5% CO2 inhalation suppresses hyperventilation-induced absence seizures in children

Epilepsy Research

Volumn 108, Issue 2, 2014, Pages 345-348

  Yang, Xiao Fan ^a,b   Shi, Xiu Yu ^a   Ju, Jun ^a   Zhang, Wei Na ^a,d   Liu, Yu Jie ^a   Li, Xiao Yan ^a,e   Zou, Li Ping ^a,c  

^a CHINESE PLA GENERAL HOSPITAL   (China)

^b NANKAI UNIVERSITY   (China)

^c BEIJING INSTITUTE FOR BRAIN DISORDERS   (China)

^d CAPITAL MEDICAL UNIVERSITY   (China)

^e CAPITAL INSTITUTE OF PEDIATRICS   (China)

Author keywords

Absence seizure; Electroencephalogram; Hypercapnia; Hyperventilation; PH

Indexed keywords

ABSENCE SEIZURE; ELECTROENCEPHALOGRAM; HYPERCAPNIA; HYPERVENTILATION; PH;

ADMINISTRATION, INHALATION; ADOLESCENT; CARBON DIOXIDE; CHILD; CHILD, PRESCHOOL; ELECTROENCEPHALOGRAPHY; EPILEPSY, ABSENCE; FEMALE; HUMANS; HYPERVENTILATION; MALE; PILOT PROJECTS;

EID: 84895074977     PISSN: 09201211     EISSN: 18726844     Source Type: Journal    
DOI: 10.1016/j.eplepsyres.2013.11.012     Document Type: Article

References (15)

1. 2 in human volunteers. Depress Anxiety 2005, 21:18-25.
2. 2. Proc. Natl. Acad. Sci. U.S.A. 2010, 107:16354-16359.
3. Chang B.S., Lowenstein D.H. Epilepsy. N. Engl. J. Med. 2003, 349:1257-1266.
4. Chesler M. Regulation and modulation of pH in the brain. Physiol. Rev. 2003, 83:1183-1221.
5. Griez E.J., Colasanti A., van Diest R., Salamon E., Schruers K. Carbon dioxide inhalation induces dose-dependent and age-related negative affectivity. PLoS One 2007, 2:e987.
6. Guaranha M.S., Garzon E., Buchpiguel C.A., Tazima S., Yacubian E.M., Sakamoto A.C. Hyperventilation revisited: physiological effects and efficacy on focal seizure activation in the era of video-EEG monitoring. Epilepsia 2005, 46:69-75.
7. Loscher W., Kohling R. Functional, metabolic, and synaptic changes after seizures as potential targets for antiepileptic therapy. Epilepsy Behav. 2010, 19:105-113.
8. Ohno Y., Sofue N., Imaoku T., Morishita E., Kumafuji K., Sasa M., Serikawa T. Serotonergic modulation of absence-like seizures in groggy rats: a novel rat model of absence epilepsy. J. Pharmacol. Sci. 2010, 114:99-105.
9. Richerson G.B. Serotonergic neurons as carbon dioxide sensors that maintain pH homeostasis. Nat Rev Neurosci 2004, 5:449-461.
10. Schuchmann S., Hauck S., Henning S., Gruters-Kieslich A., Vanhatalo S., Schmitz D., Kaila K. Respiratory alkalosis in children with febrile seizures. Epilepsia 2011, 52:1949-1955.
11. Schuchmann S., Schmitz D., Rivera C., Vanhatalo S., Salmen B., Mackie K., Sipila S.T., Voipio J., Kaila K. Experimental febrile seizures are precipitated by a hyperthermia-induced respiratory alkalosis. Nat. Med. 2006, 12:817-823.
12. 2 is a potent, fast-acting inhalation anticonvulsant. Epilepsia 2011, 52:104-114.
13. Wirrell E.C., Camfield P.R., Gordon K.E., Camfield C.S., Dooley J.M., Hanna B.D. Will a critical level of hyperventilation-induced hypocapnia always induce an absence seizureα. Epilepsia 1996, 37:459-462.
14. Xiong Z.Q., Saggau P., Stringer J.L. Activity-dependent intracellular acidification correlates with the duration of seizure activity. J. Neurosci. 2000, 20:1290-1296.
15. Ziemann A.E., Schnizler M.K., Albert G.W., Severson M.A., Howard M.A., Welsh M.J., Wemmie J.A. Seizure termination by acidosis depends on ASIC1a. Nat. Neurosci. 2008, 11:816-822.