An apolipoprotein e modified liposomal nanoparticle: Ligand dependent efficiency as a siRNA delivery carrier for mouse-derived brain endothelial cells

International Journal of Pharmaceutics

Volumn 465, Issue 1-2, 2014, Pages 77-82

  Tamaru, Mina ^a   Akita, Hidetaka ^a   Kajimoto, Kazuaki ^a   Sato, Yusuke ^a   Hatakeyama, Hiroto ^a   Harashima, Hideyoshi ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

Author keywords

Apolipoprotein E (ApoE); Brain endothelial cell; In vitro; Multifunctional envelope type nano device (MEND); siRNA delivery; YSK05

Indexed keywords

APOLIPOPROTEIN E; CHOLESTEROL; DIMYRISTOYLPHOSPHATIDYLGLYCEROL; LIPOSOME; MACROGOL; NUCLEIC ACID; SMALL INTERFERING RNA; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; LIPID; NANOPARTICLE; PIPERIDINE DERIVATIVE; YSK05;

ANIMAL CELL; ARTICLE; BRAIN CELL; BRAIN ENDOTHELIAL CELL; BRAIN FUNCTION; CAVEOLA; CELL INTERACTION; CELLULAR DISTRIBUTION; DISPERSION; ENDOCYTOSIS; ENDOSOME; ENDOTHELIUM CELL; FLUORESCENCE ANALYSIS; GENE SILENCING; GLIA CELL; IN VITRO STUDY; LIPID COMPOSITION; LIPID MEMBRANE; LIPOSOMAL DELIVERY; LYSOSOME; MOUSE; NANOENCAPSULATION; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; ZETA POTENTIAL; ANIMAL; BRAIN; CELL LINE; COATED VESICLE; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GENETICS; METABOLISM; PROCEDURES; RNA INTERFERENCE; VASCULARIZATION;

ANIMALS; APOLIPOPROTEINS E; BRAIN; CAVEOLAE; CELL LINE; CLATHRIN-COATED VESICLES; ENDOCYTOSIS; ENDOTHELIAL CELLS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASES; LIPIDS; LIPOSOMES; MICE; NANOPARTICLES; PIPERIDINES; RNA INTERFERENCE; RNA, SMALL INTERFERING; TRANSFECTION;

EID: 84895538642     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2014.02.016     Document Type: Article

References (31)

