Arbor/6/60

International Congress Series

Volumn 1263, Issue C, 2004, Pages 153-156

  Jin, Hong ^a   Lu, Bin ^a   Zhou, Helen ^a   Kemble, George ^a  

^a MEDIMMUNE   (United States)

Author keywords

A Ann Arbor 6 60; A Puerto Rico 8 34; Attenuated (att); FluMist; Influenza A vaccine; Temperature sensitive (ts)

Indexed keywords

EID: 84895858548     PISSN: 05315131     EISSN: None     Source Type: Book Series    
DOI: 10.1016/j.ics.2004.02.124     Document Type: Article

References (5)

1. Maassab, H.F., Adaptation and growth characteristics of influenza virus at 25 degrees C. Nature 213 (1967), 612–614.
2. Belshe, R.B., et al. The efficacy of live attenuated, cold-adapted, trivalent, intranasal influenza virus vaccine in children. N. Engl. J. Med. 338 (1998), 1405–1412.
3. Jin, H, et al. Multiple amino acid residues confer temperature sensitivity to human influenza virus vaccine strains (FluMist) derived from cold-adapted A/Ann Arbor/6/60. Virology 306 (2003), 18–24.
4. Hoffmann, E, et al. Eight-plasmid system for rapid generation of influenza virus vaccines. Vaccine 20 (2002), 3165–3170.
5. Jin, H, et al. Imparting temperature sensitivity and attenuation in ferrets to A/Puerto Rico/8/34 influenza virus by transferring the genetic signature for temperature sensitivity from cold adapted A/Ann Arbor/6/60. J. Virol. 78 (2003), 995–998.