Key role for CD4 T cells during mixed antibody-mediated rejection of renal allografts

American Journal of Transplantation

Volumn 14, Issue 2, 2014, Pages 284-294

  Gaughan, A ^a   Wang, J ^a   Pelletier, R P ^a   Nadasdy, T ^a   Brodsky, S ^a   Roy, S ^a   Lodder, M ^a   Bobek, D ^a   Mofatt Bruce, S ^a   Fairchild, R L ^b   Henry, M L ^a   Hadley, G A ^a  

^a THE OHIO STATE UNIVERSITY WEXNER MEDICAL CENTER   (United States)

^b LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Adoptive transfer; antibody mediated rejection; ELISPOT; graft infiltrating lymphocytes; T cell mediated rejection

Indexed keywords

ALLOANTIBODY; ALLOANTIGEN;

ALLOTRANSPLANTATION; ANIMAL; BAGG ALBINO MOUSE; C57BL MOUSE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; COMPLICATION; DBA MOUSE; FLOW CYTOMETRY; GRAFT REJECTION; IMMUNOLOGY; KIDNEY DISEASES; KIDNEY TRANSPLANTATION; KNOCKOUT MOUSE; LASER CAPTURE MICRODISSECTION; LYMPHOCYTE DEPLETION; MOUSE; TRANSGENIC MOUSE;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; FLOW CYTOMETRY; GRAFT REJECTION; ISOANTIBODIES; ISOANTIGENS; KIDNEY DISEASES; KIDNEY TRANSPLANTATION; LASER CAPTURE MICRODISSECTION; LYMPHOCYTE DEPLETION; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, INBRED DBA; MICE, KNOCKOUT; MICE, TRANSGENIC; TRANSPLANTATION, HOMOLOGOUS;

EID: 84895061750     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/ajt.12596     Document Type: Article

References (30)

