Poly(amido-amine)-based hydrogels with tailored mechanical properties and degradation rates for tissue engineering

Acta Biomaterialia

Volumn 10, Issue 3, 2014, Pages 1206-1215

  Martello, Federico ^a   Tocchio, Alessandro ^b   Tamplenizza, Margherita ^a   Gerges, Irini ^a   Pistis, Valentina ^a   Recenti, Rossella ^a   Bortolin, Monica ^c   Del Fabbro, Massimo ^c   Argentiere, Simona ^a   Milani, Paolo ^a,c   Lenardi, Cristina ^a,c  

^a Fondazione Filarete   (Italy)

^b FIRC INSTITUTE OF MOLECULAR ONCOLOGY   (Italy)

^c UNIVERSITY OF MILAN   (Italy)

Author keywords

Biomimetics; Hydrogels; Structure property relationship; Tissue engineering

Indexed keywords

ACRYLIC MONOMERS; AMIDES; AMINO ACIDS; BIOCOMPATIBILITY; BIOMECHANICS; BIOMIMETICS; CELL ADHESION; CELLS; COMPRESSIVE STRENGTH; DEGRADATION; FUNCTIONAL POLYMERS; MEDICAL APPLICATIONS; OLIGOMERS; PROFESSIONAL ASPECTS; TISSUE; TISSUE ENGINEERING;

CELLULAR ADHESION; DEGRADATION RATE; INTEGRINS; MECHANICAL; MECHANICAL DEGRADATION; MONOMERIC UNITS; POLYAMIDOAMINES; STRUCTURE-PROPERTIES RELATIONSHIPS; TISSUES ENGINEERINGS; TUNABLES;

HYDROGELS;

2 HYDROXYETHYL METHACRYLATE; ACRYLAMIDE; INTEGRIN; MONOMER; OLIGOMER; POLYAMIDOAMINE; POLYCYCLIC AROMATIC HYDROCARBON; POLYMACON; ACTIN; HYDROGEL; POLYAMINE;

ANIMAL CELL; ARTICLE; BIOMIMETICS; CELL ADHESION; CELL PROLIFERATION; COMPRESSIVE STRENGTH; CONTROLLED STUDY; CYTOTOXICITY; CYTOTOXICITY ASSAY; DEGRADATION; EPITHELIUM CELL; GEL PERMEATION CHROMATOGRAPHY; HYDROGEL; IMMUNOFLUORESCENCE; KIDNEY CELL; MDCK CELL; MECHANICS; MICHAEL ADDITION; MOLECULAR WEIGHT; NONHUMAN; POLYMERIZATION; PRIORITY JOURNAL; REACTION TIME; STRUCTURE ACTIVITY RELATION; TISSUE ENGINEERING; ANIMAL; CHEMISTRY; DOG; DRUG EFFECTS; MDCK CELL LINE; METABOLISM; PHARMACOLOGY; PROCEDURES; SYNTHESIS;

ACTINS; ANIMALS; CELL ADHESION; CELL PROLIFERATION; DOGS; HYDROGELS; MADIN DARBY CANINE KIDNEY CELLS; MECHANICAL PHENOMENA; POLYAMINES; POLYHYDROXYETHYL METHACRYLATE; TISSUE ENGINEERING;

EID: 84895067718     PISSN: 17427061     EISSN: 18787568     Source Type: Journal    
DOI: 10.1016/j.actbio.2013.12.023     Document Type: Article

References (36)

