Engineering cellular resistance to HIV

New England Journal of Medicine

Volumn 370, Issue 10, 2014, Pages 968-969

  Kay, Mark A ^a   Walker, Bruce D ^b  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; MEMBRANE PROTEIN; ZINC FINGER NUCLEASE;

CCR5 GENE; CD4+ T LYMPHOCYTE; CELL ENGINEERING; COHORT ANALYSIS; DNA CLEAVAGE; EDITORIAL; GENE; GENE DISRUPTION; GENETIC PROCEDURES; GENOME EDITING; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LYMPHOCYTE FUNCTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN PROTEIN INTERACTION; VIRUS ENVELOPE; VIRUS RESISTANCE;

CD4-POSITIVE T-LYMPHOCYTES; FEMALE; GENETIC THERAPY; HIV INFECTIONS; HUMANS; LYMPHOCYTE TRANSFUSION; MALE; RECEPTORS, CCR5;

EID: 84895428663     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMe1400593     Document Type: Editorial

References (4)

1. Liu R, Paxton WA, Choe S, et al. Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection. Cell 1996;86:367-77. (Pubitemid 26272077)
2. Allers K, Hütter G, Hofmann J, et al. Evidence for the cure of HIV infection by CCR5Δ32/Δ32 stem cell transplantation. Blood 2011;117:2791-9.
3. Tebas P, Stein D, Tang WW, et al. Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV. N Engl J Med 2014;370:901-10.
4. Gaj T, Gersbach CA, Barbas CF III. ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering. Trends Biotechnol 2013;31:397-405.