Coronary flow reserve with a turbo: A warning for the use of adenosine as a provocative test in patients receiving ticagrelor?

Journal of the American College of Cardiology

Volumn 63, Issue 9, 2014, Pages 878-879

  Voci, Paolo ^a   Pizzuto, Francesco ^a  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

Author keywords

acute coronary syndrome(s); adenosine; clopidogrel; P2Y12 ADP receptor blockers; ticagrelor

Indexed keywords

ADENOSINE; ADENOSINE DIPHOSPHATE; CYCLIC AMP; DIPYRIDAMOLE; TICAGRELOR; CLOPIDOGREL;

ACUTE CORONARY SYNDROME; CLINICAL PRACTICE; COMPARATIVE EFFECTIVENESS; CORONARY ARTERY BLOOD FLOW; CORONARY FLOW RESERVE; DISEASE ASSOCIATION; DRUG SAFETY; HUMAN; NONHUMAN; NOTE; PLEIOTROPY; PRIORITY JOURNAL; PROVOCATION TEST; TREATMENT RESPONSE; BRADYCARDIA; DOSE RESPONSE; DRUG DOSE REDUCTION; DRUG EFFICACY; DRUG MECHANISM; DYSPNEA; LOW DRUG DOSE; PROTEIN FUNCTION; STRESS ECHOCARDIOGRAPHY;

ACUTE CORONARY SYNDROME(S); ADENOSINE; CLOPIDOGREL; P2Y12-ADP RECEPTOR BLOCKERS; TICAGRELOR;

ACUTE CORONARY SYNDROME; ADENOSINE; FEMALE; HUMANS; MALE; PURINERGIC P2Y RECEPTOR ANTAGONISTS;

EID: 84895540406     PISSN: 07351097     EISSN: 15583597     Source Type: Journal    
DOI: 10.1016/j.jacc.2013.09.068     Document Type: Editorial

References (9)

1. L. Bonello, M. Laine, and N. Kipson et al. Ticagrelor increases adenosine plasma concentration in patients with an acute coronary syndrome J Am Coll Cardiol 63 2014 872 877
2. R.F. Storey, D.J. Angiolillo, and S.B. Patil et al. Inhibitory effects of ticagrelor compared with clopidogrel on platelet function in patients with acute coronary syndromes: the PLATO (Platelet Inhibition and Platelet Outcomes) PLATELET substudy J Am Coll Cardiol 56 2010 1456 1462
3. J.J. van Giezen, J. Sidaway, P. Glaves, I. Kirk, and J.A. Björkman Ticagrelor inhibits adenosine uptake in vitro and enhances adenosine-mediated hyperemia responses in a canine model J Cardiovasc Pharmacol Ther 17 2012 164 172
4. A. Wittfeldt, H. Emanuelsson, and G. Brandrup-Wognsen et al. Ticagrelor enhances adenosine-induced coronary vasodilatory responses in humans J Am Coll Cardiol 61 2013 723 727
5. S.W. Ely, and R.M. Berne Protective effect of adenosine on myocardial ischemia Circulation 85 1992 893 904
6. A.J. Watt, M.S. Bernard, and J. Webster et al. Intravenous adenosine in the treatment of supraventricular tachycardia: a dose-ranging study and interaction with dipyridamole Br J Clin Pharmacol 21 1986 227 230
7. P. Voci, and F. Pizzuto Coronary flow. How far can we go with echocardiography? J Am Coll Cardiol 38 2001 1885 1887
8. I. Biaggioni, J. Onrot, A.S. Hollister, and D. Robertson Cardiovascular effects of adenosine infusion in man and their modulation by dipyridamole Life Sci 39 1986 2229 2236
9. T.B. Conradson, C.M. Dixon, B. Clarke, and P.J. Narnes Cardiovascular effects of infused adenosine in man: potentiation by dipyridamole Acta Physiol Scand 129 1987 387 391