Investigation of an interleukin-6 receptor gene polymorphism (rs2228145) as a predictor of cardiovascular mortality in inflammatory polyarthritis: Results from the Norfolk Arthritis Register

Annals of the Rheumatic Diseases

Volumn 73, Issue 4, 2014, Pages 787-788

  Ibrahim, Ibrahim ^a   McAllister, Kate ^a   Plant, Darren ^a,b   Symmons, Deborah ^a,b   Marshall, Tarnya ^c   Barton, Anne ^a,b   Eyre, Stephen ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b MANCHESTER UNIVERSITY NHS FOUNDATION TRUST   (United Kingdom)

^c NORFOLK AND NORWICH UNIVERSITY HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; DNA; INTERLEUKIN 6 RECEPTOR;

CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; DEATH; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC CORRELATION; GENETIC VARIABILITY; GENOTYPE; HUMAN; IL6R GENE; LETTER; MAJOR CLINICAL STUDY; MORTALITY; POLYARTHRITIS; PREDICTION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SINGLE NUCLEOTIDE POLYMORPHISM; UNITED KINGDOM;

CARDIOVASCULAR DISEASE; GENE POLYMORPHISM; RHEUMATOID ARTHRITIS;

ARTHRITIS, RHEUMATOID; C-REACTIVE PROTEIN; CARDIOVASCULAR DISEASES; HUMANS; POLYMORPHISM, SINGLE NUCLEOTIDE; PROGNOSIS; RECEPTORS, INTERLEUKIN-6; REGISTRIES;

EID: 84895501506     PISSN: 00034967     EISSN: 14682060     Source Type: Journal    
DOI: 10.1136/annrheumdis-2013-204330     Document Type: Letter

References (10)

1. John H, Kitas G, Toms T, et al. Cardiovascular co-morbidity in early rheumatoid arthritis. Best Pract Res Clin Rheumatol 2009;23:71-82.
2. IL6R Genetics Consortium Emerging Risk Factors Collaboration. Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies. Lancet 2012;379:1205-13.
3. Interleukin-6 Receptor Mendelian Randomisation Analysis (IL6R MR) Consortium. The interleukin-6 receptor as a target for prevention of coronary heart disease: a Mendelian randomisation analysis. Lancet 2012;379:1214-24.
4. Eyre S, Bowes J, Diogo D, et al. High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis. Nat Genet 2012;44:1336-40.
5. Ferreira RC, Freitag DF, Cutler AJ, et al. Functional IL6R 358Ala allele impairs classical IL-6 receptor signaling and influences risk of diverse inflammatory diseases. PLoS Genet 2013;9:e1003444.
6. Heart Disease Genetics Collaboration CRPC. Association between C reactive protein and coronary heart disease: Mendelian randomisation analysis based on individual participant data. BMJ 2011;342:d548.
7. Goodson NJ, Symmons DPM, Scott DGI, et al. Baseline levels of c-reactive protein and prediction of death from cardiovascular disease in patients with inflammatory polyarthritis: a ten-year follow-up study of a primary care-based inception cohort. Arthritis Rheum 2005;52:2293-99. (Pubitemid 41117412)
8. Ibrahim I, Plant D, Lunt M, et al. Investigation of C reactive protein gene polymorphisms as predictors of cardiovascular mortality in inflammatory polyarthritis: results from the Norfolk Arthritis Register. Ann Rheum Dis 2013;72:1429-30.
9. Symmons DPM, Barrett EM, Bankhead CR, et al. The incidence of rheumatoid arthritis in the United Kingdom: results from the Norfolk Arthritis Register. Rheumatology 1994;33:735-39. (Pubitemid 24249180)
10. Lopez-Mejias R, Garcia-Bermudez M, Gonzalez-Juanatey C, et al. Lack of association of IL6R rs2228145 and IL6ST/gp130 rs2228044 gene polymorphisms with cardiovascular disease in patients with rheumatoid arthritis. Tissue Antigens 2011;78:438-41.