Injection of a soluble fragment of neural agrin (NT-1654) considerably improves the muscle pathology caused by the disassembly of the neuromuscular junction

PLoS ONE

Volumn 9, Issue 2, 2014, Pages

  Hettwer, Stefan ^a   Lin, Shuo ^b   Kucsera, Stefan ^a   Haubitz, Monika ^a   Oliveri, Filippo ^b   Fariello, Ruggero G ^a   Ruegg, Markus A ^b   Vrijbloed, Jan W ^a  

^a NEUROTUNE AG   (Switzerland)

^b UNIVERSITY OF BASEL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

AGRIN; CHOLINERGIC RECEPTOR; NEURAL AGRIN; NEUROTRYPSIN; NT 1654; TRYPSIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARBOXY TERMINAL SEQUENCE; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG MECHANISM; EXTENSOR DIGITORUM LONGUS MUSCLE; GRIP STRENGTH; MOUSE; MUSCLE ATROPHY; MUSCLE DISEASE; MUSCLE REINNERVATION; MUSCLE WEAKNESS; NERVE GROWTH; NEUROMUSCULAR JUNCTION DISORDER; NONHUMAN; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; SARCOPENIA; SCIATIC NERVE INJURY; SIGNAL TRANSDUCTION; SOLEUS MUSCLE; SOLUBILITY; WEIGHT REDUCTION;

AGRIN; ANIMALS; BODY WEIGHT; HEK293 CELLS; HUMANS; INJECTIONS; MICE; MICE, INBRED C57BL; MUSCLE FIBERS, SKELETAL; MUSCLE STRENGTH; MUSCLE, SKELETAL; NERVE CRUSH; NEUROMUSCULAR JUNCTION; PHENOTYPE; RECEPTORS, CHOLINERGIC; SARCOPENIA; SCIATIC NERVE; SERINE ENDOPEPTIDASES; SOLUBILITY;

EID: 84895542098     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0088739     Document Type: Article

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