CD99-positive undifferentiated round cell sarcoma diagnosed on fine needle aspiration cytology, later found to harbour a CIC-DUX4 translocation: A recently described entity

Cytopathology

Volumn 25, Issue 2, 2014, Pages 129-132

  Kajtar B ^a   Tornoczky T ^a   Kalman E ^a   Kuzsner, J ^a   Hogendoorn, P C W ^b   Szuhai, K ^b  

^a UNIVERSITY OF PÉCS   (Hungary)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CD99 ANTIGEN;

ADULT; ARTICLE; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER RECURRENCE; CANCER SURGERY; CASE REPORT; DISEASE COURSE; FEMALE; FINE NEEDLE ASPIRATION BIOPSY; GENE TRANSLOCATION; HISTOPATHOLOGY; HUMAN; INGUINAL LYMPH NODE; LUNG METASTASIS; MIDDLE AGED; MORPHOLOGY; MORTALITY; PRIORITY JOURNAL; SMALL CELL SARCOMA; TUMOR BIOPSY; TUMOR VOLUME; UNDIFFERENTIATED CARCINOMA; UNDIFFERENTIATED SMALL ROUND CELL SARCOMA;

ANTIGENS, CD; BIOPSY, FINE-NEEDLE; CELL ADHESION MOLECULES; FEMALE; HUMANS; MIDDLE AGED; ONCOGENE PROTEINS, FUSION; SARCOMA; TRANSLOCATION, GENETIC;

EID: 84895796759     PISSN: 09565507     EISSN: 13652303     Source Type: Journal    
DOI: 10.1111/cyt.12079     Document Type: Article

References (10)

1. Fletcher CDM, Bridge JA, Hogendoorn PCW, Mertens M (eds). World Health Organization Classification of Tumours of Soft Tissue and Bone. Lyon: IARC Press; 2013.
2. Pierron G, Tirode F, Lucchesi C et al. A new subtype of bone sarcoma defined by BCOR-CCNB3 gene fusion. Nat Genet 2012;44:461-6.
3. Szuhai K, Cleton-Jansen AM, Hogendoorn PCW, Bovée JVMG. Molecular pathology and its diagnostic use in bone tumors. Cancer Genet 2012;205:193-204.
4. Szuhai K, Ijszenga M, de Jong D et al. The NFATc2 gene is involved in a novel cloned translocation in a Ewing sarcoma variant that couples its function in immunology to oncology. Clin Cancer Res 2009;15:2259-68.
5. Graham C, Chilton-MacNeill S, Zielenska M, Somers GR. The CIC-DUX4 fusion transcript is present in a subgroup of pediatric primitive round cell sarcomas. Hum Pathol 2012;43:180-9.
6. Richkind KE, Romansky SG, Finklestein JZ. t(4;19)(q35;q13.1): a recurrent change in primitive mesenchymal tumors? Cancer Genet Cytogenet 1996;87:71-4.
7. Rakheja D, Goldman S, Wilson KS et al. Translocation (4;19)(q35;q13.1)-associated primitive round cell sarcoma: report of a case and review of the literature. Pediatr Dev Pathol 2008;11:239-44.
8. Yoshimoto M, Graham C, Chilton-MacNeill S et al. Detailed cytogenetic and array analysis of pediatric primitive sarcomas reveals a recurrent CIC-DUX4 fusion gene event. Cancer Genet Cytogenet 2009;195:1-11.
9. Kawamura-Saito M, Yamazaki Y, Kaneko K et al. Fusion between CIC and DUX4 up-regulates PEA3 family genes in Ewing-like sarcomas with t(4;19)(q35;q13) translocation. Hum Mol Genet 2006;15:2125-37.
10. Italiano A, Sung YS, Zhang L et al. High prevalence of CIC fusion with double-homeobox (DUX4) transcription factors in EWSR1-negative undifferentiated small blue round cell sarcomas. Genes Chromosomes Cancer 2012;51:207-18.