Severe clinical presentation of visceral leishmaniasis in naturally infected dogs with disruption of the splenic white pulp

PLoS ONE

Volumn 9, Issue 2, 2014, Pages

  Lima, Isadora S ^a   Silva, Joselli S ^a   Almeida, Valter A ^a   Leal Jr , Floriano G ^b   Souza, Patrício A N ^b   Larangeira, Daniela F ^c   Moura Neto, José P ^d   Fraga, Deborah B M ^a,c   De Freitas, Luiz A R ^a   Dos Santos, Washington L C ^a  

^a INSTITUTO OSWALDO CRUZ   (Brazil)

^b Centro de Referência em Doenças Endêmicas Pirajá da Silva PIEJ SESAB   (Brazil)

^c FEDERAL UNIVERSITY OF BAHIA   (Brazil)

^d Instituto de Saúde e Produção Animal   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; ASPARTATE AMINOTRANSFERASE; CREATININE;

ALBUMIN BLOOD LEVEL; ALOPECIA; ANEMIA; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CLINICAL FEATURE; CONJUNCTIVITIS; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DEHYDRATION; DERMATITIS; DISEASE CLASSIFICATION; DISEASE SEVERITY; DOG; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HISTOPATHOLOGY; LABORATORY TEST; LYMPHADENOPATHY; LYMPHOID TISSUE; MALE; NAIL DISEASE; NONHUMAN; ONYCHOGRYPOSIS; REAL TIME POLYMERASE CHAIN REACTION; SPLEEN DISEASE; ULCER; VISCERAL LEISHMANIASIS;

ANIMALS; BIOLOGICAL MARKERS; DNA, PROTOZOAN; DOG DISEASES; DOGS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; LEISHMANIA INFANTUM; LEISHMANIASIS, VISCERAL; MALE; REAL-TIME POLYMERASE CHAIN REACTION; SPLEEN;

EID: 84894619391     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0087742     Document Type: Article

References (38)

