Toward a molecular understanding of adaptive immunity: A chronology, part III

Frontiers in Immunology

Volumn 5, Issue FEB, 2014, Pages

  Smith, Kendall A ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Adaptive immunity; CD40; CD40 ligand; Cell mediated cytolysis; Granzymes; IL 4 6; Perforin; TCR signaling

Indexed keywords

CD3 ANTIGEN; CD4 ANTIGEN; CD40 LIGAND; CD8 ANTIGEN; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; T LYMPHOCYTE RECEPTOR;

ADAPTIVE IMMUNITY; ANTIBODY DEPENDENT CELLULAR CYTOTOXICITY; APOPTOSIS; B LYMPHOCYTE; CALCIUM TRANSPORT; CELL DIFFERENTIATION; CELL MEDIATED CYTOTOXICITY; CELL PROLIFERATION; CROSS REACTION; DNA FRAGMENTATION; HUMAN; IMMUNE RESPONSE; MAJOR HISTOCOMPATIBILITY COMPLEX; NONHUMAN; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE; THYMOCYTE;

EID: 84895519648     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2014.00029     Document Type: Review

References (136)

1. Nowell PC. Phytohemagglutinin: an initiator of mitosis in cultures of normal human leukocytes. Cancer Res (1960) 20:462-8.
2. Deutsch C, Holian A, Holian S, Daniele R, Wilson D. Transmembrane electrical and pH gradients across human erythrocytes and human peripheral lymphocytes. J Cell Physiol (1979) 99:79-93. doi:10.1002/jcp.1040990110.
3. Tsien R, Pouzzan T, Rink T. T-cell mitogens cause early changes in cytoplasmic free Ca2+ and membrane potential in lymphocytes. Nature (1982) 295:68-71. doi:10.1038/295068a0.
4. Nishizuka Y. Three multifunctional protein kinase systems in transmembrane control. Mol Biol Biochem Biophys (1980) 32:113-35. doi:10.1007/978-3-642-81503-4_9.
5. Nishizuka Y. Turnover of inositol phospholipids and signal transduction. Science (1984) 225:1365-70. doi:10.1126/science.6147898.
6. Weiss M, Daley J, Hodgdon J, Treinherz E. Calcium dependency of antigen-specific (T3-Ti) and alternative pathways of human T cell activation. Proc Natl Acad Sci USA (1984) 81:6836-40. doi:10.1073/pnas.81.21.6836.
7. Gillis S, Watson J. Biochemical and biological characterization of lymphocyte regulatory molecules. J Exp Med (1980) 152:1709-19. doi:10.1084/jem.152.6.1709.
8. Robb RJ, Smith KA. Heterogeneity of human T-cell growth factor(s) due to variable glycosylation. Mol Immunol (1981) 18:1087-94. doi:10.1016/0161-5890(81)90024-9.
9. Weiss A, Wiskocil R, Stobo J. The role of T3 surface molecules in the activation of human cells: a two-stimulus requirement for iL-2 production reflects events occurring at a pretranslational level. J Immunol (1984) 133:123-8.
10. Weiss A, Imboden J, Shoback D, Stobo J. Role of T3 surface molecules in human T cell activation: T3-dependent activation results in an increase in cytoplasmic free calcium. Proc Natl Acad Sci USA (1984) 81:4169-73. doi:10.1073/pnas.81.13.4169.
11. Brunner KT, Mauel J, Cerottini J-C, Chapius B. Quantitative assay of the lytic action of lymphoid cells on 51-Cr labelled allogeneic target cells in vitro. Inhibition by isoantibody and drugs. Immunology (1968) 14:181-90.
12. Dourmashkin R, Deteix P, Simone C, Henkart P. Electron microscopic demonstration of lesions in target cell membranes associated with antibody-dependent cellular cytotoxicity. Clin Exp Immunol (1980) 42:554-60.
13. Podack E, Dennert G. Assembly of two types of tubules with putative cytolytic function by cloned natural killer cells. Nature (1983) 302:442-5. doi:10.1038/302442a0.
