Detection of enterovirus in the islet cells of patients with type 1 diabetes: What do we learn from immunohistochemistry? Reply to Hansson SF, Korsgren S, Pontén F et al [letter]

Diabetologia

Volumn 57, Issue 3, 2014, Pages 647-649

  Richardson, Sarah J ^a   Leete, Pia ^a   Dhayal, Shalinee ^a   Russell, Mark A ^a   Oikarinen, Maarit ^b   Laiho, Jutta E ^b   Svedin, Emma ^c   Lind, Katharina ^c   Rosenling, Therese ^d   Chapman, Nora ^e   Bone, Adrian J ^f   Foulis, Alan K ^g   Frisk, Gun ^d   Flodström Tullberg, Malin ^c   Hober, Didier ^h   Hyoty, Heikki ^b,i   Pugliese, Alberto ^j   Morgan, Noel G ^a  

^a UNIVERSITY OF EXETER MEDICAL SCHOOL   (United Kingdom)

^b TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^c KAROLINSKA INSTITUTE   (Sweden)

^d UPPSALA UNIVERSITY   (Sweden)

^e UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^f UNIVERSITY OF BRIGHTON   (United Kingdom)

^g SOUTHERN GENERAL HOSPITAL   (United Kingdom)

^h University Lille   (France)

ⁱ FIMLAB LABORATORIES   (Finland)

^j UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

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Author keywords

ATP5B; Beta cell; Clone 5D8 1; Coxsackievirus; Creatine kinase B; Islet; VP1

Indexed keywords

CAPSID PROTEIN; MONOCLONAL ANTIBODY; OLIGOPEPTIDE;

ENTEROVIRUS; ENTEROVIRUS INFECTION; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; INSULIN DEPENDENT DIABETES MELLITUS; MALE; METABOLISM; PANCREAS; PROCEDURES;

ANTIBODIES, MONOCLONAL; CAPSID PROTEINS; DIABETES MELLITUS, TYPE 1; ENTEROVIRUS; ENTEROVIRUS INFECTIONS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; OLIGOPEPTIDES; PANCREAS;

EID: 84894573643     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-014-3167-2     Document Type: Letter

References (8)

1. Hansson SF, Korsgren S, Pontén F, Korsgren O (2013) Detection of enterovirus in the islet cells of patients with type 1 diabetes: what do we learn from immunohistochemistry? Diabetologia. doi: 10.1007/s00125-013-3138-z
2. Richardson SJ, Leete P, Dhayal S et al (2013) Evaluation of the fidelity of immunolabelling obtained with clone 5D8/1, a monoclonal antibody directed against the enteroviral capsid protein, VP1, in human pancreas. Diabetologia. doi: 10.1007/s00125-013-3094-7
3. Campbell-Thompson M, Wasserfall C, Kaddis J et al (2012) Network for Pancreatic Organ Donors with Diabetes (nPOD): developing a tissue biobank for type 1 diabetes. Diabetes Metab Res Rev 28:608-617
4. Richardson SJ, Willcox A, Bone AJ, Foulis AK, Morgan NG (2009) The prevalence of enteroviral capsid protein vp1 immunostaining in pancreatic islets in human type 1 diabetes. Diabetologia 52:1143-1151
5. Flodström M, Maday A, Balakrishna D, Cleary MM, Yoshimura A, Sarvetnick N (2002) Target cell defense prevents the development of diabetes after viral infection. Nat Immunol 3:373-382
6. Flodström-Tullberg M, Hultcrantz M, Stotland A et al (2005) RNase L and double-stranded RNA-dependent protein kinase exert complementary roles in islet cell defense during coxsackievirus infection. J Immunol 174:1171-1177
7. Hansson SF, Korsgren S, Pontén F, Korsgren O (2013) Enteroviruses and the pathogenesis of type 1 diabetes revisited: cross-reactivity of enterovirus capsid protein (VP1) antibodies with human mitochondrial proteins. J Pathol 229:719-728
8. Sistermans EA, de Kok YJM, Peters W, Ginsel LA, Jap PHK, Wieringa B (1995) Tissue- and cell-specific distribution of creatine kinase B: a new highly specific monoclonal antibody for use in immunohistochemistry. Cell Tissue Res 280:435-446