Synovitis in knee osteoarthritis assessed by contrast-enhanced magnetic resonance imaging (MRI) is associated with radiographic tibiofemoral osteoarthritis and MRI-detected widespread cartilage damage: The MOST study

Journal of Rheumatology

Volumn 41, Issue 3, 2014, Pages 501-508

  Guermazi, Ali ^a   Hayashi, Daichi ^a,b   Roemer, Frank W ^a,c   Zhu, Yanyan ^a   Niu, Jingbo ^a   Crema, Michel D ^a,d   Javaid, M Kassim ^e   Marra, Monica D ^a   Lynch, John A ^f   El Khoury, George Y ^g   Zhang, Yuqing ^a   Nevitt, Michael C ^f   Felson, David T ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^d Hospital do Coracao HCor and Teleimagem   (Brazil)

^e UNIVERSITY OF OXFORD   (United Kingdom)

^f UNIVERSITY OF CALIFORNIA   (United States)

^g UNIVERSITY OF IOWA   (United States)

Author keywords

Cartilage; Magnetic resonance imaging; Meniscus; Osteoarthritis; Synovitis

Indexed keywords

ADULT; AGED; ARTICLE; BODY MASS; CARTILAGE INJURY; CLINICAL ASSESSMENT; COHORT ANALYSIS; CONTRAST ENHANCEMENT; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DISEASE ASSOCIATION; FEMALE; HIGH RISK PATIENT; HUMAN; KELLGREN LAWRENCE GRADING; KNEE MENISCUS RUPTURE; KNEE OSTEOARTHRITIS; KNEE RADIOGRAPHY; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MULTICENTER STUDY; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PROSPECTIVE STUDY; RATING SCALE; RISK ASSESSMENT; RISK FACTOR; SCORING SYSTEM; SYNOVITIS;

CARTILAGE; MAGNETIC RESONANCE IMAGING; MENISCUS; OSTEOARTHRITIS; SYNOVITIS;

AGED; CARTILAGE, ARTICULAR; CROSS-SECTIONAL STUDIES; FEMALE; HUMANS; KNEE JOINT; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; OSTEOARTHRITIS, KNEE; SYNOVITIS;

EID: 84895425810     PISSN: 0315162X     EISSN: 14992752     Source Type: Journal    
DOI: 10.3899/jrheum.130541     Document Type: Article

References (20)