14. Dennert G, Podack E. Cytolysis by H-2-specific T killer cells: assembly of tubular complexes on target membranes. J Exp Med (1983) 157:1483-95. doi:10.1084/jem.157.5.1483.
15. Gillis S, Smith KA. Long term culture of tumour-specific cytotoxic T cells. Nature (1977) 268:154-6. doi:10.1038/268154a0.
16. Baker PE, Gillis S, Smith KA. Monoclonal cytolytic T-cell lines. J Exp Med (1979) 149:273-8. doi:10.1084/jem.149.1.273.
17. Podack ER, Koningsberg PJ. Cytolytic T cell granules. Isolation, structural, biochemical, and functional characterization. J Exp Med (1984) 160:695-710. doi:10.1084/jem.160.3.695.
18. Henkart P, Millard P, Reynolds C, Henkart M. Cytolytic activity of purified cytoplasmic granules from cytotoxic rat large granular lymphocyte tumors. J Exp Med (1984) 160:75-93. doi:10.1084/jem.160.1.75.
19. Podack ER, Young JD, Cohn ZA. Isolation and biochemical and functional characterization of perforin 1 from cytolytic T cell granules. Proc Natl Acad Sci USA (1985) 82:8629-33. doi:10.1073/pnas.82.24.8629.
20. Masson D, Tschopp J. Isolation of a lytic, pore-forming protein (perforin) from cytolytic T lymphocytes. J Biol Chem (1985) 260:9069-72.
21. Young J, Cohn Z, Podack E. The ninth component of complement and the pore-forming protein (perforin 1) from cytolytic T cells: structural, immunological, and functional similarities. Science (1986) 233:184-90. doi:10.1126/science.2425429.
22. Lowrey D, Aebischer T, Olsen K, Lichtenheld M, Rupp F, Hengartner H, et al. Cloning, analysis, and expression of murine perforin 1 cDNA, a component of cytolytic granules with homology to complement component C9. Proc Natl Acad Sci USA (1989) 86:247-51. doi:10.1073/pnas.86.1.247.
23. Chang T, Eisen H. Effects of N-tosyl-L-lysyl-chloromethylketone on the activity of cytotoxic T lymphocytes. J Immunol (1980) 124:1028-33.
24. Pasternack M, Eisen H. A novel serine esterase expressed by cytotoxic T lymphocytes. Nature (1985) 314:743-5. doi:10.1038/314743a0.
25. Gershenfeld H, Weissman I. Cloning of a cDNA for a T cell-specific serine protease from a cytotoxic T lymphocyte. Science (1986) 232:854-8. doi:10.1126/science.2422755.
26. Lobe C, Finlay L, Paranchych W, Paetkau V, Bleackley R. Novel serine proteases encoded by two cytotoxic T lymphocyte-specific genes. Science (1986) 232:858-61. doi:10.1126/science.3518058.
27. Lobe C, Havele C, Bleackley R. Cloning of two genes that are specifically expressed in activated T lymphocytes. Proc Natl Acad Sci USA (1986) 83:1448-52. doi:10.1073/pnas.83.5.1448.
28. Masson D, Tschopp J. A family of serine esterases in lytic granules of cytolytic T lymphocytes. Cell (1987) 49:679-85. doi:10.1016/0092-8674(87)90544-7.
29. Kerr J, Wyllie A, Currie A. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer (1972) 26:239-57. doi:10.1038/bjc.1972.33.
30. Russell J, Masakowski V, Dobos C. Mechanisms of immune lysis: I. Physiological distinction between target cell death mediated by cytotoxic T lymphocytes and antibody plus complement. J Immunol (1980) 124:1100-5.
31. Russell J, Dobos C. Mechanisms of immune lysis: II. CTL-induced nuclear disintegration of the target begins within minutes of cell contact. J Immunol (1980) 125:1256-61.
32. Duke R, Chervenak R, Cohen J. Endogenous endonuclease-induced DNA fragmentation: an early event in cell-mediated cytolysis. Proc Natl Acad Sci USA (1983) 80:6361-5. doi:10.1073/pnas.80.20.6361.