1. Steiniger B, Barth P (1999) Microanatomy and function of the spleen; Beck F, Brown D, Christ B, Kriz W, Marani E et al., editors. Berlin: Springer Verlag. 101 p.
2. Mebius RE, Kraal G (2005) Structure and function of the spleen. Nat Rev Immunol 5: 606-616. (Pubitemid 41113192)
3. Cesta MF (2006) Normal structure, function, and histology of the spleen. Toxicol Pathol 34: 455-465.
4. Kraal G, Mebius R (2006) New insights into the cell biology of the marginal zone of the spleen. Int Rev Cytol 250: 175-215. (Pubitemid 44067206)
5. Lester SJ, Hume JB, Phipps B (1995) Haemobartonella canis infection following splenectomy and transfusion. Can Vet J 36: 444-445.
6. Kemming G, Messick JB, Mueller W, Enders G, Meisner F, et al. (2004) Can we continue research in splenectomized dogs? Mycoplasma haemocanis: old problem-new insight. Eur Surg Res 36: 198-205. (Pubitemid 38976516)
7. Hansen K, Singer DB (2001) Asplenic-hyposplenic overwhelming sepsis: postsplenectomy sepsis revisited. Pediatr Dev Pathol 4: 105-121. (Pubitemid 32154968)
8. Benedict CA, De Trez C, Schneider K, Ha S, Patterson G, et al. (2006) Specific Remodeling of Splenic Architecture by Cytomegalovirus. PLoS Pathog 2: e16.
9. Veress B, Abdalla RE, El Hassan AM (1983) Visceral spreading depletion of thymus-dependent regions and amyloidosis in mice and hamsters infected intradermally with Leishmania isolated from Sudanese cutaneous leishmaniasis. Br J Exp Pathol 64: 505-514. (Pubitemid 14205474)
10. Engwerda CR, Ato M, Cotterell SE, Mynott TL, Tschannerl A, et al. (2002) A role for tumor necrosis factor-alpha in remodeling the splenic marginal zone during Leishmania donovani infection. Am J Pathol 161: 429-437. (Pubitemid 36142152)
11. Kumagai K, Yamaguchi R, Uchida K, Tateyama S (2004) Lymphoid apoptosis in acute canine distemper. J Vet Med Sci 66: 175-181. (Pubitemid 41380333)
12. Santana CC, Vassallo J, de Freitas LA, Oliveira GG, Pontes-de-Carvalho LC, et al. (2008) Inflammation and structural changes of splenic lymphoid tissue in visceral leishmaniasis: a study on naturally infected dogs. Parasite Immunol 30: 515-524.
13. Silva JS, Andrade AC, Santana CC, Santos LQ, Oliveira CI, et al. (2012) Low CXCL13 expression, splenic lymphoid tissue atrophy and germinal center disruption in severe canine visceral leishmaniasis. PLoS One 7: e29103.
14. Paxian S, Merkle H, Riemann M, Wilda M, Adler G, et al. (2002) Abnormal organogenesis of Peyer's patches in mice deficient for NF-kappaB1, NF-kappaB2, and Bcl-3. Gastroenterology 122: 1853-1868. (Pubitemid 34651430)
15. Aust G, Sittig D, Becherer L, Anderegg U, Schutz A, et al. (2004) The role of CXCR5 and its ligand CXCL13 in the compartmentalization of lymphocytes in thyroids affected by autoimmune thyroid diseases. Eur J Endocrinol 150: 225-234. (Pubitemid 38312815)
16. Henry RA, Kendall PL (2010) CXCL13 blockade disrupts B lymphocyte organization in tertiary lymphoid structures without altering B cell receptor bias or preventing diabetes in nonobese diabetic mice. J Immunol 185: 1460-1465.
17. de Lima VM, Fattori KR, de Souza F, Eugenio FR, dos Santos PS, et al. (2012) Apoptosis in T lymphocytes from spleen tissue and peripheral blood of L. (L.) chagasi naturally infected dogs. Vet Parasitol 184: 147-153.
18. Barrouin-Melo SM, Larangeira DF, de Andrade Filho FA, Trigo J, Juliao FS, et al. (2006) Can spleen aspirations be safely used for the parasitological diagnosis of canine visceral leishmaniosis? A study on assymptomatic and polysymptomatic animals. Vet J 171: 331-339.
19. Barrouin-Melo SM, Larangeira DF, Santos SO, Chagas-Junior AD, Paixao M, et al. (2006) A standardized cytological and immunochemical method for the analysis of fine-needle spleen aspirates: assessment of leukocyte population changes in canine visceral leishmaniosis. Vet Immunol Immunopathol 111: 251-261.
20. Ministério da Saúde do Brasil S (2006) Manual de vigilância e controle da leishmaniose visceral: Ministério da Saúde - Secretaria de Vigilância em Saúde.
21. Dos-Santos WL, Jesus EE, Paranhos-Silva M, Pereira AM, Santos JC, et al. (2008) Associations among immunological, parasitological and clinical parameters in canine visceral leishmaniasis: Emaciation, spleen parasitism, specific antibodies and leishmanin skin test reaction. Vet Immunol Immunopathol 123: 251-259.
22. Francino O, Altet L, Sanchez-Robert E, Rodriguez A, Solano-Gallego L, et al. (2006) Advantages of real-time PCR assay for diagnosis and monitoring of canine leishmaniosis. Vet Parasitol 137: 214-221.
23. Kirkwood B, Sterne J (2001) Essentials of medical statistics. Malden, MA, USA: Wiley-Blackwell.
24. Paranhos-Silva M, Oliveira GG, Reis EA, de Menezes RM, Fernandes O, et al. (2003) A follow-up of Beagle dogs intradermally infected with Leishmania chagasi in the presence or absence of sand fly saliva. Vet Parasitol 114: 97-111. (Pubitemid 36645010)
25. Fraga DB, Solca MS, Silva VM, Borja LS, Nascimento EG, et al. (2012) Temporal distribution of positive results of tests for detecting Leishmania infection in stray dogs of an endemic area of visceral leishmaniasis in the Brazilian tropics: a 13 years survey and association with human disease. Vet Parasitol 190: 591-594.
26. Berrahal F, Mary C, Roze M, Berenger A, Escoffier K, et al. (1996) Canine leishmaniasis: identification of asymptomatic carriers by polymerase chain reaction and immunoblotting. Am J Trop Med Hyg 55: 273-277. (Pubitemid 26321831)
27. Lima WG, Michalick MS, Melo MN, Tafuri WL (2004) Canine visceral leishmaniasis: a histopathological study of lymph nodes. Acta Trop 92: 43-53. (Pubitemid 39056000)
28. Corbett CE, Paes RA, Laurenti MD, Andrade Junior HF, Duarte MI (1992) Histopathology of lymphoid organs in experimental leishmaniasis. Int J Exp Pathol 73: 417-433.
29. Keenan CM, Hendricks LD, Lightner L, Johnson AJ (1984) Visceral leishmaniasis in the German shepherd dog. II. Pathology. Vet Pathol 21: 80-86.
30. Veress B, Omer A, Satir AA, El Hassan AM (1977) Morphology of the spleen and lymph nodes in fatal visceral leishmaniasis. Immunology 33: 605-610. (Pubitemid 8199185)
31. Giunchetti RC, Martins-Filho OA, Carneiro CM, Mayrink W, Marques MJ, et al. (2008) Histopathology, parasite density and cell phenotypes of the popliteal lymph node in canine visceral leishmaniasis. Vet Immunol Immunopathol 121: 23-33. (Pubitemid 350235648)
32. Carrion J, Nieto A, Iborra S, Iniesta V, Soto M, et al. (2006) Immunohistological features of visceral leishmaniasis in BALB/c mice. Parasite Immunol 28: 173-183.
33. Smelt SC, Engwerda CR, McCrossen M, Kaye PM (1997) Destruction of follicular dendritic cells during chronic visceral leishmaniasis. J Immunol 158: 3813-3821. (Pubitemid 127488739)
34. Karlsson MC, Guinamard R, Bolland S, Sankala M, Steinman RM, et al. (2003) Macrophages control the retention and trafficking of B lymphocytes in the splenic marginal zone. J Exp Med 198: 333-340. (Pubitemid 36987858)
35. Ikezawa F, Fukatsu K, Moriya T, Ueno C, Maeshima Y, et al. (2008) Reversal of parenteral nutrition-induced gut mucosal immunity impairment with small amounts of a complex enteral diet. J Trauma 65: 360-365; discussion 366.
36. McCullough B, Krakowka S, Koestner A (1974) Experimental canine distemper virus-induced lymphoid depletion. Am J Pathol 74: 155-170.
37. Stevens DR, Osburn BI (1976) Immune deficiency in a dog with distemper. J Am Vet Med Assoc 168: 493-498.
38. Andrade TM, Carvalho EM, Rocha H (1990) Bacterial infections in patients with visceral leishmaniasis. J Infect Dis 162: 1354-1359.