Shorter term aerobic exercise improves brain, cognition, and cardiovascular fitness in aging

Frontiers in Aging Neuroscience

Volumn 5, Issue NOV, 2013, Pages

  Chapman, Sandra B ^a   Aslan, Sina ^b   Spence, Jeffrey S ^a   DeFina, Laura F ^c   Keebler, Molly W ^a   Didehbani, Nyaz ^a   Lu, Hanzhang ^d  

^a UNIVERSITY OF TEXAS AT DALLAS   (United States)

^b Advance MRI LLC   (United States)

^c The Cooper Institute ^*  (United States)

^d UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Aging; CBF; Exercise; Memory; MRI

Indexed keywords

ADULT; AEROBIC EXERCISE; AGED; AGING; ANTERIOR CINGULATE; ARTICLE; BRAIN BLOOD FLOW; BRAIN FUNCTION; CARDIOVASCULAR FUNCTION; CARDIOVASCULAR PARAMETERS; COGNITION; CONTROLLED STUDY; FEMALE; FITNESS; HOSPITAL ADMISSION; HUMAN; HUMAN EXPERIMENT; MALE; MEMORY; MIDDLE AGED; NERVE CELL PLASTICITY; NORMAL HUMAN; TRAINING;

EID: 84895787092     PISSN: None     EISSN: 16634365     Source Type: Journal    
DOI: 10.3389/fnagi.2013.00075     Document Type: Article

References (44)