33. Hayes M, Berrebi G, Henkart P. Induction of target cell DNA release by the cytotoxic T lymphocyte granule protease granzyme A. J Exp Med (1989) 170:933-46. doi:10.1084/jem.170.3.933.
34. Shi L, Kraut R, Aebersold R, Greenberg A. A natural killer cell granule protein that induces DNA fragmentation and apoptosis. J Exp Med (1992) 175:553-66. doi:10.1084/jem.175.2.553.
35. Owen R. Immunogenetic consequences of vascular anastomoses between bovine twins. Science (1945) 102:400-1. doi:10.1126/science.102.2651.400.
36. Billingham RE, Brent L, Medawar PB. Actively acquired tolerance of foreign cells. Nature (1953) 172:603-6. doi:10.1038/172603a0.
37. Burnet F, Fenner F. Production of Antibodies. Melbourne: MacMillan (1949).
38. Burnet FM. The Clonal Selection Theory of Acquired Immunity. Cambridge: Cambridge University Press (1959).
39. Miller J. Effect of neonatal thymectomy on the immunological responsiveness of the mouse. Proc Roy Soc Lond B (1962) 156:415-28. doi:10.1098/rspb.1962.0048.
40. Cooper M, Peterson R, Good R. Delineation of the thymic and bursal lymphoid systems in the chicken. Nature (1965) 205:143-6. doi:10.1038/205143a0.
41. Cooper M, Peterson R, South M, Good R. The functions of the thymus system and the bursa system in the chicken. J Exp Med (1966) 123:75-102. doi:10.1084/jem.123.1.75.
42. Pernis B, Forni L, Amante L. Immunoglobulin spots on the surface of rabbit lymphocytes. J Exp Med (1970) 132:1001-18. doi:10.1084/jem.132.5.1001.
43. Raff M, Sternberg M, Taylor RB. Immunoglobulin determinants on the surface of mouse lymphoid cells. Nature (1970) 225:553-5. doi:10.1038/225553a0.
44. Meuer S, Acuto O, Hussey R, Hodgdon J, Fitzgerald K, Schlossman S, et al. Evidence for the T3-associated 90K heterodimer as the T cell antigen receptor. Nature (1983) 303:808-10. doi:10.1038/303808a0.
45. Meuer S, Cooper D, Hodgdon J, Hussey R, Fitzgerald K, Schlossman S, et al. Identification of the receptor for antigen and major histocompatibility complex on human inducer T lymphocytes. Science (1983) 222:1239-42. doi:10.1126/science.6606228.
46. Meuer SC, Fitzgerald KA, Hussey RE, Hodgdon JC, Schlossman S, Reinherz EL. Clonotypic structures involved in antigen-specific human T cell function. Relationship to the T3 molecular complex. J Exp Med (1983) 157:705-19. doi:10.1084/jem.157.2.705.
47. Kappler J, Wade T, White J, Kushnir E, Blackman M, Bill J, et al. A T cell receptor V-beta segment that imparts reactivity to a class II major histocompatibility complex product. Cell (1987) 49:263-71. doi:10.1016/0092-8674(87)90567-8.
48. Kappler J, Roehm N, Marrack P. T cell tolerance by clonal elimination in the thymus. Cell (1987) 49:273-80. doi:10.1016/0092-8674(87)90568-X.
49. MacDonald H, Schneider R, Lees R, Howe R, Acha-Orbea H, Festenstein H, et al. T-cell receptor V-beta use predicts reactivity and tolerance to Mls-encoded antigens. Nature (1988):332.
50. Kappler J, Staerz U, White J, Marrack P. Self-tolerance eliminates T cells specific for Mls-modified products of the major histocompatibility complex. Nature (1988) 332:35-40. doi:10.1038/332035a0.
51. Gordon J, Scangos G, Plotkin D, Ruddle F. Genetic transformation of mouse embryos by microinjection of purified DNA. Proc Natl Acad Sci USA (1980) 77:7380-4. doi:10.1073/pnas.77.12.7380.