1. Myers SL, Flusser D, Brandt KD, Heck DA. Prevalence of cartilage shards in synovium and their association with synovitis in patients with early and end stage osteoarthritis. J Rheumatol 1992;19:1247-51.
2. Scanzello CR, Umoh E, Pessler F, Diaz-Torne C, Miles T, Dicarlo E, et al. Local cytokine profiles in knee osteoarthritis: elevated synovial fluid interleukin-15 differentiates early from end-stage disease. Osteoarthritis Cartilage 2009;17:1040-8.
3. Roemer FW, Zhang Y, Niu J, Lynch JA, Crema MD, Marra MD, et al. Tibiofemoral joint osteoarthritis: risk factors for MR-depicted fast cartilage loss over a 30-month period in the multicenter osteoarthritis study. Radiology 2009;252:772-80.
4. Ayral X, Pickering EH, Woodworth TG, Mackillop N, Dougados M. Synovitis: a potential predictive factor of structural progression of medial tibiofemoral knee osteoarthritis - results of a 1-year longitudinal arthroscopic study in 422 patients. Osteoarthritis Cartilage 2005;13:361-7. (Pubitemid 40631281)
5. Roeddecker K, Nagelschmidt M, Koebke J, Guensche K. Meniscal healing: a histological study in rabbits. Knee Surg Sports Traumatol Arthrosc 1993;1:28-33.
6. Loeuille D, Sauliere N, Champigneulle J, Rat AC, Blum A, Chary-Valckenaere I. Comparing non-enhanced and enhanced sequences in the assessment of effusion and synovitis in knee OA: associations with clinical, macroscopic and microscopic features. Osteoarthritis Cartilage 2011;19:1433-9.
7. Guermazi A, Roemer FW, Hayashi D, Crema MD, Niu J, Zhang Y, et al. Assessment of synovitis with contrast-enhanced MRI using a whole-joint semiquantitative scoring system in people with, or at high risk of, knee osteoarthritis: the MOST study. Ann Rheum Dis 2011;70:805-11.
8. Roemer FW, Guermazi A, Hunter DJ, Niu J, Zhang Y, Englund M, et al. The association of meniscal damage with joint effusion in persons without radiographic osteoarthritis: the Framingham and MOST osteoarthritis studies. Osteoarthritis Cartilage 2009;17:748-53.
9. Krasnokutsky S, Belitskaya-Levy I, Bencardino J, Samuels J, Attur M, Regatte R, et al. Quantitative magnetic resonance imaging evidence of synovial proliferation is associated with radiographic severity of knee osteoarthritis. Arthritis Rheum 2011;63:2983-91.
10. Felson DT, Niu J, Guermazi A, Roemer F, Aliabadi P, Clancy M, et al. Correlation of the development of knee pain with enlarging bone marrow lesions on magnetic resonance imaging. Arthritis Rheum 2007;56:2986-92. (Pubitemid 47502745)
11. Peterfy CG, Guermazi A, Zaim PF. Non-fluoroscopic method for flexed radiography of the knee that allows reproducible joint-space width measurement. Arthritis Rheum 1998;41:S361.
12. Kellgren JH, Lawrence JS. Radiological assessment of osteo-arthrosis. Ann Rheum Dis 1957;16:494-502.
13. Ostergaard M, Klarlund M. Importance of timing of post-contrast MRI in rheumatoid arthritis: what happens during the first 60 minutes after IV gadolinium-DTPA? Ann Rheum Dis 2001;60:1050-4. (Pubitemid 32989178)
14. Peterfy CG, Guermazi A, Zaim S, Tirman PF, Miaux Y, White D, et al. Whole-Organ Magnetic Resonance Imaging Score (WORMS) of the knee in osteoarthritis. Osteoarthritis Cartilage 2004;12:177-90. (Pubitemid 38248067)
15. Aigner T, Sachse A, Gebhard PM, Roach HI. Osteoarthritis: pathobiology-targets and ways for therapeutic intervention. Adv Drug Deliv Rev 2006;58:128-49.
16. Scanzello CR, McKeon B, Swaim BH, DiCarlo E, Asomugha EU, Kanda V, et al. Synovial inflammation in patients undergoing arthroscopic meniscectomy: molecular characterization and relationship to symptoms. Arthritis Rheum 2011;63:391-400.
17. Baker KR, Matthan NR, Lichtenstein AH, Niu J, Guermazi A, Roemer F, et al. Association of plasma n-6 and n-3 polyunsaturated fatty acids with synovitis in the knee: the MOST study. Osteoarthritis Cartilage 2012;20:382-7.
18. Meredith DS, Losina E, Neumann G, Yoshioka H, Lang PK, Katz JN. Empirical evaluation of the inter-relationship of articular elements involved in the pathoanatomy of knee osteoarthritis using magnetic resonance imaging. BMC Musculoskelet Disord 2009;10:133.
19. Grainger AJ, Rhodes LA, Keenan AM, Emery P, Conaghan PG. Quantifying peri-meniscal synovitis and its relationship to meniscal pathology in osteoarthritis of the knee. Eur Radiol 2007;17:119-24. (Pubitemid 46063036)
20. Roemer FW, Lynch JA, Niu J, Zhang Y, Crema MD, Tolstykh I, et al. A comparison of dedicated 1.0 T extremity MRI vs large-bore 1.5 T MRI for semiquantitative whole organ assessment of osteoarthritis: the MOST study. Osteoarthritis Cartilage 2010;18:168-74.