Oral plus nasal corticosteroids improve smell, nasal congestion, and inflammation in sino-nasal polyposis

Laryngoscope

Volumn 124, Issue 1, 2014, Pages 50-56

  Alobid, Isam ^a   Benítez, Pedro ^c   Cardelús, Sara ^d   De Borja Callejas, Francisco ^e   Lehrer Coriat, Eduardo ^a   Pujols, Laura ^e,f   Picado, Cesar ^b   Mullol, Joaquim ^a  

^a HOSPITAL CLÍNIC   (Spain)

^b UNIVERSITY OF BARCELONA   (Spain)

^c Department of Otorhinolaryngology Hospital Sant Joan Despí Moisès Broggi Catalonia ^*  (Spain)

^d HOSPITAL SANT JOAN DE DÉU   (Spain)

^e INSTITUT D INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER IDIBAPS   (Spain)

^f INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

BAST 24; corticosteroids; eosinophilia; loss of smell; nasal polyposis

Indexed keywords

BUDESONIDE; NITRIC OXIDE; PREDNISONE; CORTICOSTEROID;

ADULT; AGED; ARTICLE; ASTHMA; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; CORTICOSTEROID THERAPY; DISEASE SEVERITY; DRUG DOSE REDUCTION; DRUG EFFECT; ENDOSCOPIC SINUS SURGERY; EOSINOPHIL COUNT; EOSINOPHILIA; FEMALE; FORCED CHOICE METHOD; HUMAN; HUMAN TISSUE; INFLAMMATION; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; NOSE OBSTRUCTION; NOSE POLYP; ODOR; OUTCOME ASSESSMENT; PRIORITY JOURNAL; TREATMENT DURATION; TREATMENT OUTCOME; YOUNG ADULT; COMPLICATION; INTRANASAL DRUG ADMINISTRATION; NASAL OBSTRUCTION; NASAL POLYPS; OLFACTION DISORDERS; ORAL DRUG ADMINISTRATION; PARANASAL SINUS; RANDOMIZED CONTROLLED TRIAL; RHINITIS; SINGLE BLIND PROCEDURE; SINUSITIS; VERY ELDERLY; BAST-24; CONTROLLED CLINICAL TRIAL; LOSS OF SMELL; SMELLING DISORDER;

ADMINISTRATION, INTRANASAL; ADMINISTRATION, ORAL; ADRENAL CORTEX HORMONES; ADULT; AGED; AGED, 80 AND OVER; FEMALE; HUMANS; MALE; MIDDLE AGED; NASAL OBSTRUCTION; NASAL POLYPS; OLFACTION DISORDERS; PARANASAL SINUSES; RHINITIS; SINGLE-BLIND METHOD; SINUSITIS; YOUNG ADULT;

BAST-24; CORTICOSTEROIDS; EOSINOPHILIA; LOSS OF SMELL; NASAL POLYPOSIS;

EID: 84895841457     PISSN: 0023852X     EISSN: 15314995     Source Type: Journal    
DOI: 10.1002/lary.24330     Document Type: Article

References (35)