52. Brinster R, Chen H, Trumbauer M, Senear A, Warren R, Palmiter R. Somatic expression of herpes thymidine kinase in mice following injection of a fusion gene into eggs. Cell (1981) 27:223-31. doi:10.1016/0092-8674(81)90376-7.
53. Brinster R, Chen H, Warren R, Sarthy A, Palmiter R. Regulation of metallothionein-thymidine kinase fusion plasmids injected into mouse eggs. Nature (1982) 296:39-42. doi:10.1038/296039a0.
54. von Boehmer H, Hengartner H, Nabholz M, Lernhradt W, Schreier M, Hass W. Fine specificity of a continuously growing killer cell clone specific for H-Y antigen. Eur J Immunol (1979) 9:592-7. doi:10.1002/eji.1830090804.
55. Uematsu Y, Ryser S, Dembic Z, Borgulya P, Krimpenfort P, Berns A, et al. In transgenic mice the introduced functional T cell receptor beta gene prevents expression of endogenous beta genes. Cell (1988) 52:831-41. doi:10.1016/0092-8674(88)90425-4.
56. Kisielow P, Bluthmann H, Staerz U, Steinmetz M, von Boehmer H. Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes. Nature (1988) 333:742-6. doi:10.1038/333742a0.
57. Leonard WJ, Depper JM, Uchiyama T, Smith KA, Waldmann TA, Greene WC. A monoclonal antibody that appears to recognize the receptor for human T-cell growth factor; partial characterization of the receptor. Nature (1982) 300:267-9. doi:10.1038/300267a0.
58. Malek T, Robb R, Shevach E. Identification and initial characterization of a rat monoclonal antibody reactive with the murine interleukin-2 receptor ligand complex. Proc Natl Acad Sci USA (1983) 80:5694-8. doi:10.1073/pnas.80.18.5694.
59. Ortega G, Robb R, Shevach E, Malek T. The murine IL-2 receptor. I. Monoclonal antibodies that define distinct functional epitopes on activated T cells and react with activated B cells. J Immunol (1984) 133:1970-5.
60. Raulet D. Expression and function of interleukin-2 receptors on immature thymocytes. Nature (1985) 314:101-3. doi:10.1038/314101a0.
61. Gillis S, Ferm MM, Ou W, Smith KA. T cell growth factor: parameters of production and a quantitative microarray for activity. J Immunol (1978) 120:2027-32.
62. Duke R, Cohen J. IL-2 addiction: withdrawal of growth factor activates a suicide program in dependent T cells. Lymphokine Res (1986) 5:289-99.
63. + thymocytes. Nature (1987):300.
64. Ramarli D, Fox D, Reinherz E. Selective inhibition of interleukin-2 gene function following thymocyte antigen/major histocompatibility complex receptor crosslinking: possible thymic selection mechanism. Proc Natl Acad Sci USA (1987) 84:8598-602. doi:10.1073/pnas.84.23.8598.
65. Smith C, Williams G, Kingston R, Jemkinson E, Owen J. Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures. Nature (1989) 337:181-4. doi:10.1038/337181a0.
66. Jenkinson E, Kingston R, Smith C, Williams G, Owen J. Antigen-induced apoptosis in developing T cells: a mechanism for negative selection of the T cell receptor repertoire. Eur J Immunol (1989) 19:2175-7. doi:10.1002/eji.1830191132.
67. Bjorkman PJ, Saper MA, Samaoui B, Bennett WS, Strominger JL, Wiley DC. Structure of the human class I histocompatibility antigen, HLA-A2. Nature (1987) 329:506-11. doi:10.1038/329506a0.
68. Schlossman S, Ben-Efraim S, Yaron A, Sober H. Immunochemical studies on the antigenic determinants required to elicit delayed and immediate hypersensitivity reactions. J Exp Med (1966) 123:1083-95. doi:10.1084/jem.123.6.1083.
69. Unanue E, Askonas BA. Persistence of immunogenicity of antigen after uptake by macrophages. J Exp Med (1968):127.
70. Bjorkman P, Saper M, Samaraoui B, Bennet W, Strominger J, Wiley D. The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens. Nature (1987) 329:512-8. doi:10.1038/329512a0.
