Blunted diurnal cortisol pattern is associated with frailty: A cross-sectional study of 745 participants aged 65 to 90 years

Journal of Clinical Endocrinology and Metabolism

Volumn 99, Issue 3, 2014, Pages

  Johar, Hamimatunnisa ^a   Emeny, Rebecca T ^a   Bidlingmaier, Martin ^b   Reincke, Martin ^b   Thorand, Barbara ^a   Peters, Annette ^a   Heier, Margit ^a   Ladwig, Karl Heinz ^a,c  

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROCORTISONE;

AGE DISTRIBUTION; AGED; AGING; AROUSAL; ARTICLE; CIRCADIAN RHYTHM; CONTROLLED STUDY; FEMALE; FRAIL ELDERLY; GRIP STRENGTH; HIGH RISK POPULATION; HUMAN; HYDROCORTISONE RELEASE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SALIVA LEVEL; VERY ELDERLY;

AGED; AGED, 80 AND OVER; CIRCADIAN RHYTHM; COHORT STUDIES; CROSS-SECTIONAL STUDIES; ENDOCRINE SYSTEM DISEASES; FEMALE; FRAIL ELDERLY; GERIATRIC ASSESSMENT; HUMANS; HYDROCORTISONE; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; MALE; PITUITARY-ADRENAL SYSTEM; SALIVA;

EID: 84895822026     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2013-3079     Document Type: Article

References (17)

1. Fried LP, Tangen CM, Walston J, et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001;56:M146-M156. (Pubitemid 32187141)
2. Gardner MP, Lightman S, Sayer AA, et al. Dysregulation of the hypothalamic pituitary adrenal (HPA) axis and physical performance at older ages: An individual participant meta-analysis. Psychoneuroendocrinology. 2013;38:40-49.
3. Kumari M, Badrick E, Sacker A, Kirschbaum C, Marmot M, Chandola T. Identifying patterns in cortisol secretion in an older population. Findings from the Whitehall II study. Psychoneuroendocrinology. 2010;35:1091-1099.
4. Varadhan R, Walston J, Cappola AR, Carlson MC, Wand GS, Fried LP. Higher levels and blunted diurnal variation of cortisol in frail older women. J Gerontol A Biol Sci Med Sci. 2008;63:190-195. (Pubitemid 351738451)
5. Sindi S, Juster RP, Wan N, Nair NP, Ying Kin N, Lupien SJ. Depressive symptoms, cortisol, and cognition during human aging: the role of negative aging perceptions. Stress. 2012;15:130-137.
6. Strandberg TE, Pitkälä KH. Frailty in elderly people. The Lancet. 2007;369:1328-1329. (Pubitemid 46590373)
7. Peeters GM, van Schoor NM, Visser M, et al. Relationship between cortisol and physical performance in older persons. Clin Endocrinol (Oxf). 2007;67:398-406. (Pubitemid 47283838)
8. Otte C, Hart S, Neylan TC, Marmar CR, Yaffe K, Mohr DC. A meta-analysis of cortisol response to challenge in human aging: importance of gender. Psychoneuroendocrinology. 2005;30:80-91. (Pubitemid 39195047)
9. Dmitrieva NO, Almeida DM, Dmitrieva J, Loken E, Pieper CF. A day-centered approach to modeling cortisol: Diurnal cortisol profiles and their associations among U.S. adults. Psychoneuroendocrinology. 2013;38:2354-2365.
10. Holle R, Happich M, Lowel H, Wichmann HE. KORA-a research platform for population based health research. Gesundheitswesen. 2005;67 (Suppl 1):S19 -S25.
11. Bohannon RW. Reference values for the timed up and go test: a descriptive meta-analysis. J Geriatr Phys Ther. 2006;29:64-68. (Pubitemid 44495987)
12. Chaudhry S, Jin L, Meltzer D. Use of a Self-Report-Generated Charlson Comorbidity Index for Predicting Mortality. Med Care. 2005;43:607-615. (Pubitemid 40847298)
13. Phillips AC, Ginty AT, Hughes BM. The other side of the coin: Blunted cardiovascular and cortisol reactivity are associated with negative health outcomes. Int J Psychophysiol. 2013;90:1-7.
14. Holanda CM, Guerra RO, Nóbrega PV, Costa HF, Piuvezam MR, Maciel ÁC. Salivary cortisol and frailty syndrome in elderly residents of long-stay institutions: a cross-sectional study. Arch Gerontol Geriatr. 2012;54:e146-e151.
15. Gardner MP, Lightman SL, Gallacher J, et al. Diurnal cortisol patterns are associated with physical performance in the Caerphilly Prospective Study. Int J Epidemiol. 2011;40:1693-1702.
16. Iqbal J, Denvir M, Gunn J. Frailty assessment in elderly people. The Lancet. 2013;381:1985-1986.
17. Smyth N, Clow A, Thorn L, Hucklebridge F, Evans P. Delays of 5-15 min between awakening and the start of saliva sampling matter in assessment of the cortisol awakening response. Psychoneuroendocrinology. 2013;38:1476-1483.