Pre-operative risk factors of bleeding and stroke during left ventricular assist device support: An analysis of more than 900 heartmate II outpatients

Journal of the American College of Cardiology

Volumn 63, Issue 9, 2014, Pages 880-888

  Boyle, Andrew J ^a   Jorde, Ulrich P ^b   Sun, Benjamin ^c   Park, Soon J ^d   Milano, Carmelo A ^e   Frazier, O Howard ^f   Sundareswaran, Kartik S ^g   Farrar, David J ^g   Russell, Stuart D ^h  

^a DEPARTMENT OF COLORECTAL SURGERY   (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

^c ABBOTT NORTHWESTERN HOSPITAL   (United States)

^d MAYO CLINIC   (United States)

^e DUKE UNIVERSITY   (United States)

^f Texas Heart Institute   (United States)

^g THORATEC CORPORATION   (United States)

^h JOHNS HOPKINS HOSPITAL   (United States)

Author keywords

bleeding; heart failure; HeartMate II; LVAD; pump thrombosis; stroke

Indexed keywords

ADULT; ARTICLE; BLEEDING; BLOOD TRANSFUSION; BODY MASS; BRAIN HEMORRHAGE; BRAIN ISCHEMIA; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; DIABETES MELLITUS; EPISTAXIS; ERYTHROCYTE CONCENTRATE; FEMALE; GASTROINTESTINAL HEMORRHAGE; HEART FAILURE; HEMATOCRIT; HOSPITAL DISCHARGE; HUMAN; LEFT VENTRICULAR ASSIST DEVICE; MAJOR CLINICAL STUDY; MALE; MEDICAL DEVICE COMPLICATION; OUTCOME ASSESSMENT; PATIENT ASSESSMENT; PREOPERATIVE PERIOD; PRIORITY JOURNAL; RETROSPECTIVE STUDY; RISK ASSESSMENT; RISK FACTOR; SEX DIFFERENCE; SURGICAL WOUND; ADOLESCENT; AGE; AGED; ALBUMIN BLOOD LEVEL; ANEMIA; CARDIOVASCULAR PARAMETERS; DEVICE SAFETY; GENDER; HEART INDEX; HEMOGLOBIN BLOOD LEVEL; INCIDENCE; INTERNATIONAL NORMALIZED RATIO; LEFT VENTRICULAR END DIASTOLIC DIAMETER; LEUKOCYTE COUNT; LUNG WEDGE PRESSURE; MEDICAL HISTORY; PARTIAL THROMBOPLASTIN TIME; POSTOPERATIVE HEMORRHAGE; PREVALENCE; PUMP THROMBOSIS; THROMBOCYTE COUNT; UREA NITROGEN BLOOD LEVEL; VERY ELDERLY; WOUND HEMORRHAGE;

BLEEDING; HEART FAILURE; HEARTMATE II; LVAD; PUMP THROMBOSIS; STROKE;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; FEMALE; HEART FAILURE; HEART-ASSIST DEVICES; HEMORRHAGE; HUMANS; MALE; MIDDLE AGED; OUTPATIENTS; PREOPERATIVE PERIOD; RETROSPECTIVE STUDIES; RISK FACTORS; STROKE; THROMBOSIS; YOUNG ADULT;

ALBUMIN; HEMOGLOBIN;

EID: 84895511147     PISSN: 07351097     EISSN: 15583597     Source Type: Journal    
DOI: 10.1016/j.jacc.2013.08.1656     Document Type: Article

References (23)