71. Jerne NK. The somatic generation of immune recognition. Eur J Immunol (1971) 1:1-9. doi:10.1002/eji.1830010102.
72. von Boehmer H, Haas W, Jerne N. Major histocompatibility complex-linked immune responsiveness is acquired by lymphocytes of low responder mice differentiating in thymus of high responder mice. Proc Natl Acad Sci USA (1978) 75:2439-42. doi:10.1073/pnas.75.5.2439.
73. Zinkernagel R, Callahan G, Althage A, Cooper S, Klein P, Klein J. On the thymus in the differentiation of "H-2 self recognition" by T cells: evidence for dual recognition? J Exp Med (1978) 147:882-96. doi:10.1084/jem.147.3.882.
74. Reinherz E, Kung P, Goldstein G, Schlossman S. Further characterization of the human inducer T cell subset defined by monoclonal antibody. J Immunol (1979) 123:2894-6.
75. Reinherz E, Kung P, Goldstein G, Schlossman S. A monoclonal antibody reactive with the human cytotoxic/suppressor T cell subset previously defined by a heteroantiserum termed TH2. J Immunol (1980) 124:1301-7.
76. Meuer S, Schlossman S, Reinherz E. Clonal analysis of human cytolytic T lymphocytes: T4+ and T8+ effector T cells recognize products of different major histocompatibility regions. Proc Natl Acad Sci USA (1982) 79:4395-9. doi:10.1073/pnas.79.14.4395.
77. Swain S, Dialynas D, Fitch F, English M. Monoclonal antibody to L3T4 blocks the function of T cells specific for class 2 major histocompatibility complex antigens. J Immunol (1984) 132:1118-23.
78. Teh H, Kisielow P, Scott B, Kishi H, Uematsu Y, Bluthmann H, et al. Thymic major histocompatibility complex antigens and the alpha beta T-cell receptor determine the CD4/CD8 phenotype of T cells. Nature (1988) 335:229-33. doi:10.1038/335229a0.
79. Kisielow P, Teh H, Bluthmann H, von Boehmer H. Positive selection of antigen-specific T cells in thymus by restricting MHC molecules. Nature (1988) 335:730-3. doi:10.1038/335730a0.
80. Schreier M, Iscove N, Tees R, Aarden L, Von Boehmer H. Clones of killer and helper T cells: growth requirements, specificity and retention of function in long-term culture. Immunol Rev (1980) 51:315-36. doi:10.1111/j.1600-065X.1980.tb00326.x.
81. Tees R, Schreier M. Selective reconstitution of nude mice with long-term cultured and cloned specific helper cells. Nature (1980) 283:780-1. doi:10.1038/283780a0.
82. Hapel A, Lee J, Farrar W, Ihle J. Establishment of continuous cultures of Thy1.2+, Lyt1+, 2-T cells with purified interleukin-3. Cell (1981) 25:179-86. doi:10.1016/0092-8674(81)90242-7.
83. Reinherz EL, Kung PC, Goldstein G, Schlossman SF. Separation of functional subsets of human T cells by a monoclonal antibody. Proc Natl Acad Sci USA (1979) 76:4061-5. doi:10.1073/pnas.76.8.4061.
84. Ledbetter J, Rouse R, Micklem H, Herzenberg L. T cell subsets defined by expression of Lyt 1,2,3 and Thy1 antigens. Two parameter immunofluorescence and cytotoxicity analysis with monoclonal antibodies modifies current views. J Exp Med (1980) 152:280. doi:10.1084/jem.152.2.280.
85. Weinstein Y. Twenty-alpha-hydroxysteroid dehydrogenase: a T lymphocyte-associated enzyme. J Immunol (1977) 119:1223-8.
86. Ihle J, Pepersack L, Rebar L. Regulation of T cell differentiation: in vitro induction of 20alpha-hydroxysteroid dehydrogenase in splenic lymphocytes from athymic mice by a unique lymphokine. J Immunol (1981) 126:2184-9.