1. Fokkens W, Lund V, Mullol J,; European Position Paper on Rhinosinusitis and Nasal Polyps Group. EP3OS 2007: European position paper on rhinosinusitis and nasal polyps 2007. A summary for otorhinolaryngologists. Rhinology 2007; 45: 97-101.
2. Mullol J, C Picado,. Chronic rhinosinusitis and nasal polyps in aspirin-exacerbated respiratory disease. Immunol Allergy Clin N Am 2013; 33: 163-176. doi: 10.1016/j.iac.2012.11.002. Epub 2012.
3. Guilemany JM, Angrill J, Alobid I, Centellas S, Prades E, Roca J, et al. United airways: the impact of chronic rhinosinusitis and nasal polyps in bronchiectasic patient's quality of life. Allergy 2009; 64: 1524-1529.
4. Rosenfield RM, Andes D, Bhattacharrya N, et al. Clinical practice guideline: adult sinusitis. Otolaryngol Head Neck Surg 2007; 137 (suppl 3): 1-31.
5. Alobid I, Benitez P, Bernal-Sprekelsen M, Roca J, Alonso J, Picado C, et al. Nasal polyposis and its impact on quality of life. Comparison between the effects of medical and surgical treatments. Allergy 2005; 60: 452-8.
6. Alobid I, Benitez P, Bernal-Sprekelsen M, Guilemany JM, Picado C, Mullol J,. The impact of asthma and aspirin sensitivity on quality of life of patients with nasal polyposis. Qual Life Res 2005; 14: 789-793.
7. Benitez P, Alobid I, de Haro J, Berenguer J, Bernal-Sprekelsen M, Pujols L, et al. A short course of oral prednisone followed by long term intranasal budesonide is an effective treatment of severe nasal polyps. Comparative study of various methods of assessment. Laryngoscope 2006; 116: 770-775.
8. Soler ZM, Sauer DA, Mace J, Smith TL,. Relationship between clinical measures and histopathologic findings in chronic rhinosinusitis. Otolaryngol Head Neck Surg 2009; 141: 454-461.
9. Wrobel BB, Leopold DA,. Clinical Assessment of Patients with Smell and Taste Disorders. Otolaryngol Clin North Am 2004; 37: 1127-1142.
10. Guilemany JM, Alobid I, Mullol J,. Controversies in the treatment of chronic rhinosinusitis. Expert Rev Respir Med 2010; 4: 463-477.
11. Mullol J, Obando A, Pujols L, Alobid I,. Corticosteroid treatment in chronic rhinosinusitis: the possibilities and the limits. Immunol Allergy Clin North Am 2009; 29: 657-668.
12. Mullol J, Alobid I,. Combined oral and intranasal corticosteroid therapy: an advance in the management of nasal polyposis? Ann Intern Med 2011; 154: 365-367.
13. Cardesin A, Alobid I, Benitez P, Sierra E, de Haro J, Bernal-Sprekelsen M, et al. Barcelona Smell Test-24 (BAST-24): Validation and Smell Characteristics in the Healthy Spanish Population. Rhinology 2006; 44: 83-89.
14. Alobid I, Cardelus S, Benitez P, et al. Persistent asthma has an accumulative impact on the loss of smell in patients with nasal polyposis. Rhinology 2011; 49: 519-524.
15. Guilemany JM, Garcia-Pinero A, Alobid I, Cardelus S, Centellas S, Bartra J, et al. Persistent allergic rhinitis has a moderate impact on the sense of smell, depending on both nasal congestion and inflammation. Laryngoscope 2009; 119: 233-238.
16. Guilemany JM, Angrill J, Alobid I, Centellas S, Pujols L, Bartra J, et al. United airways again: high prevalence of rhinosinusitis and nasal polyps in bronchiectasis. Allergy 2009; 64: 790-797.
17. Likert R,. A technique for the measurement of attitudes. Archives of Psychology 1932; 140: 1-55.
18. ATS/ERS. Recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide. Am J Respir Crit Care Med 2005; 171: 912-930.
19. Lildholdt T, Rundcrantz H, Lindqvist N,. Efficacy of Topical Corticosteroid Powder for Nasal Polyps: a Double Blind, Placebo-Controlled Study of Budesonide. Clin Otolaryngol 1995; 20: 26-30.
20. Lund VJ, Mackay I,. Staging in Rhinosinusitis. Rhinology 1993; 31: 183-184.
21. Kondo H, Matsuda T, Hashiba M, Baba S,. A study of the relationship between the T&T olfactometer and the University of Pennsylvania Smell Identification Test in a Japanese population. Am J Rhinol 1998; 12: 353-358.
22. Litvack JR, Fong K, Mace J, James KE, Smith TL,. Predictors of olfactory dysfunction in patients with chronic rhinosinusitis. Laryngoscope 2008; 118: 2225-2230.
23. Vento SI, Simola M, Ertama LO, Malmberg CHO,. Sense of smell in long-standing nasal polyposis. Am J Rhinol 2001; 15: 159-163.
24. Soler ZM, Sauer DA, Mace J, Smith TL,. Relationship between clinical measures and histopathologic findings in chronic rhinosinusitis. Otolaryngol Head Neck Surg 2009; 141: 454-461.
25. Cowart BJ, Flynn-Rodden K, McGeady SJ, Lowry LD,. Hyposmia in allergic rhinitis. J Allergy Clin Immunol 1993; 91: 747-751.
26. Ehnhage A, Olsson P, Kolbeck KG, Skedinger M, Dahlen B, Alenius M, et al. Functional endoscopic sinus surgery improved asthma symptoms as well as PEFR and olfaction in patients with nasal polyposis. Allergy 2009; 64: 762-769.
27. Doty RL, Mishra A,. Olfaction and its alteration by nasal obstruction, rhinitis, and rhinosinusitis. Laryngoscope 2001; 111: 409-423.
28. Kern RC,. Chronic sinusitis and anosmia: pathologic changes in the olfactory mucosa. Laryngoscope 2000; 110: 1071-77.
29. Patiar S, Reece P,. Oral steroids for nasal polyps. Cochrane Database Syst Rev 2007;(1): CD005232.
30. Alobid I, Benitez P, Pujols L, et al. Severe nasal polyposis and its impact on quality of life. The effect of a short course of oral steroids followed by long-term intranasal steroid treatment. Rhinology 2006; 44: 8-13.
31. Hissaria P, Smith W, Wormald PJ, Taylor J, Vadas M, Gillis D, et al. Short course of systemic corticosteroids in sinonasal polyposis: a double-blind, randomized, placebo-controlled trial with evaluation of outcome measures. J Allergy Clin Immunol 2006; 118: 128-133.
32. Van Zele T, Gevaert P, Holtappels G, Beule A, Wormald PJ, Mayr S, et al. Oral steroids and doxycycline: two different approaches to treat nasal polyps. J Allergy Clin Immunol 2010; 125: 1069-1076.
33. Vaidyanathan S, Barnes M, Williamson P, Hopkinson P, Donnan PT, Lipworth B,. Treatment of chronic rhinosinusitis with nasal polyposis with oral steroids followed by topical steroids: a randomized trial. Ann Intern Med 2011; 154: 293-302.
34. Pade J, Hummel T,. Olfactory function following nasal surgery. Laryngoscope 2008; 118: 1260-1264.
35. Soler ZM, Sauer DA, Mace JC, Smith TL,. Ethmoid histopathology does not predict olfactory outcomes after endoscopic sinus surgery. Am J Rhinol Allergy 2010; 24: 281-285.