1. A. Akinc, W. Querbes, and S. De et al. Targeted delivery of RNAi therapeutics with endogenous and exogenous ligand-based mechanisms Molecular Therapy 18 2010 1357 1364
2. L. Alvarez-Erviti, Y. Seow, H. Yin, C. Betts, S. Lakhal, and M.J. Wood Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes Nature Biotechnology 29 2011 341 345
3. P. Candela, F. Gosselet, F. Miller, V. Buee-Scherrer, G. Torpier, R. Cecchelli, and L. Fenart Physiological pathway for low-density lipoproteins across the blood-brain barrier: transcytosis through brain capillary endothelial cells in vitro Endothelium 15 2008 254 264
4. P. Grammas Neurovascular dysfunction, inflammation and endothelial activation: implications for the pathogenesis of Alzheimer's disease Journal of Neuroinflammation 8 2011 26
5. H. Hatakeyama, H. Akita, and E. Ito et al. Systemic delivery of siRNA to tumors using a lipid nanoparticle containing a tumor-specific cleavable PEG-lipid Biomaterials 32 2011 4306 4316
6. D.M. Hatters, C.A. Peters-Libeu, and K.H. Weisgraber Apolipoprotein E structure: insights into function Trends in Biochemical Sciences 31 2006 445 454
7. W. Ke, K. Shao, and R. Huang et al. Gene delivery targeted to the brain using an Angiopep-conjugated polyethyleneglycol-modified polyamidoamine dendrimer Biomaterials 30 2009 6976 6985
8. I.A. Khalil, Y. Hayashi, R. Mizuno, and H. Harashima Octaarginine- and pH sensitive fusogenic peptide-modified nanoparticles for liver gene delivery Journal of Controlled Release 156 2011 374 380
9. K. Kogure, H. Akita, Y. Yamada, and H. Harashima Multifunctional envelope-type nano device (MEND) as a non-viral gene delivery system Advanced Drug Delivery Reviews 60 2008 559 571
10. H. Kuwahara, K. Nishina, and K. Yoshida et al. Efficient in vivo delivery of siRNA into brain capillary endothelial cells along with endogenous lipoprotein Molecular Therapy 19 2011 2213 2221
11. E. Leupold, H. Nikolenko, and M. Dathe Apolipoprotein E peptide-modified colloidal carriers: the design determines the mechanism of uptake in vascular endothelial cells Biochimica et Biophysica Acta 1788 2009 442 449
12. Mac Arthur, J.M. Bishop, J.R. Stanford, K.I. Wang, L. Bensadoun, A. Witztum, J.L. Esko, and J. D Liver heparan sulfate proteoglycans mediate clearance of triglyceride-rich lipoproteins independently of LDL receptor family members The Journal of Clinical Investigation 117 2007 153 164
13. T. Nakamura, H. Akita, Y. Yamada, H. Hatakeyama, and H. Harashima A multifunctional envelope-type nanodevice for use in nanomedicine: concept and applications Accounts of Chemical Research 45 2012 1113 1121
14. A. Nykjaer, and T.E. Willnow The low-density lipoprotein receptor gene family: a cellular Swiss army knife? Trends in Cell Biology 12 2002 273 280
15. M. Ogris, S. Brunner, S. Schuller, R. Kircheis, and E. Wagner PEGylated DNA/transferrin-PEI complexes: reduced interaction with blood components, extended circulation in blood and potential for systemic gene delivery Gene Therapy 6 1999 595 605
16. W.M. Pardridge Blood-brain barrier delivery of protein and non-viral gene therapeutics with molecular Trojan horses Journal of Controlled Release 122 2007 345 348
17. J. Paul, S. Strickland, and J.P. Melchor Fibrin deposition accelerates neurovascular damage and neuroinflammation in mouse models of Alzheimer's disease Journal of Experimental Medicine 204 2007 1999 2008
18. C.A. Peters-Libeu, Y. Newhouse, D.M. Hatters, and K.H. Weisgraber Model of biologically active apolipoprotein E bound to dipalmitoylphosphatidylcholine Journal of Biological Chemistry 281 2006 1073 1079
19. F. Sakurai, T. Nishioka, and H. Saito et al. Interaction between DNA-cationic liposome complexes and erythrocytes is an important factor in systemic gene transfer via the intravenous route in mice: the role of the neutral helper lipid Gene Therapy 8 2001 677 686
20. Y. Sakurai, H. Hatakeyama, Y. Sato, H. Akita, K. Takayama, S. Kobayashi, S. Futaki, and H. Harashima Endosomal escape and the knockdown efficiency of liposomal-siRNA by the fusogenic peptide shGALA Biomaterials 32 2011 5733 5742
21. Y. Sakurai, H. Hatakeyama, Y. Sato, M. Hyodo, H. Akita, and H. Harashima Gene silencing via RNAi and siRNA quantification in tumor tissue using MEND, a liposomal siRNA delivery system Molecular Therapy 21 2013 1195 1203
22. Y. Sato, H. Hatakeyama, Y. Sakurai, M. Hyodo, H. Akita, and H. Harashima A pH-sensitive cationic lipid facilitates the delivery of liposomal siRNA and gene silencing activity in vitro and in vivo Journal of Controlled Release 163 2012 267 276
23. I. Sauer, I.R. Dunay, K. Weisgraber, M. Bienert, and M. Dathe An apolipoprotein E-derived peptide mediates uptake of sterically stabilized liposomes into brain capillary endothelial cells Biochemistry 44 2005 2021 2029
24. D.B. Stanimirovic, and A. Friedman Pathophysiology of the neurovascular unit: disease cause or consequence? Journal of Cerebral Blood Flow and Metabolism 32 2012 1207 1221
25. I. van Rooy, E. Mastrobattista, G. Storm, W.E. Hennink, and R.M. Schiffelers Comparison of five different targeting ligands to enhance accumulation of liposomes into the brain Journal of Controlled Release 150 2011 30 36
26. S. Wagner, A. Zensi, and S.L. Wien et al. Uptake mechanism of ApoE-modified nanoparticles on brain capillary endothelial cells as a blood-brain barrier model Public Library of Science 7 2012 e32568
27. A. Zensi, D. Begley, C. Pontikis, C. Legros, L. Mihoreanu, S. Wagner, C. Büchel, H. von Briesen, and J. Kreuter Albumin nanoparticles targeted with Apo E enter the CNS by transcytosis and are delivered to neurones Journal of Controlled Release 137 2009 78 86
28. Z. Zhong, H. Ilieva, and L. Hallagan et al. Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells The Journal of Clinical Investigation 119 2009 3437 3449
29. B.V. Zlokovic The blood-brain barrier in health and chronic neurodegenerative disorders Neuron 57 2008 178 201
30. B.V. Zlokovic Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders Nature Reviews. Neuroscience 12 2011 723 738
31. B.V. Zlokovic Cerebrovascular effects of apolipoprotein E: implications for Alzheimer disease JAMA Neurology 70 2013 440 444