87. Schrader J. The in vitro production and cloning of the P cell, a bone marrow-derived null cell that expresses H-2 and Ia antigens, hast mast cell-like granules, and is regulated by a factor released by activated T cells. J Immunol (1981) 126:452-8.
88. Schrader J, Lewis S, Clark-Lewis I, Culvenor J. The persisting cell: histamine content, regulation by a T cell-derived factor, origin from a bone marrow precursor, and relationship to mast cells. Proc Natl Acad Sci USA (1981) 78:323-7. doi:10.1073/pnas.78.1.323.
89. Schrader J, Clark-Lewis I. A T cell-derived factor stimulating multipotential hematopoietic stem cells: molecular weight and distinction from T cell growth factor and T cell-derived granulocyte-macrophage colony-stimulating factor. J Immunol (1982) 129:30-5.
90. Fung M, Hapel A, Ymer S, Cohen D, Johnson R, Campbell H, et al. Molecular cloning of cDNA for murine interleukin-3. Nature (1984) 307:233-7. doi:10.1038/307233a0.
91. Smith KA, Favata MF, Oroszlan S. Production and characterization of monoclonal antibodies to human interleukin 2: strategy and tactics. J Immunol (1983) 131:1808-15.
92. Taniguchi T, Matsui H, Fujita T, Takaoka C, Kashima N, Yoshimoto R, et al. Structure and expression of a cloned cDNA for human interleukin-2. Nature (1983) 302:305-10. doi:10.1038/302305a0.
93. Hapel A, Fung M, Johnson R, Young I, Johnson G, Metcalf D. Biological properties of molecularly cloned and expressed murine interleukin-3. Blood (1985) 65:1453-9.
94. Smith K. Toward a molecular understanding of adaptive immunity: a chronology, Part I. Front Immunol (2012) 3:369. doi:10.3389/fimmu.2012.00369.
95. Mitchison N. The carrier effect in the secondary response to hapten-protein conjugates. II Cellular cooperation. Eur J Immunol (1971) 1:18-27. doi:10.1002/eji.1830010103.
96. Hoffman M, Dutton R. Immune response restoration with macrophage culture supernatants. Science (1971) 172:1047-8. doi:10.1126/science.172.3987.1047.
97. Schimpl A, Wecker E. Replacement of T cell function by a T cell product. Nat New Biol (1972) 237:15-7. doi:10.1038/newbio237015a0.
98. Jerne NK, Nordin AA. Antibody formation in agar by single antibody-producing cells. Science (1963) 140:405. doi:10.1126/science.140.3565.405.
99. Mishell R, Dutton R. Immunization of dissociated spleen cell cultures from normal mice. J Exp Med (1967) 126:423-42. doi:10.1084/jem.126.3.423.
100. Andersson J, Schreier M, Melchers F. T-cell-dependent B-cell stimulations H-2-restricted and antigen-dependent only at the resting B-cell level. Proc Natl Acad Sci USA (1980) 77:1612-6. doi:10.1073/pnas.77.3.1612.
101. Melchers F, Andersson J, Lernhardt W, Schreier M. H-2-unrestricted polyclonal maturation without replication of small B cells induced by antigen-activated T cell helper factors. Eur J Immunol (1980) 10:679-85. doi:10.1002/eji.1830100905.
102. Andersson J, Moller G, Sjoberg O. Selective induction of DNA synthesis in T and B lymphocytes. Cell Immunol (1972) 4:381-93. doi:10.1016/0008-8749(72)90040-8.
103. Schreier M, Iscove N. Hematopoietic growth factors are released in cultures of H-2-restricted helper T cells, accessory cells and specific antigen. Nature (1980) 287:228-30. doi:10.1038/287228a0.
104. Pure E, Isakson P, Takatsu K, Hamaoka T, Swain S, Dutton R, et al. Induction of B cell differentiation by T cell factors. I. Stimulation of IgM secretion by products of a T cell hybridoma and a T cell line. J Immunol (1981) 127:1953-8.
105. Swain S, Dennert G, Warner J, Dutton R. Culture supernatants of a stimulated T-cell line have helper activity that acts synergistically with interleukin-2 in the response of B cells to antigen. Proc Natl Acad Sci USA (1981) 78:2517-21. doi:10.1073/pnas.78.4.2517.