1. M.S. Slaughter, J.G. Rogers, and C.A. Milano et al. Advanced heart failure treated with continuous-flow left ventricular assist device N Engl J Med 361 2009 2241 2251
2. L.W. Miller, F.D. Pagani, and S.D. Russell et al. Use of a continuous-flow device in patients awaiting heart transplantation N Engl J Med 357 2007 885 896
3. F.D. Pagani, L.W. Miller, and S.D. Russell et al. Extended mechanical circulatory support with a continuous-flow rotary left ventricular assist device J Am Coll Cardiol 54 2009 312 321
4. S.J. Park, C.A. Milano, and A.J. Tatooles et al. Outcomes in advanced heart failure patients with left ventricular assist devices for destination therapy Circ Heart Fail 5 2012 241 248
5. R. John, Y. Naka, and N.G. Smedira et al. Continuous flow left ventricular assist device outcomes in commercial use compared with the prior clinical trial Ann Thorac Surg 92 2011 1406 1413 discussion 1413
6. S. Crow, D. Chen, and C. Milano et al. Acquired von Willebrand syndrome in continuous-flow ventricular assist device recipients Ann Thorac Surg 90 2010 1263 1269 discussion 1269
7. A.L. Meyer, D. Malehsa, and C. Bara et al. Acquired von Willebrand syndrome in patients with an axial flow left ventricular assist device Circ Heart Fail 3 2010 675 681
8. N. Uriel, S.W. Pak, and U.P. Jorde et al. Acquired von Willebrand syndrome after continuous-flow mechanical device support contributes to a high prevalence of bleeding during long-term support and at the time of transplantation J Am Coll Cardiol 56 2010 1207 1213
9. J. Klovaite, F. Gustafsson, S.A. Mortensen, K. Sander, and L.B. Nielsen Severely impaired von Willebrand factor-dependent platelet aggregation in patients with a continuous-flow left ventricular assist device (HeartMate II) J Am Coll Cardiol 53 2009 2162 2167
10. U. Geisen, C. Heilmann, and F. Beyersdorf et al. Non-surgical bleeding in patients with ventricular assist devices could be explained by acquired von Willebrand disease Eur J Cardiothorac Surg 33 2008 679 684
11. A.J. Boyle, S.D. Russell, and J.J. Teuteberg et al. Low thromboembolism and pump thrombosis with the HeartMate II left ventricular assist device: analysis of outpatient anti-coagulation J Heart Lung Transplant 28 2009 881 887
12. M.S. Slaughter, F.D. Pagani, and J.G. Rogers et al. Clinical management of continuous-flow left ventricular assist devices in advanced heart failure J Heart Lung Transplant 29 2010 S1 39
13. S. Crow, R. John, and A. Boyle et al. Gastrointestinal bleeding rates in recipients of nonpulsatile and pulsatile left ventricular assist devices J Thorac Cardiovasc Surg 137 2009 208 215
14. Z.T. Demirozu, R. Radovancevic, and L.F. Hochman et al. Arteriovenous malformation and gastrointestinal bleeding in patients with the HeartMate II left ventricular assist device J Heart Lung Transplant 30 2011 849 853
15. J.A. Morgan, G. Paone, and H.W. Nemeh et al. Gastrointestinal bleeding with the HeartMate II left ventricular assist device J Heart Lung Transplant 31 2012 715 718
16. R. John, F. Kamdar, and K. Liao et al. Low thromboembolic risk for patients with the Heartmate II left ventricular assist device J Thorac Cardiovasc Surg 136 2008 1318 1323
17. A.K. Menon, A. Götzenich, H. Sassmannshausen, M. Haushofer, R. Autschbach, and J.W. Spillner Low stroke rate and few thrombo-embolic events after HeartMate II implantation under mild anticoagulation Eur J Cardiothorac Surg 42 2012 319 323 discussion 323
18. T.S. Kato, P.C. Schulze, and J. Yang et al. Pre-operative and post-operative risk factors associated with neurologic complications in patients with advanced heart failure supported by a left ventricular assist device J Heart Lung Transplant 31 2012 1 8
19. I. Nakajima, T.S. Kato, and K. Komamura et al. Pre- and post-operative risk factors associated with cerebrovascular accidents in patients supported by left ventricular assist device. Single center's experience in Japan Circ J 75 2011 1138 1146
20. R.C. Bogaev, S.V. Pamboukian, and S.A. Moore et al. Comparison of outcomes in women versus men using a continuous-flow left ventricular assist device as a bridge to transplantation J Heart Lung Transplant 30 2011 515 522
21. E. Daly, M.P. Vessey, M.M. Hawkins, J.L. Carson, P. Gough, and S. Marsh Risk of venous thromboembolism in users of hormone replacement therapy Lancet 348 1996 977 980
22. J.P. Vandenbroucke, J. Rosing, and K.W. Bloemenkamp et al. Oral contraceptives and the risk of venous thrombosis N Engl J Med 344 2001 1527 1535
23. L.D. Lisabeth, A.S. Beiser, D.L. Brown, J.M. Murabito, M. Kelly-Hayes, and P.A. Wolf Age at natural menopause and risk of ischemic stroke: the Framingham Heart Study Stroke 40 2009 1044 1049