1. Ades, P. A., Savage, P. D., Lischke, S., Toth, M. J., Harvey-Berino, J., Bunn, J. Y., et al. (2011). The effect of weight loss and exercise training on flow-mediated dilatation in coronary heart disease: a randomized trial. Chest 140, 1420-1427. doi: 10.1378/chest.10-3289.
2. Alsop, D. C., and Detre, J. A. (1996). Reduced transit-time sensitivity in noninvasive magnetic resonance imaging of human cerebral blood flow. J. Cereb. Blood Flow Metab. 16, 1236-1249. doi: 10.1097/00004647-199611000-00019.
3. Aslan, S., and Lu, H. (2010). On the sensitivity of ASL MRI in detecting regional differences in cerebral blood flow. Magn. Reson. Imaging 28, 928-935. doi: 10.1016/j.mri.2010.03.037.
4. Aslan, S., Xu, F., Wang, P. L., Uh, J., Yezhuvath, U. S., Van Osch, M., et al. (2010). Estimation of labeling efficiency in pseudocontinuous arterial spin labeling. Magn. Reson. Med. 63, 765-771. doi: 10.1002/mrm.22245.
5. Benjamini, Y., and Hochberg, Y. (1995). Controlling the false discovery rate-a practical and powerful approach to multiple testing. J. R. Stat. Soc. Series B Methodological 57, 289-300.
6. Biswal, B. B., Eldreth, D. A., Motes, M. A., and Rypma, B. (2010). Task-dependent individual differences in prefrontal connectivity. Cereb. Cortex 20, 2188-2197. doi: 10.1093/cercor/bhp284.
7. Blumenthal, J. A., Babyak, M. A., Moore, K. A., Craighead, W. E., Herman, S., Khatri, P., et al. (1999). Effects of exercise training on older patients with major depression. Arch. Intern. Med. 159, 2349-2356. doi: 10.1001/archinte.159.19.2349.
8. Borg, G. (1990). Psychophysical scaling with applications in physical work and the perception of exertion. Scand. J. Work Environ. Health 16(Suppl. 1), 55-58. doi: 10.5271/sjweh.1815.
9. Bouchard, C., and Rankinen, T. (2001). Individual differences in response to regular physical activity. Med. Sci. Sports Exerc. 33, S446-S451. discussion: S452-S443. doi: 10.1097/00005768-200106001-00013.
10. Bruel-Jungerman, E., Davis, S., and Laroche, S. (2007). Brain plasticity mechanisms and memory: a party of four. Neuroscientist 13, 492-505. doi: 10.1177/1073858407302725.
11. Buchman, A. S., Boyle, P. A., Wilson, R. S., Bienias, J. L., and Bennett, D. A. (2007). Physical activity and motor decline in older persons. Muscle Nerve 35, 354-362. doi: 10.1002/mus.20702.
12. Burdette, J. H., Laurienti, P. J., Espeland, M. A., Morgan, A., Telesford, Q., Vechlekar, C. D., et al. (2010). Using network science to evaluate exercise-associated brain changes in older adults. Front. Aging Neurosci. 2:23. doi: 10.3389/fnagi.2010.00023.
13. Chapman, S. B., Aslan, S., Spence, J. S., Hart, J. J., Bartz, E. K., Didehbani, N., et al. (2013). Neural mechanisms of brain plasticity with complex cognitive training in healthy seniors. Cereb. Cortex. doi: 10.1093/cercor/bht234. [Epub ahead of print].
14. Chen, J. J., Rosas, H. D., and Salat, D. H. (2011). Age-associated reductions in cerebral blood flow are independent from regional atrophy. Neuroimage 55, 468-478. doi: 10.1016/j.neuroimage.2010.12.032.
15. Colcombe, S. J., Erickson, K. I., Scalf, P. E., Kim, J. S., Prakash, R., McAuley, E., et al. (2006). Aerobic exercise training increases brain volume in aging humans. J. Gerontol. A Biol. Sci. Med. Sci. 61, 1166-1170. doi: 10.1093/gerona/61.11.1166.
16. Colcombe, S. J., Kramer, A. F., Erickson, K. I., Scalf, P., McAuley, E., Cohen, N. J., et al. (2004). Cardiovascular fitness, cortical plasticity, and aging. Proc. Natl. Acad. Sci. U.S.A. 101, 3316-3321. doi: 10.1073/pnas.0400266101.
17. Conti, A. A., and Macchi, C. (2013). Protective effects of regular physical activity on human vascular system. Clin. Ter. 164, 293-294. doi: 10.7417/CT.2013.1575.
18. Dregan, A., and Gulliford, M. C. (2013). Leisure-time physical activity over the life course and cognitive functioning in late mid-adult years: a cohort-based investigation. Psychol. Med. 43, 2447-2458. doi: 10.1017/S0033291713000305.
19. Engstrom, M., Landtblom, A. M., and Karlsson, T. (2013). Brain and effort: brain activation and effort-related working memory in healthy participants and patients with working memory deficits. Front. Hum. Neurosci. 7:140. doi: 10.3389/fnhum.2013.00140.
20. Erickson, K. I., Voss, M. W., Prakash, R. S., Basak, C., Szabo, A., Chaddock, L., et al. (2011). Exercise training increases size of hippocampus and improves memory. Proc. Natl. Acad. Sci. U.S.A. 108, 3017-3022. doi: 10.1073/pnas.1015950108.
21. Greicius, M. D., Srivastava, G., Reiss, A. L., and Menon, V. (2004). Default-mode network activity distinguishes Alzheimer's disease from healthy aging: evidence from functional MRI. Proc. Natl. Acad. Sci. U.S.A. 101, 4637-4642. doi: 10.1073/pnas.0308627101.
22. Gusnard, D. A., Akbudak, E., Shulman, G. L., and Raichle, M. E. (2001). Medial prefrontal cortex and self-referential mental activity: relation to a default mode of brain function. Proc. Natl. Acad. Sci. U.S.A. 98, 4259-4264. doi: 10.1073/pnas.071043098.
