Low-density lipoprotein levels and not mutation status predict Intima-media thickness in familial hypercholesterolemia

Annals of Vascular Surgery

Volumn 28, Issue 2, 2014, Pages 421-426

  Fahed, Akl C ^a,b   Habib, Robert H ^b   Nemer, Georges M ^b   Azar, Sami T ^b   Andary, Rabih R ^b   Arabi, Mariam T ^b   Moubarak, Elie M ^c   Bitar, Fadi F ^b   Haddad, Fady F ^b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b AMERICAN UNIVERSITY OF BEIRUT   (Lebanon)

^c National LDL Apheresis Center   (Lebanon)

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENT; ADULT; AGE FACTORS; APOLIPOPROTEINS E; BIOLOGICAL MARKERS; BLOOD COMPONENT REMOVAL; CAROTID ARTERY DISEASES; CAROTID INTIMA-MEDIA THICKNESS; CASE-CONTROL STUDIES; CHILD; DNA MUTATIONAL ANALYSIS; GENETIC PREDISPOSITION TO DISEASE; GENETIC TESTING; HETEROZYGOTE; HOMOZYGOTE; HUMANS; HYPERLIPOPROTEINEMIA TYPE II; LIPOPROTEINS, LDL; MIDDLE AGED; MUTATION; PHENOTYPE; PREDICTIVE VALUE OF TESTS; RECEPTORS, LDL; RISK FACTORS; SEVERITY OF ILLNESS INDEX; YOUNG ADULT;

EID: 84895075770     PISSN: 08905096     EISSN: 16155947     Source Type: Journal    
DOI: 10.1016/j.avsg.2013.02.024     Document Type: Article

References (9)

1. S.B. Feinstein, P. Voci, and F. Pizzuto Noninvasive surrogate markers of atherosclerosis Am J Cardiol 89 2002 31C 43C
2. O. Guardamagna, G. Restagno, and E. Rolfo et al. The type of LDLR gene mutation predicts cardiovascular risk in children with familial hypercholesterolemia J Pediatr 155 2009 199 204
3. O.S. Descamps, J.P. Gilbeau, X. Leysen, F. van Leuven, and F.R. Heller Impact of genetic defects on atherosclerosis in patients suspected of familial hypercholesterolaemia Eur J Clin Invest 31 2001 958 965
4. A.C. Fahed, and G.M. Nemer Familial hypercholesterolemia: the lipids or the genes? Nutr Metab (Lond) 8 2011 23
5. A.C. Fahed, R.M. Safa, and F.F. Haddad et al. Homozygous familial hypercholesterolemia in Lebanon: a genotype/phenotype correlation Mol Genet Metab 102 2011 181 188
6. N. Koga, K. Watanabe, Y. Kurashige, T. Sato, and T. Hiroki Long-term effects of LDL apheresis on carotid arterial atherosclerosis in familial hypercholesterolaemic patients J Intern Med 246 1999 35 43
7. P.R. Nolting, E. de Groot, A.H. Zwinderman, R.J. Buirma, M.D. Trip, and J.J. Kastelein Regression of carotid and femoral artery intima-media thickness in familial hypercholesterolemia: treatment with simvastatin Arch Intern Med 163 2003 1837 1841
8. J.J. Kastelein, F. Akdim, and E.S. Stroes et al. Simvastatin with or without ezetimibe in familial hypercholesterolemia N Engl J Med 358 2008 1431 1443
9. J.J. Kastelein, S.I. van Leuven, and L. Burgess et al. Effect of torcetrapib on carotid atherosclerosis in familial hypercholesterolemia N Engl J Med 356 2007 1620 1630