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PD-1 and its ligands in T-cell immunity
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Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade
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Phase i study of single-agent Anti-Programmed Death-1 (MDX-1106) in refractory solid tumors: Safety, clinical activity, pharmodynamics, and immunologic correlates
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1:CAS:528:DC%2BC3cXpslajtLw%3D 20516446 10.1200/JCO.2009.26.7609
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1:CAS:528:DC%2BC38XhtV2rs7fN 3544539 22658127 10.1056/NEJMoa1200690 In this study, Topalian et al. describe for the first time a PD-1 blocking agent (an Anti-PD-1 antibody) that generated durable objective responses in patients with advanced RCC, melanoma, and non-small cell lung cancer
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Topalian SL, Hodi FS, Brahmer JR, et al. Safety, activity, and immune correlates of Anti-PD-1 antibody in cancer. N Engl J Med. 2012;366:2443-54. In this study, Topalian et al. describe for the first time a PD-1 blocking agent (an Anti-PD-1 antibody) that generated durable objective responses in patients with advanced RCC, melanoma, and non-small cell lung cancer.
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Safety and activity of Anti-PD-L1 antibody in patients with advanced cancer
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In this study by Brahmer et al. Anti-PD-L1 antibody resulted in an objective response rate of 6 %-17% with durability in advanced RCC, melanoma, and non-small cell lung cancer
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Brahmer JR, Tykodi SS, Chow LQ, et al. Safety and activity of Anti-PD-L1 antibody in patients with advanced cancer. N Engl J Med. 2012. In this study by Brahmer et al. Anti-PD-L1 antibody resulted in an objective response rate of 6 %-17% with durability in advanced RCC, melanoma, and non-small cell lung cancer.
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Brahmer, J.R.1
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Topalian SL. Nivolumab (Anti-PD-1; BMS-936558; ONO-4538) in patients with advanced solid tumors: survival and long-term safety in a phase I trial. Am Soc Clin Oncol. 2013. [Abstract #3002].
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Topalian, S.L.1
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Survival, safety, and response duration results of nivolumab (Anti-PD-1; BMS-936558; ONO-4538) in a phase i trial in patients with previously treated metastatic renal cell carcinoma (mRCC): Long-term patient follow-up
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Drake CG. Survival, safety, and response duration results of nivolumab (Anti-PD-1; BMS-936558; ONO-4538) in a phase I trial in patients with previously treated metastatic renal cell carcinoma (mRCC): long-term patient follow-up. Am Soc Clin Oncol. 2013. [Abstract #4514].
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Drake, C.G.1
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84879759020
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Safety and tumor responses with lambrolizumab (Anti-PD-1) in melanoma
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1:CAS:528:DC%2BC3sXht1emsbjP 23724846 10.1056/NEJMoa1305133 In this study by Hamid et al. a novel Anti-PD-1 antibody was shown to produce durable objective responses in patients with advanced melanoma, and interestingly, the response rate did not differ significantly between patients who had received prior Anti-CTLA-4 antibody treatment and those who had not
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Hamid O, Robert C, Daud A, et al. Safety and tumor responses with lambrolizumab (Anti-PD-1) in melanoma. N Engl J Med. 2013;369:134-44. In this study by Hamid et al. a novel Anti-PD-1 antibody was shown to produce durable objective responses in patients with advanced melanoma, and interestingly, the response rate did not differ significantly between patients who had received prior Anti-CTLA-4 antibody treatment and those who had not.
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Herbst, R.S.1
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Cho, D.C.1
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13
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Wolchok, J.D.1
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