106. Isakson P, Pure E, Vitteta E, Krammer P. T cell-derived B cell differentiation factor(s): effect on the isotype switch of murine B cells. J Exp Med (1982) 155:734-48. doi:10.1084/jem.155.3.734.
107. Howard M, Farrar J, Hilfiker M, Johnson B, Takatsu K, Hamaoka T, et al. Identification of a T cell-derived B cell growth factor distinct from interleukin 2. J Exp Med (1982) 155:914-23. doi:10.1084/jem.155.3.914.
108. Parker D. Induction and suppression of polyclonal antibody responses by anti-Ig reagents and antigen-nonspecific helper factors. Immunol Rev (1980) 52:115-35. doi:10.1111/j.1600-065X.1980.tb00333.x.
109. Smith KA. T-cell growth factor. Immunol Rev (1980) 51:337-57. doi:10.1111/j.1600-065X.1980.tb00327.x.
110. Cantrell DA, Smith KA. The interleukin-2 T-cell system: a new cell growth model. Science (1984) 224:1312-6. doi:10.1126/science.6427923.
111. Howard M, Mizel S, Lachman L, Ansel J, Johnson B, Paul W. Role of interleukin-1 in anti-immunoglobulin induced B cell proliferation. J Exp Med (1983) 157:1529-43. doi:10.1084/jem.157.5.1529.
112. Smith KA, Gilbride KJ, Favata MF. Lymphocyte activating factor promotes T-cell growth factor production by cloned murine lymphoma cells. Nature (1980) 287:853-5. doi:10.1038/287853a0.
113. Smith KA, Lachman LB, Oppenheim JJ, Favata MF. The functional relationship of the interleukins. J Exp Med (1980) 151:1551-6. doi:10.1084/jem.151.6.1551.
114. Swain S, Howard M, Kappler J, Marrack P, Watson J, Booth R, et al. Evidence for two distinct classes of murine B cell growth factors with activities in different functional assays. J Exp Med (1983) 158:822-35. doi:10.1084/jem.158.3.822.
115. Howard M, Matis L, Malek T, Shevach E, Kell W, Cohen D, et al. Interleukin-2 induces antigen-reactive T cell lines to secrete BCGF-I. J Exp Med (1983) 158:2024-39. doi:10.1084/jem.158.6.2024.
116. Sideras P, Bergstedt-Lindqvist S, Macdonald H, Severinson E. Secretion of IgG1 induction factor by T cell clones and hybridomas. Eur J Immunol (1985) 15:586-93. doi:10.1002/eji.1830150611.
117. Ohara J, Paul W. Production of a monoclonal antibody to and molecular characterization of B cell stimulatory factor-1. Nature (1985) 315:333-6. doi:10.1038/315333a0.
118. Sideras P, Bergstedt-Lindqvist S, Severinson E. Partial biochemical characterization of IgG-inducing factor. Eur J Immunol (1985) 15:593-8. doi:10.1002/eji.1830150612.
119. Noma Y, Sideras P, Naito T, Bergstedt-Lindqvist ZC, Severinson E, Tanabe T, et al. Cloning of cDNA encoding the murine IgG1 induction factor by a novel strategy using SP6 promoter. Nature (1986) 319:640-6. doi:10.1038/319640a0.
120. Lee F, Yokota T, Otsuka T, Meyerson P, Villaret D, Coffman R, et al. Isolation and characterization of a mouse interleukin cDNA clone that expresses B cell stimulatory factor-1 activities and T cell-and mast cell-stimulating activities. Proc Natl Acad Sci USA (1986) 83:2061-5. doi:10.1073/pnas.83.7.2061.
121. Sanderson C, O'Garra A, Warren D, Klaus G. Eosinophil differentiation factor also has B cell growth factor activity: proposed name interleukin-4. Proc Natl Acad Sci USA (1986) 83:437-40. doi:10.1073/pnas.83.2.437.