1. Baldwin WM III, Valujskikh A, Fairchild RL., Antibody-mediated rejection: Emergence of animal models to answer clinical questions. Am J Transplant 2010; 10: 1135-1142.
2. Collins AB, Schneeberger EE, Pascual MA, et al. Complement activation in acute humoral renal allograft rejection: Diagnostic significance of C4d deposits in peritubular capillaries. J Am Soc Nephrol 1999; 10: 2208-2214.
3. Bohmig GA, Exner M, Habicht A, et al. Capillary C4d deposition in kidney allografts: A specific marker of alloantibody-dependent graft injury. J Am Soc Nephrol 2002; 13: 1091-1099.
4. Nakashima S, Qian Z, Rahimi S, Wasowska BA, Baldwin WM III., Membrane attack complex contributes to destruction of vascular integrity in acute lung allograft rejection. J Immunol 2002; 169: 4620-4627.
5. Colvin RB., Antibody-mediated renal allograft rejection: Diagnosis and pathogenesis. J Am Soc Nephrol 2007; 18: 1046-1056.
6. Smith JD, Lawson C, Yacoub MH, Rose ML., Activation of NF-kappa B in human endothelial cells induced by monoclonal and allospecific HLA antibodies. Int Immunol 2000; 12: 563-571.
7. Jin YP, Singh RP, Du ZY, Rajasekaran AK, Rozengurt E, Reed EF., Ligation of HLA class I molecules on endothelial cells induces phosphorylation of Src, paxillin, and focal adhesion kinase in an actin-dependent manner. J Immunol 2002; 168: 5415-5423.
8. Nickeleit V, Andreoni K., The classification and treatment of antibody-mediated renal allograft injury: Where do we stand ? Kidney Int 2007; 71: 7-11.
9. Sun Q, Liu ZH, Cheng Z, et al. Treatment of early mixed cellular, humoral renal allograft rejection with tacrolimus, mycophenolate mofetil. Kidney Int 2007; 71: 24-30.
10. Singh N, Sun Q, Nadasdy T, et al. The pathogenesis of acute allograft dysfunction in desensitized renal transplant recipients. Clin Transplant 2012; 26: E402-E411.
11. Bickerstaff A, Pelletier R, Wang JJ, et al. An experimental model of acute humoral rejection of renal allografts associated with concomitant cellular rejection. Am J Pathol 2008; 173: 347-357.
12. Steele DJ, Laufer TM, Smiley ST, et al. Two levels of help for B cell alloantibody production. J Exp Med 1996; 183: 699-703.
13. Mombaerts P, Iacomini J, Johnson RS, Herrup K, Tonegawa S, Papaioannou VE., RAG-1-deficient mice have no mature B and T lymphocytes. Cell 1992; 68: 869-877.
14. Jindra PT, Hsueh A, Hong L, et al. Anti-MHC class I antibody activation of proliferation, survival signaling in murine cardiac allografts. J Immunol 2008; 180: 2214-2224.
15. Goldrath AW, Bogatzki LY, Bevan MJ., Naive T cells transiently acquire a memory-like phenotype during homeostasis-driven proliferation. J Exp Med 2000; 192: 557-564.
16. Cho BK, Rao VP, Ge Q, Eisen HN, Chen J., Homeostasis-stimulated proliferation drives naive T cells to differentiate directly into memory T cells. J Exp Med 2000; 192: 549-556.
17. Chan SY, DeBruyne LA, Goodman RE, Eichwald EJ, Bishop DK., In vivo depletion of CD8+ T cells results in Th2 cytokine production and alternate mechanisms of allograft rejection. Transplantation 1995; 59: 1155-1161.
18. Krieger NR, Yin DP, Fathman CG., CD4+ but not CD8+ cells are essential for allorejection. J Exp Med 1996; 184: 2013-2018.
19. Perez-Diez A, Joncker NT, Choi K, et al. CD4 cells can be more efficient at tumor rejection than CD8 cells. Blood 2007; 109: 5346-5354.
20. Liu Y, Janeway CA Jr., Interferon gamma plays a critical role in induced cell death of effector T cell: A possible third mechanism of self-tolerance. J Exp Med 1990; 172: 1735-1739.
21. Gattoni A, Parlato A, Vangieri B, Bresciani M, Derna R., Interferon-gamma: Biologic functions and HCV therapy (type I/II) (1 of 2 parts). Clin Ter 2006; 157: 377-386.
22. Brennan TV, Jaigirdar A, Hoang V, et al. Preferential priming of alloreactive T cells with indirect reactivity. Am J Transplant 2009; 9: 709-718.
23. Poggio ED, Clemente M, Riley J, et al. Alloreactivity in renal transplant recipients with and without chronic allograft nephropathy. J Am Soc Nephrol 2004; 15: 1952-1960.
24. Nozaki T, Amano H, Bickerstaff A, et al. Antibody-mediated rejection of cardiac allografts in CCR5-deficient recipients. J Immunol 2007; 179: 5238-5245.
25. Bickerstaff A, Nozaki T, Wang JJ, et al. Acute humoral rejection of renal allografts in CCR5(-/-) recipients. Am J Transplant 2008; 8: 557-566.
26. Wasowska BA, Qian Z, Cangello DL, et al. Passive transfer of alloantibodies restores acute cardiac rejection in IgKO mice. Transplantation 2001; 71: 727-736.
27. Nickeleit V, Zeiler M, Gudat F, Thiel G, Mihatsch MJ., Detection of the complement degradation product C4d in renal allografts: Diagnostic and therapeutic implications. J Am Soc Nephrol 2002; 13: 242-251.
28. Crawford A, Macleod M, Schumacher T, Corlett L, Gray D., Primary T cell expansion and differentiation in vivo requires antigen presentation by B cells. J Immunol 2006; 176: 3498-3506.
29. Noorchashm H, Reed AJ, Rostami SY, et al. B cell-mediated antigen presentation is required for the pathogenesis of acute cardiac allograft rejection. J Immunol 2006; 177: 7715-7722.
30. Seite JF, Shoenfeld Y, Youinou P, Hillion S., What is the contents of the magic draft IVIg ? Autoimmun Rev 2008; 7: 435-439.