23. Harrison, T. M., Weintraub, S., Mesulam, M. M., and Rogalski, E. (2012). Superior memory and higher cortical volumes in unusually successful cognitive aging. J. Int. Neuropsychol. Soc. 18, 1081-1085. doi: 10.1017/S1355617712000847.
24. Heo, S., Prakash, R. S., Voss, M. W., Erickson, K. I., Ouyang, C., Sutton, B. P., et al. (2010). Resting hippocampal blood flow, spatial memory and aging. Brain Res. 1315, 119-127. doi: 10.1016/j.brainres.2009.12.020.
25. Hillman, C. H., Erickson, K. I., and Kramer, A. F. (2008). Be smart, exercise your heart: exercise effects on brain and cognition. Nat. Rev. Neurosci. 9, 58-65. doi: 10.1038/nrn2298.
26. Horne, J. (2013). Exercise benefits for the aging brain depend on the accompanying cognitive load: insights from sleep electroencephalogram. Sleep Med. 14, 1208-1213. doi: 10.1016/j.sleep.2013.05.019.
27. Kadoglou, N. P., Fotiadis, G., Athanasiadou, Z., Vitta, I., Lampropoulos, S., and Vrabas, I. S. (2012). The effects of resistance training on ApoB/ApoA-I ratio, Lp(a) and inflammatory markers in patients with type 2 diabetes. Endocrine 42, 561-569. doi: 10.1007/s12020-012-9650-y.
28. Kondo, H., Morishita, M., Osaka, N., Osaka, M., Fukuyama, H., and Shibasaki, H. (2004). Functional roles of the cingulo-frontal network in performance on working memory. Neuroimage 21, 2-14. doi: 10.1016/j.neuroimage.2003.09.046.
29. Kramer, A. F., Colcombe, S. J., McAuley, E., Scalf, P. E., and Erickson, K. I. (2005). Fitness, aging and neurocognitive function. Neurobiol Aging 26(Suppl. 1), 124-127. doi: 10.1016/j.neurobiolaging.2005.09.009.
30. Lu, H., Xu, F., Rodrigue, K. M., Kennedy, K. M., Cheng, Y., Flicker, B., et al. (2011). Alterations in cerebral metabolic rate and blood supply across the adult lifespan. Cereb. Cortex 21, 1426-1434. doi: 10.1093/cercor/bhq224.
31. Macintosh, B. J., Crane, D., and Rajab, A. S. (2012). Cerebral blood flow changes associated with a single aerobic exercise session. ISMRM Scientific Workshop Oral Session 4, 39.
32. Mesulam, M. M., Nobre, A. C., Kim, Y. H., Parrish, T. B., and Gitelman, D. R. (2001). Heterogeneity of cingulate contributions to spatial attention. Neuroimage 13, 1065-1072. doi: 10.1006/nimg.2001.0768.
33. Pereira, A. C., Huddleston, D. E., Brickman, A. M., Sosunov, A. A., Hen, R., McKhann, G. M., et al. (2007). An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus. Proc. Natl. Acad. Sci. U.S.A. 104, 5638-5643. doi: 10.1073/pnas.0611721104.
34. Prakash, R. S., Snook, E. M., Motl, R. W., and Kramer, A. F. (2010). Aerobic fitness is associated with gray matter volume and white matter integrity in multiple sclerosis. Brain Res. 1341, 41-51. doi: 10.1016/j.brainres.2009.06.063.
35. Risius, U. M., Staniloiu, A., Piefke, M., Maderwald, S., Schulte, F. P., Brand, M., et al. (2013). Retrieval, monitoring, and control processes: a 7 tesla FMRI approach to memory accuracy. Front. Behav. Neurosci. 7:24. doi: 10.3389/fnbeh.2013.00024.
36. Salthouse, T. A. (2009). When does age-related cognitive decline begin. Neurobiol. Aging 30, 507-514. doi: 10.1016/j.neurobiolaging.2008.09.023.
37. Schaie, K. W., and Strother, C. R. (1968). A cross-sequential study of age changes in cognitive behavior. Psychol. Bull. 70, 671-680. doi: 10.1037/h0026811.
38. Shay, K. A., and Roth, D. L. (1992). Association between aerobic fitness and visuospatial performance in healthy older adults. Psychol. Aging 7, 15-24. doi: 10.1037/0882-7974.7.1.15.
39. Shibata, S., and Levine, B. D. (2012). Effect of exercise training on biologic vascular age in healthy seniors. Am. J. Physiol. Heart Circ. Physiol. 302, H1340-H1346. doi: 10.1152/ajpheart.00511.2011.
40. Smith, J. C., Paulson, E. S., Cook, D. B., Verber, M. D., and Tian, Q. (2010). Detecting changes in human cerebral blood flow after acute exercise using arterial spin labeling: implications for fMRI. J. Neurosci. Methods 191, 258-262. doi: 10.1016/j.jneumeth.2010.06.028.
41. Steinhaus, L. A., Dustman, R. E., Ruhling, R. O., Emmerson, R. Y., Johnson, S. C., Shearer, D. E., et al. (1988). Cardio-respiratory fitness of young and older active and sedentary men. Br. J. Sports Med. 22, 163-166. doi: 10.1136/bjsm.22.4.163.
42. Thomas, B. P., Yezhuvath, U. S., Tseng, B. Y., Liu, P., Levine, B. D., Zhang, R., et al. (2013). Life-long aerobic exercise preserved baseline cerebral blood flow but reduced vascular reactivity to CO. J. Magn. Reson. Imaging 38, 1177-1183. doi: 10.1002/jmri.24090.
43. Tzourio-Mazoyer, N., Landeau, B., Papathanassiou, D., Crivello, F., Etard, O., Delcroix, N., et al. (2002). Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain. Neuroimage 15, 273-289. doi: 10.1006/nimg.2001.0978.
44. Voss, M. W., Prakash, R. S., Erickson, K. I., Basak, C., Chaddock, L., Kim, J. S., et al. (2010). Plasticity of brain networks in a randomized intervention trial of exercise training in older adults. Front. Aging Neurosci. 2:32. doi: 10.3389/fnagi.2010.00032.