122. Kinashi T, Harada N, Severinson E, Tanabe T, Sideras P, Konishi M, et al. Cloning of complementary DNA encoding T cell replacing factor and identity with B cell growth factor II. Nature (1986) 324:70-3. doi:10.1038/324070a0.
123. Hirano T, Taga T, Kakano N, Yaskawa K, Kashiwamura S, Shimizu K, et al. Purification to homogeneity and characterization of human B cell differentiation factor (BCDF or BSFp-2). Proc Natl Acad Sci USA (1985) 82:5490-4. doi:10.1073/pnas.82.16.5490.
124. Hirano T, Yasukawa K, Harada H, Taga T, Watanabe Y, Matsuda T, et al. Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin. Nature (1986) 324:73-6. doi:10.1038/324073a0.
125. Hirano T, Taga T, Nakano N, Yasukawa K, Kashiwamura S, Shimizu K, et al. Purification to homogeneity and characterization of human B-cell differentiation factor (BCDF or BSFp-2). Proc Natl Acad Sci USA (1985) 82:5490-4. doi:10.1073/pnas.82.16.5490.
126. Clark E, Ledbetter J. Activation of human B cells mediated through two distinct cell surface differentiation antigens, Bp35 and Bp50. Proc Natl Acad Sci USA (1986) 83:4494-8. doi:10.1073/pnas.83.12.4494.
127. Blanchereau J, De Pauli P, Valle A, Garcia E, Rousset F. Long-term human B cell lines dependent on interleukin-4 and antibody to CD40. Science (1991) 251:70-2. doi:10.1126/science.1702555.
128. Lederman S, Yellin M, Krichevsky A, Belko J, Lee J, Ches L. Identification of a novel surface protein on activated CD4+ T cells that induces contact-dependent B cell differentiation (help). J Exp Med (1992) 175:1091-9. doi:10.1084/jem.175.4.1091.
129. Lederman S, Yellin MJ, Inghirami G, Lee JJ, Knowels DM, Chess L. Molecular interactions mediating T-B lymphocyte collaboration in human lymphoid follicles. Roles of T cell-B cell activating molecules (5c8 antigen) and CD40 in contact-dependent help. J Immunol (1992) 149:3817-26.
130. Bartlett W, Mccann J, Shepherd D, Roy M, Noelle R. Cognate interactions between helper T cells and B cells. IV. Requirements for the expression of effector phase activity by helper T cells. J Immunol (1990) 145:3956-62.
131. Noelle R, Roy M, Shepherd D, Stamenkovic I, Ledbetter J, Aruffo A. A 39-kDa protein on activated helper T cells binds CD40 and transduces the signal for cognate activation of B cells. Proc Natl Acad Sci USA (1992) 89:6550-4. doi:10.1073/pnas.89.14.6550.
132. Graf D, Korthauer G, Mages H, Senger G, Kroczek R. Cloning of TRAP, a ligand for CD40 on human T cells. Eur J Immunol (1992) 22:3191-4. doi:10.1002/eji.1830221226.
133. Spriggs M, Armitage R, Strockbine L, Clifford K, Macduff B, Sato T, et al. Recombinant human CD40 ligand stimulates B cell proliferation and immunoglobulin E secretion. J Exp Med (1992) 176:1543-50. doi:10.1084/jem.176.6.1543.
134. DiSanto J, Bonnefoy J, Gauchat J, Fischer A, De Saint Basile G. CD40 ligand mutations in X-linked hyper IgM. Nature (1993) 361:341-3. doi:10.1038/361541a0.
135. Fuleihan R, Ramesh N, Loh R, Jabara H, Rosen F, Chatila T, et al. Defective expression of the CD40 ligand in X chromosome-linked immunoglobulin deficiency with normal or elevated IgM. Proc Natl Acad Sci USA (1993) 90:2170-3. doi:10.1073/pnas.90.6.2170.
136. Korthauer U, Graf D, Mages H, Brieres F, Padayachee M, Malcom S, et al. Defective expression of T-cell CD40 ligand causes X-linked immunodeficiency with hyper IgM. Nature (1993) 361:539-41. doi:10.1038/361539a0.