Blood-brain transfer of Pittsburgh compound B in humans

Frontiers in Aging Neuroscience

Volumn 5, Issue NOV, 2013, Pages

  Gjedde, Albert ^a,b,c,d,e   Aanerud, Joel ^b   Braendgaard, Hans ^b   Rodell, Anders B ^b  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b AARHUS UNIVERSITY HOSPITAL   (Denmark)

^c AARHUS UNIVERSITY   (Denmark)

^d MCGILL UNIVERSITY   (Canada)

^e JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Alzheimers disease; Blood brain barrier; Cerebral blood flow measurement; Permeability surface area product; Pittsburgh compound B

Indexed keywords

CARBON 11; OXYGEN 15; PITTSBURGH COMPOUND B;

ADULT; ALZHEIMER DISEASE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN BLOOD FLOW; BRAIN CORTEX; BRAIN REGION; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FRONTAL LOBE; HUMAN; MALE; POSITRON EMISSION TOMOGRAPHY;

EID: 84895825026     PISSN: None     EISSN: 16634365     Source Type: Journal    
DOI: 10.3389/fnagi.2013.00070     Document Type: Article

References (33)

1. Aanerud, J., Borghammer, P., Chakravarty, M. M., Vang, K., Rodell, A. B., Jónsdottir, K. Y., et al. (2012). Brain energy metabolism and blood flow differences in healthy aging. J. Cereb. Blood Flow Metab. 32, 1177-1187. doi: 10.1038/jcbfm.2012.18.
2. Blomqvist, G. (1984). On the construction of functional maps in positron emission tomography. J. Cereb. Blood Flow Metab. 4, 629-632. doi: 10.1038/jcbfm.1984.89.
3. Blomqvist, G., Engler, H., Nordberg, A., Ringheim, A., Wall, A., Forsberg, A., et al. (2008). Unidirectional influx and net accumulation of PIB. Open Neuroimag J. 2, 114-125. doi: 10.2174/1874440000802010114.
4. Collins, D. L., and Evans, A. C. (1997). Animal: validation and applications of nonlinear registration-based segmentation. Int. J. Pattern Recognit. Artif. Intell. 11, 1271-1294. doi: 10.1142/S0218001497000597.
5. Crone, C. (1963). The permeability of capillaries in various organs as determined by the use of the 'indicator diffusion' method. Acta Physiol. Scand. 58, 292-305. doi: 10.1111/j.1748-1716.1963.tb02652.x.
6. Crone, C. (1965). The permeability of brain capillaries to non-electrolytes. Acta Physiol. Scand. 64, 407-417. doi: 10.1111/j.1748-1716.1965.tb04198.x.
7. Forsberg, A., Engler, H., Blomqvist, G., Långström, B., and Nordberg, A. (2012). The use of PIB-PET as a dual pathological and functional biomarker in AD. Biochim. Biophys. Acta 1822, 380-385. doi: 10.1016/j.bbadis.2011.11.006.
8. Gjedde, A. (1981). High-and low-affinity transport of D-glucose from blood to brain. J. Neurochem. 36, 1463-1471. doi: 10.1111/j.1471-4159.1981.tb00587.x.
9. Gjedde, A. (1982). Calculation of cerebral glucose phosphorylation from brain uptake of glucose analogs in vivo: a re-examination. Brain Res. 257, 237-274. doi: 10.1016/0165-0173(82)90018-2.
10. Gjedde, A., Andersson, J., and Eklöf, B. (1975). Brain uptake of lactate, antipyrine, water and ethanol. Acta Physiol Scand. 93, 145-149. doi: 10.1111/j.1748-1716.1975.tb05802.x.
11. Gjedde, A., and Christensen, O. (1984). Estimates of Michaelis-Menten constants for the two membranes of the brain endothelium. J. Cereb. Blood Flow Metab. 4, 241-249. doi: 10.1038/jcbfm.1984.33.
12. Gjedde, A., Hansen, A. J., and Siemkowicz, E. (1980). Rapid simultaneous determination of regional blood flow and blood-brain glucose transfer in brain of rat. Acta Physiol. Scand. 108, 321-330. doi: 10.1111/j.1748-1716.1980.tb06540.x.
13. Gjedde, A., and Wong, D. F. (2001). Quantification of neuroreceptors in living human brain. V. Endogenous neurotransmitter inhibition of haloperidol binding in psychosis. J. Cereb. Blood Flow Metab. 21, 982-994. doi: 10.1097/00004647-200108000-00011.
14. Hardy, J., and Selkoe, D. J. (2002). The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297, 353-336. (2002). Review. Erratum in: Science 297, 2209. doi: 10.1126/science.1072994.
15. Ikonomovic, M. D., Klunk, W. E., Abrahamson, E. E., Mathis, C. A., Price, J. C., Tsopelas, N. D., et al. (2008). Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease. Brain 131(Pt 6), 1630-1645. doi: 10.1093/brain/awn016.