1. J.L. Drury, and D.J. Mooney Hydrogels for tissue engineering: scaffold design variables and applications Biomaterials 24 2003 4337 4351
2. K.Y. Lee, and D.J. Mooney Hydrogels for tissue engineering Chem Rev 101 2001 1869 1879
3. B.K. Mann Biologic gels in tissue engineering Clin Plast Surg 30 2003 601
4. M.L. Mather, and P.E. Tomlins Hydrogels in regenerative medicine: towards understanding structure-function relationships Regen Med 5 2010 809 821
5. J. Montheard, M. Chatzopoulos, and D. Chappard 2-Hydroxyethylmethacrylate (HEMA) - chemical properties and applications in biomedical fields J Macromol Sci R M C C32 1992 1 34
6. A. Clayton, T.V. Chirila, and P.D. Dalton Hydrophilic sponges based on 2-hydroxyethyl methacrylate. 3. Effect of incorporating a hydrophilic crosslinking agent on the equilibrium water content and pore structure Polym Int 42 1997 45 56
7. P.D. Dalton, L. Flynn, and M.S. Shoichet Manufacture of poly(2-hydroxyethyl methacrylate-co-methyl methacrylate) hydrogel tubes for use as nerve guidance channels Biomaterials 23 2002 3843 3851
8. S. Atzet, S. Curtin, P. Trinh, S. Bryant, and B. Ratner Degradable poly(2-hydroxyethyl methacrylate)-co-polycaprolactone hydrogels for tissue engineering scaffolds Biomacromolecules 9 2008 3370 3377
9. R. Filmon, F. Grizon, M.F. Basle, and D. Chappaard Effects of negatively charged groups (carboxymethyl) on the calcification of poly(2-hydroxyethyl methacrylate) Biomaterials 23 2002 3053 3059
10. P. Ferruti, M.A. Marchisio, and R. Duncan Poly(amido-amine)s: biomedical applications Macromol Rapid Commun 23 2002 332 355
11. R. Jain, S.M. Standley, and J.M.J. Frechet Synthesis and degradation of pH-sensitive linear poly(amidoamine)s Macromolecules 40 2007 452 457
12. E. Emilitri, E. Ranucci, and P. Ferruti New poly(amidoamine)s containing disulfide linkages in their main chain J Polym Sci Pol Chem 43 2005 1404 1416
13. N. Lavignac, M. Lazenby, J. Franchini, P. Ferruti, and R. Duncan Synthesis and preliminary evaluation of poly(amidoamine)-melittin conjugates as endosomolytic polymers and/or potential anticancer therapeutics Int J Pharm 300 2005 102 112
14. V. Magnaghi, V. Conte, P. Procacci, G. Pivato, P. Cortese, and E. Cavalli et al. Biological performance of a novel biodegradable polyamidoamine hydrogel as guide for peripheral nerve regeneration J Biomed Mater Res A 98 2011 19 30
15. P. Ferruti, S. Bianchi, E. Ranucci, F. Chiellini, and A.M. Piras Novel agmatine-containing poly(amidoamine) hydrogels as scaffolds for tissue engineering Biomacromolecules 6 2005 2229 2235
16. C. Lin, Z. Zhong, M.C. Lok, X. Jiang, W.E. Hennink, and J. Feijen et al. Novel bioreducible poly(amido amine)s for highly efficient gene delivery Bioconjug Chem 18 2007 138 145
17. E. Emilitri, F. Guizzardi, C. Lenardi, M. Suardi, E. Ranucci, and P. Ferruti Novel poly(amidoamine)-based hydrogels as scaffolds for tissue engineering Macromol Symp 266 2008 41 47
18. G. Dos Reis, F. Fenili, A. Gianfelice, G. Bongiorno, D. Marchesi, and P.E. Scopelliti et al. Direct microfabrication of topographical and chemical cues for the guided growth of neural cell networks on polyamidoamine hydrogels Macromol Biosci 10 2010 842 852
19. F. Martello, M. Piest, J.F. Engbersen, and P. Ferruti Effects of branched or linear architecture of bioreducible poly(amido amine)s on their in vitro gene delivery properties J Control Release 164 2012 372 379
