NUT midline carcinoma

Nature Reviews Cancer

Volumn 14, Issue 3, 2014, Pages 149-150

  French, Christopher ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRD4 PROTEIN, HUMAN; NUCLEAR PROTEIN; NUT PROTEIN, HUMAN; ONCOPROTEIN; TRANSCRIPTION FACTOR;

CARCINOMA, SQUAMOUS CELL; GENE FUSION; GENE REARRANGEMENT; GENETICS; HUMAN; PATHOLOGY;

CARCINOMA, SQUAMOUS CELL; GENE FUSION; GENE REARRANGEMENT; HUMANS; NUCLEAR PROTEINS; ONCOGENE PROTEINS; TRANSCRIPTION FACTORS;

EID: 84894594808     PISSN: 1474175X     EISSN: 14741768     Source Type: Journal    
DOI: 10.1038/nrc3659     Document Type: Review

References (7)

1. French, C. A. et al. BRD-NUT oncoproteins: a family of closely related nuclear proteins that block epithelial differentiation and maintain the growth of carcinoma cells. Oncogene 27, 2237-2242 (2008).
2. Bauer, D. et al. Clinicopathologic features and long-term outcomes of NUT midline carcinoma. Clin. Cancer Res. 18, 5773-5779 (2012).
3. Haack, H. et al. Diagnosis of NUT midline carcinoma using a NUT-specific monoclonal antibody. Am. J. Surg. Pathol. 33, 984-991 (2009).
4. Filippakopoulos, P. et al. Selective inhibition of BET bromodomains. Nature 468, 1067-1073 (2010).
5. Reynoird, N. et al. Oncogenesis by sequestration of CBP/p300 in transcriptionally inactive hyperacetylated chromatin domains. EMBO J. 29, 2943-2952 (2010).
6. Grayson, A. R. et al. MYC, a downstream target of BRD-NUT, is necessary and sufficient for the blockade of differentiation in NUT midline carcinoma. Oncogene http://dx.doi.org/10.1038/onc.2013.126 (2013).
7. Schwartz, B. E. et al. Differentiation of NUT midline carcinoma by epigenomic reprogramming. Cancer Res. 71, 2686-2696 (2011).