16. Jack, C. R. Jr., Knopman, D. S., Jagust, W. J., Shaw, L. M., Aisen, P. S., Weiner, M. W., et al. (2010). Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade. Lancet Neurol. 9, 119-128. doi: 10.1016/S1474-4422(09)70299-6.
17. Johannsen, P., Jakobsen, J., and Gjedde, A. (2000). Statistical maps of cerebral blood flow deficits in Alzheimer's disease. Eur. J. Neurol. 7, 385-392. doi: 10.1046/j.1468-1331.2000.00088.x.
18. Klunk, W. E., Engler, H., Nordberg, A., Wang, Y., Blomqvist, G., Holt, D. P., et al. (2004). Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B. Ann Neurol. 55, 306-319. doi: 10.1002/ana.20009.
19. Lawson, G., and Hanson, R. J. (1974). Solving Least Squares Problems. New Jersey, NJ: Society for Industrial and Applied Mathematics.
20. Lockhart, A., Lamb, J. R., Osredkar, T., Sue, L. I., Joyce, J. N., Ye, L., et al. (2007). PIB is a non-specific imaging marker of amyloid-beta (Abeta) peptide-related cerebral amyloidosis. Brain 130(Pt 10), 2607-2615. doi: 10.1093/brain/awm191.
21. Lolk, A., Nielsen, H., Andersen, K., Andersen, J., and Kragh-Sørensen, P. (2000). CAMCOG as a screening instrument for dementia: the Odense study. Cambridge Cognitive Examination. Acta Psychiatr. Scand. 102, 331-335. doi: 10.1034/j.1600-0447.2000.102005331.x.
22. Lopresti, B. J., Klunk, W. E., Mathis, C. A., Hoge, J. A., Ziolko, S. K., Lu, X., et al. (2005). Simplified quantification of Pittsburgh Compound B amyloid imaging PET studies: a comparative analysis. J. Nucl. Med. 46, 1959-1972.
23. McKhann, G. M., Knopman, D. S., Chertkow, H., Hyman, B. T., Jack, C. R. Jr., Kawas, C. H., et al. (2011). The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement. 7, 263-269. doi: 10.1016/j.jalz.2011.03.005.
24. Mintun, M. A., Larossa, G. N., Sheline, Y. I., Dence, C. S., Lee, S. Y., Mach, R. H., et al. (2006). [11C]PIB in a nondemented population: potential antecedent marker of Alzheimer disease. Neurology 67, 446-452. doi: 10.1212/01.wnl.0000228230.26044.a4.
25. 15O]water clearance in humans determined by PET: I. Theory and normal values. J. Cereb. Blood Flow Metab. 16, 765-780. doi: 10.1097/00004647-199609000-00002.
26. Ohta, S., Meyer, E., Thompson, C. J., and Gjedde, A. (1992). Oxygen consumption of the living human brain measured after a single inhalation of positron emitting oxygen. J. Cereb. Blood Flow Metab. 12, 179-192. doi: 10.1038/jcbfm.1992.28.
27. Patlak, C. S., Blasberg, R. G., and Fenstermacher, J. D. (1983). Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. J. Cereb. Blood Flow Metab. 3, 1-7. doi: 10.1038/jcbfm.1983.1.
28. Price, J. C., Klunk, W. E., Lopresti, B. J., Lu, X., Hoge, J. A., Ziolko, S. K., et al. (2005). Kinetic modeling of amyloid binding in humans using PET imaging and Pittsburgh Compound-B. J. Cereb. Blood Flow Metab. 25, 1528-1547. doi: 10.1038/sj.jcbfm.9600146.
29. Rodell, A. B., Aanerud, J., Braendgaard, H., and Gjedde, A. (2012). Low residual CBF variability in Alzheimer's Disease after correction for CO(2) Effect. Front Neuroenergetics 4:8. doi: 10.3389/fnene.2012.00008.
30. Rostomian, A. H., Madison, C., Rabinovici, G. D., and Jagust, W. J. (2011). Early 11C-PIB frames and 18F-FDG PET measures are comparable: a study validated in a cohort of AD and FTLD patients. J. Nucl. Med. 52, 173-179. doi: 10.2967/jnumed.110.082057.
31. Sakurada, O., Kennedy, C., Jehle, J., Brown, J. D., Carbin, G. L., Sokoloff, L. (1978). Measurement of local cerebral blood flow with iodo[14C] antipyrine. Am. J. Physiol. 234, H59-H66.
32. Varrone, A., Sjöholm, N., Eriksson, L., Gulyás, B., Halldin, C., and Farde, L. (2009). Advancement in PET quantification using 3D-OP-OSEM point spread function reconstruction with the HRRT. Eur. J. Nucl. Med. Mol. Imaging 36, 1639-1650. doi: 10.1007/s00259-009-1156-3.
33. Wong, D. F., Moghekar, A. R., Rigamonti, D., Brasic, J. R., Rousset, O., Willis, W., et al. (2013). An in vivo evaluation of cerebral cortical amyloid with [18F]flutemetamol using positron emission tomography compared with parietal biopsy samples in living normal pressure hydrocephalus patients. Mol. Imaging Biol. 15, 230-237. doi: 10.1007/s11307-012-0583-x.