20. N. Mauro, E. Ranucci, P. Procacci, M. Laus, D. Antonioli, and C. Mantovani et al. Degradable poly(amidoamine) hydrogels as scaffolds for in vitro culturing of peripheral nervous system cells Macromol Biosci 13 2012 332 347
21. W.D. Chan, H.A. Goldberg, G.K. Hunter, S.J. Dixon, and A.S. Rizkalla Modification of polymer networks with bone sialoprotein promotes cell attachment and spreading J Biomed Mater Res A 94 2010 945 952
22. H. Shin, S. Jo, and A.G. Mikos Biomimetic materials for tissue engineering Biomaterials 24 2003 4353 4364
23. Z. Zhang, Y.X. Lai, L. Yu, and J.D. Ding Effects of immobilizing sites of RGD peptides in amphiphilic block copolymers on efficacy of cell adhesion Biomaterials 31 2010 7873 7882
24. S.P. Massia, and J.A. Hubbell An RGD spacing of 440 nm is sufficient for integrin alpha V beta 3-mediated fibroblast spreading and 140 nm for focal contact and stress fiber formation J Cell Biol 114 1991 1089 1100
25. Ferruti P, Ranucci E, Trotta M. Biocompatible polymers of bisacrylamides and aminoacids. PCT No. WO2008152475, 2008.
26. K. Tanahashi, S. Jo, and A.G. Mikos Synthesis and characterization of biodegradable cationic poly(propylene fumarate-co-ethylene glycol) copolymer hydrogels modified with agmatine for enhanced cell adhesion Biomacromolecules 3 2002 1030 1037
27. P. Ferruti, S. Bianchi, E. Ranucci, F. Chiellini, and V. Caruso Novel poly(amido-amine)-based hydrogels as scaffolds for tissue engineering Macromol Biosci 5 2005 613 622
28. J. Franchini, E. Ranucci, P. Ferruti, M. Rossi, and R. Cavalli Synthesis, physicochemical properties, and preliminary biological characterizations of a novel amphoteric agmatine-based poly(amidoamine) with RGD-like repeating units Biomacromolecules 7 2006 1215 1222
29. P. Ferruti, E. Ranucci, F. Trotta, E. Gianasi, E.G. Evagorou, and M. Wasil et al. Synthesis, characterisation and antitumour activity of platinum(II) complexes of novel functionalised poly(amido amine)s Macromol Chem Phys 200 1999 1644 1654
30. K. Mukae, M. Sakurai, S. Sawamura, K. Makino, S.W. Kim, and I. Ueda et al. Swelling of poly(N-isopropylacrylamide) gels in water-alcohol (C1-C4) mixed-solvents J Phys Chem-US 97 3 1993 737 741
31. E. Jacchetti, E. Emilitri, S. Rodighiero, M. Indrieri, A. Gianfelice, and C. Lenardi et al. Biomimetic poly(amidoamine) hydrogels as synthetic materials for cell culture J Nanobiotechnol 6 2008 14
32. W. Zhao, C. Lenardi, P. Webb, C. Liu, T. Santaniello, and F. Gassa A methodology to analyse and simulate mechanical characteristics of poly(2-hydroxyethyl methacrylate) hydrogel Polym Int 62 2013 1059 1067
33. E. Karpushkin, M. Duskova-Smrckova, T. Remmler, M. Lapcikova, and K. Dusek Rheological properties of homogeneous and heterogeneous poly(2-hydroxyethyl methacrylate) hydrogels Polym Int 61 2012 328 336
34. A. Guiseppi-Elie, C.B. Dong, and C.Z. Dinu Crosslink density of a biomimetic poly(HEMA)-based hydrogel influences growth and proliferation of attachment dependent RMS 13 cells J Mater Chem 22 2012 19529 19539
35. K.K. Goli, O.J. Rojas, and J. Genzer Formation and antifouling properties of amphiphilic coatings on polypropylene fibers Biomacromolecules 13 2012 3769 3779
36. T. Yeung, P.C. Georges, L.A. Flanagan, B. Marg, M. Ortiz, and M. Funaki et al. Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion Cell Motil Cytoskeleton 60 2005 24 34